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1. 发明授权

US08835492B2 Temperature and pH sensitive block copolymer and polymeric hydrogels using the same 有权
标题翻译：温度和pH敏感的嵌段共聚物和使用其的聚合物水凝胶
公开(公告)号：US08835492B2
公开(公告)日：2014-09-16
申请号：US11815960
申请日：2006-03-31
申请人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
发明人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
IPC分类号： A61K31/21 , C08G81/00 , C08L71/02 , C08G65/333 , C08L53/00 , C08G65/332 , C08G73/02 , C08G65/331 , C08L67/00
CPC分类号： C08G65/33306 , C08G65/331 , C08G65/3322 , C08G65/3324 , C08G73/028 , C08G81/00 , C08L53/00 , C08L67/00 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/02 , C08L2666/18
摘要： Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly(β-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly(β-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer. Therefore, the block copolymer can form a polymeric hydrogel structure due to its amphiphilicity resulting from the combination of a hydrophilic group and a hydrophobic group in the copolymer and ionization characteristics depending on pH variations, and thus can be used as a drug carrier for target-directed drug delivery depending on pH variations in the body.
摘要翻译：公开了通过将以下组分彼此偶联而形成的嵌段共聚物：（a）聚乙二醇（PEG）型化合物与可生物降解聚合物的共聚物（A）和（b）至少一种选自聚（亚氨基酯）和聚（酰氨基胺）的低聚物（B）。还公开了制备相同嵌段共聚物的方法和包含温度和pH敏感性嵌段共聚物的聚合物水凝胶型药物组合物和可以用嵌段共聚物包封的生理活性物质。多嵌段共聚物通过pH敏感的聚（酰胺基胺）和/或聚（酰氨基胺）型低聚物，亲水和温度敏感的聚乙二醇型化合物和疏水和可生物降解的聚合物共聚得到。因此，嵌段共聚物由于其在共聚物中的亲水基团和疏水基团的组合引起的两亲性而形成聚合物水凝胶结构，并且根据pH变化而具有电离特性，因此可以用作靶向的药物载体，定向药物递送取决于体内的pH变化。

2. 发明申请

US20080293827A1 Temperature and Ph Sensitive Block Copolymer and Polymeric Hydrogels Using the Same 有权
标题翻译：温度和Ph敏感嵌段共聚物和聚合物水凝胶使用它
公开(公告)号：US20080293827A1
公开(公告)日：2008-11-27
申请号：US11815960
申请日：2006-03-31
申请人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
发明人： Doo Sung Lee , Min Sang Kim , Je Sun You , Huynh Dai Phu , Bong Sup Kim , Minh Khanh Nguyen
IPC分类号： A61K47/32 , C08L71/00 , C08G65/08
CPC分类号： C08G65/33306 , C08G65/331 , C08G65/3322 , C08G65/3324 , C08G73/028 , C08G81/00 , C08L53/00 , C08L67/00 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/02 , C08L2666/18
摘要： Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly(β-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly(β-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer. Therefore, the block copolymer can form a polymeric hydrogel structure due to its amphiphilicity resulting from the combination of a hydrophilic group and a hydrophobic group in the copolymer and ionization characteristics depending on pH variations, and thus can be used as a drug carrier for target-directed drug delivery depending on pH variations in the body.
摘要翻译：公开了通过将以下组分彼此偶联而形成的嵌段共聚物：（a）聚乙二醇（PEG）型化合物与可生物降解聚合物的共聚物（A）和（b）至少一种选自聚（β-氨基酯）和聚（酰氨基胺）的低聚物（B）。还公开了制备相同嵌段共聚物的方法和包含温度和pH敏感性嵌段共聚物的聚合物水凝胶型药物组合物和可以用嵌段共聚物包封的生理活性物质。多嵌段共聚物通过pH敏感的聚（β-氨基酯）和/或聚（酰氨基胺）型低聚物，亲水和温度敏感的聚乙二醇型化合物和疏水和可生物降解的聚合物共聚获得。因此，嵌段共聚物由于其在共聚物中的亲水基团和疏水基团的组合引起的两亲性而形成聚合物水凝胶结构，并且根据pH变化而具有电离特性，因此可以用作靶向的药物载体，定向药物递送取决于体内的pH变化。

