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1. 发明授权

US4885503A Color cathode-ray tube 失效
标题翻译：彩色阴极射线管
公开(公告)号：US4885503A
公开(公告)日：1989-12-05
申请号：US272065
申请日：1988-11-16
申请人： Eiki Takahashi , Masahiro Miyazaki , Kiyoshi Nakamura
发明人： Eiki Takahashi , Masahiro Miyazaki , Kiyoshi Nakamura
IPC分类号： H01J29/48
CPC分类号： H01J29/484 , H01J2229/882
摘要： A particle shielding element of a shape memory metal is installed between an electroconductive layer on the inner peripheral surface of a neck glass tube of a cathode-ray tube and a shield cup of an electron gun therein to close a gap between the neck glass tube and the shield cup for thereby guarding the electronic gun against invasion of particles, Before the particle shielding element is inserted into the neck glass tube, the element is deformed to reduce its outer diameter so that the element can be inserted into the neck glass tube without scratching the electroconductive layer. After the element has been installed in Position in the neck glass tube, the temperature therein is adjusted to cause the element to recovery to its initial shape into dust sealing engagement with the electroconductive layer.
摘要翻译：形状记忆金属的粒子屏蔽元件安装在阴极射线管的颈部玻璃管的内周面上的导电层和电子枪的屏蔽杯之间，以封闭颈部玻璃管与颈部玻璃管之间的间隙屏蔽杯，从而防止电子枪侵入颗粒。在将颗粒屏蔽元件插入颈部玻璃管之前，元件变形以减小其外径，使得元件可以插入颈部玻璃管而不会刮伤导电层。在元件已经安装在颈部玻璃管中的位置之后，调节其中的温度以使元件恢复到其初始形状，使其与导电层成灰尘密封接合。

2. 发明申请

US20100333216A1 Non-human gene-disrupted animal with disrupted Adam11 gene 失效
标题翻译：非人基因破坏动物与Adam11基因被破坏
公开(公告)号：US20100333216A1
公开(公告)日：2010-12-30
申请号：US11988619
申请日：2006-07-12
申请人： Koji Sagane , Eiki Takahashi , Kazuto Yamazaki , Turo Oki
发明人： Koji Sagane , Eiki Takahashi , Kazuto Yamazaki , Turo Oki
IPC分类号： G01N33/00 , A01K67/00 , A01K67/027 , C12N5/16 , C12N5/18 , C12N15/873 , A61K38/48 , C12N9/50 , C12N15/85 , A61K31/7088 , A61P25/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K38/00 , C12N9/6489 , C12N15/8509 , G01N33/5088
摘要： It is an object of the present invention to provide a non-human gene-disrupted animal with a disrupted ADAM11 gene. According to the present invention, a non-human gene-disrupted animal, wherein either one of or both alleles of an ADAM11 gene are disrupted, is provided.
摘要翻译：本发明的目的是提供具有破坏的ADAM11基因的非人基因破坏的动物。根据本发明，提供了非人基因破坏的动物，其中ADAM11基因的一个或两个等位基因被破坏。

3. 发明授权

US07067714B1 N-calcium channel knockout animal 有权
标题翻译： N-钙通道敲除动物
公开(公告)号：US07067714B1
公开(公告)日：2006-06-27
申请号：US10111827
申请日：2000-10-26
申请人： Mitsuhiro Ino , Norimasa Miyamoto , Eiki Takahashi , Toru Oki , Takashi Yoshinaga , Shinji Hatakeyama , Tetsuhiro Niidome , Kohei Sawada , Yukio Nishizawa , Isao Tanaka
发明人： Mitsuhiro Ino , Norimasa Miyamoto , Eiki Takahashi , Toru Oki , Takashi Yoshinaga , Shinji Hatakeyama , Tetsuhiro Niidome , Kohei Sawada , Yukio Nishizawa , Isao Tanaka
IPC分类号： G01N33/00 , A01K67/00 , A01K67/003 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/035 , A01K2267/0375
摘要： A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological action on blood pressure control, transmission of pain, blood sugar level control and so forth by using the animal.
摘要翻译：其中编码N型钙通道的基因被破坏以缺乏功能性N型钙通道的非人动物，以及用于筛选具有对血压控制，传播疼痛，血液的药理作用的物质的方法糖水平控制等等。

