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1. 发明授权

US09416173B2 Peptide and conjugate vaccines for fungal infections 有权
标题翻译：用于真菌感染的肽和缀合疫苗
公开(公告)号：US09416173B2
公开(公告)日：2016-08-16
申请号：US14112561
申请日：2012-04-20
申请人： Hong Xin , Jim E. Cutler
发明人： Hong Xin , Jim E. Cutler
IPC分类号： A61K39/00 , C07K16/14 , C07K14/40 , C07K16/40 , A61K47/48
CPC分类号： C07K16/14 , A61K39/0002 , A61K47/6415 , A61K47/646 , A61K2039/505 , A61K2039/5158 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/6037 , C07K14/40 , C07K16/40 , C07K2319/00
摘要： Several new peptides have been developed that show effectiveness as vaccines against candidiasis and other fungal diseases. A new conjugate vaccine of a β-mannotriose linked to a fungal peptide linked to tetanus toxin has been shown to be effective as a vaccine with or without use of an adjuvant. In addition, a monoclonal antibody has been identified that offers protection from a Candida infection.
摘要翻译：已经开发了几种新的肽，其显示出作为针对念珠菌病和其它真菌疾病的疫苗的有效性。已经显示与连接到破伤风毒素的真菌肽连接的β-甘露三糖的新缀合疫苗作为具有或不使用佐剂的疫苗是有效的。此外，已经鉴定出提供针对念珠菌感染的保护的单克隆抗体。

2. 发明授权

US08947392B2 Multi-driver touch panel 有权
标题翻译：多驱动器触摸面板
公开(公告)号：US08947392B2
公开(公告)日：2015-02-03
申请号：US12928452
申请日：2010-12-10
申请人： Ding Hua Long , Hong Xin Mo
发明人： Ding Hua Long , Hong Xin Mo
IPC分类号： G06F3/045 , G06F3/044
CPC分类号： G06F3/044
摘要： A novel capacitive touch system includes a first controller having a plurality of channels, a first sensor row having a first discrete sensor element and a second discrete sensor element, a second sensor row having a first discrete sensor element and a second discrete sensor element, a first sensor column, a second sensor column, and a first signal line electrically coupling one of the plurality of channels of the controller to both the first and second discrete sensor elements of the first sensor row. In a particular embodiment, the first controller includes a second channel electrically connected to both the first and second discrete sensor elements of the second sensor row. In another particular embodiment, the capacitive touch system includes a second controller having a plurality of channels, the first sensor column includes a first discrete sensor element and a second discrete sensor element, and a first channel of the second controller is electrically coupled to both the first and second discrete sensor elements of the first sensor column.
摘要翻译：一种新颖的电容触摸系统包括具有多个通道的第一控制器，具有第一离散传感器元件和第二离散传感器元件的第一传感器行，具有第一离散传感器元件和第二离散传感器元件的第二传感器行，第一传感器列，第二传感器列和将控制器的多个通道中的一个电气耦合到第一传感器行的第一和第二离散传感器元件的第一信号线。在特定实施例中，第一控制器包括电连接到第二传感器行的第一和第二离散传感器元件的第二通道。在另一特定实施例中，电容式触摸系统包括具有多个通道的第二控制器，第一传感器列包括第一离散传感器元件和第二离散传感器元件，并且第二控制器的第一通道电耦合到第一传感器列的第一和第二离散传感器元件。

