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1. 发明授权

US06465002B1 Liquid crystalline polymers 有权
标题翻译：液晶聚合物
公开(公告)号：US06465002B1
公开(公告)日：2002-10-15
申请号：US09523887
申请日：2000-03-13
申请人： Edith Mathiowitz , Jules S. Jacob , Yong S. Jong , Donald E. Chickering, III , Edwin E. Edwards
发明人： Edith Mathiowitz , Jules S. Jacob , Yong S. Jong , Donald E. Chickering, III , Edwin E. Edwards
IPC分类号： A61F1300
CPC分类号： C09K19/38 , B29C55/00 , B29C55/18 , B29K2105/0079
摘要： Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics. The liquid crystalline polymers can be used in the controlled release or retention of substances encapsulated in the polymers. The polymer can be in a variety of forms including films, film laminants, and microparticles. In a preferred embodiment, the LC polymers are used to encapsulate therapeutic, diagnostic, or prophylactic agents for use in medical or pharmaceutical applications.
摘要翻译：已经开发了用于诱导可以是非介晶的热塑性聚合物以显示液晶性质的方法。该方法包括以下步骤：（a）将聚合物从低于其玻璃化转变温度（Tg）的初始温度加热至大于其Tg并低于其熔融温度（Tm）的温度; （b）将聚合物暴露于大于约2公吨/ in2的压力下，优选约2至10公吨/ in 2，优选至少约1分钟，同时保持温度高于其Tg; 和（c）在保持升高的压力的同时将聚合物冷却至Tg以下。与可逆的许多现有技术的过渡过程不同，该方法提供可在环境条件下保持多年的液晶状态。在优选的实施方案中，塑料是可生物腐蚀的热塑性聚合物，例如聚酐，一些聚酯，聚酰胺和多芳族化合物。液晶聚合物可用于控制或保留包封在聚合物中的物质。聚合物可以是各种形式，包括膜，膜层压剂和微粒。在优选的实施方案中，LC聚合物用于包封用于医疗或药物应用的治疗剂，诊断剂或预防剂。

2. 发明申请

US20100172998A1 PROCESS FOR PREPARING MICROPARTICLES THROUGH PHASE INVERSION PHENOMENA 审中-公开
标题翻译：通过相变反应准备微量元素的方法
公开(公告)号：US20100172998A1
公开(公告)日：2010-07-08
申请号：US12171275
申请日：2008-07-10
申请人： Edith Mathiowitz , Donald E. Chickering, III , Yong S. Jong , Jules S. Jacob
发明人： Edith Mathiowitz , Donald E. Chickering, III , Yong S. Jong , Jules S. Jacob
IPC分类号： B01J13/02 , A61K9/50 , A61K38/28 , A61K31/7088
CPC分类号： A61K9/5153 , A61K9/1641 , A61K9/1694 , A61K9/5089 , A61K9/5138 , A61K9/5146 , A61K9/5192 , A61K48/00 , B01J13/04 , B01J13/06
摘要： A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.
摘要翻译：提供了制备纳米颗粒和微粒的方法。该方法包括形成聚合物和溶剂的混合物，其中溶剂以连续相存在并将混合物引入有效量的非溶剂中以引起微粒的自发形成。

3. 发明授权

US06528035B1 Multiwall polymeric microcapsules from hydrophilic polymers 失效
标题翻译：来自亲水聚合物的多壁聚合物微胶囊
公开(公告)号：US06528035B1
公开(公告)日：2003-03-04
申请号：US09707440
申请日：2000-11-06
申请人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Leach
发明人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Leach
IPC分类号： B32B516
CPC分类号： B01J13/04 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , B29K2003/00 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.
摘要翻译：在特定浓度和温度下彼此不溶的但在溶液中具有正扩散系数的两种或更多种亲水性聚合物用于形成多层聚合物微球体。通过该方法制备的多层微球的特征在于非常均匀的尺寸聚合物层和实际掺入待输送到聚合物层中的物质。在该方法的优选实施方案中，将两种聚合物溶解在水性溶剂中，将待加入的物质分散或溶解在聚合物溶液中，将混合物悬浮在有机溶剂或聚合物/水混合物中并搅拌，并将溶剂缓慢蒸发，产生具有由一种聚合物形成的内芯和由第二聚合物形成的外层的微球。

