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    • 4. 发明申请
    • POLY(PHENYLENE ETHER) COPOLYMER AND METHOD OF MAKING
    • 聚(苯乙烯)共聚物及其制备方法
    • US20150038667A1
    • 2015-02-05
    • US13881480
    • 2012-07-27
    • Alvaro CarrilloScott Michael FisherHua GuoStephan MoysesEylem Tarkin-Tas
    • Alvaro CarrilloScott Michael FisherHua GuoStephan MoysesEylem Tarkin-Tas
    • C08G65/44C08G65/46
    • C08G65/44C08G65/38C08G65/46C08L71/12
    • A poly(phenylene ether) copolymer comprising about 5 to 40 mole percent repeat units derived from 2-phenylphenol and 60 to about 95 mole percent repeat units derived from 2,6-dimethylphenol, wherein the poly(phenylene ether) copolymer has a weight average molecular weight of at least 8,000 atomic mass units, is disclosed. Also disclosed is a method of preparing the poly(phenylene ether) copolymer, the method comprising oxidatively copolymerizing a monomer mixture comprising about 5 to 40 mole percent 2-phenylphenol and about 60 to about 95 mole percent 2,6-dimethylphenol in the presence of a solvent, molecular oxygen, and a polymerization catalyst comprising a metal ion and at least one amine ligand to form a solution of the poly(phenylene ether) copolymer in the solvent, wherein a ratio of total moles of 2-phenylphenol and 2,6-dimethylphenol to moles of metal ion is about 10:1 to about 1200:1.
    • 包含约5-40摩尔%的衍生自2-苯基苯酚的重复单元和衍生自2,6-二甲基苯酚的重均分子量为60-约95摩尔%的聚(苯醚)共聚物,其中聚苯醚共聚物具有重均分子量 分子量至少为8,000原子质量单位。 还公开了制备聚(苯醚)共聚物的方法,该方法包括在包含约5至40摩尔%的2-苯基苯酚和约60至约95摩尔%2,6-二甲基苯酚的单体混合物的存在下, 溶剂,分子氧和包含金属离子和至少一种胺配体的聚合催化剂,以在溶剂中形成聚(苯醚)共聚物的溶液,其中2-苯基苯酚和2,6-二羟基苯酚的总摩尔比 二甲基酚与金属离子的摩尔数为约10:1至约1200:1。
    • 7. 发明申请
    • LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM
    • 线性可扩展单一使用生物反应器系统
    • US20130288346A1
    • 2013-10-31
    • US13978726
    • 2012-01-11
    • Colin TuoheyTed DeloggioThomas ErdenbergerKenneth P. ClappRichard DamrenParrish M. GalliherPatrick GuertinJiyoung LeeMichael Fisher
    • Colin TuoheyTed DeloggioThomas ErdenbergerKenneth P. ClappRichard DamrenParrish M. GalliherPatrick GuertinJiyoung LeeMichael Fisher
    • C12M1/00
    • C12M23/28C12M23/02C12M23/14C12M23/26C12M27/02
    • Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.
    • 公开了一种一次性生物反应器袋设计,其在叶轮尖端处提供基本上等效的最大剪切速率,并且在每单位工作体积和生物培养处理所需的rpm的功率范围内的平均或体积剪切速率。 袋子设计的剪切轮廓的均匀性在用作缩小或放大平台时提供了独特的优势。 还公开了一种线性可伸缩的一次性生物反应器系统,用于进行可扩展的生物制造过程,该系统包括两个不同体积的单次使用的生物反应器袋,其中工作体积H的高度比H / D 到罐的直径D或袋的直径D等于约1.5,并且每个袋中的体积剪切基本上是恒定的。 所披露的小规模系统从剪切/可扩展性/性能基础以及从验证和监管的角度来模拟更大规模的系统。 总之,所公开的10L生物反应器系统通过使用相同或基本上模拟相同的容器几何形状,气体喷射系统,叶轮形状和类型,柔性袋/部件的聚合物组成,过程控制系统和 剪切速率为较大的50-5000 L系统。
    • 9. 发明授权
    • Knee balancing for revision procedures
    • 膝关节平衡修正程序
    • US08506571B2
    • 2013-08-13
    • US12757486
    • 2010-04-09
    • Barjinder ChanaMichael Fisher
    • Barjinder ChanaMichael Fisher
    • A61B17/56
    • A61B17/1764A61B17/155A61B17/157A61B17/72A61F2/38A61F2/4684
    • Methods, systems and devices are provided for facilitating a surgical procedure on a knee, particularly, a revision total knee replacement procedure. Prior femoral and tibial prostheses are removed. A cut end of a distal femur is engaged with a femoral adjustment member, which will typically center itself about an intramedullary rod placed into the femur. The lateral and medial forces exerted by lateral and medial sides of the femoral adjustment member and the cut tibial plateau against each other are measured. The femoral adjustment member is adjusted to apply and/or adjust tension to the lateral collateral ligament and/or the medial collateral ligament based on the measured forces, for example, such that the measured lateral force and the measured medial force are matched. Based on the position of the adjusted femoral member, guided clean-up cuts for placement of a new femoral prostheses are made on the cut end of the distal femur.
    • 提供了方法,系统和装置,以便于膝盖上的外科手术,特别是修正全膝关节置换手术。 先前的股骨和胫骨假体被去除。 远端股骨的切割端与股骨调节构件接合,股骨调节构件通常将其本身围绕放置在股骨中的髓内杆围绕。 测量股骨调节构件的侧面和内侧以及切断的胫骨平台之间的横向和内侧力。 调整股骨调节构件以基于所测量的力施加和/或调整侧向侧韧带和/或内侧副韧带的张力,例如使得所测量的横向力和所测量的内侧力匹配。 根据调整后的股骨构件的位置,在远端股骨的切割端上形成用于放置新的股骨假体的导向清理切口。