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1. 外观设计

USD309342S Electronic indicator faucet 失效
公开(公告)号：USD309342S
公开(公告)日：1990-07-17
申请号：US894762
申请日：1986-08-08
申请人： Duane D. Nowlin , John R. Nelson , Christopher M. Wilker
设计人： Duane D. Nowlin , John R. Nelson , Christopher M. Wilker

2. 发明申请

US20100105109A1 MULTIPLY-PRIMED AMPLIFICATION OF CIRCULAR NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：圆形核酸序列的多重增殖放大
公开(公告)号：US20100105109A1
公开(公告)日：2010-04-29
申请号：US12532228
申请日：2008-03-18
申请人： Haiguang Xiao , John R. Nelson , Galina Chernaya , Haiying Wang , Paul Mitsis , Gyanendra Kumar , Carl F. Fuller , Yuyang Christine Cai
发明人： Haiguang Xiao , John R. Nelson , Galina Chernaya , Haiying Wang , Paul Mitsis , Gyanendra Kumar , Carl F. Fuller , Yuyang Christine Cai
IPC分类号： C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2531/125 , C12Q2521/319
摘要： Improved processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed. The product of this amplification is used for analysis by restriction enzyme digestion or DNA sequencing and other analyses that involve hybridization. Kits containing components for use in the method are also described. Also described are further uses of this amplified DNA in sequencing, genotyping and haplotyping, and other molecular biology applications.
摘要翻译：公开了使用多个特异性和/或随机序列寡核苷酸引物扩增单链或双链环状DNA分子，特别是存在于菌落和斑块提取物中的靶DNA序列的改进方法。该扩增产物用于通过限制酶消化或DNA测序和涉及杂交的其他分析进行分析。还描述了包含用于该方法的组分的试剂盒。还描述了这种扩增的DNA在测序，基因分型和单元分型以及其他分子生物学应用中的进一步使用。

3. 发明授权

US06215992B1 Universal dictation input apparatus and method 失效
标题翻译：通用听写输入装置及方法
公开(公告)号：US06215992B1
公开(公告)日：2001-04-10
申请号：US08902589
申请日：1997-07-29
申请人： Dennis S. Howell , Donald E. Latson , Jason D. Gaines , Richard Ford , Franklin B. Parks , Robert W. Ross , John R. Nelson
发明人： Dennis S. Howell , Donald E. Latson , Jason D. Gaines , Richard Ford , Franklin B. Parks , Robert W. Ross , John R. Nelson
IPC分类号： H04B106
CPC分类号： H04M11/10 , G10L15/30 , G10L2015/225 , H04M1/7255 , H04M1/733
摘要： The universal dictation input apparatus and method disclosed employs multiple wireless dictation devices (“WDD”) and base stations each of which include a 900 MHz radio for communicating with one another over selected radio frequency (“RF”) channel pairs to conduct dictation sessions on centralized dictation systems (“CDSs”). Each base station is uniquely assigned a single channel pair. The WDDs are programmed with code representing the exclusive channels of a select number of base stations. When a user takes a WDD off-hook, a WDD sequentially and cyclically scans for carrier transmitted by authorized base stations until an idle base station is identified and linked to over the authorized channel. The user of a WDD must be authorized to conduct dictation sessions on one or more CDSs. To this end the WDDs includes a dialing address keypad to address authorized CDSs. The CDSs are third party systems addressed from a WDD by DTMF dialing digits. Dictation sessions are conducted by sending dictation commands, for example “record” and “play” in the form of DTMF digits to the CDSs. The WDDs send data as ASCII codes in packets to a base station. The transmitted data includes dialing digits and system commands for the base station. The WDDs generate data from the dialing keypad, programmable keys customized to send frequently used dictation commands to a CDS and to provide other specialized features and a barcode reader. Specific setup data is downloaded to a base station to enable it to execute commands and dialing, digits unique to CDS of different vendors and to prepare for receipt of verbal dictation commands. A base station includes a voice recognition algorithm to translate verbal commands spoken at a WDD, such as “record” and “play,” into codes forwarded to a CDS as DTMF digits.
摘要翻译：所公开的通用听写输入装置和方法使用多个无线听写设备（“WDD”）和基站，每个基站包括900MHz无线电装置，用于在选定的射频（“RF”）信道对上彼此进行通信，以进行听写会话集中听写系统（“CDS”）。每个基站被唯一分配一个通道对。 WDD用代表选定数量的基站的排他通道的代码进行编程。当用户采取WDD摘机状态时，WDD会顺序循环扫描授权基站发送的载波，直到空闲基站识别并通过授权信道进行链接。必须授权WDD的用户在一个或多个CDS上执行听写会话。为此，WDD包括一个拨号地址小键盘来解决授权的CDS。 CDS是通过DTMF拨号数字从WDD寻址的第三方系统。通过发送听写命令来进行听写会话，例如以CDF的DTMF数字形式的“录音”和“播放”。 WDD将数据作为ASCII码以数据包的形式发送到基站。所发送的数据包括用于基站的拨号数字和系统命令。 WDD从拨号键盘生成数据，可定制的可编程键将经常使用的听写命令发送到CDS，并提供其他专门功能和条形码读取器。特定的设置数据被下载到基站以使其能够执行命令和拨号，不同供应商的CDS特有的数字，并准备接收口头听写命令。基站包括语音识别算法，用于将转发到CDS的代码的语音命令（例如“记录”和“播放”）转换为作为DTMF数字的CDS。

