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1. 发明授权

US6133431A Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device 有权
标题翻译：免疫球蛋白吸附剂及其配合物，吸附方法和吸附装置
公开(公告)号：US6133431A
公开(公告)日：2000-10-17
申请号：US117233
申请日：1998-10-20
申请人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
发明人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
IPC分类号： A61K35/14 , A61M1/36 , B01J20/32 , C07K17/00 , C07K17/02 , A61K39/00
CPC分类号： C07K17/02 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3282 , C07K17/00 , A61M1/3679 , A61M2202/0417
摘要： An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.
摘要翻译： PCT No.PCT / JP97 / 00161 Sec。 371日期：1998年10月20日 102（e）日期1998年10月20日PCT 1997年1月24日PCT公布。第WO97 / 26930号公报日期1997年7月31日在吸附免疫球蛋白和/或其复合物中显示高特异性的吸附剂在灭菌或储存期间吸附特性的降低极度降低，是高度稳定和安全的，并且通过固定在水上制备 - 不溶性支持已经在具有特定氨基酸序列或氨基酸序列的肽中经历了氨基酸的缺失，取代，插入或添加中的至少一个的肽衍生物，或上述已经经历在其氨基和/或羧基末端添加Lyn或Cys; 用于通过将吸附剂包装在装有流出物防止装置的容器中而进行吸附和除去的装置; 以及利用吸附剂吸收和除去血液，血浆或其他体液中所含的免疫球蛋白和/或其复合物的方法。

2. 发明授权

US5902877A Adsorbent of interleukins, process for removing the same, and adsorber for the same 失效
标题翻译：白细胞介素的吸附剂，其除去方法和吸附剂
公开(公告)号：US5902877A
公开(公告)日：1999-05-11
申请号：US646266
申请日：1996-05-20
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
IPC分类号： B01J20/26 , B01J20/32 , C07K14/54 , A23J1/00
CPC分类号： B01J20/3212 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3251 , C07K14/54
摘要： The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.
摘要翻译： PCT No.PCT / JP95 / 01859 Sec。 371日期：1996年5月20日 102（e）日期1996年5月20日PCT提交1995年9月18日PCT公布。出版物WO96 / 09115 日期：1996年3月28日本发明涉及能够有效吸附和去除体液中的白细胞介素的吸附剂，如果需要，涉及吸附和除去体液中的白细胞介素的方法。根据本发明，提供一种白细胞介素的吸附剂，其包含具有阴离子官能团的水不溶性载体，使用其的吸附，除去和回收白细胞介素的方法和使用该吸附剂的吸附剂。

3. 发明授权

US06387362B1 Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber 失效
标题翻译：用于缓激肽的吸附剂，通过吸附除去其的方法和吸附剂
公开(公告)号：US06387362B1
公开(公告)日：2002-05-14
申请号：US09043537
申请日：1998-08-14
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
IPC分类号： A61K31795
CPC分类号： B01J20/26 , A61M1/3679
摘要： An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.
摘要翻译：提供了包含具有磺酸基的苯乙烯 - 二乙烯基苯共聚物的吸附剂或缓激肽以及吸收和去除缓激肽的方法，包括使吸附剂与含有缓激肽的流体接触。还提供了用于吸附缓冲激肽的吸附剂，其中将吸附剂装入具有流体入口和出口的容器中。

4. 发明授权

US06315907B1 Method for removing toxic shock syndrome toxin-1 in body fluids by adsorption 有权
标题翻译：通过吸附去除体液中毒性休克综合征毒素-1的方法
公开(公告)号：US06315907B1
公开(公告)日：2001-11-13
申请号：US09403281
申请日：1999-10-19
申请人： Fumiyasu Hirai , Eiji Ogino , Hiroyuki Maruyama , Takayuki Sakogawa , Takashi Asahi , Nobutaka Tani
发明人： Fumiyasu Hirai , Eiji Ogino , Hiroyuki Maruyama , Takayuki Sakogawa , Takashi Asahi , Nobutaka Tani
IPC分类号： B01D1500
CPC分类号： B01J20/3242 , A61M1/3679 , B01D15/00 , B01J20/22 , B01J20/28078 , B01J20/3092 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3255 , B01J2220/58
摘要： An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.
摘要翻译：用于毒性休克综合征毒素-1（TSST-1）的吸附剂，其包含log P值至少为2.50的化合物，其中P是辛醇 - 水体系中的分配系数并固定在水不溶性载体上; 一种通过吸附除去TSST-1体液的方法，其包括使含有TSST-1的体液与吸附剂接触; 用于TSST-1的吸附器，其包括填充在具有用于体液的入口和出口的容器中的吸附剂和用于防止吸附剂从容器流出的装置; 并使用吸附剂。体液中的TSST-1可以被吸附剂有效地去除。

