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1. 发明授权

US09101705B2 Fluid delivery system having a plurality of resilient pressurizing chambers 有权
标题翻译：流体输送系统具有多个弹性加压室
公开(公告)号：US09101705B2
公开(公告)日：2015-08-11
申请号：US13400435
申请日：2012-02-20
申请人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
发明人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
IPC分类号： A61M5/00 , A61M5/142 , A61M5/168
CPC分类号： A61M5/1422 , A61M5/002 , A61M5/007 , A61M5/16827 , A61M5/16881 , A61M2205/128 , A61M2206/22
摘要： A fluid delivery system includes a fluid container, two or more pressurizing chambers in fluid connection with the fluid container, a drive mechanism in operative connection with the two or more pressurizing chambers to pump fluid from the fluid container and an outlet in fluid connection with the two or more pressurizing chambers. Each of the two or more pressurizing chambers is formed from a flexible, resilient material that is adapted to be compressed to pressurize fluid therewithin.
摘要翻译：流体输送系统包括流体容器，与流体容器流体连接的两个或更多个加压室，与两个或更多个加压室可操作地连接以从流体容器泵送流体的驱动机构和与流体容器流体连接的出口两个或更多个加压室。两个或更多个加压室中的每一个由柔性弹性材料形成，其适于被压缩以在其中加压流体。

2. 发明申请

US20120150116A1 FLUID DELIVERY SYSTEM HAVING A PLURALITY OF RESILIENT PRESSURIZING CHAMBERS 有权
标题翻译：流体输送系统具有多种强力的压力容器
公开(公告)号：US20120150116A1
公开(公告)日：2012-06-14
申请号：US13400435
申请日：2012-02-20
申请人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
发明人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
IPC分类号： A61M5/148
CPC分类号： A61M5/1422 , A61M5/002 , A61M5/007 , A61M5/16827 , A61M5/16881 , A61M2205/128 , A61M2206/22
摘要： A fluid delivery system includes a fluid container, two or more pressurizing chambers in fluid connection with the fluid container, a drive mechanism in operative connection with the two or more pressurizing chambers to pump fluid from the fluid container and an outlet in fluid connection with the two or more pressurizing chambers. Each of the two or more pressurizing chambers is formed from a flexible, resilient material that is adapted to be compressed to pressurize fluid therewithin.
摘要翻译：流体输送系统包括流体容器，与流体容器流体连接的两个或更多个加压室，与两个或更多个加压室可操作地连接以从流体容器泵送流体的驱动机构和与流体容器流体连接的出口两个或更多个加压室。两个或更多个加压室中的每一个由柔性弹性材料形成，其适于被压缩以在其中加压流体。

3. 发明授权

US08133205B2 Fluid delivery system having a plurality of resilient pressurizing chambers 有权
标题翻译：流体输送系统具有多个弹性加压室
公开(公告)号：US08133205B2
公开(公告)日：2012-03-13
申请号：US11942772
申请日：2007-11-20
申请人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
发明人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
IPC分类号： A61M1/00
CPC分类号： A61M5/1422 , A61M5/002 , A61M5/007 , A61M5/16827 , A61M5/16881 , A61M2205/128 , A61M2206/22
摘要： A fluid delivery system includes a fluid container, two or more pressurizing chambers in fluid connection with the fluid container, a drive mechanism in operative connection with the two or more pressurizing chambers to pump fluid from the fluid container and an outlet in fluid connection with the two or more pressurizing chambers. Each of the two or more pressurizing chambers is formed from a flexible, resilient material that is adapted to be compressed to pressurize fluid therewithin.
摘要翻译：流体输送系统包括流体容器，与流体容器流体连接的两个或更多个加压室，与两个或更多个加压室可操作地连接以从流体容器泵送流体的驱动机构和与流体容器流体连接的出口两个或更多个加压室。两个或更多个加压室中的每一个由柔性弹性材料形成，其适于被压缩以在其中加压流体。

