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1. 发明申请

US20060069256A1 Ophthalmic compositions for treating ocular hypertension 失效
公开(公告)号：US20060069256A1
公开(公告)日：2006-03-30
申请号：US10542169
申请日：2004-03-24
申请人： Edward Boyd , Michael Fisher , Maria Garcia , Gregory Kaczorowski , Peter Meinke , William Parsons , Stephen Price , John Stibbard
发明人： Edward Boyd , Michael Fisher , Maria Garcia , Gregory Kaczorowski , Peter Meinke , William Parsons , Stephen Price , John Stibbard
IPC分类号： C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07D209/28 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

2. 发明申请

US20060293339A1 Biaryl substituted 6-membered heterocycles as sodium channel blockers 审中-公开
标题翻译：二芳基取代的6元杂环作为钠通道阻断剂
公开(公告)号：US20060293339A1
公开(公告)日：2006-12-28
申请号：US10550641
申请日：2004-03-19
申请人： Prasun Chakravarty , Michael Fisher , William Parsons , Jun Liang , Bishan Zhou
发明人： Prasun Chakravarty , Michael Fisher , William Parsons , Jun Liang , Bishan Zhou
IPC分类号： A61K31/506 , A61K31/4965 , A61K31/497 , A61K31/455 , A61K31/4439 , C07D403/02 , A61K31/5377 , C07D413/02
CPC分类号： C07D213/26 , C07D213/55 , C07D213/56 , C07D239/26 , C07D401/04 , C07D403/04
摘要： Biaryl substituted pyridine, pyrimidine and pyrazine compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.
摘要翻译：双芳基取代的吡啶，嘧啶和吡嗪化合物是可用于治疗疼痛的钠通道阻滞剂。药物组合物包含单独的或与一种或多种治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。

3. 发明申请

US20060183897A1 Biaryl substituted triazoles as sodium channel blockers 审中-公开
公开(公告)号：US20060183897A1
公开(公告)日：2006-08-17
申请号：US10549790
申请日：2004-03-12
申请人： Prasun Chakravarty , Michael Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
发明人： Prasun Chakravarty , Michael Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
IPC分类号： C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

4. 发明申请

US20060020006A1 Substituted triazoles as sodium channel blockers 有权
标题翻译：取代的三唑作为钠通道阻断剂
公开(公告)号：US20060020006A1
公开(公告)日：2006-01-26
申请号：US10985592
申请日：2004-11-10
申请人： Min Park , Prasun Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William Parsons , Rosemary Sisco , Michael Fisher , Louis Zuegner
发明人： Min Park , Prasun Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William Parsons , Rosemary Sisco , Michael Fisher , Louis Zuegner
IPC分类号： A61K31/4196 , C07D403/02
CPC分类号： C07D249/10 , C07D403/10
摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

5. 发明申请

US20060183785A1 Biaryl substituted pyrazoles as sodium channel blockers 失效
公开(公告)号：US20060183785A1
公开(公告)日：2006-08-17
申请号：US10552024
申请日：2004-03-30
申请人： Prasun Chakravarty , Michael Fisher , William Parsons , Sriram Tyagarajan , Bishan Zhou , Jeffrey Fisher
发明人： Prasun Chakravarty , Michael Fisher , William Parsons , Sriram Tyagarajan , Bishan Zhou , Jeffrey Fisher
IPC分类号： A61K31/416 , C07D231/02 , C07D231/12 , C07D403/04
CPC分类号： C07D401/04 , C07D231/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D409/10 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Biaryl substituted pyrazole compounds are sodium channel blockers useful for the treatment of pain and other conditions. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.

6. 发明申请

US20070060584A1 Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers 审中-公开
标题翻译：二芳基取代的噻唑，恶唑和咪唑作为钠通道阻断剂
公开(公告)号：US20070060584A1
公开(公告)日：2007-03-15
申请号：US10553554
申请日：2004-04-14
申请人： Prasun Chakravarty , Michael Fisher , William Parsons , Sriram Tyagarajan , Bishan Zhou , Jeffrey Fisher
发明人： Prasun Chakravarty , Michael Fisher , William Parsons , Sriram Tyagarajan , Bishan Zhou , Jeffrey Fisher
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , C07D413/02 , C07D417/02 , C07D403/02
CPC分类号： C07D233/64 , C07D233/68 , C07D233/90 , C07D233/96 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/56 , C07D403/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Biaryl substituted thiazole, oxazole and imidazole compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment or prevention of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.
摘要翻译：双芳基取代的噻唑，恶唑和咪唑化合物是可用于治疗疼痛的钠通道阻滞剂。药物组合物包含单独的或与一种或多种治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗或预防包括急性疼痛，慢性疼痛，内脏痛，炎性疼痛和神经性疼痛的病症的方法包括单独施用有效量的本发明化合物或与一种或多种治疗活性化合物组合施用。

