专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09469728B2 Temperature and pH-sensitive block copolymer having excellent safty in vivo and hydrogel and drug delivery system using thereof 有权
标题翻译：温度和pH敏感的嵌段共聚物具有优异的体内安全性和使用其的水凝胶和药物递送系统
公开(公告)号：US09469728B2
公开(公告)日：2016-10-18
申请号：US12676828
申请日：2008-09-05
申请人： Doo Sung Lee , Minh Khanh Nguyen , Bong Sup Kim
发明人： Doo Sung Lee , Minh Khanh Nguyen , Bong Sup Kim
IPC分类号： A61K9/00 , A61K47/34 , C08G65/30 , C08G65/332 , C08G65/333
CPC分类号： C08G65/30 , A61K9/0024 , A61K47/34 , C08G65/3322 , C08G65/33317 , C08G65/33324 , C08L2203/02 , C08L2205/05
摘要： Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (β-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (β-amino ester)-based oligomer and then coupling them.
摘要翻译：本文公开了具有优异安全性的pH和温度敏感性嵌段共聚物及其制备方法以及使用该嵌段共聚物的水凝胶和药物载体。根据本发明，pH和温度敏感性嵌段共聚物包括：（a）聚乙二醇基化合物（A）的共聚获得的; 和（b）聚（β-氨基酯）基低聚物（B）或聚（酰氨基胺）基低聚物（C）或其混合物（D）的偶联。为了控制生物降解速率，将嵌段共聚物与基于聚（酰氨基胺）的低聚物代替聚（β-氨基酯）的低聚物混合，然后将其偶联。

2. 发明申请

US20080293827A1 Temperature and Ph Sensitive Block Copolymer and Polymeric Hydrogels Using the Same 有权
标题翻译：温度和Ph敏感嵌段共聚物和聚合物水凝胶使用它
公开(公告)号：US20080293827A1
公开(公告)日：2008-11-27
申请号：US11815960
申请日：2006-03-31
申请人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
发明人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
IPC分类号： A61K47/32 , C08L71/00 , C08G65/08
CPC分类号： C08G65/33306 , C08G65/331 , C08G65/3322 , C08G65/3324 , C08G73/028 , C08G81/00 , C08L53/00 , C08L67/00 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/02 , C08L2666/18
摘要： Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly(β-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly(β-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer. Therefore, the block copolymer can form a polymeric hydrogel structure due to its amphiphilicity resulting from the combination of a hydrophilic group and a hydrophobic group in the copolymer and ionization characteristics depending on pH variations, and thus can be used as a drug carrier for target-directed drug delivery depending on pH variations in the body.
摘要翻译：公开了通过将以下组分彼此偶联而形成的嵌段共聚物：（a）聚乙二醇（PEG）型化合物与可生物降解聚合物的共聚物（A）和（b）至少一种选自聚（β-氨基酯）和聚（酰氨基胺）的低聚物（B）。还公开了制备相同嵌段共聚物的方法和包含温度和pH敏感性嵌段共聚物的聚合物水凝胶型药物组合物和可以用嵌段共聚物包封的生理活性物质。多嵌段共聚物通过pH敏感的聚（β-氨基酯）和/或聚（酰氨基胺）型低聚物，亲水和温度敏感的聚乙二醇型化合物和疏水和可生物降解的聚合物共聚获得。因此，嵌段共聚物由于其在共聚物中的亲水基团和疏水基团的组合引起的两亲性而形成聚合物水凝胶结构，并且根据pH变化而具有电离特性，因此可以用作靶向的药物载体，定向药物递送取决于体内的pH变化。

3. 发明授权

US08835492B2 Temperature and pH sensitive block copolymer and polymeric hydrogels using the same 有权
标题翻译：温度和pH敏感的嵌段共聚物和使用其的聚合物水凝胶
公开(公告)号：US08835492B2
公开(公告)日：2014-09-16
申请号：US11815960
申请日：2006-03-31
申请人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
发明人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
IPC分类号： A61K31/21 , C08G81/00 , C08L71/02 , C08G65/333 , C08L53/00 , C08G65/332 , C08G73/02 , C08G65/331 , C08L67/00
CPC分类号： C08G65/33306 , C08G65/331 , C08G65/3322 , C08G65/3324 , C08G73/028 , C08G81/00 , C08L53/00 , C08L67/00 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/02 , C08L2666/18
摘要： Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly(β-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly(β-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer. Therefore, the block copolymer can form a polymeric hydrogel structure due to its amphiphilicity resulting from the combination of a hydrophilic group and a hydrophobic group in the copolymer and ionization characteristics depending on pH variations, and thus can be used as a drug carrier for target-directed drug delivery depending on pH variations in the body.
摘要翻译：公开了通过将以下组分彼此偶联而形成的嵌段共聚物：（a）聚乙二醇（PEG）型化合物与可生物降解聚合物的共聚物（A）和（b）至少一种选自聚（亚氨基酯）和聚（酰氨基胺）的低聚物（B）。还公开了制备相同嵌段共聚物的方法和包含温度和pH敏感性嵌段共聚物的聚合物水凝胶型药物组合物和可以用嵌段共聚物包封的生理活性物质。多嵌段共聚物通过pH敏感的聚（酰胺基胺）和/或聚（酰氨基胺）型低聚物，亲水和温度敏感的聚乙二醇型化合物和疏水和可生物降解的聚合物共聚得到。因此，嵌段共聚物由于其在共聚物中的亲水基团和疏水基团的组合引起的两亲性而形成聚合物水凝胶结构，并且根据pH变化而具有电离特性，因此可以用作靶向的药物载体，定向药物递送取决于体内的pH变化。

