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1. 发明申请

US20100168014A1 Screening method 审中-公开
标题翻译：筛选方法
公开(公告)号：US20100168014A1
公开(公告)日：2010-07-01
申请号：US12591105
申请日：2009-11-09
申请人： Takayuki Hida , Tomoko Sekiya , Toru Sawai , Takashi Seiki , Eiki Takahashi , Michiko Kosasa , Kokichi Harada , Toru Arai
发明人： Takayuki Hida , Tomoko Sekiya , Toru Sawai , Takashi Seiki , Eiki Takahashi , Michiko Kosasa , Kokichi Harada , Toru Arai
IPC分类号： A61K38/22 , G01N33/53
CPC分类号： A61K38/17 , G01N33/566 , G01N2500/04 , Y02A50/406
摘要： The present inventors have found that relaxin-3 has a feeding-stimulating activity, a body weight increasing activity, and fat weight increasing activity by intracerebroventricularly administering relaxin-3 to rats and observing the amount of feeding, body weight and fat weight, and so on after the administration. According to the present invention, a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing said polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of said polypeptide; a kit for said screening; and an agent which comprises a substance which inhibits expression of said polypeptide, such as a feeding-surpressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.
摘要翻译：本发明人已经发现松弛素-3具有喂养刺激活性，体重增加活性和通过脑内给予松弛素-3对大鼠的体重增加活性，观察喂养量，体重和脂肪重量等在管理之后。根据本发明，具有刺激进食，增加体重和育肥的有效作用的多肽; 含有所述多肽的治疗剂; 筛选活化或抑制所述多肽受体的化合物，物质或其盐的方法; 用于筛选的试剂盒; 以及包含抑制所述多肽表达的物质的试剂，例如饲料抑制剂，治疗肥胖症的治疗剂和治疗糖尿病的治疗剂。

2. 发明申请

US20090311185A1 Peptide having antianxiety activity and screening method therefor 审中-公开
标题翻译：具有抗焦虑活性的肽及其筛选方法
公开(公告)号：US20090311185A1
公开(公告)日：2009-12-17
申请号：US11919145
申请日：2006-04-26
申请人： Takayuki Hida , Toru Arai , Tomoko Sekiya , Eiki Takahashi , Kodo Shikata
发明人： Takayuki Hida , Toru Arai , Tomoko Sekiya , Eiki Takahashi , Kodo Shikata
IPC分类号： A61K49/00 , C07K14/64 , C12Q1/02
CPC分类号： G01N33/6896 , A61K38/2221 , C07K14/64 , G01N2500/04 , G01N2800/301
摘要： The objects of the present invention are to provide a polypeptide having an antianxiety activity; a therapeutic agent containing the polypeptide; a method for treating anxiety using the polypeptide; a method of screening for a compound capable of activating or suppressing a receptor for the polypeptide and involved in the regulation of anxiety, a salt thereof, or a hydrate of them; and a kit for the screening. There is provided an antianxiety agent containing relaxin-3.
摘要翻译：本发明的目的是提供具有抗焦虑活性的多肽; 含有该多肽的治疗剂; 使用该多肽治疗焦虑症的方法; 筛选能够激活或抑制多肽受体并参与焦虑调节的化合物，其盐或其水合物的方法; 和一个试剂盒进行筛选。提供含有松弛素-3的抗焦虑剂。

