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1. 发明授权

US06432534B1 Process for the production of tablets and tablets 有权
标题翻译：生产片剂和片剂的方法
公开(公告)号：US06432534B1
公开(公告)日：2002-08-13
申请号：US09555660
申请日：2000-09-14
申请人： Eiji Hayakawa , Motohiro Ohta , Hiroyuki Morimoto , Kiyoshi Morimoto , Yasushi Watanabe , Kunio Ito , Sanji Tokuno
发明人： Eiji Hayakawa , Motohiro Ohta , Hiroyuki Morimoto , Kiyoshi Morimoto , Yasushi Watanabe , Kunio Ito , Sanji Tokuno
IPC分类号： B32B516
CPC分类号： A61J3/10 , B30B11/08 , B30B15/0011 , Y10T428/2991
摘要： A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied
摘要翻译：一种通过设置有冲头和模具的压片机生产包含活性成分，稀释剂和润滑剂的片剂的方法，包括以下步骤：制备包括活性组分，稀释剂和润滑剂的一部分的成型材料; 将大部分剩余量的润滑剂施加到冲头的表面和模具的表面上; 并通过施加润滑剂的表面的冲头和施加润滑剂的表面的模具对成型材料进行压片

2. 发明授权

US08357396B2 Intrabuccally rapidly disintegrating tablet and a production method of the tablets 有权
公开(公告)号：US08357396B2
公开(公告)日：2013-01-22
申请号：US13282271
申请日：2011-10-26
申请人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

3. 发明申请

US20120135076A1 INTRABUCCALLY RAPIDLY DISINTEGRATING TABLET AND A PRODUCTION METHOD OF THE TABLETS 有权
标题翻译：快速消毒片和片剂的生产方法
公开(公告)号：US20120135076A1
公开(公告)日：2012-05-31
申请号：US13282271
申请日：2011-10-26
申请人： Motohiro OHTA , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro OHTA , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20 , B02C23/00
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
摘要翻译：通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

4. 发明授权

US08071128B2 Intrabuccally rapidly disintegrating tablet and a production method of the tablets 有权
标题翻译：片剂快速崩解片剂及其制备方法
公开(公告)号：US08071128B2
公开(公告)日：2011-12-06
申请号：US10356641
申请日：2003-06-20
申请人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
摘要翻译：通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

5. 发明授权

US06062826A Pulsating vibration air generation means 失效
标题翻译：脉动振动空气产生装置
公开(公告)号：US06062826A
公开(公告)日：2000-05-16
申请号：US713128
申请日：1996-09-16
申请人： Kiyoshi Morimoto , Yasushi Watanabe , Yoshika Sanada , Sanji Tokuno , Kazue Murata
发明人： Kiyoshi Morimoto , Yasushi Watanabe , Yoshika Sanada , Sanji Tokuno , Kazue Murata
IPC分类号： B06B1/12 , B06B1/14 , F16K31/524 , F04B49/00
CPC分类号： F16K31/52408 , Y10T74/18296
摘要： A pulsating vibration air generator in which wave height, frequency and wave shape of the pulsating vibration air can be optionally modified and such pulsating vibration air can be periodically and continuously emitted. The pulsating vibration air generator has a valve chamber with an inlet port and an outlet port where a valve plug and a valve seat with a control opening are provided and a cam mechanism which moves the valve plug to open or close the opening of the valve seat, whereby positive or negative pulsating vibration air is emitted from the outlet port while pressurized air is supplied into the inlet port or air is sucked from the inlet port.
摘要翻译：脉动振动空气发生器可以可选地改变脉动振动空气的波浪高度，频率和波形，并且可以周期性地连续地发射这种脉动的振动空气。脉动振动空气发生器具有带有入口和出口的阀室，其中设置有阀塞和具有控制开口的阀座，以及凸轮机构，其使阀塞移动以打开或关闭阀座的开口从而当加压空气被供给到入口或从入口吸入空气时，从出口端口发出正或负脉动的振动空气。

6. 发明授权

US06302573B1 Mixing method of powdered or granular material utilizing pulsating vibration air 失效
标题翻译：使用脉动振动空气的粉末或颗粒材料的混合方法
公开(公告)号：US06302573B1
公开(公告)日：2001-10-16
申请号：US09289556
申请日：1999-04-12
申请人： Kiyoshi Morimoto , Yasushi Watanabe , Yoshika Sanada , Sanji Tokuno , Kazue Murata
发明人： Kiyoshi Morimoto , Yasushi Watanabe , Yoshika Sanada , Sanji Tokuno , Kazue Murata
IPC分类号： B01F1302
CPC分类号： B01F13/0266 , B01F3/18 , B65G53/22
摘要： A mixing and blending method for powdered or granular material includes supplying pulsating vibration air into an airtight tank from a bottom thereof. An airtight tank having a porous bottom plate on which the material is stored is provided for the mixing and blending method. In the system pulsating vibration air is generated by periodically increasing and decreasing the amount of blowing air at a low frequency. Pulsating vibration air is introduced into the airtight tank from the bottom of the airtight tank so as to generate air flow going upward through the porous bottom of the airtight tank. As a result, powdered or granular material stored on the porous bottom plate in the airtight tank is uniformly mixed and blended in the airtight tank while continuously moving up and down as in a convectional manner.
摘要翻译：用于粉末或颗粒材料的混合和混合方法包括将脉动振动空气从其底部供应到气密罐中。提供了一种具有多孔底板的密封罐，其上储存有材料用于混合和混合方法。在该系统中，通过周期性地增加和减少低频吹送空气的量来产生脉动振动空气。脉动振动空气从密封罐的底部引入密封罐中，以产生向上通过密封罐的多孔底部的空气流。结果，将保存在密封罐中的多孔底板上的粉状或颗粒状材料均匀地混合并混合在密封罐中，同时以对流方式连续上下移动。