3. 发明申请

US20110181543A1 Multi-driver touch panel 有权
标题翻译：多驱动器触摸面板
公开(公告)号：US20110181543A1
公开(公告)日：2011-07-28
申请号：US12928452
申请日：2010-12-10
申请人： Ding Hua Long , Hong Xin Mo
发明人： Ding Hua Long , Hong Xin Mo
IPC分类号： G06F3/045
CPC分类号： G06F3/044
摘要： A novel capacitive touch system includes a first controller having a plurality of channels, a first sensor row having a first discrete sensor element and a second discrete sensor element, a second sensor row having a first discrete sensor element and a second discrete sensor element, a first sensor column, a second sensor column, and a first signal line electrically coupling one of the plurality of channels of the controller to both the first and second discrete sensor elements of the first sensor row. In a particular embodiment, the first controller includes a second channel electrically connected to both the first and second discrete sensor elements of the second sensor row. In another particular embodiment, the capacitive touch system includes a second controller having a plurality of channels, the first sensor column includes a first discrete sensor element and a second discrete sensor element, and a first channel of the second controller is electrically coupled to both the first and second discrete sensor elements of the first sensor column.
摘要翻译：一种新颖的电容触摸系统包括具有多个通道的第一控制器，具有第一离散传感器元件和第二离散传感器元件的第一传感器行，具有第一离散传感器元件和第二离散传感器元件的第二传感器行，第一传感器列，第二传感器列和将控制器的多个通道中的一个电气耦合到第一传感器行的第一和第二离散传感器元件的第一信号线。在特定实施例中，第一控制器包括电连接到第二传感器行的第一和第二离散传感器元件的第二通道。在另一特定实施例中，电容式触摸系统包括具有多个通道的第二控制器，第一传感器列包括第一离散传感器元件和第二离散传感器元件，并且第二控制器的第一通道电耦合到第一传感器列的第一和第二离散传感器元件。

4. 发明申请

US20100217057A1 ZSM-5, ITS PREPARATION AND USE IN ETHYLBENZENE DEALKYLATION 有权
标题翻译： ZSM-5，其制备和用于乙二醇处理
公开(公告)号：US20100217057A1
公开(公告)日：2010-08-26
申请号：US12677009
申请日：2008-09-10
申请人： László Domokos , Ralph Haswell , Hong-Xin Li
发明人： László Domokos , Ralph Haswell , Hong-Xin Li
IPC分类号： C07C4/12 , C01B39/02 , B01J29/06 , B01J29/46 , B01J29/40 , B01J29/44
CPC分类号： B01J29/46 , B01J29/40 , B01J29/405 , B01J29/44 , B01J37/0009 , B01J2229/16 , B01J2229/20 , B01J2229/42 , C01B39/38 , C01B39/40 , C07C4/18 , C07C2529/40 , C07C2529/42 , C07C2529/44 , C07C2529/46 , C07C2529/48 , Y02P20/52 , C07C15/08
摘要： A new configuration of ZSM-5 is provided whereby the crystals have a higher average silica to alumina ratio at the edges of each crystallite than in the centre as determined from a narrow slit line scan profile obtained from SEM/EDX or TEM/EDX elemental analysis. Such ZSM-5 crystals are obtained by a preparation process using L-tartaric acid. The new configuration ZSM-5 provides significantly reduced xylene losses in ethylbenzene dealkylation, especially when combined with silica as binder, and one or more hydrogenation metals selected from platinum, tin, lead, silver, copper, and nickel. Further advantages are found if used in combination with a small crystal size ZSM-5.
摘要翻译：提供了一种ZSM-5的新结构，由此，从SEM / EDX或TEM / EDX元素分析得到的窄缝线扫描轮廓确定，晶体在每个微晶边缘处的平均二氧化硅与氧化铝之比高于中心。通过使用L-酒石酸的制备方法获得这样的ZSM-5晶体。新配置ZSM-5在乙苯脱烷基化中显着降低二甲苯损失，特别是当与二氧化硅作为粘合剂组合时，以及一种或多种选自铂，锡，铅，银，铜和镍的氢化金属。如果与小型晶体尺寸的ZSM-5结合使用，可以发现更多的优点。

