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1. 发明授权

US08927760B2 Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives 有权
标题翻译：秋水仙碱衍生物或其药学上可接受的盐，制备所述衍生物的方法和包含所述衍生物的药物组合物
公开(公告)号：US08927760B2
公开(公告)日：2015-01-06
申请号：US13579704
申请日：2011-02-18
申请人： Duck Jong Han , Sung-eun Yoo , Jeehee Suh
发明人： Duck Jong Han , Sung-eun Yoo , Jeehee Suh
IPC分类号： C07C321/00 , C07C235/56 , C07C233/32 , A61K45/06 , C07C271/24 , A61K31/165
CPC分类号： C07C271/24 , A61K31/165 , A61K45/06 , C07C233/32 , C07C235/56 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07C2603/34 , A61K2300/00
摘要： The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
摘要翻译：本发明涉及化学式1表示的秋水仙碱衍生物或其药学上可接受的盐，涉及制备所述衍生物的方法，以及包含所述衍生物的药物组合物。根据本发明的秋水仙碱衍生物与常规的免疫调节剂或秋水仙素相比表现出优异的免疫调节作用，因此可以有价值地用作调节器官移植中急性或慢性免疫应答的免疫调节剂。

2. 发明申请

US20130011417A1 COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES 有权
标题翻译：化合物衍生物或其药学上可接受的盐，制备所述衍生物的方法和包含所述衍生物的药物组合物
公开(公告)号：US20130011417A1
公开(公告)日：2013-01-10
申请号：US13579704
申请日：2011-02-18
申请人： Duck Jong Han , Sung-eun Yoo , Jeehee Suh
发明人： Duck Jong Han , Sung-eun Yoo , Jeehee Suh
IPC分类号： A61K31/27 , C07C233/32 , A61K31/165 , A61P37/06 , A61K31/17 , A61K39/00 , A61K39/395 , C07C271/30 , C07C275/26
CPC分类号： C07C271/24 , A61K31/165 , A61K45/06 , C07C233/32 , C07C235/56 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07C2603/34 , A61K2300/00
摘要： The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
摘要翻译：本发明涉及化学式1表示的秋水仙碱衍生物或其药学上可接受的盐，涉及制备所述衍生物的方法，以及包含所述衍生物的药物组合物。根据本发明的秋水仙碱衍生物与常规的免疫调节剂或秋水仙素相比表现出优异的免疫调节作用，因此可以有价值地用作调节器官移植中急性或慢性免疫应答的免疫调节剂。

3. 发明授权

US07939550B2 Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same 有权
标题翻译：氨基吡唑衍生物，其制备方法和用于预防或治疗含有该组合物的缺血性疾病的组合物
公开(公告)号：US07939550B2
公开(公告)日：2011-05-10
申请号：US12447394
申请日：2007-10-26
申请人： Yong-Sam Jung , Eunhee Kim , Nakjeong Kim , Yun-Suk Lee , Jeehee Suh , Haeyoung Suh , Kyu Yang Yi , Sung-eun Yoo
发明人： Yong-Sam Jung , Eunhee Kim , Nakjeong Kim , Yun-Suk Lee , Jeehee Suh , Haeyoung Suh , Kyu Yang Yi , Sung-eun Yoo
IPC分类号： A61K31/44 , A61K31/415 , C07D231/00
CPC分类号： C07D231/38 , C07D231/40 , C07D401/12 , C07D413/04 , C07D413/12
摘要： Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.
摘要翻译：提供氨基吡唑衍生物，其制备方法和用于预防或治疗含有该组合物的缺血性疾病的组合物。由于本发明的氨基吡唑衍生物可显着减少缺血性细胞死亡，因此可有效地用于预防和治疗缺血性细胞死亡或器官保护的缺血性疾病。