4. 发明授权

US08383153B2 Poly(amidoamine) oligomer hydrogel for drug delivery and drug carrier using the same 有权
标题翻译：用于药物递送的聚（酰氨基胺）低聚物水凝胶和使用其的药物载体
公开(公告)号：US08383153B2
公开(公告)日：2013-02-26
申请号：US12938852
申请日：2010-11-03
申请人： Doo Sung Lee , Bong Sup Kim , Minh Khanh Nguyen
发明人： Doo Sung Lee , Bong Sup Kim , Minh Khanh Nguyen
IPC分类号： A61K38/19 , A61K38/27 , A61K38/18 , A61K31/56 , A61K39/395 , A61K39/00 , A61K38/22 , A61K38/30 , A61K38/21 , A61K31/337 , A61K31/196 , A61P35/00 , A61P31/12 , A61P31/04 , A61P37/06 , A61P29/00
CPC分类号： C07D211/26 , A61K9/0024 , A61K47/34 , C08G73/028 , C08G73/0627
摘要： Disclosed is a temperature- and pH-sensitive hydrogel composed of a poly(amidoamine) oligomer only. The hydrogel is prepared in a simple manner and is readily released from the body. Further disclosed are a method for preparing the hydrogel and a drug carrier using the hydrogel.
摘要翻译：公开了仅由聚（酰氨基胺）低聚物组成的温度和pH敏感的水凝胶。水凝胶以简单的方式制备并容易从体内释放。进一步公开的是制备水凝胶的方法和使用该水凝胶的药物载体。

5. 发明申请

US20100233264A1 TEMPERATURE AND pH-SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT SAFTY IN VIVO AND HYDROGEL AND DRUG DELIVERY SYSTEM USING THEREOF 有权
标题翻译：温度和pH敏感性嵌段共聚物在血液和水凝胶和药物输送系统中具有优异的保湿性
公开(公告)号：US20100233264A1
公开(公告)日：2010-09-16
申请号：US12676828
申请日：2008-09-05
申请人： Doo Sung Lee , Minh Khanh Nguyen , Bong Sup Kim
发明人： Doo Sung Lee , Minh Khanh Nguyen , Bong Sup Kim
IPC分类号： A61K9/10 , A61K38/21 , A61K39/395 , A61K31/337 , A61K31/195 , A61K38/28 , A61K45/00 , A61K38/16 , A61P31/12 , A61P29/00 , A61P37/00 , A61P23/00 , A61P5/24 , A61P31/00 , A61K39/00 , A61K47/30 , C08F220/00
CPC分类号： C08G65/30 , A61K9/0024 , A61K47/34 , C08G65/3322 , C08G65/33317 , C08G65/33324 , C08L2203/02 , C08L2205/05
摘要： Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (β-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (β-amino ester)-based oligomer and then coupling them.
摘要翻译：本文公开了具有优异安全性的pH和温度敏感性嵌段共聚物及其制备方法以及使用该嵌段共聚物的水凝胶和药物载体。根据本发明，pH和温度敏感性嵌段共聚物包括：（a）聚乙二醇基化合物（A）的共聚获得的; 和（b）聚（（bgr。 - 氨基酯）的低聚物（B）或聚（酰氨基胺）的低聚物（C）或其混合物（D）的偶联。为了控制生物降解速率，将嵌段共聚物与基于聚（酰胺基胺）的低聚物混合，而不是基于聚（（ - （ - 氨基酯））的低聚物，然后偶联它们。

