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1. 发明授权

US06465002B1 Liquid crystalline polymers 有权
标题翻译：液晶聚合物
公开(公告)号：US06465002B1
公开(公告)日：2002-10-15
申请号：US09523887
申请日：2000-03-13
申请人： Edith Mathiowitz , Jules S. Jacob , Yong S. Jong , Donald E. Chickering, III , Edwin E. Edwards
发明人： Edith Mathiowitz , Jules S. Jacob , Yong S. Jong , Donald E. Chickering, III , Edwin E. Edwards
IPC分类号： A61F1300
CPC分类号： C09K19/38 , B29C55/00 , B29C55/18 , B29K2105/0079
摘要： Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics. The liquid crystalline polymers can be used in the controlled release or retention of substances encapsulated in the polymers. The polymer can be in a variety of forms including films, film laminants, and microparticles. In a preferred embodiment, the LC polymers are used to encapsulate therapeutic, diagnostic, or prophylactic agents for use in medical or pharmaceutical applications.
摘要翻译：已经开发了用于诱导可以是非介晶的热塑性聚合物以显示液晶性质的方法。该方法包括以下步骤：（a）将聚合物从低于其玻璃化转变温度（Tg）的初始温度加热至大于其Tg并低于其熔融温度（Tm）的温度; （b）将聚合物暴露于大于约2公吨/ in2的压力下，优选约2至10公吨/ in 2，优选至少约1分钟，同时保持温度高于其Tg; 和（c）在保持升高的压力的同时将聚合物冷却至Tg以下。与可逆的许多现有技术的过渡过程不同，该方法提供可在环境条件下保持多年的液晶状态。在优选的实施方案中，塑料是可生物腐蚀的热塑性聚合物，例如聚酐，一些聚酯，聚酰胺和多芳族化合物。液晶聚合物可用于控制或保留包封在聚合物中的物质。聚合物可以是各种形式，包括膜，膜层压剂和微粒。在优选的实施方案中，LC聚合物用于包封用于医疗或药物应用的治疗剂，诊断剂或预防剂。

2. 发明申请

US20100172998A1 PROCESS FOR PREPARING MICROPARTICLES THROUGH PHASE INVERSION PHENOMENA 审中-公开
标题翻译：通过相变反应准备微量元素的方法
公开(公告)号：US20100172998A1
公开(公告)日：2010-07-08
申请号：US12171275
申请日：2008-07-10
申请人： Edith Mathiowitz , Donald E. Chickering, III , Yong S. Jong , Jules S. Jacob
发明人： Edith Mathiowitz , Donald E. Chickering, III , Yong S. Jong , Jules S. Jacob
IPC分类号： B01J13/02 , A61K9/50 , A61K38/28 , A61K31/7088
CPC分类号： A61K9/5153 , A61K9/1641 , A61K9/1694 , A61K9/5089 , A61K9/5138 , A61K9/5146 , A61K9/5192 , A61K48/00 , B01J13/04 , B01J13/06
摘要： A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.
摘要翻译：提供了制备纳米颗粒和微粒的方法。该方法包括形成聚合物和溶剂的混合物，其中溶剂以连续相存在并将混合物引入有效量的非溶剂中以引起微粒的自发形成。

3. 发明授权

US06696075B2 Liquid crystalline polymers 有权
标题翻译：液晶聚合物
公开(公告)号：US06696075B2
公开(公告)日：2004-02-24
申请号：US10231723
申请日：2002-08-30
申请人： Edith Mathiowitz , Jules S. Jacob , Yong S. Jong , Donald E. Chickering , Edwin E. Edwards
发明人： Edith Mathiowitz , Jules S. Jacob , Yong S. Jong , Donald E. Chickering , Edwin E. Edwards
IPC分类号： A61F1300
CPC分类号： C09K19/38 , B29C55/00 , B29C55/18 , B29K2105/0079
摘要： Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics. The liquid crystalline polymers can be used in the controlled release or retention of substances encapsulated in the polymers. The polymer can be in a variety of forms including films, film laminants, and microparticles. In a preferred embodiment, the LC polymers are used to encapsulate therapeutic, diagnostic, or prophylactic agents for use in medical or pharmaceutical applications.
摘要翻译：已经开发了用于诱导可以是非介晶的热塑性聚合物以显示液晶性质的方法。该方法包括以下步骤：（a）将聚合物从低于其玻璃化转变温度（Tg）的初始温度加热至大于其Tg并低于其熔融温度（Tm）的温度; （b）将聚合物暴露于大于约2公吨/ in 2的压力下，优选在约2至10公吨/ in 2之间，优选至少约1分钟，同时保持温度高于其 Tg; 和（c）在保持升高的压力的同时将聚合物冷却至Tg以下。与可逆的许多现有技术的过渡过程不同，该方法提供可在环境条件下保持多年的液晶状态。在优选的实施方案中，塑料是可生物腐蚀的热塑性聚合物，例如聚酐，一些聚酯，聚酰胺和多芳族化合物。液晶聚合物可用于控制或保留包封在聚合物中的物质。聚合物可以是各种形式，包括膜，膜层压剂和微粒。在优选的实施方案中，LC聚合物用于包封用于医疗或药物应用的治疗剂，诊断剂或预防剂。

4. 发明授权

US5985354A Preparation of multiwall polymeric microcapsules from hydrophilic polymers 失效
公开(公告)号：US5985354A
公开(公告)日：1999-11-16
申请号：US478103
申请日：1995-06-07
申请人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
发明人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , B01J13/04 , B01J13/06 , B01J13/20
CPC分类号： B01J13/04 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , B29K2003/00 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.