4. 发明申请

US20100063106A1 AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME 有权
标题翻译：氨基吡唑衍生物，其制备方法和用于预防或治疗含有其的异种疾病的组合物
公开(公告)号：US20100063106A1
公开(公告)日：2010-03-11
申请号：US12447394
申请日：2007-10-26
申请人： Yong-Sam JUNG , Eunhee Kim , Nakjeong Kim , Yun-Sun Lee , Jeehee Suh , Haeyoung Suh , Kyu Yang Yi , Sung-eun Yoo
发明人： Yong-Sam JUNG , Eunhee Kim , Nakjeong Kim , Yun-Sun Lee , Jeehee Suh , Haeyoung Suh , Kyu Yang Yi , Sung-eun Yoo
IPC分类号： A61K31/4439 , A61K31/422 , A61K31/415 , C07D401/02 , C07D413/02 , C07D231/00
CPC分类号： C07D231/38 , C07D231/40 , C07D401/12 , C07D413/04 , C07D413/12
摘要： Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.
摘要翻译：提供氨基吡唑衍生物，其制备方法和用于预防或治疗含有该组合物的缺血性疾病的组合物。由于本发明的氨基吡唑衍生物可显着减少缺血性细胞死亡，因此可有效地用于预防和治疗缺血性细胞死亡或器官保护的缺血性疾病。

5. 发明申请

US20070049621A1 6-Alkylamino-2-methyl-2'-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor 失效
标题翻译： 6-烷基氨基-2-甲基-2' - （N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物作为抗炎抑制剂
公开(公告)号：US20070049621A1
公开(公告)日：2007-03-01
申请号：US11491320
申请日：2006-07-21
申请人： Young-Dae Gong , Hyae-Gyeong Cheon , Moon-Kook Jeon , Cho Sik , Jong Hwang , Choi Sub , Jeon Suk , Soon-Hee Hwang , Song Sook , Kim Hyun , Sung-eun Yoo
发明人： Young-Dae Gong , Hyae-Gyeong Cheon , Moon-Kook Jeon , Cho Sik , Jong Hwang , Choi Sub , Jeon Suk , Soon-Hee Hwang , Song Sook , Kim Hyun , Sung-eun Yoo
IPC分类号： A61K31/4433 , A61K31/381 , A61K31/353 , C07D409/02 , C07D405/02
CPC分类号： C07D311/58 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic techniques, and a use of the novel compound showing a high inhibitory effect to 5-lipoxygenase (5-LO) activity for preventing and treating leukotriene (LTA4, B4, C4, D4) activation-related diseases such as inflammatory diseases, rheumatoid arthritis, colitis, asthma and psoriasis.
摘要翻译：本发明涉及6-烷基氨基-2-甲基-2' - （N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物，其使用平行合成法制备高效的方法，一种的组合化学合成技术的用途，以及对预防和治疗白三烯（LTA4，B4，C4，D4）活化相关疾病如炎性疾病的5-脂氧合酶（5-LO）活性具有高抑制作用的新化合物的用途，类风湿关节炎，结肠炎，哮喘和牛皮癣。

6. 发明授权

US08143307B2 Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same 有权
标题翻译：苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物
公开(公告)号：US08143307B2
公开(公告)日：2012-03-27
申请号：US11794238
申请日：2005-12-27
申请人： Kyu Yang Yi , SunKyung Lee , Jee Hee Suh , Nak Jeong Kim , Hyunsuk Lee , Byung-Ho Lee , Sung-eun Yoo , Kyung-Hee Lee , Yong Oh Lee
发明人： Kyu Yang Yi , SunKyung Lee , Jee Hee Suh , Nak Jeong Kim , Hyunsuk Lee , Byung-Ho Lee , Sung-eun Yoo , Kyung-Hee Lee , Yong Oh Lee
IPC分类号： A61K31/381 , C07D333/56
CPC分类号： C07D333/70
摘要： The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.
摘要翻译：本发明涉及苯并噻吩-2-羰基胍衍生物，其制备方法和含有它们的药物组合物。该衍生物对钠/氢交换器NHE-1具有有效的抑制作用，改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复，并显着降低了体内缺血动物模型中的心肌梗死面积，从而显示良好的心脏保护作用。此外，衍生物保护神经元细胞和脑，如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。该衍生物可以有效地用于预防和治疗心肌梗塞，心律失常，心绞痛等缺血性心脏病，脑血管疾病如脑卒中，并用作心脏保护剂，用于接受再灌注治疗的患者，包括化学药剂作为溶栓剂，或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。