5. 发明申请

US20100092362A1 HIGH SILICA CHABAZITE FOR SELECTIVE CATALYTIC REDUCTION, METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于选择性催化还原的高二氧化硅，制备和使用它们的方法
公开(公告)号：US20100092362A1
公开(公告)日：2010-04-15
申请号：US12641201
申请日：2009-12-17
申请人： Hong-Xin LI , William E. Cormier , Bjorn Moden
发明人： Hong-Xin LI , William E. Cormier , Bjorn Moden
IPC分类号： B01D53/94 , B01J29/06 , B01J29/072
CPC分类号： B01D53/9418 , B01D2251/2062 , B01D2251/2067 , B01D2255/20738 , B01D2255/20761 , B01D2255/50 , B01D2255/92 , B01D2255/9205 , B01D2255/9207 , B01J29/7015 , B01J29/763 , B01J29/85 , B01J35/002 , B01J35/023 , B01J35/1023 , B01J35/1038 , B01J37/0201 , B01J37/10 , B01J2229/18 , B01J2229/186
摘要： There is disclosed a microporous crystalline material comprising a metal containing chabazite having a crystal size greater than 0.5 microns and a silica-to-alumina ratio (SAR) greater than 15, wherein the metal containing chabazite retains at least 80% of its initial surface area and micropore volume after exposure to temperatures of up to 900° C. in the presence of up to 10 volume percent water vapor for up to 1 hour. Methods of using the disclosed crystalline material, such as in the SCR of NOx in exhaust gas are also disclosed, as are methods of making such materials.
摘要翻译：公开了一种微孔结晶材料，其包含具有大于0.5微米的晶体尺寸和大于15的二氧化硅 - 氧化铝比（SAR）的含金属的菱沸石，其中含金属的菱沸石保留其初始表面积的至少80％在高达10体积％的水蒸汽存在下长达1小时，暴露于高达900℃的温度下的微孔体积。还公开了使用所公开的结晶材料的方法，例如在排气中的NOx的SCR中，以及制造这种材料的方法。

6. 发明申请

US20080287309A1 Methods for Discovering Antibodies Specific to Cancer Cells and Antibodies Discovered Thereby 审中-公开
标题翻译：发现癌细胞和抗体特异性抗体的方法
公开(公告)号：US20080287309A1
公开(公告)日：2008-11-20
申请号：US11631911
申请日：2005-07-08
申请人： Katherine S. Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
发明人： Katherine S. Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
IPC分类号： C40B30/04 , A01N1/02 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C07K14/4748 , A61K2039/5152 , C07K16/28 , C07K16/2842 , C07K16/2845 , C07K16/2848 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/55 , C07K2317/56 , C07K2317/565
摘要： This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for identifying antibodies which bind to cancer cells, but which do not bind to human red blood cells, white blood cells or normal tissue cells. Antibodies of the disclosure can be used for therapeutic and/or diagnostic purposes.
摘要翻译：本公开涉及从不同抗体群体中选择具有所需特征的抗体的方法。更具体地，本公开提供了用于鉴定结合癌细胞但不结合人红细胞，白细胞或正常组织细胞的抗体的方法。本公开的抗体可用于治疗和/或诊断目的。

7. 发明申请

US20080008719A1 Methods and compositions for the treatment of prostate cancer 审中-公开
标题翻译：用于治疗前列腺癌的方法和组合物
公开(公告)号：US20080008719A1
公开(公告)日：2008-01-10
申请号：US11789556
申请日：2007-04-24
申请人： Katherine Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
发明人： Katherine Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
IPC分类号： A61K39/395 , A61P35/00 , C07K16/18
CPC分类号： C07K16/3069 , A61K39/39558 , C07K16/30 , C07K2317/55 , C07K2317/565 , C07K2317/77
摘要： The present application relates to methods and compositions for the treatment of cancer. In specific embodiments, the application relates to the use of antibodies capable of modulating CDCP1 as therapeutic agents for the treatment of cancer and as diagnostic agents for the detection of and/or prognosis of cancer.
摘要翻译：本申请涉及用于治疗癌症的方法和组合物。在具体实施方案中，本申请涉及能够调节CDCP1作为治疗癌症的治疗剂的抗体的使用以及用于癌症的检测和/或预后的诊断剂。