4. 发明授权

US08309792B2 Non-human gene-disrupted animal with disrupted ADAM11 gene 失效
标题翻译：具有破坏的ADAM11基因的非人基因破坏的动物
公开(公告)号：US08309792B2
公开(公告)日：2012-11-13
申请号：US11988619
申请日：2006-07-12
申请人： Koji Sagane , Eiki Takahashi , Kazuto Yamazaki , Turo Oki
发明人： Koji Sagane , Eiki Takahashi , Kazuto Yamazaki , Turo Oki
IPC分类号： A01K67/027 , C12N15/00 , G01N30/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K38/00 , C12N9/6489 , C12N15/8509 , G01N33/5088
摘要： It is an object of the present invention to provide a non-human gene-disrupted animal with a disrupted ADAM11 gene. According to the present invention, a non-human gene-disrupted animal, wherein either one of or both alleles of an ADAM11 gene are disrupted, is provided.
摘要翻译：本发明的目的是提供具有破坏的ADAM11基因的非人基因破坏的动物。根据本发明，提供了非人基因破坏的动物，其中ADAM11基因的一个或两个等位基因被破坏。

5. 发明授权

US07148011B2 Method of testing for allergic diseases 失效
标题翻译：过敏性疾病检测方法
公开(公告)号：US07148011B2
公开(公告)日：2006-12-12
申请号：US10380254
申请日：2001-09-21
申请人： Yuji Sugita , Ryoichi Hashida , Kaoru Ogawa , Tomoko Fujishima , Takeshi Nagasu , Gozoh Tsujimoto , Eiki Takahashi
发明人： Yuji Sugita , Ryoichi Hashida , Kaoru Ogawa , Tomoko Fujishima , Takeshi Nagasu , Gozoh Tsujimoto , Eiki Takahashi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： The differential display method was used to search for a gene whose expression level in eosinophils collected from patients with atopic dermatitis differs in the exacerbation stage and in the remission stage. As a result, gene “2090-05” showing a significant increase in expression in eosinophils of patients in the remission stage was isolated. This gene is usable in testing for an allergic disease and screening for a candidate compound for a therapeutic agent therefor an allergic disease.
摘要翻译：差异显示法用于寻找在特应性皮炎患者中收集的嗜酸性粒细胞的表达水平在恶化阶段和缓解期不同的基因。结果，分离出在缓解期患者嗜酸性粒细胞中表达显着增加的基因“2090-05”。该基因可用于测试过敏性疾病并筛选用于治疗剂的候选化合物用于过敏性疾病。

6. 发明授权

US5031308A Method of manufacturing multilayered printed-wiring-board 失效
标题翻译：制造多层印刷布线板的方法
公开(公告)号：US5031308A
公开(公告)日：1991-07-16
申请号：US456946
申请日：1989-12-26
申请人： Kazuo Yamashita , Eiki Takahashi , Osamu Teshigawara , Masaki Kinoshita , Takeshi Eimura , Takao Ohiwa
发明人： Kazuo Yamashita , Eiki Takahashi , Osamu Teshigawara , Masaki Kinoshita , Takeshi Eimura , Takao Ohiwa
IPC分类号： H05K1/18 , H05K3/28 , H05K3/34 , H05K3/40 , H05K3/46
CPC分类号： H05K3/462 , H05K1/182 , H05K1/185 , H05K2201/0215 , H05K2201/0305 , H05K2201/09536 , H05K2201/10666 , H05K2201/2036 , H05K2203/1189 , H05K2203/1572 , H05K3/28 , H05K3/3484 , H05K3/4038 , H05K3/4623 , Y10T29/49126 , Y10T29/49144
摘要： A method of manufacturing a mutilayered printed-wiring-board comprises attaching conductive members on conductive layers, superimposing a plurality of printed-wiring boards, and electrically connecting the conductive layers with one another by the conductive members.

7. 发明授权

US4368448A Water cooling apparatus for electric circuit elements 失效
标题翻译：电路元件用水冷却装置
公开(公告)号：US4368448A
公开(公告)日：1983-01-11
申请号：US166702
申请日：1980-07-03
申请人： Shigeo Kobayashi , Kazuo Kobayashi , Eiki Takahashi
发明人： Shigeo Kobayashi , Kazuo Kobayashi , Eiki Takahashi
IPC分类号： H01L23/34 , H01L23/36 , H01L23/473 , H01F27/10
CPC分类号： H01L23/473 , H01L2924/0002
摘要： A water cooling apparatus for an electric circuit element is disclosed in which an internal waterway is connected with an external waterway by a connector with the whole body, the forward end or the inside part of the forward end thereof alone made of an alloy containing iron, nickel and/or chromium as main components. The water cooling apparatus may further comprise a net of an alloy containing iron, nickel and chromium as main components, the net being stretched in said waterway at the inside part of the forward end of the connector.
摘要翻译：公开了一种用于电路元件的水冷却装置，其中内部水路通过连接器与外部水路连接，全连接器，其前端的前端或内侧单独由含铁的合金制成，镍和/或铬为主要成分。水冷却装置还可以包括以铁，镍和铬为主要成分的合金网，该网在连接器前端内部的所述水路中拉伸。

