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1. 发明申请

US20050038228A1 Novel peptide, novel adsorbent, adsorption unit and adsorption method 有权
标题翻译：新型肽，新型吸附剂，吸附装置及吸附方法
公开(公告)号：US20050038228A1
公开(公告)日：2005-02-17
申请号：US10489202
申请日：2002-09-18
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
IPC分类号： C12N15/09 , C07K7/06 , C07K14/00 , C07K17/06 , C07K17/08 , C07K17/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C07H21/04 , C07K14/47
CPC分类号： C07K7/06 , C07K17/06 , C07K17/08
摘要： The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要翻译：本发明提供一种吸附剂，吸附单元和吸附方法，其可以有效地选择性地吸附存在于体液（例如血液，血浆等）中的免疫球蛋白和/或免疫复合物，而无需预处理体流体。通过将具有免疫球蛋白和/或免疫复合物的结合活性的化合物固定在水不溶性载体上，可以获得具有极好的吸附能力的吸附剂。

2. 发明申请

US20070059800A1 Novel peptide, novel adsorbent, adsorption unit and adsorption method 审中-公开
标题翻译：新型肽，新型吸附剂，吸附装置及吸附方法
公开(公告)号：US20070059800A1
公开(公告)日：2007-03-15
申请号：US11599281
申请日：2006-11-15
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
IPC分类号： C07K14/195 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74
CPC分类号： C07K7/06 , C07K17/06 , C07K17/08
摘要： The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要翻译：本发明提供一种吸附剂，吸附单元和吸附方法，其可以有效地选择性地吸附存在于体液（例如血液，血浆等）中的免疫球蛋白和/或免疫复合物，而无需预处理体流体。通过将具有免疫球蛋白和/或免疫复合物的结合活性的化合物固定在水不溶性载体上，可以获得具有极好的吸附能力的吸附剂。

3. 发明授权

US07153945B2 Peptide, novel adsorbent, adsorption unit and adsorption method 有权
标题翻译：肽，新型吸附剂，吸附装置及吸附方法
公开(公告)号：US07153945B2
公开(公告)日：2006-12-26
申请号：US10489202
申请日：2002-09-18
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
IPC分类号： A61K39/00
CPC分类号： C07K7/06 , C07K17/06 , C07K17/08
摘要： The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要翻译：本发明提供一种吸附剂，吸附单元和吸附方法，其可以有效地选择性地吸附存在于体液（例如血液，血浆等）中的免疫球蛋白和/或免疫复合物，而无需预处理体流体。通过将具有免疫球蛋白和/或免疫复合物的结合活性的化合物固定在水不溶性载体上，可以获得具有极好的吸附能力的吸附剂。

4. 发明授权

US06252054B1 Immobilization of SH group-containing compounds in the presence of a sulfite-containing antioxidant 有权
标题翻译：含硫基化合物在含亚硫酸盐的抗氧化剂存在下的固定化
公开(公告)号：US06252054B1
公开(公告)日：2001-06-26
申请号：US09444305
申请日：1999-11-22
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura
IPC分类号： C07K1702
CPC分类号： C07K17/02 , G01N33/54393 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815
摘要： Immobilization of SH group-containing compounds on a solvent-insoluble support is carried out in the presence of an antioxidant to prevent oxidation of SH groups to S—S bonds. This improves immobilization efficiency and suppresses deterioration of inherent characteristics of the SH group-containing compound. Antioxidants include sodium pyrosulfite (sodium disulfite), sodium sulfite, sodium hydrogensulfite, sodium hydrosulfite and L-ascorbic acid. SH group-containing compounds include cysteine, peptides or proteins containing cysteine and thiol compounds such as ethanethiol, aminoethanethiol, benzylthiol and thiophenol. Preferably, the SH group-containing compound has a molecular weight not more than 3×104. The support may be activated by a functional group such as glycidyl, imidocarbonato, tosyl, tresyl, carboxyl, amino, azido or hydroxyl. The support can be inorganic such as glass beads or organic such as a synthetic polymer or a polysaccharide.
摘要翻译：在溶剂不溶性载体上固定含SH基团的化合物在抗氧化剂存在下进行，以防止SH基团氧化成S-S键。这提高了固定效率并抑制含SH基化合物的固有特性的劣化。抗氧化剂包括焦亚硫酸钠（亚硫酸氢钠），亚硫酸钠，亚硫酸氢钠，连二亚硫酸钠和L-抗坏血酸。含SH基团的化合物包括半胱氨酸，含有半胱氨酸和巯基化合物的肽或蛋白质，例如乙硫醇，氨基乙硫醇，苄硫醇和苯硫酚。优选地，含SH基团的化合物的分子量不大于3×10 4。载体可以被诸如缩水甘油基，亚氨基碳酸根，甲苯磺酰基，甲酚基，羧基，氨基，叠氮基或羟基之类的官能团活化。载体可以是无机的，例如玻璃珠或有机如合成聚合物或多糖。