3. 发明授权

US08722831B2 Process for production of cross copolymers, cross copolymers obtained by the process, and use thereof 有权
标题翻译：用于生产交联共聚物的方法，通过该方法获得的交联共聚物及其用途
公开(公告)号：US08722831B2
公开(公告)日：2014-05-13
申请号：US12302818
申请日：2007-05-29
申请人： Toru Arai , Masaru Hasegawa , Ayumu Tsukamoto , Akira Miyama , Shigeru Suzuki
发明人： Toru Arai , Masaru Hasegawa , Ayumu Tsukamoto , Akira Miyama , Shigeru Suzuki
IPC分类号： C08F212/06 , C08F4/76 , C08F4/48 , C08J9/00
CPC分类号： C08F210/02 , C08F4/65912 , C08F4/6592 , C08F4/65927 , C08F110/06 , C08F212/08 , C08F255/02 , C08F295/00 , C08F297/02 , C08L23/12 , C08L25/08 , C08L53/00 , C08L53/02 , C08L55/02 , Y10T428/139 , C08L2666/04 , C08L2666/02 , C08L2666/24 , C08F2500/15 , C08F2500/20 , C08F212/36
摘要： To provide a novel cross copolymer and resin composition which are improved in heat resistance and compatibility over conventional ethylene/aromatic vinyl compound copolymers and which have low crystallinity, are excellent in softness, transparency and compatibility and show mechanical properties similar to soft vinyl chloride resins, as compared with conventional cross copolymers.A process for producing a cross copolymer, which comprises a coordination polymerization step and a subsequent anionic polymerization step, wherein in the coordination polymerization step, copolymerization of an olefin monomer, an aromatic vinyl compound monomer and an aromatic polyene is carried out by using a single-site coordination polymerization catalyst to synthesize an olefin/aromatic vinyl compound/aromatic polyene copolymer, and then, in the anionic polymerization step, polymerization is carried out in the coexistence of such an olefin/aromatic vinyl compound/aromatic polyene copolymer and an anionic polymerizable vinyl compound monomer by using an anionic polymerization initiator.
摘要翻译：为了提供与常规乙烯/芳族乙烯基化合物共聚物相比耐热性和相容性提高并且结晶度低的新型交联共聚物和树脂组合物，其柔软性，透明性和相容性优异，并且具有类似于软氯乙烯树脂的机械性能，与常规交联共聚物相比。一种制备交联共聚物的方法，其包括配位聚合步骤和随后的阴离子聚合步骤，其中在配位聚合步骤中，烯烃单体，芳族乙烯基化合物单体和芳族多烯的共聚通过使用单 - 配位聚合催化剂合成烯烃/芳族乙烯基化合物/芳族多烯共聚物，然后在阴离子聚合步骤中，聚合是在这种烯烃/芳族乙烯基化合物/芳族多烯共聚物和阴离子可聚合的共聚物共存的情况下进行的乙烯基化合物单体。

4. 发明授权

US07598694B2 Power supply apparatus 有权
标题翻译：电源设备
公开(公告)号：US07598694B2
公开(公告)日：2009-10-06
申请号：US11712679
申请日：2007-02-28
申请人： Hideo Ishii , Toru Arai
发明人： Hideo Ishii , Toru Arai
IPC分类号： G05B5/00
CPC分类号： H05K7/20209 , H02M3/00
摘要： A power supply unit includes an input-side rectifying circuit (4), an inverter (8) and an output-side rectifying circuit (12), which include power semiconductor devices. The power supply unit is powered during a powering period, and the powering is interrupted during a pausing period. The powering and pausing periods alternate. A fan (18) is driven during each powering period to cool the power semiconductor devices. A temperature detector (30) measures the temperature of the power semiconductor devices and develops a measured-temperature representative signal. A setter (38) produces a reference value, which decreases over the pausing period from the measured-temperature representative signal at the beginning of the pausing period to an intended-temperature representative signal representing the temperature to be attained by the power semiconductor devices at the end of the pausing period. The reference value is prepared from the measured-temperature representative signal at the beginning of the pausing period, the intended-temperature representative signal, and the length of the pausing period. An error amplifier (36) and a fan control unit (22) control the rotation rate of the fan (18) to make the measured-temperature representative signal track the reference value.
摘要翻译：电源单元包括输入侧整流电路（4），反相器（8）和输出侧整流电路（12），其包括功率半导体器件。电源单元在供电期间供电，并且在暂停期间中断供电。供电和暂停时段交替使用。在每个供电周期期间驱动风扇（18）以冷却功率半导体器件。温度检测器（30）测量功率半导体器件的温度并产生测量温度的代表信号。设定器（38）产生参考值，其在暂停期间从测量温度代表信号在暂停期开始时减小到预期温度代表信号，该预期温度代表信号表示功率半导体器件在暂停期结束。参考值由暂停期开始时的测量温度代表信号，预期温度代表信号和暂停时间段的长度来制备。误差放大器（36）和风扇控制单元（22）控制风扇（18）的旋转速度，使得测量温度代表信号跟踪参考值。