4. 发明授权

US06511749B1 Preparation of multiwall polymeric microcapsules from hydrophilic polymers 失效
标题翻译：从亲水聚合物制备多壁聚合物微胶囊
公开(公告)号：US06511749B1
公开(公告)日：2003-01-28
申请号：US08990365
申请日：1997-12-15
申请人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
发明人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
IPC分类号： B32B1502
CPC分类号： B01J13/04 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , B29K2003/00 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.
摘要翻译：在特定浓度和温度下彼此不溶的但在溶液中具有正扩散系数的两种或更多种亲水性聚合物用于形成多层聚合物微球体。通过该方法制备的多层微球的特征在于非常均匀的尺寸聚合物层和实际掺入待输送到聚合物层中的物质。在该方法的优选实施方案中，将两种聚合物溶解在水性溶剂中，将待加入的物质分散或溶解在聚合物溶液中，将混合物悬浮在有机溶剂或聚合物/水混合物中并搅拌，并将溶剂缓慢蒸发，产生具有由一种聚合物形成的内芯和由第二聚合物形成的外层的微球。

5. 发明授权

US5985354A Preparation of multiwall polymeric microcapsules from hydrophilic polymers 失效
公开(公告)号：US5985354A
公开(公告)日：1999-11-16
申请号：US478103
申请日：1995-06-07
申请人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
发明人： Edith Mathiowitz , Jules S. Jacob , Donald E. Chickering, III , Kathleen Jo Pekarek
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , B01J13/04 , B01J13/06 , B01J13/20
CPC分类号： B01J13/04 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , B29K2003/00 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.

6. 发明授权

US06365187B2 Bioadhesive microspheres and their use as drug delivery and imaging systems 失效
标题翻译：生物粘附微球及其作为药物递送和成像系统的用途
公开(公告)号：US06365187B2
公开(公告)日：2002-04-02
申请号：US09773229
申请日：2001-01-31
申请人： Edith Mathiowitz , Donald E. Chickering, III , Jules Serge Jacob
发明人： Edith Mathiowitz , Donald E. Chickering, III , Jules Serge Jacob
IPC分类号： A61K914
CPC分类号： A61K9/1641 , A61K9/167 , Y10S514/962 , Y10S977/906 , Y10S977/915 , Y10S977/928
摘要： Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm2 (110 N/m2) Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. This quantitative method provides a means to establish a correlation between the chemical nature, the surface morphology and the dimensions of drug-loaded microspheres on one hand and bioadhesive forces on the other, allowing the screening of the most promising materials from a relatively large group of natural and synthetic polymers which, from theoretical consideration, should be used for making bioadhesive microspheres.
摘要翻译：描述了可以用作胃肠道疾病中的治疗或诊断目的的药物或生物活性物质的形式或作为包衣形式的生物粘附聚合物。聚合物微球全部具有至少11mN / cm 2（110N / m 2）的生物附着力。用于制造生物粘附性微球的技术以及用于测量微球和体外胃肠道选定区段之间的生物粘附力的方法是也描述。这种定量方法提供了一种手段来建立化学性质，表面形态和药物负载微球的尺寸与生物粘附力之间的相关性，另一方面可以从相对较大的组中筛选出最有希望的材料天然和合成的聚合物，从理论上考虑，应用于制造生物粘附微球。

7. 发明申请

US20130138058A9 DELIVERING AND/OR RECEIVING FLUIDS 有权
公开(公告)号：US20130138058A9
公开(公告)日：2013-05-30
申请号：US13456570
申请日：2012-04-26
申请人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse
发明人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse
IPC分类号： A61M1/00
CPC分类号： A61B5/150374 , A61B5/1411 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15144 , A61B5/154 , A61B5/411 , A61B5/685 , A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/008 , A61M37/0015 , G06F19/00 , G16H10/40
摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