3. 发明授权

US07786220B2 pH and temperature sensitive hydrogels 有权
标题翻译： pH和温度敏感水凝胶
公开(公告)号：US07786220B2
公开(公告)日：2010-08-31
申请号：US10590959
申请日：2005-01-26
申请人： Doo Sung Lee , Woo Sun Shim , You Han Bae , Je Sun You , Min Sang Kim , Huynh Dai Phu
发明人： Doo Sung Lee , Woo Sun Shim , You Han Bae , Je Sun You , Min Sang Kim , Huynh Dai Phu
IPC分类号： C08L77/00
CPC分类号： A61L27/50 , A61L27/26 , A61L27/52 , C08F265/10 , C08F290/06 , C08F293/005 , C08G63/664 , C08G63/6852 , C08G63/6882 , C08G63/912 , C08G75/30 , C08G81/00 , C08G2261/126 , C08J3/075 , C08J2300/16 , C08J2367/04 , C08L53/00 , C08L67/00 , Y10S524/916 , C08L71/02 , C08L81/10 , C08L2666/02
摘要： The present invention relates to a block copolymer formed by coupling the following components with each other, as well as a hydrogel composition comprising the block copolymer and a hydrogel formed from the composition: (a) a copolymer of a polyethylene glycol (PEG)-based compound with a biodegradable polymer; and (b) a sulfonamide-based oligomer. The inventive block copolymer shows the sol-gel transition behavior sensitive to changes in not only temperature but also pH. Thus, the inventive block copolymer overcomes the shortcomings of temperature-sensitive copolymers, form a more strong and stable hydrogel, and is stable in vivo. Accordingly, the inventive block copolymer can be used in various applications in the medical and drug delivery fields.
摘要翻译：本发明涉及通过将以下组分彼此偶联而形成的嵌段共聚物，以及包含嵌段共聚物和由以下组合物形成的水凝胶的水凝胶组合物：（a）基于聚乙二醇（PEG）与生物降解聚合物的化合物; 和（b）磺酰胺类低聚物。本发明的嵌段共聚物显示溶胶 - 凝胶转变行为不仅对温度而且pH的变化敏感。因此，本发明的嵌段共聚物克服了温度敏感性共聚物的缺点，形成了更强和稳定的水凝胶，并且在体内是稳定的。因此，本发明的嵌段共聚物可用于医药和药物输送领域的各种应用。

4. 发明授权

US09080049B2 PH-sensitive graft copolymer, manufacturing method for same, and polymer micelles using method 有权
标题翻译： PH敏感接枝共聚物，其制备方法和聚合物胶束的使用方法
公开(公告)号：US09080049B2
公开(公告)日：2015-07-14
申请号：US13263452
申请日：2010-04-09
申请人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
发明人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
IPC分类号： A61K8/72 , C08L71/02 , A61K9/107 , A61K47/34 , A61K49/00 , C08G63/91 , C08G81/00 , C08L77/00 , A61K9/127 , A61K47/48 , C08L87/00
CPC分类号： C08L71/02 , A61K9/1075 , A61K9/1273 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6911 , A61K49/0021 , A61K49/0054 , C08G63/916 , C08G81/00 , C08L77/00 , C08L87/00 , C08L2205/05 , C08L2666/24 , C08L2666/18
摘要： The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly (β-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds.
摘要翻译：本文件涉及用于pH敏感性接枝聚合物胶束的制造方法和含有接枝共聚物的聚合物胶束型药物组合物。 pH敏感性接枝共聚物胶束可用作各种用于诊断和治疗疾病的分子图像的标记物和造影剂，以及根据疾病递送各种药物的载体。 pH敏感的接枝共聚物形成胶束，其可以根据身体pH的变化用于靶向诊断和药物释放。聚合物胶束通过诱导聚（（β-氨基酯））化合物的接枝共聚物，其在水中的溶解度取决于pH，但是由于自组装现象而不能形成胶束，并且亲水性聚（乙二醇）化合物。