8. 发明申请

US20050033091A1 N-methylated amines from selective vapor phase amination of amino ether alcohols 失效
标题翻译：来自氨基醚醇的选择性气相胺化的N-甲基化胺
公开(公告)号：US20050033091A1
公开(公告)日：2005-02-10
申请号：US10634516
申请日：2003-08-04
申请人： John Mitchell , Richard Underwood , Michael Ford , Gamini Vedage , Hong-Xin Li
发明人： John Mitchell , Richard Underwood , Michael Ford , Gamini Vedage , Hong-Xin Li
IPC分类号： C07C213/08 , C07B61/00 , C07C213/02 , C07C213/10 , C07C217/08 , C07C217/42
CPC分类号： C07C213/02 , C07C217/08
摘要： A method for converting amino ether alcohols to amino ether amines by amination in the vapor phase with a catalyst comprising copper and zinc. The catalyst may also comprise an alkali, alkaline earth, or lanthanide element as a promoter.
摘要翻译：通过在含有铜和锌的催化剂的气相中胺化将氨基醚醇转化为氨基醚胺的方法。催化剂还可以包含作为助催化剂的碱金属，碱土金属或镧系元素。

9. 发明授权

US6150559A Process for the production of bis (N,N-dialkylaminoalkyl) ether 失效
标题翻译：制备双（N，N-二烷基氨基烷基）醚的方法
公开(公告)号：US6150559A
公开(公告)日：2000-11-21
申请号：US431912
申请日：1999-11-02
申请人： Richard Paul Underwood , Hong-Xin Li
发明人： Richard Paul Underwood , Hong-Xin Li
IPC分类号： C07C213/06 , C07C217/08 , C07C85/24
CPC分类号： C07C213/06
摘要： An improved process for the production of bis (N,N-dialkylaminoalkyl)ether having the formula (R.sub.2 NR').sub.2 O, wherein R is methyl or ethyl and R' is ethyl or propyl, by reacting vaporized N,N-dialkylaminoalkanol of the formula R.sub.2 NR'OH, wherein R and R' are as defined above, in the presence of a heterogeneous solid basic catalyst. The bis (N,N-dialkylaminoalkyl)ether compounds, especially bis (N,N-dimethylamino)ethyl ether, are useful in the production of polyurethane foams.
摘要翻译：制备式（R2NR'）2O的双（N，N-二烷基氨基烷基）醚的改进方法，其中R是甲基或乙基，R'是乙基或丙基，通过使式 R2NR'OH，其中R和R'如上定义，在非均相固体碱性催化剂存在下。双（N，N-二烷基氨基烷基）醚化合物，特别是双（N，N-二甲基氨基）乙醚，可用于生产聚氨酯泡沫体。

10. 发明授权

US5756741A Process for the production of triethylenediamine 失效
标题翻译：三亚乙基二胺生产工艺
公开(公告)号：US5756741A
公开(公告)日：1998-05-26
申请号：US751142
申请日：1996-11-15
申请人： John Nelson Armor , Jose Guadalupe Santiesteban , Hong-Xin Li
发明人： John Nelson Armor , Jose Guadalupe Santiesteban , Hong-Xin Li
IPC分类号： B01J29/40 , C07B61/00 , C07C209/60 , C07C209/62 , C07C211/09 , C07D487/08
CPC分类号： C07D487/08
摘要： A process for preparing triethylenediamine by passing an amine compound over a catalyst at elevated temperature to afford a reaction product containing triethylenediamine and piperazine, the amine compound having, in the molecule, a moiety represented by the following general formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and X is oxygen or nitrogen characterized by adding an ethylating compound containing at least one nitrogen and/or oxygen atom to the reaction product and contacting the reaction product, under conditions sufficient to produce triethylenediamine from the ethylating compound and piperazine, with a condensation/cyclization shape-selective zeolite catalyst demonstrating a triethylenediamine/piperazine weight ratio uptake value of at least 6:1.
摘要翻译：一种通过使胺化合物在升高的温度下通过催化剂制备三亚乙基二胺的方法，得到含有三亚乙基二胺和哌嗪的反应产物，所述胺化合物在分子中具有由以下通式表示的部分，其中R1，R2 R 3和R 4独立地是氢原子或具有1至4个碳原子的烷基，X是氧或氮，其特征在于向反应产物中加入含有至少一个氮原子和/或氧原子的乙基化合物，并使反应产物在足以从乙基化合物和哌嗪产生三亚乙基二胺的条件下，使用缩合/环化形状选择性沸石催化剂，证明三亚乙基二胺/哌嗪的重量比吸收值至少为6:1。

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