7. 发明授权

US06908942B2 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives and their construction by parallel synthesis on solid-phase 失效
标题翻译： 6-氨基-2,2-二甲基-3,4,6-三取代苯并吡喃衍生物及其在固相上的并行合成的构建
公开(公告)号：US06908942B2
公开(公告)日：2005-06-21
申请号：US10461433
申请日：2003-06-16
申请人： Young-Dae Gong , Jin-Soo Seo , Jong Yeon Hwang , Sung-eun Yoo
发明人： Young-Dae Gong , Jin-Soo Seo , Jong Yeon Hwang , Sung-eun Yoo
IPC分类号： C07D311/70 , A61K31/353 , A61K31/381 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P35/00 , A61P39/06 , A61P43/00 , C07D311/22 , C07D407/12 , C07D409/12 , A61K31/35 , C07D311/76
CPC分类号： C07D407/12 , C07D311/22 , C07D409/12
摘要： The present invention provides (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing benzopyran derivatives with high efficiency by parallel synthesis on a solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products.
摘要翻译：本发明提供（i）6-氨基-2,2-二甲基-3,4,6-三取代的苯并吡喃衍生物; （ii）通过作为组合化学合成技术之一的固相上的并行合成来高效合成苯并吡喃衍生物的方法; 和（iii）苯并吡喃衍生物用于预防和治疗通过促进脂质过氧化或氧化产物积累而引起的疾病或病症的用途。

8. 发明授权

US4450172A Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols 失效
标题翻译：抗高血压多卤羟基异丙基苯基（e）烷基氨基羟基丙氧基苯基烷基醇的酸性酸酯
公开(公告)号：US4450172A
公开(公告)日：1984-05-22
申请号：US356712
申请日：1982-03-10
申请人： Sung-eun Yoo
发明人： Sung-eun Yoo
IPC分类号： A61K31/235 , C07C69/612 , C07C69/618
CPC分类号： A61K31/235 , C07C69/612
摘要： Polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols, such as 2-(4-((2-hydroxy-3-(1-methylethylamino)-phenyl)ethyl 3-(4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl))benzene propanoate, are useful as antihypertensive agents. Preferred compounds give vasodilatory activity and reduced tachycardia.
摘要翻译：多卤代羟基异丙基苯基烷基（e）烷基氨基羟基丙氧基苯基烷基醇的酸性酯，例如2-（4 - （（2-羟基-3-（1-甲基乙基氨基） - 苯基）乙基3-（4-（2,2,2-三氟 - 1-羟基-1-三氟甲基乙基））苯丙酸酯，可用作抗高血压剂。优选的化合物具有血管舒张活性和降低的心动过速。

9. 发明授权

US08143262B2 7-(3′,4′-Dialkoxyphenyl)[1,2,4]-triazolo[1,5-A]pyrimidine compounds, process for preparing thereof, and pharmaceutical composition for treating or preventing asthma, chronic obstructive pulmonary disease, arthritis, atopic dermatitis, tumor and degenerative brain diseases comprising the same 有权
标题翻译： 7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-A]嘧啶化合物，其制备方法和用于治疗或预防哮喘，慢性阻塞性肺病，关节炎，特应性皮炎，包括其的肿瘤和退行性脑疾病
公开(公告)号：US08143262B2
公开(公告)日：2012-03-27
申请号：US12531818
申请日：2008-03-07
申请人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
发明人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel {7-(3′,4′-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.
摘要翻译：本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法，以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

10. 发明申请

US20100105704A1 7-(3',4'-Dialkoxyphenyl)-[1,2,4]-Triazolo[1,5-A]Pyrimidine Compounds, Process for Preparing Thereof, and Pharmaceutical Composition for Treating or Preventing Asthma, Chronic Obstructive Pulmonary Disease, Arthritis, Atopic Dermatitis, Tumor and Degenerative Brain Diseases Comprising the Same 有权
标题翻译： 7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-A]嘧啶化合物，其制备方法和用于治疗或预防哮喘，慢性阻塞性肺疾病的药物组合物，关节炎，特应性皮炎，包括肿瘤和退行性脑疾病
公开(公告)号：US20100105704A1
公开(公告)日：2010-04-29
申请号：US12531818
申请日：2008-03-07
申请人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
发明人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
IPC分类号： A61K31/519 , C07D487/04 , A61P25/00 , A61P11/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel {7-(3′,4′-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.
摘要翻译：本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法，以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

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