8. 发明申请

US20100168014A1 Screening method 审中-公开
标题翻译：筛选方法
公开(公告)号：US20100168014A1
公开(公告)日：2010-07-01
申请号：US12591105
申请日：2009-11-09
申请人： Takayuki Hida , Tomoko Sekiya , Toru Sawai , Takashi Seiki , Eiki Takahashi , Michiko Kosasa , Kokichi Harada , Toru Arai
发明人： Takayuki Hida , Tomoko Sekiya , Toru Sawai , Takashi Seiki , Eiki Takahashi , Michiko Kosasa , Kokichi Harada , Toru Arai
IPC分类号： A61K38/22 , G01N33/53
CPC分类号： A61K38/17 , G01N33/566 , G01N2500/04 , Y02A50/406
摘要： The present inventors have found that relaxin-3 has a feeding-stimulating activity, a body weight increasing activity, and fat weight increasing activity by intracerebroventricularly administering relaxin-3 to rats and observing the amount of feeding, body weight and fat weight, and so on after the administration. According to the present invention, a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing said polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of said polypeptide; a kit for said screening; and an agent which comprises a substance which inhibits expression of said polypeptide, such as a feeding-surpressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.
摘要翻译：本发明人已经发现松弛素-3具有喂养刺激活性，体重增加活性和通过脑内给予松弛素-3对大鼠的体重增加活性，观察喂养量，体重和脂肪重量等在管理之后。根据本发明，具有刺激进食，增加体重和育肥的有效作用的多肽; 含有所述多肽的治疗剂; 筛选活化或抑制所述多肽受体的化合物，物质或其盐的方法; 用于筛选的试剂盒; 以及包含抑制所述多肽表达的物质的试剂，例如饲料抑制剂，治疗肥胖症的治疗剂和治疗糖尿病的治疗剂。

9. 发明申请

US20090311185A1 Peptide having antianxiety activity and screening method therefor 审中-公开
标题翻译：具有抗焦虑活性的肽及其筛选方法
公开(公告)号：US20090311185A1
公开(公告)日：2009-12-17
申请号：US11919145
申请日：2006-04-26
申请人： Takayuki Hida , Toru Arai , Tomoko Sekiya , Eiki Takahashi , Kodo Shikata
发明人： Takayuki Hida , Toru Arai , Tomoko Sekiya , Eiki Takahashi , Kodo Shikata
IPC分类号： A61K49/00 , C07K14/64 , C12Q1/02
CPC分类号： G01N33/6896 , A61K38/2221 , C07K14/64 , G01N2500/04 , G01N2800/301
摘要： The objects of the present invention are to provide a polypeptide having an antianxiety activity; a therapeutic agent containing the polypeptide; a method for treating anxiety using the polypeptide; a method of screening for a compound capable of activating or suppressing a receptor for the polypeptide and involved in the regulation of anxiety, a salt thereof, or a hydrate of them; and a kit for the screening. There is provided an antianxiety agent containing relaxin-3.
摘要翻译：本发明的目的是提供具有抗焦虑活性的多肽; 含有该多肽的治疗剂; 使用该多肽治疗焦虑症的方法; 筛选能够激活或抑制多肽受体并参与焦虑调节的化合物，其盐或其水合物的方法; 和一个试剂盒进行筛选。提供含有松弛素-3的抗焦虑剂。

10. 发明授权

US07638490B2 Methods of affecting feeding and weight in mammals by administration of relaxin-3 失效
标题翻译：通过施用松弛素-3影响哺乳动物饲喂和体重的方法
公开(公告)号：US07638490B2
公开(公告)日：2009-12-29
申请号：US10588542
申请日：2005-02-09
申请人： Takayuki Hida , Tomoko Sekiya , Toru Sawai , Takashi Seiki , Eiki Takahashi , Michiko Kosasa , Kokichi Harada , Tohru Arai
发明人： Takayuki Hida , Tomoko Sekiya , Toru Sawai , Takashi Seiki , Eiki Takahashi , Michiko Kosasa , Kokichi Harada , Tohru Arai
IPC分类号： A61K38/00 , A01N37/18
CPC分类号： A61K38/17 , G01N33/566 , G01N2500/04 , Y02A50/406
摘要： Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.
摘要翻译：发现松弛素-3在给予松弛素-3后，通过观察饲喂量，体重和脂肪重量，通过大鼠脑室内施用，具有摄食刺激活性，体重增加活性和脂肪增加活性。本发明包括：具有刺激喂养，增加体重和育肥的有效作用的多肽; 含有该多肽的治疗剂; 筛选活化或抑制多肽受体的化合物，物质或其盐的方法; 一套筛选工具; 以及具有抑制多肽表达的物质，例如进食抑制剂，治疗肥胖症的治疗剂和用于治疗糖尿病的治疗剂的药剂。

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