5. 发明授权

US06600014B2 Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method 失效
标题翻译：用于消除丙型肝炎病毒的吸附剂，吸附剂和吸附方法
公开(公告)号：US06600014B2
公开(公告)日：2003-07-29
申请号：US09380644
申请日：1999-11-09
申请人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
发明人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
IPC分类号： C07K1700
CPC分类号： A61M1/3633 , A61M1/3679 , A61M2205/7509 , B01J20/262 , B01J20/265 , B01J20/28078 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J2220/58 , Y10S530/81
摘要： An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided. An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.
摘要翻译：一种用于除去丙型肝炎病毒的吸附剂，其具有从患者身体血液中安全地并以高效率和高选择性安全地吸收HCV颗粒，特别是免疫复合物HCV颗粒的能力，以提高干扰素疗法的功效，HCV吸附装置包括所述吸附剂和用于除去HCV的吸附方法。一种用于除去丙型肝炎病毒的吸附剂，其包含固定在水不溶性载体上的能够吸附丙型肝炎病毒的化合物，包括所述吸附剂的吸附装置和吸附方法去除HCV。

6. 发明授权

US07056507B2 Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method 失效
标题翻译：用于消除丙型肝炎病毒的吸附剂，吸附剂和吸附方法
公开(公告)号：US07056507B2
公开(公告)日：2006-06-06
申请号：US10458297
申请日：2003-06-11
申请人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
发明人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
IPC分类号： A61K39/42 , C07K1/22 , B01D15/08
CPC分类号： A61M1/3633 , A61M1/3679 , A61M2205/7509 , B01J20/262 , B01J20/265 , B01J20/28078 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J2220/58 , Y10S530/81
摘要： An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided.An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.
摘要翻译：一种用于除去丙型肝炎病毒的吸附剂，其具有从患者身体血液中安全地并以高效率和高选择性安全地吸收HCV颗粒，特别是免疫复合物HCV颗粒的能力，以提高干扰素疗法的功效，HCV吸附装置包括所述吸附剂和用于除去HCV的吸附方法。一种用于除去丙型肝炎病毒的吸附剂，其包含能够吸附固定在水不溶性载体上的丙型肝炎病毒的化合物，包括所述吸附剂的吸附装置和用于除去HCV的吸附方法。