6. 发明授权

US08586087B2 Temperature and pH-sensitive block copolymer having excellent gel strength 有权
标题翻译：具有优异凝胶强度的温度和pH敏感性嵌段共聚物
公开(公告)号：US08586087B2
公开(公告)日：2013-11-19
申请号：US12061322
申请日：2008-04-02
申请人： Doo Sung Lee , Kasala Dayananda , Bong Sup Kim
发明人： Doo Sung Lee , Kasala Dayananda , Bong Sup Kim
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K47/34 , C08G18/3293 , C08G18/4277 , C08G18/428 , C08G18/73 , C08G2210/00 , C08G2230/00
摘要： An amphiphilic pentablock copolymer that is temperature- and pH-sensitive and has superior and sustained gel strength, includes (a) a hydrophilic triblock copolymer that is temperature-sensitive and that is a copolymer of a poly(ethylene glycol)-based compound and a biodegradable polymer that is one or more polymer selected from the group consisting of polylactide, polyglycolide, polycaprolactone, poly(caprolactone-lactide) random copolymer, poly(caprolactone-glycolide) random copolymer, poly(lactide-glycolide) random copolymer, and mixtures thereof; coupled with (b) a polyurethane-based oligomer (PU) that is pH sensitive and that includes a diisocyanate compound represented by a Formula as follows: OCN—(CH2)n—NCO, where n is an integer of 4 to 10, polymerized with a diol compound having a tertiary amine on a main chain thereof that is one or more of 1,3-bis{1-(2-hydroxyethyl) -4-pyridyl}propane and 1,4-bis(2-hydroxyethyl)piperazine, and is represented by Formulae as follows: where R and R′ are alkyl groups of 1 to 8 carbon atoms, respectively.
摘要翻译：具有温度和pH敏感性并具有优异和持续的凝胶强度的两亲性五嵌段共聚物包括（a）温度敏感的亲水性三嵌段共聚物，并且是聚（乙二醇）基化合物和一种或多种选自聚丙交酯，聚乙交酯，聚己内酯，聚（己内酯 - 丙交酯）无规共聚物，聚（己内酯 - 乙交酯）无规共聚物，聚（丙交酯 - 乙交酯）无规共聚物及其混合物的聚合物的生物可降解聚合物 ; 与（b）pH敏感的聚氨酯类低聚物（PU）结合，并且包括由下式表示的二异氰酸酯化合物：OCN-（CH 2）n -NCO，其中n为4至10的整数，聚合与主链上具有叔胺的二醇化合物是1,3-双{1-（2-羟乙基）-4-吡啶基}丙烷和1,4-双（2-羟乙基）哌嗪中的一种或多种并且由式如下表示：其中R和R'分别为1-8个碳原子的烷基。

7. 发明授权

US09080049B2 PH-sensitive graft copolymer, manufacturing method for same, and polymer micelles using method 有权
标题翻译： PH敏感接枝共聚物，其制备方法和聚合物胶束的使用方法
公开(公告)号：US09080049B2
公开(公告)日：2015-07-14
申请号：US13263452
申请日：2010-04-09
申请人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
发明人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
IPC分类号： A61K8/72 , C08L71/02 , A61K9/107 , A61K47/34 , A61K49/00 , C08G63/91 , C08G81/00 , C08L77/00 , A61K9/127 , A61K47/48 , C08L87/00
CPC分类号： C08L71/02 , A61K9/1075 , A61K9/1273 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6911 , A61K49/0021 , A61K49/0054 , C08G63/916 , C08G81/00 , C08L77/00 , C08L87/00 , C08L2205/05 , C08L2666/24 , C08L2666/18
摘要： The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly (β-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds.
摘要翻译：本文件涉及用于pH敏感性接枝聚合物胶束的制造方法和含有接枝共聚物的聚合物胶束型药物组合物。 pH敏感性接枝共聚物胶束可用作各种用于诊断和治疗疾病的分子图像的标记物和造影剂，以及根据疾病递送各种药物的载体。 pH敏感的接枝共聚物形成胶束，其可以根据身体pH的变化用于靶向诊断和药物释放。聚合物胶束通过诱导聚（（β-氨基酯））化合物的接枝共聚物，其在水中的溶解度取决于pH，但是由于自组装现象而不能形成胶束，并且亲水性聚（乙二醇）化合物。

