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1. 发明申请

US20080294096A1 Delivery of Agents Such as Cells to Tissue 有权
标题翻译：将细胞递送给组织
公开(公告)号：US20080294096A1
公开(公告)日：2008-11-27
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
发明人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是前体细胞或干细胞。

2. 发明申请

US20130172811A1 Systems and Methods of Delivering a Dilated Slurry to a Patient 有权
标题翻译：向患者提供稀释的浆液的系统和方法
公开(公告)号：US20130172811A1
公开(公告)日：2013-07-04
申请号：US13772849
申请日：2013-02-21
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
IPC分类号： A61M5/14 , A61M5/172
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate.
摘要翻译：用于将浆料递送到患者的系统包括流体，在流体中不可溶或不混溶的材料，从而形成浆料，适于容纳浆料的容器和浆料的上清液，容器限定出口通过其将浆料输送到患者，与容器相关联的流化系统，适于产生压力以使容纳在容器内的浆液流动以输送到患者的加压机构，以及与该患者连接并适应的控制单元以控制流化系统和加压机构。流化系统适于在保持至少一部分上清液的同时实现浆料的扩张。

3. 发明授权

US08382704B2 Systems and methods of delivering a dilated slurry to a patient 有权
标题翻译：将扩张的浆液递送到患者的系统和方法
公开(公告)号：US08382704B2
公开(公告)日：2013-02-26
申请号：US11960968
申请日：2007-12-20
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
IPC分类号： A61M37/00
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movement of the dilated cell-slurry.
摘要翻译：用于将细胞浆料递送到患者的系统可以包括流体，在流体中不可溶或不混溶的细胞，从而形成细胞浆液，适于容纳细胞浆液和细胞上清液的注射器 - 注射器限定具有出口的第一端，细胞浆料通过该出口传送到患者，与注射器相关联的适于用一部分上清液进行细胞浆液的扩张的流化系统，形成扩张的细胞浆液，将扩张的细胞浆液从流化系统转移到注射器，同时保持至少一部分上清液，细胞浆液和上清液从流化系统转移到注射器，加压机构适于产生压力以使得包含在注射器内的扩张的细胞浆液流动以传递给患者，以及与控制流化系统连通并适于控制流化系统的控制单元扩散细胞浆的机制和运动。

4. 发明申请

US20090012497A1 SYSTEMS AND METHODS OF DELIVERING A DILATED SLURRY TO A PATIENT 有权
标题翻译：向患者提供一种稀释浆液的系统和方法
公开(公告)号：US20090012497A1
公开(公告)日：2009-01-08
申请号：US11960968
申请日：2007-12-20
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate.
摘要翻译：用于将浆料递送到患者的系统包括流体，在流体中不可溶或不混溶的材料，从而形成浆料，适于容纳浆料的容器和浆料的上清液，容器限定出口通过其将浆料输送到患者，与容器相关联的流化系统，适于产生压力以使容纳在容器内的浆液流动以输送到患者的加压机构，以及与该患者连接并适应的控制单元以控制流化系统和加压机构。流化系统适于在保持至少一部分上清液的同时实现浆料的扩张。

5. 发明申请

US20130126559A1 Displacement Syringe 审中-公开
标题翻译：置换注射器
公开(公告)号：US20130126559A1
公开(公告)日：2013-05-23
申请号：US13695189
申请日：2011-05-02
申请人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
发明人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
IPC分类号： B65D88/54 , G01F11/00
CPC分类号： B65D83/0005 , A61M5/204 , A61M5/315 , A61M5/31505 , A61M5/31513 , A61M5/31525 , A61M5/31573 , A61M5/3158 , A61M5/31591 , A61M5/31595 , A61M2005/3101 , A61M2005/3121 , A61M2005/3128 , A61M2005/31598
摘要： A displacement syringe having a housing with a distal tip and a proximal end; a moveable outer plunger within the housing having an elongated passageway; at least one moveable inner plunger within the passageway of the outer plunger; at least one first seal between the outer plunger and the housing; and at least one second seal between the inner plunger and the outer plunger is disclosed herein. The syringe may have a lock at the proximal end of the housing and/or a valve at the distal tip of the housing. The syringe may also have a plurality of inner plungers of various diameters. A transfer system and delivery system are also disclosed herein. Methods to accurately and efficiently deliver small volumes using the displacement syringe are also disclosed.
摘要翻译：一种置换式注射器，其具有具有远侧末端和近端的壳体; 壳体内的可移动外柱塞具有细长通道; 在所述外柱塞的通道内的至少一个可动内柱塞; 所述外柱塞和所述壳体之间的至少一个第一密封; 并且本文公开了内柱塞和外柱塞之间的至少一个第二密封。注射器可以在壳体的近端处具有锁定和/或在壳体的远侧末端处的阀。注射器还可以具有多个各种直径的内部柱塞。本文还公开了传送系统和传送系统。还公开了使用位移注射器精确和有效地递送小体积的方法。