5. 发明授权

US6132610A Endotoxin adsorption system 失效
标题翻译：内毒素吸附系统
公开(公告)号：US6132610A
公开(公告)日：2000-10-17
申请号：US905710
申请日：1997-08-05
申请人： Fumiyasu Hirai , Eiji Ogino , Takashi Asahi , Nobutaka Tani
发明人： Fumiyasu Hirai , Eiji Ogino , Takashi Asahi , Nobutaka Tani
IPC分类号： A61M1/36 , B01J39/04 , B01J47/00 , B01J47/02 , B01J47/04
CPC分类号： B01J39/04 , B01J47/003
摘要： An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.
摘要翻译：本发明的内毒素吸附系统包括具有钠作为抗衡离子的阳离子交换树脂和具有钠和一种或多种除了钠之外的金属离子作为抗衡离子的阳离子交换树脂的组合，并且不降低内毒素吸附内毒素阳离子的浓度。

6. 发明授权

US5866387A Method for immobilizing ligand or compound having ligand bonded thereto 失效
标题翻译：固定具有配体键合的配体或化合物的方法
公开(公告)号：US5866387A
公开(公告)日：1999-02-02
申请号：US894782
申请日：1997-08-28
申请人： Eiji Ogino , Kazuo Suzuki , Nobutaka Tani
发明人： Eiji Ogino , Kazuo Suzuki , Nobutaka Tani
IPC分类号： B01J20/32 , C12N11/04 , C12N11/06 , C12N11/08 , G01N33/544
CPC分类号： B01J20/3274 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3251 , B01J20/3255 , Y10S530/814 , Y10S530/815 , Y10S530/816
摘要： There is provided a method for immobilizing a ligand by reacting a solvent-insoluble carrier having aldehyde group with a compound shown by the general formula: ##STR1## wherein X is --S-- or --O--, R.sup.1, R.sup.2 and R.sup.6 are the same or different, each of which is hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 is hydrogen atom or a substituent wherein an atom adjacent to nitrogen atom shown in the above-mentioned general formula has no unsaturated bond, R.sup.4, R.sup.5 and R.sup.7 are arbitrary substituents; provided that only one partial chemical structure of HX--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above or HX--C--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above is contained in one compound described above by which, a ligand or a compound to which a ligand is bonded can react specifically and effectively with aldehyde group in a solvent-insoluble carrier at a prescribed position to form a stable bond.
摘要翻译： PCT No.PCT / JP96 / 00450 Sec。 371日期1997年8月28日 102（e）日期1997年8月28日PCT 1996年2月26日PCT公布。第WO96 / 26786号公报日期1996年6月9日提供了通过使具有醛基的溶剂不溶性载体与通式如下的化合物反应来固定配体的方法：其中X是-S-或-O-，R 1，R 2 R6相同或不同，分别为氢原子或碳原子数1〜4的烷基，R3为氢原子或上述通式所示的与氮原子相邻的原子没有不饱和基团的取代基键，R4，R5和R7是任意的取代基; 只要其中X和R 3与上述定义相同的HX-CC-NHR3的仅一部分化学结构或其中X和R 3与上述相同的HX-CCC-NHR 3包含在上述一种化合物中，其中a 配体或配体所结合的化合物可以在规定的位置上与溶剂不溶性载体中的醛基特异性和有效地反应以形成稳定的键。

7. 发明授权

US4721730A Adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain 失效
标题翻译：用于β2-微球蛋白和免疫球蛋白L链的吸附剂
公开(公告)号：US4721730A
公开(公告)日：1988-01-26
申请号：US55387
申请日：1987-05-29
申请人： Shigeo Furuyoshi , Eiji Ogino , Nobutaka Tani
发明人： Shigeo Furuyoshi , Eiji Ogino , Nobutaka Tani
IPC分类号： B01J20/28 , B01J20/32 , C08J9/36
CPC分类号： B01J20/28014 , B01J20/28047 , B01J20/28057 , B01J20/28078 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3255 , B01J2220/58
摘要： An adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain suitable for use in an extracorporeal circulation treatment, which comprises a porous water-insoluble carrier and a compound immobilized onto said carrier, said compound satisfying that the value of log P, in which P is a partition coefficient in an octanol-water system, is not less than 2.5. The adsorbent is inexpensive, and efficiently adsorb and remove .beta..sub.2 -microglobulin and immunoglobulin L-chain contained in a body fluid.
摘要翻译：适用于体外循环治疗的β2-微球蛋白和免疫球蛋白L链的吸附剂，其包含多孔水不溶性载体和固定在所述载体上的化合物，所述化合物满足log P的值，其中P 是辛醇 - 水体系中的分配系数，不小于2.5。吸附剂便宜，有效地吸附和去除体液中所含的β2-微球蛋白和免疫球蛋白L链。