4. 发明授权

US07914983B2 Detection method for gene expression 有权
标题翻译：基因表达检测方法
公开(公告)号：US07914983B2
公开(公告)日：2011-03-29
申请号：US11427395
申请日：2006-06-29
申请人： Chockalingam Palaniappan , Carl W. Fuller , John R. Nelson
发明人： Chockalingam Palaniappan , Carl W. Fuller , John R. Nelson
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , C07H21/04
CPC分类号： C12Q1/6809 , C12Q2565/501 , C12Q2521/131 , C12Q2563/155 , C12Q2535/101
摘要： Provided is a novel approach for generating oligonucleotide probes and the use of these probes in gene expression profiling, by hybridization to test oligonucleotides on arrays or beads. This approach involves labeling of the complement oligonucleotide probes using a mixture of dye or hapten labeled-ddNTPs in solution. The labeled oligonucleotide probes are then used to hybridize to the test oligonucleotides on the solid support. Success in hybridization is monitored by associated signal on the solid support. This approach greatly reduces hybridization time, due to the simplification of the probe content. It is especially useful when analyzing a small number of genes, such as a signature set of genes for a disease or condition.
摘要翻译：提供了一种用于产生寡核苷酸探针的新方法，以及这些探针在基因表达谱中的应用，通过与测试寡核苷酸与阵列或珠粒杂交。该方法包括使用染料或半抗原标记的ddNTP在溶液中的混合物来标记补体寡核苷酸探针。然后将标记的寡核苷酸探针与固体支持物上的测试寡核苷酸杂交。通过固相支持物上的相关信号监测杂交成功。由于探针含量的简化，这种方法大大减少了杂交时间。当分析少量基因（例如疾病或病症的基因的签名集）时，它是特别有用的。

5. 发明授权

US07871771B2 Method for nucleic acid analysis 有权
标题翻译：核酸分析方法
公开(公告)号：US07871771B2
公开(公告)日：2011-01-18
申请号：US11570347
申请日：2005-06-09
申请人： Carl W. Fuller , John R. Nelson
发明人： Carl W. Fuller , John R. Nelson
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6834 , C12Q1/6869 , C12Q2565/519 , C12Q2565/301 , C12Q2563/137 , C12Q2527/127 , C12Q2523/113
摘要： This invention provides methods for nucleic acid analysis. A closed complex of nucleic acid template, nucleotide and polymerase can be formed during polymerase reaction, absent divalent metal ion. This is used to trap the labeled nucleotide complementary to the next template nucleotide in the closed complex. Detection of the label allows determination of the identity of this next correct nucleotide. Identification can be either in place, as part of the complex, or as the dye is eluted from the complex when the reaction cycle is completed by the addition of divalent metal ion. In this way, sequential nucleotides of a DNA can be identified, effectively determining the DNA sequence. This method can be applied to nucleic acid single molecules or to collections of identical or nearly identical sequence such as PCR products or clones. Multiple templates can be sequenced in parallel, particularly if they are immobilized on a solid support.
摘要翻译：本发明提供核酸分析方法。可以在聚合酶反应期间形成核酸模板，核苷酸和聚合酶的闭合复合物，不存在二价金属离子。这用于捕获与封闭复合物中下一个模板核苷酸互补的标记核苷酸。标签的检测允许确定下一个正确的核苷酸的身份。识别可以作为复合物的一部分就位，或当通过添加二价金属离子完成反应循环时染料从络合物中洗脱出来。以这种方式，可以鉴定DNA的连续核苷酸，有效地确定DNA序列。该方法可以应用于核酸单分子或相同或几乎相同序列的集合，例如PCR产物或克隆。多个模板可以并行测序，特别是如果它们固定在固体支持物上。

6. 发明申请

US20080287305A1 Method for Nucleic Acid Analysis 有权
标题翻译：核酸分析方法
公开(公告)号：US20080287305A1
公开(公告)日：2008-11-20
申请号：US11570347
申请日：2005-06-09
申请人： Carl W. Fuller , John R. Nelson
发明人： Carl W. Fuller , John R. Nelson
IPC分类号： C40B20/04 , C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6869 , C12Q2565/519 , C12Q2565/301 , C12Q2563/137 , C12Q2527/127 , C12Q2523/113
摘要： This invention provides methods for nucleic acid analysis. A closed complex of nucleic acid template, nucleotide and polymerase can be formed during polymerase reaction, absent divalent metal ion. This is used to trap the labeled nucleotide complementary to the next template nucleotide in the closed complex. Detection of the label allows determination of the identity of this next correct nucleotide. Identification can be either in place, as part of the complex, or as the dye is eluted from the complex when the reaction cycle is completed by the addition of divalent metal ion. In this way, sequential nucleotides of a DNA can be identified, effectively determining the DNA sequence. This method can be applied to nucleic acid single molecules or to collections of identical or nearly identical sequence such as PCR products or clones. Multiple templates can be sequenced in parallel, particularly if they are immobilized on a solid support.
摘要翻译：本发明提供核酸分析方法。可以在聚合酶反应期间形成核酸模板，核苷酸和聚合酶的闭合复合物，不存在二价金属离子。这用于捕获与封闭复合物中下一个模板核苷酸互补的标记核苷酸。标签的检测允许确定下一个正确的核苷酸的身份。识别可以作为复合物的一部分就位，或当通过添加二价金属离子完成反应循环时染料从络合物中洗脱出来。以这种方式，可以鉴定DNA的连续核苷酸，有效地确定DNA序列。该方法可以应用于核酸单分子或相同或几乎相同序列的集合，例如PCR产物或克隆。多个模板可以并行测序，特别是如果它们固定在固体支持物上。