5. 发明授权

US06528035B1 Multiwall polymeric microcapsules from hydrophilic polymers 失效
标题翻译：来自亲水聚合物的多壁聚合物微胶囊
公开(公告)号：US06528035B1
公开(公告)日：2003-03-04
申请号：US09707440
申请日：2000-11-06
申请人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Leach
发明人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Leach
IPC分类号： B32B516
CPC分类号： B01J13/04 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , B29K2003/00 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.
摘要翻译：在特定浓度和温度下彼此不溶的但在溶液中具有正扩散系数的两种或更多种亲水性聚合物用于形成多层聚合物微球体。通过该方法制备的多层微球的特征在于非常均匀的尺寸聚合物层和实际掺入待输送到聚合物层中的物质。在该方法的优选实施方案中，将两种聚合物溶解在水性溶剂中，将待加入的物质分散或溶解在聚合物溶液中，将混合物悬浮在有机溶剂或聚合物/水混合物中并搅拌，并将溶剂缓慢蒸发，产生具有由一种聚合物形成的内芯和由第二聚合物形成的外层的微球。

6. 发明授权

US06511749B1 Preparation of multiwall polymeric microcapsules from hydrophilic polymers 失效
标题翻译：从亲水聚合物制备多壁聚合物微胶囊
公开(公告)号：US06511749B1
公开(公告)日：2003-01-28
申请号：US08990365
申请日：1997-12-15
申请人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
发明人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
IPC分类号： B32B1502
CPC分类号： B01J13/04 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , B29K2003/00 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.
摘要翻译：在特定浓度和温度下彼此不溶的但在溶液中具有正扩散系数的两种或更多种亲水性聚合物用于形成多层聚合物微球体。通过该方法制备的多层微球的特征在于非常均匀的尺寸聚合物层和实际掺入待输送到聚合物层中的物质。在该方法的优选实施方案中，将两种聚合物溶解在水性溶剂中，将待加入的物质分散或溶解在聚合物溶液中，将混合物悬浮在有机溶剂或聚合物/水混合物中并搅拌，并将溶剂缓慢蒸发，产生具有由一种聚合物形成的内芯和由第二聚合物形成的外层的微球。

7. 发明授权

US06235224B1 Process for preparing microparticles through phase inversion phenomena 有权
公开(公告)号：US06235224B1
公开(公告)日：2001-05-22
申请号：US09442723
申请日：1999-11-18
申请人： Edith Mathiowitz , Donald Chickering, III , Yong S. Jong , Jules S. Jacob
发明人： Edith Mathiowitz , Donald Chickering, III , Yong S. Jong , Jules S. Jacob
IPC分类号： B01J1304
CPC分类号： A61K9/5153 , A61K9/1641 , A61K9/1694 , A61K9/5089 , A61K9/5138 , A61K9/5146 , A61K9/5192 , A61K48/00 , B01J13/04 , B01J13/06
摘要： A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.

8. 发明授权

US06677313B1 Method for gene therapy using nucleic acid loaded polymeric microparticles 失效
标题翻译：使用加载有核酸的聚合物微粒进行基因治疗的方法
公开(公告)号：US06677313B1
公开(公告)日：2004-01-13
申请号：US09678764
申请日：2000-10-03
申请人： Edith Mathiowitz , Yong S. Jong , Gerardo Carino , Jules S. Jacob
发明人： Edith Mathiowitz , Yong S. Jong , Gerardo Carino , Jules S. Jacob
IPC分类号： A61K4800
CPC分类号： A61K9/5153 , A61K9/1641 , A61K9/1694 , A61K9/5089 , A61K48/00 , B01J13/04 , B01J13/06
摘要： The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.
摘要翻译：本发明涉及用于口服基因治疗的方法和产品。启动子控制下的基因保护性地包含在微粒中并以可操作形式递送至细胞，从而获得用于基因治疗的非侵入性基因递送。

9. 发明授权

US06248720B1 Method for gene therapy using nucleic acid loaded polymeric microparticles 失效
标题翻译：使用加载有核酸的聚合物微粒进行基因治疗的方法
公开(公告)号：US06248720B1
公开(公告)日：2001-06-19
申请号：US08675454
申请日：1996-07-03
申请人： Edith Mathiowitz , Yong S. Jong , Gerardo Carino , Jules S. Jacob
发明人： Edith Mathiowitz , Yong S. Jong , Gerardo Carino , Jules S. Jacob
IPC分类号： A61K4800
CPC分类号： A61K9/5138 , A61K9/1641 , A61K9/5153 , A61K48/00
摘要： The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.
摘要翻译：本发明涉及用于口服基因治疗的方法和产品。启动子控制下的基因保护性地包含在微粒中并以可操作形式递送至细胞，从而获得用于基因治疗的非侵入性基因递送。

10. 发明授权

US6143211A Process for preparing microparticles through phase inversion phenomena 失效
公开(公告)号：US6143211A
公开(公告)日：2000-11-07
申请号：US686928
申请日：1996-07-03
申请人： Edith Mathiowitz , Donald Chickering, III , Yong S. Jong , Jules S. Jacob
发明人： Edith Mathiowitz , Donald Chickering, III , Yong S. Jong , Jules S. Jacob
IPC分类号： A61K9/16 , A61K9/50 , A61K9/51 , A61K9/52 , A61K48/00 , B01J13/04 , B01J13/06
CPC分类号： A61K9/5153 , A61K48/00 , A61K9/1641 , A61K9/1694 , A61K9/5089 , A61K9/5138 , A61K9/5146 , A61K9/5192 , B01J13/04 , B01J13/06
摘要： A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.

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