4. 发明授权

US07905861B2 Injection system having readable information stores and method for controlling the operation thereof 有权
标题翻译：具有可读信息存储器的注入系统和用于控制其操作的方法
公开(公告)号：US07905861B2
公开(公告)日：2011-03-15
申请号：US11943735
申请日：2007-11-21
申请人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
发明人： Edward J. Rhinehart , Dennis P. Hack , David M. Reilly , John F. Kalafut
IPC分类号： A61M1/00
CPC分类号： A61M5/1422 , A61M5/002 , A61M5/007 , A61M5/16827 , A61M5/16881 , A61M2205/128 , A61M2206/22
摘要： An injection system includes a fluid delivery system, a drive mechanism, a controller and a tubing set. The fluid delivery system includes a fluid container and a pumping mechanism having an inlet in fluid connection with the fluid container and an outlet. The tubing set is adapted to be placed in removable fluid connection with the outlet of the pumping mechanism and a patient. The drive mechanism is in operative connection with the pumping mechanism to pump fluid from the fluid container. First and second information stores, such as bar codes or RFID tags, are associated with the pumping mechanism and the tubing set, respectively. The controller is in operative connection with the drive mechanism and adapted to read the first information store and the second information store to at least partly control the operation of the drive mechanism based thereon.
摘要翻译：注射系统包括流体递送系统，驱动机构，控制器和管道组。流体输送系统包括流体容器和泵送机构，其具有与流体容器和出口流体连接的入口。管组适于放置在与泵送机构的出口和患者的可移除的流体连接中。驱动机构与泵送机构操作连接以从流体容器泵送流体。第一和第二信息存储（例如条形码或RFID标签）分别与泵送机构和管道组相关联。控制器与驱动机构可操作地连接，并且适于读取第一信息存储器和第二信息存储器，以至少部分地基于此控制驱动机构的操作。

5. 发明申请

US20100174183A1 MULTIPLE LUMEN DIFFUSION CATHETER 有权
标题翻译：多功能扩散吸管
公开(公告)号：US20100174183A1
公开(公告)日：2010-07-08
申请号：US12515981
申请日：2007-11-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III , Arthur E. Uber, III
发明人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III , Arthur E. Uber, III
IPC分类号： A61B6/00 , A61M25/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

6. 发明申请

US20090240197A1 CENTRAL VENOUS CATHETERS AND RELATED EQUIPMENT 审中-公开
标题翻译：中央通风管和相关设备
公开(公告)号：US20090240197A1
公开(公告)日：2009-09-24
申请号：US12297637
申请日：2007-04-19
申请人： Kevin P. Cowan , Eugene A. Gelblum , Alan D. Hirschman , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III
发明人： Kevin P. Cowan , Eugene A. Gelblum , Alan D. Hirschman , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III
IPC分类号： A61M25/092 , A61M25/09 , A61M25/10
CPC分类号： A61M25/0125 , A61M25/0053 , A61M25/007 , A61M25/0082 , A61M25/0113 , A61M25/0116 , A61M25/0119 , A61M25/0122 , A61M2025/0058
摘要： Systems, devices, and methods towards improved diagnosis and therapy in connection with central venous catheters (including PICC lines). Included among the many improvements broadly contemplated herein are: arrangements via which a venous catheter can move passively into position in central venous circulation; arrangements via which a catheter can be actively guided without the use of a needle or guide wire; arrangements via which a catheter can be packaged to facilitate easy, rapid, and positionally accurate deployment by medical personnel while maintaining device sterility; and arrangements via which a catheter tip can be imaged during and after insertion.
摘要翻译：与中心静脉导管（包括PICC系）相关的改进诊断和治疗的系统，装置和方法。包括在这里广泛考虑的许多改进之中：静脉导管可以被动地移动到中心静脉循环中的位置的布置; 可以不使用针或引导线而可以主动地引导导管的布置; 导管可以被包装的布置，以便医疗人员容易，快速和定位准确的部署，同时保持装置不育; 以及在插入期间和之后可以使导管尖端成像的布置。

7. 发明申请

US20080294096A1 Delivery of Agents Such as Cells to Tissue 有权
标题翻译：将细胞递送给组织
公开(公告)号：US20080294096A1
公开(公告)日：2008-11-27
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
发明人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是前体细胞或干细胞。

8. 发明授权

US06984222B1 Plunger systems 失效
公开(公告)号：US06984222B1
公开(公告)日：2006-01-10
申请号：US09436612
申请日：1999-11-09
申请人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Thomas L. Dufalla , Robert J. Masarik
发明人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Thomas L. Dufalla , Robert J. Masarik
IPC分类号： A61M5/315
CPC分类号： A61M5/14546 , A61M5/14566 , A61M5/1458
摘要： The plunger systems for use in an injector-actuated syringe of the present invention include a dynamic wedge seal which improves the sealing engagement between the plunger cover and syringe barrel, and flexible capture members extending from the rear surface of the plunger which permit the engagement and disengagement of the plunger from the injector drive means at any plunger position within the syringe. Further, the plunger systems include a contrast saving tip which expells the injection liquid from the syringe tip.