7. 外观设计

USD311062S Housing for medical instrument 失效
公开(公告)号：USD311062S
公开(公告)日：1990-10-02
申请号：US109249
申请日：1987-10-15
申请人： John R. Nelson
设计人： John R. Nelson

8. 外观设计

USD292610S IV fluid flow rate meter 失效
公开(公告)号：USD292610S
公开(公告)日：1987-11-03
申请号：US714634
申请日：1985-03-21
申请人： John R. Nelson
设计人： John R. Nelson

9. 发明授权

US07613632B2 System and method for performing automated testing of a merchant message 有权
标题翻译：用于执行商业消息的自动测试的系统和方法
公开(公告)号：US07613632B2
公开(公告)日：2009-11-03
申请号：US11273002
申请日：2005-11-14
申请人： Steve T. Chiappetti , John R. Nelson
发明人： Steve T. Chiappetti , John R. Nelson
IPC分类号： G06G1/12 , G06F17/60
CPC分类号： G06Q20/20 , G06Q20/10 , G06Q20/202
摘要： Error-testing of merchant messages to be used with point-of-sale (POS) devices is performed by an automated system that receives a formatted message to be tested from a merchant or an agent of the merchant, performs a computer-implemented evaluation of the message according to predefined message-validation rules to detect one or more errors, and notifies the merchant or the agent of evaluation results. The evaluation results include a listing of each detected error, if any.
摘要翻译：用于销售点（POS）设备的商家消息的错误测试由自动化系统执行，该系统从商家的商家或代理接收要测试的格式化消息，执行计算机实现的评估该消息根据预定义的消息验证规则来检测一个或多个错误，并通知商家或代理评估结果。评估结果包括每个检测到的错误（如果有的话）的列表。

10. 发明授权

US5592528A Battery charging and signalling interconnect arrangement for craftsperson's 失效
标题翻译：手机信号处理和通信单元的电池充电和信号互连布置
公开(公告)号：US5592528A
公开(公告)日：1997-01-07
申请号：US339906
申请日：1994-11-14
申请人： John R. Nelson , Gregory J. Pettit , Tim G. Godfrey , Wayne K. Wong
发明人： John R. Nelson , Gregory J. Pettit , Tim G. Godfrey , Wayne K. Wong
IPC分类号： H02J7/00 , H04M1/24 , H04M3/30 , H01H31/02 , H01H31/04 , H04B17/00
CPC分类号： H02J7/0045 , H04M1/24 , H04M3/30
摘要： To prevent entry of contaminants into a craft unit, each of a telephone signal connector (RJ11 jack) and DIN-type digital signalling link connector is replaced with a sealed, multi-pin plug/receptacle type connector which integrates the routing of both telephone communication signals and digital communication signals between the craft unit and an external device. When stored in a storage and battery-charging station, the craft unit is maintained in a communication-ready state, by providing each of the battery-charging holder and the portable craft unit with an additional multi-pin interconnect arrangement, that contains a charging path for the craft unit's internal battery, and a multi-pin signalling path. This multi-pin interconnect arrangement contains both a set of communication signalling pins and a set of terminal pins through which the internal battery of the portable craft unit is charged. Within a receiving cup-like portion of the storage and battery charging unit, a plurality of male connector pins are nested in a compact linear arrangement to engage a corresponding set of female connector terminals supported within the portable craft unit.
摘要翻译：为了防止污染物进入工艺单元，电话信号连接器（RJ11插孔）和DIN型数字信号连接器连接器中的每一个被替换为密封的多针插头/插座型连接器，其将电话通信的路由信号和数字通信信号在工艺单元和外部设备之间。当存储在存储和充电站中时，通过为电池充电保持器和便携式手术单元中的每一个提供额外的多针互连装置，使手术单元维持在通信就绪状态，其中包含充电工艺单元内部电池的路径，以及多针信号通路。这种多引脚互连装置包含一组通信信号引脚和一组端子引脚，便携式工艺单元的内部电池通过该端子引脚充电。在存储和电池充电单元的接收杯状部分内，多个公连接器针被嵌套在紧凑的线性布置中以接合支撑在便携式手术单元内的相应的一组阴连接器端子。

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