8. 发明授权

US5821193A Adsorbent having a terminal hydrazine group and a method for removing ketoamine-containing protein 失效
标题翻译：具有末端肼基团的吸附剂和用于除去含有含有酮胺的蛋白质的方法
公开(公告)号：US5821193A
公开(公告)日：1998-10-13
申请号：US557092
申请日：1995-12-06
申请人： Nobutaka Tani , Eiji Ogino
发明人： Nobutaka Tani , Eiji Ogino
IPC分类号： A61M1/36 , B01J20/22 , B01J20/28 , B01J20/32 , B01J20/00 , A23J1/00 , C12N11/06
CPC分类号： B01J20/3253 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3248
摘要： An adsorbent for removing ketoamine-containing protein, which comprises carrying a compound having a terminal functional group of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is an organic group and X is 0 or 1, on a porous water-insoluble carrier, a process for removing ketoamine-containing protein by employing the above adsorbent, a process for preventing or treating for diabetic complication by removing ketoamine-containing protein with the above adsorbent and an adsorber for removing ketoamine-containing protein.
摘要翻译： PCT No.PCT / JP95 / 00683 Sec。 371 1995年12月6日第 102（e）日期1995年12月6日PCT 1995年4月6日PCT PCT。公开号WO95 / 27559 日期1995年10月19日一种用于除去含有酮胺的蛋白质的吸附剂，其包括携带具有下式的末端官能团的化合物：其中R1和R2各自为有机基团，X为0或1，多孔水不溶性载体，通过使用上述吸附剂除去含有酮胺的蛋白质的方法，通过用上述吸附剂除去含有酮胺的蛋白质和除去含有酮胺的蛋白质的吸附剂来预防或治疗糖尿病并发症的方法。

9. 发明授权

US06127528A Process for adsorbing and removing tumor necrosis factor-.alpha. 有权
标题翻译：吸附和去除肿瘤坏死因子-α的方法
公开(公告)号：US06127528A
公开(公告)日：2000-10-03
申请号：US283964
申请日：1999-04-02
申请人： Fumiyasu Hirai , Nobutaka Tani , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takashi Asahi
IPC分类号： C07K14/525 , C07K1/22 , A61K38/19 , C07K1/14 , C07K14/00
CPC分类号： C07K14/525 , Y10S930/144
摘要： The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.
摘要翻译：本发明涉及能够有效地去除体液中的肿瘤坏死因子-α（TNF-α）的吸附剂，使用吸附剂的吸附剂和吸附和去除TNF-α的方法，即TNF-α的吸附剂其特征在于，在水不溶性载体上具有由式（I）表示的官能团的化合物：其中，X为阴离子官能团，A为阴离子官能团以外的取代基，n为0〜 4，在n至少为2的情况下，其数目为n的基团A可以相同或不同; 一种吸附和去除TNF-α的方法，其包括使吸附剂与体液接触; 和用于吸附TNF-α的吸附器，其中具有用于体液的入口和出口的容器并且装备有用于防止吸附剂流向容器外部的装置的吸附器装入吸附剂。

10. 发明申请

US20120264687A1 MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED 审中-公开
标题翻译：添加了可溶性长链分子的改良的红细胞膜蛋白
公开(公告)号：US20120264687A1
公开(公告)日：2012-10-18
申请号：US13395534
申请日：2010-09-15
申请人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
发明人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
IPC分类号： A61K38/18 , A61P7/06
CPC分类号： A61K9/0019 , A61K38/1816 , A61K47/60
摘要： An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain.
摘要翻译：本发明的目的是提供一种含有促红细胞生成素作为活性成分并且在人和/或动物中施用时持续不少于7天的造血作用的药物组合物。本发明提供一种药物组合物，其含量等于不少于总促红细胞生成素的50％，红细胞生成素，其中加入了两种或更多种水溶性长链分子。本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中水溶性长链分子的分子量不小于30kDa。本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中所述水溶性长链分子具有支链。

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