5. 发明申请

US20050176901A1 Process for producing polymer 有权
标题翻译：生产聚合物的方法
公开(公告)号：US20050176901A1
公开(公告)日：2005-08-11
申请号：US10486242
申请日：2002-08-06
申请人： Toru Arai , Shingo Hanazato , Masataka Nakajima
发明人： Toru Arai , Shingo Hanazato , Masataka Nakajima
IPC分类号： C08F4/642 , C08F4/659 , C08F10/00 , C08F110/02 , C08F210/16 , C08F4/44
CPC分类号： C08F10/00 , C08F4/65912 , C08F110/02 , C08F210/16 , Y10S526/943 , C08F4/65927 , C08F2500/12 , C08F2500/03 , C08F2500/01 , C08F210/14
摘要： A process for producing an olefin polymer with high polymerization activity without using an expensive co-catalyst or using a limited amount of the co-catalyst, more particularly a process for producing a high molecular weight (co)polymer with high polymerization activity even at a high polymerization temperature which is more practical. At least one olefin is polymerized by means of a polymerization catalyst comprising at least one transition metal compound selected from transition metal compounds which have a substituted indenyl group, represented by a certain specific chemical formula, and an organoaluminum compound represented by the formula Al(R)3.
摘要翻译：一种制备具有高聚合活性的烯烃聚合物的方法，而不使用昂贵的助催化剂或使用有限量的助催化剂，更具体地，即使在高催化剂下生产具有高聚合活性的高分子量（共）聚合物的方法高聚合温度更实用。至少一种烯烃通过聚合催化剂聚合，所述聚合催化剂包含至少一种选自具有取代的茚基的过渡金属化合物的过渡金属化合物，由一定的具体化学式表示，和由式Al（R ）3 。

6. 发明授权

US06666960B2 Electroplating current supply system 有权
公开(公告)号：US06666960B2
公开(公告)日：2003-12-23
申请号：US10061600
申请日：2002-02-01
申请人： Toru Arai , Makoto Sakurada , Yoshiyuki Nishioka
发明人： Toru Arai , Makoto Sakurada , Yoshiyuki Nishioka
IPC分类号： B23H714
CPC分类号： C25D17/00 , C25D5/18 , C25D21/12 , H02J1/108 , H05K3/241
摘要： An electroplating current supply system includes a power supply unit for supplying an object to be plated (4) with an electroplating current whose polarity is inverted at predetermined intervals. The power supply unit includes a first DC power supply (3A) supplying a positive current and a second power supply (3B) supplying a negative current. The system includes further a processing unit (58) for controlling the ratio in magnitude and duration of the positive current (I2) to the negative current (I1) supplied to the object so as to plate the object with a uniform coating.

7. 发明授权

US06559234B1 Cross-copolymerized olefin/styrene/diene copolymer, process for the production of the same and uses thereof 有权
标题翻译：交联共聚的烯烃/苯乙烯/二烯共聚物，其制备方法及其用途
公开(公告)号：US06559234B1
公开(公告)日：2003-05-06
申请号：US09831380
申请日：2001-05-17
申请人： Toru Arai , Masataka Nakajima , Toshiaki Otsu
发明人： Toru Arai , Masataka Nakajima , Toshiaki Otsu
IPC分类号： C08L4500
CPC分类号： C08F279/02 , C08F4/65912 , C08F4/6592 , C08F210/02 , C08F210/16 , C08J5/18 , C08J9/06 , C08J2325/08 , C08J2325/10 , C08L51/003 , C08F212/08 , C08L25/06 , C08F212/36 , C08F236/06 , C08F2500/03 , C08F2500/11 , C08F2500/12 , C08F236/08 , C08F210/14 , C08F4/65927
摘要： The present invention firstly provides a novel olefin/styrene/diene type cross-copolymer having excellent physical properties and mechanical properties, and a novel, efficient and economically excellent process for its production. Further, it provides an efficient and economically excellent process for producing various cross-copolymers such as an olefin/diene type cross-copolymer. The present invention secondly provides various resin compositions or processed products containing cross-copolymers, having problems of various conventional resin compositions or processed products solved and improved, as applications of cross-copolymers of the present invention.
摘要翻译：本发明首先提供具有优异的物理性能和机械性能的新型烯烃/苯乙烯/二烯型交联共聚物，以及一种新颖，高效和经济上优异的生产方法。此外，它提供了生产各种交联共聚物如烯烃/二烯型交联共聚物的有效且经济上优良的方法。本发明其次提供各种树脂组合物或含有交联共聚物的加工产品，其具有各种常规树脂组合物或加工产品得到解决和改进，作为本发明的交联共聚物的应用。