9. 发明授权

US5947935A Syringes, syringe plungers and injector systems 失效
标题翻译：注射器，注射器柱塞和注射器系统
公开(公告)号：US5947935A
公开(公告)日：1999-09-07
申请号：US978226
申请日：1997-11-25
申请人： Edward J. Rhinehart , David M. Reilly , Mark W. Hitchins , Anthony S. McCoppin
发明人： Edward J. Rhinehart , David M. Reilly , Mark W. Hitchins , Anthony S. McCoppin
IPC分类号： A61M5/145 , A61M25/18 , A61M25/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M5/31515
摘要： The present invention provides a connection mechanism adapted to make a releasable connection between a syringe plunger and a drive member of an injector. The drive member is preferably movable in a generally reciprocal linear manner to control movement of the plunger within the syringe. The connection mechanism comprises at least one capture member attached to the plunger. The capture member forms a releasable connection with the drive member upon contact of the drive member during linear forward motion of the drive member when the capture member is rotated relative to the drive member to an engagement position. The capture member is further adapted to disconnect from the drive member upon rotation of the capture member relative to the drive member to a disengagement position.
摘要翻译：本发明提供了一种适于在注射器柱塞和注射器的驱动构件之间进行可释放连接的连接机构。驱动构件优选地以大致往复的线性方式移动以控制柱塞在注射器内的移动。连接机构包括附接到柱塞的至少一个捕获构件。当捕获构件相对于驱动构件旋转到接合位置时，捕获构件在驱动构件的线性向前运动期间与驱动构件接触时形成与驱动构件的可释放连接。捕获构件还适于在捕获构件相对于驱动构件旋转到脱离位置时与驱动构件断开连接。

10. 发明授权

US06189195B1 Manufacture of prefilled syringes 失效
标题翻译：制造预充式注射器
公开(公告)号：US06189195B1
公开(公告)日：2001-02-20
申请号：US08517645
申请日：1995-08-22
申请人： David M. Reilly , Edward J. Rhinehart , Eugene A. Gelblum , Mark W. Hitchins , Michelle Robinson
发明人： David M. Reilly , Edward J. Rhinehart , Eugene A. Gelblum , Mark W. Hitchins , Michelle Robinson
IPC分类号： B23P1500
CPC分类号： B65B3/003 , Y10T29/49808 , Y10T29/4984
摘要： This invention relates to a process for manufacturing prefilled syringes where at least one of the syringe components is manufactured in at least a class 100 environment. The process includes the steps of manufacturing syringe components, such as the barrel and plunger substrate, within at least a class 100 and MCB-3 environment; manufacturing syringe components, such as the plunger cover and tip seal in an environment less clean than a class 100 environment; decontaminating the plunger cover and tip seal; lubricating at least one of the barrel, plunger substrate, plunger cover and tip seal; assembling the barrel and tip seal to form a barrel/tip seal combination; assembling the plunger cover and plunger substrate to form a plunger; filling the barrel/tip seal combination with a predetermined amount of fluid; and final assembling of the prefilled syringe by inserting the plunger into the barrel/tip seal combination. When the syringe components are manufactured at different locations, each component is tripled-bagged to maintain the component substantially free from contaminants, and transported to an assembly site where the components are unpackaged and assembled into the barrel/tip seal combination and plunger. When filling and final assembly of the barrel/tip seal combination takes place at a location separate from its assembly site, the barrel/tip seal combination is tripled-bagged to maintain it substantially free from contaminants, and transported to a filling and final assembling site for filling and final assembling into a prefilled syringe.
摘要翻译：本发明涉及一种用于制造预充式注射器的方法，其中至少一个注射器组件在至少100级环境中制造。该方法包括在至少100级和MCB-3环境中制造注射器部件（例如筒体和柱塞基底）的步骤; 在比100级环境更干净的环境中制造注射器部件，例如柱塞盖和末端密封; 净化柱塞盖和顶端密封; 润滑桶，柱塞基板，柱塞盖和端盖密封件中的至少一个; 组装筒和尖端密封以形成筒/尖端密封组合; 组装柱塞盖和柱塞基板以形成柱塞; 用预定量的流体填充桶/尖端密封组合; 以及通过将柱塞插入筒/尖端密封组合中来预填充注射器的最终组装。当注射器组件在不同位置制造时，每个组件被三倍重装，以保持组件基本上没有污染物，并被运输到组件的未被包装并组装到筒/尖端密封组合和柱塞中的组装位置。当筒/尖端密封组合的填充和最终组装在与其组装位置分离的位置处发生时，筒/尖端密封组合被三倍重装，以使其基本上不含污染物，并被运送到填充和最终组装位置用于填充和最终组装成预充式注射器。

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