8. 发明申请

US20110181410A1 MONITORING OR FEEDBACK SYSTEMS AND METHODS 有权
标题翻译：监控或反馈系统和方法
公开(公告)号：US20110181410A1
公开(公告)日：2011-07-28
申请号：US13016575
申请日：2011-01-28
申请人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
IPC分类号： G08B21/00
CPC分类号： G06F19/3456 , G06F19/00 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
摘要翻译：本发明一般涉及用于监测和/或提供受试者所采取的药物或其他药物的反馈的系统和方法。一方面，本发明涉及用于确定受试者皮肤内物种的装置和方法; 并根据物种的确定向对象产生反馈。反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于物种的确定的信息可以被传输到另一个实体，例如医疗保健提供者，计算机，相对等，其然后可以以某种方式向受试者提供反馈。在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受物种影响的化合物是否为存在等。然而，在一些实施例中，反馈也可以是间接的。例如，受试者可以例如基于皮肤内物种的确定来呈现外部奖励。例如，可以基于主体的合规级别来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。本发明的其它方面通常涉及涉及这种装置的试剂盒（有或没有待监测的药物），促进这种系统的方法等。

9. 发明申请

US20100256465A1 DEVICES AND TECHNIQUES ASSOCIATED WITH DIAGNOSTICS, THERAPIES, AND OTHER APPLICATIONS, INCLUDING SKIN-ASSOCIATED APPLICATIONS 有权
标题翻译：与诊断，治疗和其他应用相关的设备和技术，包括皮肤相关应用
公开(公告)号：US20100256465A1
公开(公告)日：2010-10-07
申请号：US12716229
申请日：2010-03-02
申请人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
发明人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
IPC分类号： A61B5/00 , A61B5/145 , G01N21/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

10. 再颁专利

USRE40493E1 Porous paclitaxel matrices and methods of manufacture thereof 有权
标题翻译：多孔紫杉醇基质及其制备方法
公开(公告)号：USRE40493E1
公开(公告)日：2008-09-09
申请号：US11213257
申请日：2005-08-26
申请人： Julie A. Straub , Howard Bernstein , Donald E. Chickering, III , Sarwat Khattak , Greg Randall
发明人： Julie A. Straub , Howard Bernstein , Donald E. Chickering, III , Sarwat Khattak , Greg Randall
IPC分类号： A61K9/14 , A61K9/70 , A61F2/00
CPC分类号： A61K9/1623 , A61K9/1611 , A61K9/1635 , A61K9/1694 , Y10S977/906
摘要： Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process that includes (i) dissolving paclitaxel in a volatile solvent to form a paclitaxel solution, (ii) combining at least one pore forming agent with the paclitaxel solution to form an emulsion, suspension, or second solution, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of paclitaxel. The pore forming agent can be either a volatile liquid that is immiscible with the paclitaxel solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. In a preferred embodiment, microparticles of the porous paclitaxel matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.
摘要翻译：紫杉醇以多孔基质形式提供，其允许药物在没有Cremophor的情况下配制并作为大剂量给药。紫杉醇基质优选使用包括（i）将紫杉醇溶解在挥发性溶剂中以形成紫杉醇溶液的方法制备，（ii）将至少一种成孔剂与紫杉醇溶液组合以形成乳液，悬浮液或第二溶液，和（iii）从乳液，悬浮液或第二溶液中除去挥发性溶剂和成孔剂以产生紫杉醇的多孔基质。成孔剂可以是与紫杉醇溶剂或挥发性固体化合物，优选挥发性盐不混溶的挥发性液体。在优选的实施方案中，使用喷雾干燥来除去溶剂和成孔剂。在优选的实施方案中，多孔紫杉醇基质的微粒用水性介质重新配制，并肠胃外给药，或使用标准技术加工成用于口服给药的片剂或胶囊。

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