8. 发明授权

US06469921B2 Power supply apparatus 有权
标题翻译：电源设备
公开(公告)号：US06469921B2
公开(公告)日：2002-10-22
申请号：US09813384
申请日：2001-03-21
申请人： Toru Arai , Tetsuro Ikeda , Goro Nakano , Hideo Ishii
发明人： Toru Arai , Tetsuro Ikeda , Goro Nakano , Hideo Ishii
IPC分类号： H02M324
CPC分类号： H02M3/285
摘要： A DC voltage from a DC supply is applied to inverters of two power supply units connected in parallel with each other. The inverters convert the received DC voltages into high-frequency voltages, which are, in turn, voltage-transformed in transformers. The outputs of the transformers are rectified in two rectifiers, respectively, and smoothed in two reactors. The smoothed voltages are supplied between output terminals. The reactors are formed on a single core, being loosely coupled with each other.
摘要翻译：来自直流电源的直流电压被施加到彼此并联连接的两个电源单元的逆变器。逆变器将接收到的直流电压转换为变压器中的电压变换的高频电压。变压器的输出分别在两个整流器中整流，并在两个反应器中平滑。平滑的电压在输出端子之间提供。反应器形成在单个芯上，彼此松耦合。

9. 发明授权

US06069811A DC power supply apparatus 有权
标题翻译：直流电源装置
公开(公告)号：US06069811A
公开(公告)日：2000-05-30
申请号：US212159
申请日：1998-12-15
申请人： Haruo Moriguchi , Toru Arai , Tetsuro Ikeda , Toshikazu Fujiyoshi , Masayuki Ono , Hideo Ishii
发明人： Haruo Moriguchi , Toru Arai , Tetsuro Ikeda , Toshikazu Fujiyoshi , Masayuki Ono , Hideo Ishii
IPC分类号： B23K9/073 , H02H7/125 , H02H9/00 , H02M1/08 , H02M3/155 , H02M3/28 , H02M3/337 , H02M7/12 , H02M7/217 , H02M1/10
CPC分类号： H02M1/4225 , H02H7/1257 , H02M3/337 , H02H9/001 , H02M1/32 , H02M1/36
摘要： A DC power supply apparatus includes a rectifier circuit which rectifies an input commercial AC voltage. The rectifier output voltage is smoothed in a smoothing capacitor. The DC voltage from the capacitor is converted to a high-frequency voltage in an inverter. The high-frequency voltage from the inverter is voltage-transformed by a transformer into a voltage-transformed, high-frequency voltage, which is then converted back into a DC voltage in a high-frequency-to-DC converter circuit. When an input commercial AC voltage is applied to the DC power supply apparatus, a pre-charging circuit pre-charges the smoothing capacitor from the input AC voltage. If a voltage having a magnitude larger than a prescribed value is applied to the DC power supply apparatus, an overvoltage protection circuit renders the rectifier circuit and the pre-charging circuit inoperative.
摘要翻译：直流电源装置包括整流电路，其对输入的商用交流电压进行整流。整流器输出电压在平滑电容器中平滑化。来自电容器的直流电压在逆变器中转换成高频电压。来自变频器的高频电压由变压器电压转换为电压变换的高频电压，然后将其转换回高频至直流转换电路中的直流电压。当输入商用交流电压被施加到直流电源装置时，预充电电路从输入的交流电压对平滑电容器进行预充电。如果将具有大于规定值的电压的电压施加到直流电源装置，则过电压保护电路使整流电路和预充电电路不起作用。

10. 发明授权

US6066709A Ethylene-aromatic vinyl compound copolymer and method for its production 有权
标题翻译：乙烯 - 芳族乙烯基化合物共聚物及其制备方法
公开(公告)号：US6066709A
公开(公告)日：2000-05-23
申请号：US203488
申请日：1998-12-02
申请人： Toru Arai , Akihiko Nakamura , Shigeru Suzuki , Toshiaki Otsu , Akio Okamoto
发明人： Toru Arai , Akihiko Nakamura , Shigeru Suzuki , Toshiaki Otsu , Akio Okamoto
IPC分类号： C08F4/64 , C08F4/642 , C08F4/659 , C08F4/6592 , C08F210/02 , C08F212/04 , C08L25/08
CPC分类号： C08F210/02 , C08F4/65912 , C08F4/65927 , Y10S526/943
摘要： An ethylene-aromatic vinyl compound copolymer having an aromatic vinyl compound content of from 1 to less than 55% by molar fraction, prepared in the presence of a transition metal compound containing two unsubstituted or substituted indenyl groups or a transition metal compound containing one unsubstituted or substituted cyclopentadienyl group and one unsubstituted or substituted indenyl group.
摘要翻译：在含有两个未取代或取代的茚基的过渡金属化合物或含有一个未取代或未取代的茚基的过渡金属化合物存在下制备的芳族乙烯基化合物含量为1至小于55摩尔％的乙烯 - 芳族乙烯基化合物共聚物，取代的环戊二烯基和一个未取代或取代的茚基。

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