7. 发明授权

US5996902A Spray for spraying powdered material activated by pulsating vibration air and method 失效
标题翻译：用于喷雾通过脉动振动空气激活的粉末材料的喷雾器和方法
公开(公告)号：US5996902A
公开(公告)日：1999-12-07
申请号：US878944
申请日：1997-06-19
申请人： Kiyoshi Morimoto , Yasushi Watanabe , Kimiaki Hayakawa , Sanji Tokuno
发明人： Kiyoshi Morimoto , Yasushi Watanabe , Kimiaki Hayakawa , Sanji Tokuno
IPC分类号： B65B1/16 , A61J3/06 , B01J2/02 , B01J2/18 , B01J4/02 , B05B7/14 , B30B15/00 , B65G53/40 , B05B17/04
CPC分类号： B05B7/1445 , B01J2/02 , B01J2/18 , B30B15/0011
摘要： A sprayer and method for spraying powdered material activated by pulsating vibration air. The sprayer comprises an elastic membrane, a storage tank for storing powdered material provided with the elastic membrane at the bottom opening, and a pulsating vibration air generator for supplying pulsating vibration air to the elastic membrane. The sprayer so constructed is designed to uniformly and diffusely spray the powdered material stored in the storage tank when the elastic membrane is forcedly vibrated up and down in compliance with the frequency of the pulsating vibration air by receiving pulsating vibration air from the pulsating vibration air generator.
摘要翻译：一种用于喷射通过脉动振动空气激活的粉末材料的喷雾器和方法。喷雾器包括弹性膜，用于储存在底部开口处设置有弹性膜的粉末材料的储罐和用于向弹性膜供应脉动振动空气的脉动振动空气发生器。这样构造的喷雾器被设计成当弹性膜通过从脉动振动空气发生器接收到脉动的振动空气而与脉动振动空气的频率一致地上下强制地振动时，均匀地并且漫射喷射存储在储罐中的粉末材料。

8. 发明授权

US06464737B1 Production method and system for granulating powdered material 失效
标题翻译：造粒方法和制粉系统
公开(公告)号：US06464737B1
公开(公告)日：2002-10-15
申请号：US09084919
申请日：1998-05-28
申请人： Kiyoshi Morimoto , Hirokazu Yoshimoto , Sanji Tokuno , Hiroshi Tada , Kazue Murata
发明人： Kiyoshi Morimoto , Hirokazu Yoshimoto , Sanji Tokuno , Hiroshi Tada , Kazue Murata
IPC分类号： C05B1900
CPC分类号： B01J2/16 , B01J2/18 , F26B3/0926
摘要： A production method and system for granulating powdered material wherein powdered material is fluidized by applying heated pulsating vibration air, and the fluidized powdered material is suspended up and down at a regular cycle by means of heated pulsating vibration air, the aggregated material is compressed by further vibration of pulsating vibration air, whereby the aggregated powdered material is efficiently made into granulated material with high density and rather small specific volume without causing projection on the surface and without being made porous. The production system is comprised of a granulation tank for storing powdered material to be granulated, the granulation tank having a supply port for introducing heated air at the bottom thereof, a discharge port for discharging the introduced heated air at the top thereof, and a fluidization bed provided above the supply port for receiving the powdered material. A spray apparatus for spraying a binder solution provided in the granulation tank for aggregating the powdered material stored in the granulation tank for growing the material is provided. An air source connected to the supply port of the granulation tank via a conduit pipe; heating apparatus interposed in the conduit pipe for heating the air generated from the air source; and a pulsating vibration air generation means interposed in the conduit pipe for converting the air generated from the air source to pulsating vibration air.
摘要翻译：通过施加加热的脉动振动空气使粉末材料流化的制粉方法和制造方法，流化粉末材料通过加热的脉动振动空气以规律的周期上下悬浮，聚集的材料进一步压缩脉动振动空气的振动，由此将聚集的粉末材料有效地制成具有高密度和相当小的比体积的粒状材料，而不会在表面上产生突起而不被制成多孔。该生产系统包括用于储存待造粒的粉末材料的造粒罐，该造粒罐具有用于在其底部引入加热空气的供给口，用于在其顶部排出引入的加热空气的排出口，提供在供应口上方的用于接收粉末材料的床。提供一种喷雾装置，用于喷射设置在造粒罐中的粘合剂溶液，用于聚集存储在造粒罐中用于生长材料的粉末材料。通过管道连接到造粒罐的供应口的空气源; 插入导管中的加热装置，用于加热从空气源产生的空气; 以及插入在导管中的脉动振动空气产生装置，用于将从空气源产生的空气转换成脉动的振动空气。

9. 发明授权

US4638642A Heat pump 失效
标题翻译：热泵
公开(公告)号：US4638642A
公开(公告)日：1987-01-27
申请号：US689805
申请日：1985-01-08
申请人： Sanji Tokuno
发明人： Sanji Tokuno
IPC分类号： F25B1/053 , B01D3/00 , F22B3/04 , F24J3/00 , F25B1/00 , F25B29/00 , F25B30/02
CPC分类号： F22B3/045 , B01D3/007 , F25B1/00 , F25B29/00 , Y02B30/52
摘要： A heat pump using water as a refrigerant comprises an evaporator equipped with a feedwater control device and a draining device, a compressor and a condenser equipped with a vacuum generating means.
摘要翻译：使用水作为制冷剂的热泵包括配备有给水控制装置和排水装置的蒸发器，压缩机和配备有真空发生装置的冷凝器。

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