8. 发明授权

US08911775B2 pH-sensitive block copolymer forming polyionic complex micelles and drug or protein carrier using the same 有权
标题翻译：形成多聚离子复合物胶束的pH敏感嵌段共聚物和使用其的药物或蛋白质载体
公开(公告)号：US08911775B2
公开(公告)日：2014-12-16
申请号：US12842388
申请日：2010-07-23
申请人： Doo Sung Lee , Bong Sup Kim , Jung Hee Lee , Guanghui Gao
发明人： Doo Sung Lee , Bong Sup Kim , Jung Hee Lee , Guanghui Gao
IPC分类号： A61K38/38 , C08G73/06 , A61K9/127 , A61P35/00 , A61P9/10 , A61P29/00 , A61P19/02 , C08L71/02 , C08F299/02 , B82Y5/00 , C08F290/06 , A61K9/107
CPC分类号： C08F290/062 , A61K9/1075 , B82Y5/00 , C08F299/024 , C08G2261/126 , C08L71/02 , C08L2201/06 , C08L2203/02 , C08L2205/05 , C08L67/00
摘要： Disclosed is a pH-sensitive block copolymer that forms polyionic complex micelles. The block copolymer is prepared by copolymerization of (a) a polyethylene glycol compound, (b) a poly(amino acid) compound, and (c) a heterocyclic alkyl amine compound having the ability to induce the formation of ionic complexes. Further disclosed is a drug or protein carrier using the block copolymer.
摘要翻译：公开了形成聚离子复合物胶束的pH敏感性嵌段共聚物。嵌段共聚物通过（a）聚乙二醇化合物，（b）聚（氨基酸）化合物和（c）具有诱导形成离子络合物的能力的杂环烷基胺化合物的共聚制备。还公开了使用嵌段共聚物的药物或蛋白质载体。

9. 发明申请

US20120027690A1 PH-SENSITIVE GRAFT COPOLYMER, MANUFACTURING METHOD FOR SAME, AND POLYMER MICELLES USING METHOD 有权
标题翻译：敏感性共聚物，其制造方法和使用方法的聚合物微粒
公开(公告)号：US20120027690A1
公开(公告)日：2012-02-02
申请号：US13263452
申请日：2010-04-09
申请人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
发明人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
IPC分类号： A61K49/06 , A61K49/00 , A61K9/00 , A61K31/704 , A61K31/337 , A61K38/27 , A61K38/38 , A61K47/34 , A61P29/00 , A61P37/06 , A61P5/24 , A61P31/12 , A61P23/00 , A61P1/08 , A61P37/08 , A61P35/00 , A61P31/04 , C08G63/91 , B82Y5/00 , B82Y15/00
CPC分类号： C08L71/02 , A61K9/1075 , A61K9/1273 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6911 , A61K49/0021 , A61K49/0054 , C08G63/916 , C08G81/00 , C08L77/00 , C08L87/00 , C08L2205/05 , C08L2666/24 , C08L2666/18
摘要： The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly(β-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds.
摘要翻译：本文件涉及用于pH敏感性接枝聚合物胶束的制造方法和含有接枝共聚物的聚合物胶束型药物组合物。 pH敏感性接枝共聚物胶束可用作各种用于诊断和治疗疾病的分子图像的标记物和造影剂，以及根据疾病递送各种药物的载体。 pH敏感的接枝共聚物形成胶束，其可以根据身体pH的变化用于靶向诊断和药物释放。聚合物胶束是通过诱导聚（（β-氨基酯））化合物的接枝共聚物，其在水中具有溶解度，取决于pH值，但由于自组装现象而不能形成胶束，而亲水性聚（乙二醇）化合物

10. 发明申请

US20130022545A1 DRUG DELIVERY SYSTEM FOR TREATMENT OF LIVER CANCER BASED ON INTERVENTIONAL INJECTION OF TEMPERATURE AND pH-SENSITIVE HYDROGEL 审中-公开
标题翻译：基于传统注射温度和pH敏感性水凝胶治疗肝癌的药物输送系统
公开(公告)号：US20130022545A1
公开(公告)日：2013-01-24
申请号：US13551889
申请日：2012-07-18
申请人： Doo Sung Lee , Bong Sup Kim , Cong Truc Huynh
发明人： Doo Sung Lee , Bong Sup Kim , Cong Truc Huynh
IPC分类号： A61K31/785 , A61K31/795 , A61P35/00 , A61K49/00
CPC分类号： A61K9/0024 , A61K9/0004 , A61K9/0019 , A61K31/337 , A61K31/704 , A61K47/06 , A61K47/34
摘要： A drug delivery system for the treatment of liver cancer that is based on interventional injection of a temperature and pH-sensitive hydrogel is provided. The drug delivery system is composed of a block copolymer applicable to hepatic arterial catheterization and a therapeutic agent is loaded inside the drug delivery system, and the drug delivery system is in the sol state outside, and undergoes a phase transition into the gel state inside the hepatic artery, thereby delaying or blocking blood supply of the hepatic artery, and slowly releasing the therapeutic agent during the phase transition into the gel state inside the hepatic artery.
摘要翻译：提供了一种用于治疗基于介入注射温度和pH敏感性水凝胶的肝癌的药物递送系统。药物递送系统由适用于肝动脉导管插入物的嵌段共聚物组成，药物递送系统内装载有治疗剂，药物输送系统在外部处于溶胶状态，并在其内部进行凝胶状态的相变肝动脉，从而延缓或阻断肝动脉的血液供应，并且在肝动脉内的凝胶状态期间缓慢释放治疗剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式