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    • 1. 发明申请
    • LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM
    • 线性可扩展单一使用生物反应器系统
    • US20130288346A1
    • 2013-10-31
    • US13978726
    • 2012-01-11
    • Colin TuoheyTed DeloggioThomas ErdenbergerKenneth P. ClappRichard DamrenParrish M. GalliherPatrick GuertinJiyoung LeeMichael Fisher
    • Colin TuoheyTed DeloggioThomas ErdenbergerKenneth P. ClappRichard DamrenParrish M. GalliherPatrick GuertinJiyoung LeeMichael Fisher
    • C12M1/00
    • C12M23/28C12M23/02C12M23/14C12M23/26C12M27/02
    • Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.
    • 公开了一种一次性生物反应器袋设计,其在叶轮尖端处提供基本上等效的最大剪切速率,并且在每单位工作体积和生物培养处理所需的rpm的功率范围内的平均或体积剪切速率。 袋子设计的剪切轮廓的均匀性在用作缩小或放大平台时提供了独特的优势。 还公开了一种线性可伸缩的一次性生物反应器系统,用于进行可扩展的生物制造过程,该系统包括两个不同体积的单次使用的生物反应器袋,其中工作体积H的高度比H / D 到罐的直径D或袋的直径D等于约1.5,并且每个袋中的体积剪切基本上是恒定的。 所披露的小规模系统从剪切/可扩展性/性能基础以及从验证和监管的角度来模拟更大规模的系统。 总之,所公开的10L生物反应器系统通过使用相同或基本上模拟相同的容器几何形状,气体喷射系统,叶轮形状和类型,柔性袋/部件的聚合物组成,过程控制系统和 剪切速率为较大的50-5000 L系统。
    • 6. 发明授权
    • Tape guide angle controlling apparatus for magnetic tape recorder-player
    • 磁带录音机用磁带引导角控制装置
    • US5901011A
    • 1999-05-04
    • US701576
    • 1996-08-22
    • Youseok ChaeJiyoung Lee
    • Youseok ChaeJiyoung Lee
    • G11B15/60
    • G11B15/60
    • A tape guide angle controlling apparatus for a magnetic tape recorder-player includes a main base, a shaft bushing provided in the main base and having a shaft hole in the center thereof, a tape guide arm having at one end portion thereof a rotation shaft rotatably inserted into the shaft hole and at the other end portion thereof having a tape guide, a tape guide horizontal-rotating member for horizontally rotating the tape guide arm, and a tape guide vertical-operating member driven by the tape guide horizontal-rotating member for vertically operating the tape guide arm. The apparatus is characterized in slanting to a certain degree the tape guide which guides a magnetic tape in a reverse running mode, thereby improving the magnetic tape running property in reverse running mode.
    • 一种用于磁带录音机的磁带引导角度控制装置包括:主基座,设置在主基座中的轴衬,其中心具有轴孔;带导向臂,其一端部具有可旋转的旋转轴 插入到轴孔中,并且在其另一端部具有带导向件,用于使带导向臂水平旋转的带引导水平旋转构件和由导带水平旋转构件驱动的带导向垂直操作构件, 垂直操作带导向臂。 该装置的特征在于在一定程度上使导带器以一种反向运行模式引导磁带,从而提高了反向运行模式下的磁带运行性能。
    • 8. 发明授权
    • Tape guide angle controlling apparatus for magnetic tape recorder-player
    • 磁带录音机用磁带引导角控制装置
    • US6104569A
    • 2000-08-15
    • US245283
    • 1999-02-05
    • Youseok ChaeJiyoung Lee
    • Youseok ChaeJiyoung Lee
    • G11B15/60
    • G11B15/60
    • A tape guide angle controlling apparatus for controlling an orientation of a tape guide in a magnetic tape recorder-player includes a main base, a shaft bushing provided in the main base and having a shaft hole formed in the center thereof, a tape guide arm having at one end portion thereof a rotation shaft rotatably inserted into the shaft hole and at the other end portion thereof having a tape guide, a tape guide horizontal-rotating mechanism for horizontally rotating the tape guide arm, and a tape guide vertical-operating mechanism driven by the tape guide horizontal-rotating member for vertically moving the tape guide arm. The apparatus slants the tape guide which guides a magnetic tape in a reverse running mode, thereby improving the magnetic tape running operation in a reverse running mode.
    • 一种用于控制磁带录音机中的磁带引导件的定向的磁带引导角控制装置,包括主基座,设置在主基座中的轴衬,并且具有形成在其中心的轴孔;带引导臂, 在其一端部具有可旋转地插入到轴孔中并且在其另一端部的旋转轴,该旋转轴具有带引导件,用于水平旋转带引导臂的带引导水平旋转机构和驱动带引导件垂直操作机构 通过用于垂直移动带引导臂的带引导件水平旋转构件。 该装置倾斜磁带引导件,其以反向运行模式引导磁带,从而以反向运行模式改进磁带运行操作。