7. 发明申请

US20050119261A1 Biaryl substituted triazoles as sodium channnel blockers 有权
标题翻译：二芳基取代三唑作为钠通道阻断剂
公开(公告)号：US20050119261A1
公开(公告)日：2005-06-02
申请号：US10799230
申请日：2004-03-12
申请人： Prasun Chakravarty , Michael Fisher , Jeffrey Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
发明人： Prasun Chakravarty , Michael Fisher , Jeffrey Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
IPC分类号： A61K31/4196 , A61P25/00 , C07D249/08 , C07D249/10 , C07D413/02 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D417/02 , C07D43/02
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及其制备方法。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

8. 发明申请

US20230035372A1 TRI-REGIME COMPOSITE SOLID PROPELLANT 有权
公开(公告)号：US20230035372A1
公开(公告)日：2023-02-02
申请号：US17740520
申请日：2022-05-10
申请人： David Reid , Michael Fisher , Catherine Anne Marie Dillier , Andrew Robert Demko , Eric L. Petersen
发明人： David Reid , Michael Fisher , Catherine Anne Marie Dillier , Andrew Robert Demko , Eric L. Petersen
IPC分类号： F02K9/12 , C06B33/02 , C06B45/10 , C06B45/08
摘要： The present invention is a composite solid propellant designed to operate in three distinct combustion regimes under various pressure states in the combustion chamber of a solid rocket motor. The design of this propellant facilitates desirable rocket motor operational characteristics, including throttleability, extinguishment, and self-destruction or detonability. The propellant contains ingredients that modify the propellant combustion characteristics to provide the desired behavior, including a surfactant and unaggregated, unagglomerated dispersed primary nanoparticles of aluminum in a polymer binder.

9. 发明授权

US08584933B1 Systems and methods to perform credit valuation adjustment analyses 有权
公开(公告)号：US08584933B1
公开(公告)日：2013-11-19
申请号：US13290221
申请日：2011-11-07
申请人： Markus Finkemeier , Yongshan Huang , Arun Palakurthy , Philippe Khuong-huu , Michael Stanley , Michael Fisher , Andrew Hudis , Jonathan Loflin
发明人： Markus Finkemeier , Yongshan Huang , Arun Palakurthy , Philippe Khuong-huu , Michael Stanley , Michael Fisher , Andrew Hudis , Jonathan Loflin
IPC分类号： G07F19/00
CPC分类号： G06Q40/06 , G06Q40/00 , G06Q40/02
摘要： Systems and methods are provided to perform credit valuation adjustment analyses.

10. 发明申请

US20130288346A1 LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM 有权
标题翻译：线性可扩展单一使用生物反应器系统
公开(公告)号：US20130288346A1
公开(公告)日：2013-10-31
申请号：US13978726
申请日：2012-01-11
申请人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
发明人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
IPC分类号： C12M1/00
CPC分类号： C12M23/28 , C12M23/02 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.
摘要翻译：公开了一种一次性生物反应器袋设计，其在叶轮尖端处提供基本上等效的最大剪切速率，并且在每单位工作体积和生物培养处理所需的rpm的功率范围内的平均或体积剪切速率。袋子设计的剪切轮廓的均匀性在用作缩小或放大平台时提供了独特的优势。还公开了一种线性可伸缩的一次性生物反应器系统，用于进行可扩展的生物制造过程，该系统包括两个不同体积的单次使用的生物反应器袋，其中工作体积H的高度比H / D 到罐的直径D或袋的直径D等于约1.5，并且每个袋中的体积剪切基本上是恒定的。所披露的小规模系统从剪切/可扩展性/性能基础以及从验证和监管的角度来模拟更大规模的系统。总之，所公开的10L生物反应器系统通过使用相同或基本上模拟相同的容器几何形状，气体喷射系统，叶轮形状和类型，柔性袋/部件的聚合物组成，过程控制系统和剪切速率为较大的50-5000 L系统。

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