5. 发明申请

US20120027690A1 PH-SENSITIVE GRAFT COPOLYMER, MANUFACTURING METHOD FOR SAME, AND POLYMER MICELLES USING METHOD 有权
标题翻译：敏感性共聚物，其制造方法和使用方法的聚合物微粒
公开(公告)号：US20120027690A1
公开(公告)日：2012-02-02
申请号：US13263452
申请日：2010-04-09
申请人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
发明人： Doo Sung Lee , Min Sang Kim , Bong Sup Kim
IPC分类号： A61K49/06 , A61K49/00 , A61K9/00 , A61K31/704 , A61K31/337 , A61K38/27 , A61K38/38 , A61K47/34 , A61P29/00 , A61P37/06 , A61P5/24 , A61P31/12 , A61P23/00 , A61P1/08 , A61P37/08 , A61P35/00 , A61P31/04 , C08G63/91 , B82Y5/00 , B82Y15/00
CPC分类号： C08L71/02 , A61K9/1075 , A61K9/1273 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6911 , A61K49/0021 , A61K49/0054 , C08G63/916 , C08G81/00 , C08L77/00 , C08L87/00 , C08L2205/05 , C08L2666/24 , C08L2666/18
摘要： The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly(β-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds.
摘要翻译：本文件涉及用于pH敏感性接枝聚合物胶束的制造方法和含有接枝共聚物的聚合物胶束型药物组合物。 pH敏感性接枝共聚物胶束可用作各种用于诊断和治疗疾病的分子图像的标记物和造影剂，以及根据疾病递送各种药物的载体。 pH敏感的接枝共聚物形成胶束，其可以根据身体pH的变化用于靶向诊断和药物释放。聚合物胶束是通过诱导聚（（β-氨基酯））化合物的接枝共聚物，其在水中具有溶解度，取决于pH值，但由于自组装现象而不能形成胶束，而亲水性聚（乙二醇）化合物

6. 发明授权

US08318204B2 pH sensitive block copolymer and polymeric micelle using the same 有权
标题翻译： pH敏感嵌段共聚物和使用其的聚合物胶束
公开(公告)号：US08318204B2
公开(公告)日：2012-11-27
申请号：US11573858
申请日：2005-12-27
申请人： Doo Sung Lee , Min Sang Kim
发明人： Doo Sung Lee , Min Sang Kim
IPC分类号： A61K9/14 , A61K47/00
CPC分类号： C08F299/024
摘要： Disclosed is a pH-sensitive block copolymer obtained by copolymerization of: (a) a polyethylene glycol compound (A); and (b) at least one poly(amino acid) compound selected from the group consisting of a poly(β-amino ester) and poly(amido amine) or a copolymer thereof (B). A method for preparing the same block copolymer, and a polymer micelle type drug composition comprising the pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The pH-sensitive block copolymer is obtained by polymerization of a hydrophilic polyethylene glycol compound with a pH-sensitive biodegradable poly(amino acid) compound. Therefore, the pH-sensitive block copolymer can form a micelle structure due to its amphiphilicity and ionization characteristics depending on pH variations, and thus can be used as drug carrier for target-directed drug delivery depending on pH variations in the body.
摘要翻译：公开了通过以下方法获得的pH敏感性嵌段共聚物：（a）聚乙二醇化合物（A）; 和（b）至少一种选自聚（亚氨基酯）和聚（酰氨基胺）或其共聚物（B）的聚（氨基酸）化合物。还公开了制备相同嵌段共聚物的方法，以及包含该pH敏感性嵌段共聚物的聚合物胶束型药物组合物和可以用嵌段共聚物包封的生理活性物质。通过亲水性聚乙二醇化合物与pH敏感的可生物降解的聚（氨基酸）化合物的聚合获得pH敏感性嵌段共聚物。因此，pH敏感性嵌段共聚物由于其两亲性和离子化特性而根据pH变化而形成胶束结构，因此可以根据体内的pH变化用作靶向药物递送的药物载体。

7. 发明授权

US08511885B2 Light emitting device assembly, backlight unit and display device having the same 有权
标题翻译：发光器件组件，背光单元和具有其的显示器件
公开(公告)号：US08511885B2
公开(公告)日：2013-08-20
申请号：US13184054
申请日：2011-07-15
申请人： Moon Jeong Kim , Kum Tae Lee , Min Sang Kim
发明人： Moon Jeong Kim , Kum Tae Lee , Min Sang Kim
IPC分类号： F21V7/04
CPC分类号： G02B6/0091 , G02B6/0031 , G02B6/0055 , G02B6/0068 , G02B6/008 , G02F1/1336 , G02F1/133608 , G02F1/133615
摘要： Disclosed herein are a light emitting device assembly, a backlight unit and a display device having the same. The light emitting device assembly includes a light emitting device module having a light emitting device disposed on a board, a light guide plate to emit light incident from the light emitting device module in a direction differing from a light incidence direction, and a first fixing cover and a second fixing cover to connect the light emitting device module and the light guide plate. The first fixing cover and the second fixing cover are coupled by fixing members, protrusions are disposed on the second fixing cover at first regions corresponding to the fixing members, and the edge of the second fixing cover at second regions is bent.
摘要翻译：这里公开了发光器件组件，背光单元和具有该发光器件组件的显示器件。发光器件组件包括发光器件模块，其具有布置在板上的发光器件，导光板以不同于光入射方向的方式发射从发光器件模块入射的光;以及第一固定盖以及用于连接发光器件模块和导光板的第二固定盖。第一固定盖和第二固定盖通过固定构件联接，突起在与固定构件对应的第一区域设置在第二固定盖上，第二区域的第二固定盖的边缘弯曲。

