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1. 发明申请

US20130143885A1 CHEMICAL INDUCERS OF NEUROGENESIS 有权
标题翻译：化学发现神经细胞
公开(公告)号：US20130143885A1
公开(公告)日：2013-06-06
申请号：US13487963
申请日：2012-06-04
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： C07D413/04 , A61K31/5377 , C07D417/04 , C07D403/14 , A61K31/496 , C07D413/14
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

2. 发明授权

US08318951B2 Stem cell differentiating agents and uses therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US08318951B2
公开(公告)日：2012-11-27
申请号：US13116574
申请日：2011-05-26
申请人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： C07D405/14 , C07D413/04 , A61K31/4155 , A61K31/422 , A61P29/00 , C12N5/0775 , C12N5/0797
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

3. 发明申请

US20120029200A1 Stem Cell Differentiating Agents and Uses Therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US20120029200A1
公开(公告)日：2012-02-02
申请号：US13116574
申请日：2011-05-26
申请人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

4. 发明授权

US07981935B2 Stem cell differentiating agents and uses therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US07981935B2
公开(公告)日：2011-07-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C07C311/49 , C12N5/074
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

5. 发明申请

US20090036451A1 Chemical inducers of neurogenesis 有权
标题翻译：化学诱导剂的神经发生
公开(公告)号：US20090036451A1
公开(公告)日：2009-02-05
申请号：US11974479
申请日：2007-10-12
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： A61K31/422 , C07D261/18 , C07D249/10 , C07D271/06 , A61P35/00 , C12N1/38 , A61K31/5377
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

6. 发明申请

US20060183897A1 Biaryl substituted triazoles as sodium channel blockers 审中-公开
公开(公告)号：US20060183897A1
公开(公告)日：2006-08-17
申请号：US10549790
申请日：2004-03-12
申请人： Prasun Chakravarty , Michael Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
发明人： Prasun Chakravarty , Michael Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
IPC分类号： C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

7. 发明授权

US08660855B2 System and method using extended authorization hold period 有权
标题翻译：使用延长授权保留期的系统和方法
公开(公告)号：US08660855B2
公开(公告)日：2014-02-25
申请号：US11760244
申请日：2007-06-08
申请人： Stacy Pourfallah , Janet Pruitt , Douglas Frantz , Roxanna Kayoumi
发明人： Stacy Pourfallah , Janet Pruitt , Douglas Frantz , Roxanna Kayoumi
IPC分类号： G06Q50/00 , G06Q10/00
CPC分类号： G06Q10/10 , G06F19/00 , G06Q40/02 , G06Q50/22
摘要： Embodiments of the present invention relate to methods and apparatuses serving to provide assurance that healthcare providers will receive payment for services rendered. In one embodiment, a payment card (or other portable consumer device) provides an extended authorization hold period (for example up to 21 days). This hold period allows the healthcare provider to request authorization for payment from the patient's credit, debit, FSA, HRA, or HSA payment card, submit the insurance claim, and then upon receipt of a health insurance carrier's Explanation of Benefits (EOB) within the hold period, submit for settlement only that amount actually due from the patient. In accordance with an alternative embodiment, pending receipt of the EOB from the insurer, the healthcare provider flags a transaction in a point-of-sale (POS) terminal device or server for storage and delayed submittal over an electronic payment network. Embodiments in accordance with the present invention are particularly applicable to payment of claims in healthcare plans following adjudication by a payer.
摘要翻译：本发明的实施例涉及用于提供医疗保健提供者将接收对所呈现的服务的支付的保证的方法和装置。在一个实施例中，支付卡（或其他便携式消费者设备）提供延长的授权保留期限（例如长达21天）。该持续期允许医务人员从病人的信用卡，借记卡，FSA，HRA或HSA支付卡中请求授权，提交保险索赔，然后在收到健康保险运营商的福利解释（EOB）内持有期间，仅提交实际到期的患者人数。根据替代实施例，在从保险公司收到EOB之前，医疗保健提供者标记在销售点（POS）终端设备或服务器中的交易以存储并通过电子支付网络延迟提交。根据本发明的实施例特别适用于在付款人裁决之后支付医疗保健计划中的索赔。

8. 发明申请

US20090076103A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR 有权
标题翻译：干细胞分化试剂及其用途
公开(公告)号：US20090076103A1
公开(公告)日：2009-03-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C12N5/06 , C12Q1/66 , C12Q1/68 , A01K67/027 , C07C311/15 , A61P35/00 , C07D413/04 , C07D405/06 , C07D409/06 , A61K31/422 , A61K31/4155
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

9. 发明申请

US20080140447A1 SYSTEM AND METHOD USING EXTENDED AUTHORIZATION HOLD PERIOD 有权
标题翻译：使用延长授权期限的系统和方法
公开(公告)号：US20080140447A1
公开(公告)日：2008-06-12
申请号：US11760244
申请日：2007-06-08
申请人： Stacy Pourfallah , Janet Pruitt , Douglas Frantz , Roxanna Kayoumi
发明人： Stacy Pourfallah , Janet Pruitt , Douglas Frantz , Roxanna Kayoumi
IPC分类号： G06Q50/00
CPC分类号： G06Q10/10 , G06F19/00 , G06Q40/02 , G06Q50/22
摘要： Embodiments of the present invention relate to methods and apparatuses serving to provide assurance that healthcare providers will receive payment for services rendered. In one embodiment, a payment card (or other portable consumer device) provides an extended authorization hold period (for example up to 21 days). This hold period allows the healthcare provider to request authorization for payment from the patient's credit, debit, FSA, HRA, or HSA payment card, submit the insurance claim, and then upon receipt of a health insurance carrier's Explanation of Benefits (EOB) within the hold period, submit for settlement only that amount actually due from the patient. In accordance with an alternative embodiment, pending receipt of the EOB from the insurer, the healthcare provider flags a transaction in a point-of-sale (POS) terminal device or server for storage and delayed submittal over an electronic payment network. Embodiments in accordance with the present invention are particularly applicable to payment of claims in healthcare plans following adjudication by a payer.
摘要翻译：本发明的实施例涉及用于提供医疗保健提供者将接收对所呈现的服务的支付的保证的方法和装置。在一个实施例中，支付卡（或其他便携式消费者设备）提供延长的授权保留期限（例如长达21天）。该持续期允许医务人员从病人的信用卡，借记卡，FSA，HRA或HSA支付卡中请求授权，提交保险索赔，然后在收到健康保险运营商的福利解释（EOB）内持有期间，仅提交实际到期的患者人数。根据替代实施例，在从保险公司收到EOB之前，医疗保健提供者标记在销售点（POS）终端设备或服务器中的交易以存储并通过电子支付网络延迟提交。根据本发明的实施例特别适用于在付款人裁决之后支付医疗保健计划中的索赔。

10. 发明授权

US08778940B2 Chemical inducers of neurogenesis 有权
标题翻译：化学诱导剂的神经发生
公开(公告)号：US08778940B2
公开(公告)日：2014-07-15
申请号：US13487963
申请日：2012-06-04
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/415 , A61K31/4155 , A61K31/42
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

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