6. 发明授权

US09326742B2 Systems for integrated radiopharmaceutical generation, preparation, transportation and administration 有权
标题翻译：综合放射性药物生成，制备，运输和管理系统
公开(公告)号：US09326742B2
公开(公告)日：2016-05-03
申请号：US12595165
申请日：2007-12-28
申请人： Alan D. Hirschman , Arthur E. Uber, III , David M. Reilly , John Kalafut , Frederick W. Trombley, III , Steven J. Remis , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths , Marc A. Mabie , Mark Trocki
发明人： Alan D. Hirschman , Arthur E. Uber, III , David M. Reilly , John Kalafut , Frederick W. Trombley, III , Steven J. Remis , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths , Marc A. Mabie , Mark Trocki
IPC分类号： A61M3/00 , A61B6/00 , A61B6/03 , A61B6/04 , A61M5/172 , G06F19/00 , G21G4/08 , A61B6/10 , A61B5/0205 , A61B5/00 , A61M5/00 , A61M5/145 , A61M5/168 , A61M5/178
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/00 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要： A hazardous fluid handling system which includes a housing having a radiation shielded internal chamber disposed therein which may accommodate a container holding a radioactive fluid, one or more radioactivity detectors positioned within the shielded internal chamber in operational proximity to the radioactive fluid in the container, and a dosimeter control device electronically coupled to the radioactivity detector(s) is disclosed. The dosimeter control device is operational for determining information regarding the radioactive fluid in the container based on individual measurements received from the one or more radioactivity detectors. The hazardous fluid handling system may be integrated into a patient support platform which includes a patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with the patient, and an integrated system controller.
摘要翻译：一种危险的流体处理系统，其包括具有设置在其中的辐射屏蔽内部室的壳体，其可以容纳容纳放射性流体的容器，位于屏蔽内部室内的一个或多个放射性检测器，其操作接近容器中的放射性流体;以及公开了一种电子耦合到放射性检测器的剂量计控制装置。剂量计控制装置可操作用于基于从一个或多个放射性检测器接收的各个测量值来确定关于容器中的放射性流体的信息。有害流体处理系统可以集成到患者支撑平台中，该患者支撑平台包括患者刺激装置，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，病人和一个集成的系统控制器。

7. 发明授权

US09056200B2 Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids 有权
标题翻译：用于向患者输送流体注射剂并处理有害流体的装置和方法
公开(公告)号：US09056200B2
公开(公告)日：2015-06-16
申请号：US12996520
申请日：2009-06-05
申请人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
发明人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
IPC分类号： A61N5/00 , A61N5/10 , A61M5/00 , A61M5/168 , A61M5/178 , A61M5/14
CPC分类号： A61N5/1007 , A61M5/007 , A61M5/16827 , A61M5/1785 , A61M2005/1402 , A61M2202/0225 , A61M2202/049 , A61M2206/11 , A61M2206/18 , Y10T137/0318
摘要： A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.
摘要翻译：公开了一种危险流体输送容器和危险流体输送系统。危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。此外，公开了一种用于注射器或其他容器的放射性流体输送容器。放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

8. 发明授权

US07713232B2 System for washing and processing of cells for delivery thereof to tissue 失效
标题翻译：用于洗涤和处理细胞以将其递送至组织的系统
公开(公告)号：US07713232B2
公开(公告)日：2010-05-11
申请号：US11460635
申请日：2006-07-28
申请人： Arthur E. Uber, III , Frederick W. Trombley, III , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , Frederick W. Trombley, III , Kevin P. Cowan , Mark Trocki
IPC分类号： G01N35/10
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：用于将注射器注射到患者体内的系统包括用于保持注射器的第一可加压容器; 与所述第一可加压容器流体连接的患者接口，所述患者接口适于将所述注射器通入患者的组织; 动力注射器，其与所述第一可加压容器可操作地连接以对所述注射器加压; 与动力注射器操作连接的控制器系统; 以及适于与病人界面操作连接的立体定向定位框架，以协助控制患者界面的定位。用于处理细胞（和/或其它注射组分）的系统包括适于可滑动地定位在容器内的容器和柱塞。该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于经由入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物港口。

9. 发明申请

US20130211248A1 BLADDER SYRINGE FLUID DELIVERY SYSTEM 审中-公开
标题翻译： BLADDER SYRINGE流体输送系统
公开(公告)号：US20130211248A1
公开(公告)日：2013-08-15
申请号：US13881072
申请日：2011-10-25
申请人： Kevin P. Cowan , Raymond C. Hoffman , Charles A. Lang , Mark Trocki , Arthur E. Uber, III , Joseph C. Mator , Edward P. Liscio , Bernard J. Hobi , L. Robert Crouthamel , Glen P. Williams , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
发明人： Kevin P. Cowan , Raymond C. Hoffman , Charles A. Lang , Mark Trocki , Arthur E. Uber, III , Joseph C. Mator , Edward P. Liscio , Bernard J. Hobi , L. Robert Crouthamel , Glen P. Williams , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
IPC分类号： A61M5/00
CPC分类号： A61M5/007 , A61M5/1452 , A61M5/148 , A61M5/2425 , A61M5/31511
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

10. 发明申请

US20110028908A1 SYSTEM FOR PROCESSING CELLS AND CONTAINER FOR USE THEREWITH 有权
标题翻译：用于处理细胞和容器的系统用于其中
公开(公告)号：US20110028908A1
公开(公告)日：2011-02-03
申请号：US12732250
申请日：2010-03-26
申请人： Arthur E. Uber, III , Mark Trocki , Frederick W. Trombley, III , Kevin P. Cowan
发明人： Arthur E. Uber, III , Mark Trocki , Frederick W. Trombley, III , Kevin P. Cowan
IPC分类号： A61M5/31 , A61J1/00
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：用于处理细胞（和/或其它注射组分）的系统包括适于可滑动地定位在容器内的容器和柱塞。该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于经由入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物港口。

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