8. 发明申请

US20120140443A1 BACKLIGHT UNIT AND DISPLAY APPARATUS USING THE SAME 有权
标题翻译：背光单元和显示装置
公开(公告)号：US20120140443A1
公开(公告)日：2012-06-07
申请号：US13368673
申请日：2012-02-08
申请人： Min Sang Kim , Jung In Seo
发明人： Min Sang Kim , Jung In Seo
IPC分类号： G09F13/04
CPC分类号： G02B6/0021 , G02B6/0038 , G02B6/0055 , G02B6/0068 , G02B6/0073
摘要： The backlight unit includes a plurality of light source groups, each of which includes at least one light source, and a light guide plate to guide light irradiated from the plurality of light source groups, and the light guide plate includes first grooves disposed in a first direction, the plurality of light source groups being disposed within the first grooves, and at least one second groove disposed in a second direction differing from the first direction.
摘要翻译：背光单元包括多个光源组，每个光源组包括至少一个光源，以及导光板，用于引导从多个光源组照射的光，并且导光板包括设置在第一所述多个光源组设置在所述第一凹槽内，以及至少一个第二凹槽，所述第二凹槽沿与第一方向不同的第二方向设置。

9. 发明授权

US08033676B2 Optical assembly, backlight unit having the same, and display apparatus thereof 有权
标题翻译：光学组件，具有该组件的背光单元及其显示装置
公开(公告)号：US08033676B2
公开(公告)日：2011-10-11
申请号：US12985213
申请日：2011-01-05
申请人： Kum Tae Lee , Min Sang Kim , Moon Jeong Kim , Sung Young Park , Jeong Hwan Kim
发明人： Kum Tae Lee , Min Sang Kim , Moon Jeong Kim , Sung Young Park , Jeong Hwan Kim
IPC分类号： G09F13/04 , G02F1/1335
CPC分类号： G02B6/0083 , G02B6/0068 , G02B6/008 , G02B6/0091
摘要： The backlight unit may include a plurality of optical assemblies, which each include a light emitting module having a substrate, a plurality of light emitting devices on a top surface of the substrate, and a connector provided on a bottom surface of the substrate and electrically connected to a power supply unit. The optical assembly may also include a light guide plate including a first part through which the light is received and a second part to output the light, which is laterally received from the first part, through a top surface thereof. A first side cover may be provided over the light emitting module and the first part of the light guide plate. A second side cover may be formed under the light emitting module and the light guide plate, the second side cover having a plurality of connector holes. The connector may be provided in one of the connector holes.
摘要翻译：背光单元可以包括多个光学组件，每个光学组件包括具有衬底的发光模块，在衬底的顶表面上的多个发光器件，以及设置在衬底的底表面上的电连接到电源单元。光学组件还可以包括导光板，该导光板包括容纳光的第一部分和通过其顶表面输出从第一部分侧向接收的光的第二部分。可以在发光模块和导光板的第一部分之上设置第一侧盖。第二侧盖可以形成在发光模块下面和导光板之下，第二侧盖具有多个连接孔。连接器可以设置在连接器孔中的一个中。

10. 发明授权

US09775803B2 Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof 有权
公开(公告)号：US09775803B2
公开(公告)日：2017-10-03
申请号：US13608617
申请日：2012-09-10
申请人： Min Sang Kim , Hyun Ryoung Kim , Jae Chan Park , Su Young Chae , Sang Joon Park
发明人： Min Sang Kim , Hyun Ryoung Kim , Jae Chan Park , Su Young Chae , Sang Joon Park
IPC分类号： A61K9/127 , A61K47/42 , A61M37/00 , A61K47/48 , A61K31/704 , B82Y5/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/704 , A61K47/42 , A61K47/6911 , A61M37/00 , B82Y5/00 , Y10S977/797 , Y10S977/907
摘要： A liposome including an elastin-like polypeptide (ELP) and a tumor cell targeting material, a pharmaceutical composition including the liposome, and a method of delivering an active agent to a target site using the liposome.

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