7. 发明授权

US6133431A Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device 有权
标题翻译：免疫球蛋白吸附剂及其配合物，吸附方法和吸附装置
公开(公告)号：US6133431A
公开(公告)日：2000-10-17
申请号：US117233
申请日：1998-10-20
申请人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
发明人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
IPC分类号： A61K35/14 , A61M1/36 , B01J20/32 , C07K17/00 , C07K17/02 , A61K39/00
CPC分类号： C07K17/02 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3282 , C07K17/00 , A61M1/3679 , A61M2202/0417
摘要： An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.
摘要翻译： PCT No.PCT / JP97 / 00161 Sec。 371日期：1998年10月20日 102（e）日期1998年10月20日PCT 1997年1月24日PCT公布。第WO97 / 26930号公报日期1997年7月31日在吸附免疫球蛋白和/或其复合物中显示高特异性的吸附剂在灭菌或储存期间吸附特性的降低极度降低，是高度稳定和安全的，并且通过固定在水上制备 - 不溶性支持已经在具有特定氨基酸序列或氨基酸序列的肽中经历了氨基酸的缺失，取代，插入或添加中的至少一个的肽衍生物，或上述已经经历在其氨基和/或羧基末端添加Lyn或Cys; 用于通过将吸附剂包装在装有流出物防止装置的容器中而进行吸附和除去的装置; 以及利用吸附剂吸收和除去血液，血浆或其他体液中所含的免疫球蛋白和/或其复合物的方法。

8. 发明授权

US07071349B2 Purification method of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine 失效
标题翻译： N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酸的纯化方法
公开(公告)号：US07071349B2
公开(公告)日：2006-07-04
申请号：US10311060
申请日：2002-03-19
申请人： Akira Matsumoto , Michio Nomura , Yoshikazu Kogame , Yasuyoshi Ueda
发明人： Akira Matsumoto , Michio Nomura , Yoshikazu Kogame , Yasuyoshi Ueda
IPC分类号： C07C229/00
CPC分类号： C07C227/42 , C07C229/36
摘要： The present invention is to provide a purification method of obtaining N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application.An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.
摘要翻译：本发明提供以高生产率获得高质量的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酸的纯化方法，因此适用于商业规模应用。杂质污染的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酸从酒精和水的混合溶剂中以醇/水的体积比为1至20结晶，以除去污染杂质母液，得到N-（1（S） - 乙氧羰基-3-苯基丙基）-L-丙氨酸晶体。

9. 发明授权

US4925969A Process for preparing ethyl-alpha-amino-gamma-oxo-gamma-phenybutyrate derivatives 失效
标题翻译：制备乙基-γ-氨基-γ-氧代-γ-苯基丁酸酯衍生物的方法
公开(公告)号：US4925969A
公开(公告)日：1990-05-15
申请号：US324497
申请日：1989-03-16
申请人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
发明人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
IPC分类号： C07C227/08 , C07C233/46 , C07C271/06
CPC分类号： C07C233/46 , C07C227/08 , C07C271/06
摘要： Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.
摘要翻译：乙基-β-苯甲酸酯与（S） - 丙氨酸的碱金属盐或N6-三氟乙酰基-L-赖氨酸的碱金属盐反应形成相应的迈克尔加成产物，加入不少于等量的酸完成迈克尔加成以防止（S，S）形式的产物转化为（R，S）形式。

10. 发明授权

US5902877A Adsorbent of interleukins, process for removing the same, and adsorber for the same 失效
标题翻译：白细胞介素的吸附剂，其除去方法和吸附剂
公开(公告)号：US5902877A
公开(公告)日：1999-05-11
申请号：US646266
申请日：1996-05-20
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
IPC分类号： B01J20/26 , B01J20/32 , C07K14/54 , A23J1/00
CPC分类号： B01J20/3212 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3251 , C07K14/54
摘要： The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.
摘要翻译： PCT No.PCT / JP95 / 01859 Sec。 371日期：1996年5月20日 102（e）日期1996年5月20日PCT提交1995年9月18日PCT公布。出版物WO96 / 09115 日期：1996年3月28日本发明涉及能够有效吸附和去除体液中的白细胞介素的吸附剂，如果需要，涉及吸附和除去体液中的白细胞介素的方法。根据本发明，提供一种白细胞介素的吸附剂，其包含具有阴离子官能团的水不溶性载体，使用其的吸附，除去和回收白细胞介素的方法和使用该吸附剂的吸附剂。

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