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1. 发明申请

US20180028664A1 COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS 审中-公开
公开(公告)号：US20180028664A1
公开(公告)日：2018-02-01
申请号：US15674872
申请日：2017-08-11
申请人： ModernaTX, Inc.
发明人： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC分类号： A61K47/10 , C12N15/117 , A61K39/39 , C08G65/333 , C08G65/332 , C08G65/335 , A61K31/713 , C08G65/334
CPC分类号： A61K48/0033 , A61K9/127 , A61K31/7115 , A61K31/713 , A61K39/39 , A61K47/10 , A61K47/543 , A61K47/544 , A61K47/60 , A61K47/6929 , A61K48/0066 , A61K2039/55555 , C08G65/3322 , C08G65/3326 , C08G65/33306 , C08G65/3331 , C08G65/33317 , C08G65/33324 , C08G65/3348 , C08G65/3356 , C08G2650/04 , C12N15/117 , C12N15/88 , C12N2310/141 , C12N2310/17 , C12N2320/32
摘要： This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

2. 发明申请

US20170107325A1 HYDROPHILIC POLYMER DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER 审中-公开
公开(公告)号：US20170107325A1
公开(公告)日：2017-04-20
申请号：US15300699
申请日：2015-03-30
申请人： NOF CORPORATION
发明人： Takuma TSUBUSAKI , Yuji YAMAMOTO
IPC分类号： C08G65/333 , C07D317/24 , C07D405/06 , C07D317/20
CPC分类号： C08G65/33396 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/28 , C07D405/06 , C08G65/329 , C08G65/3317 , C08G65/333 , C08G65/33324 , C08G65/33337 , C08G65/33341 , C08G65/3346 , C08G65/337
摘要： A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer, s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.

3. 发明授权

US08829109B2 Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery 有权
标题翻译：可还原的聚（酰氨基亚乙基亚胺）的可修饰修饰以增强核苷酸的传递
公开(公告)号：US08829109B2
公开(公告)日：2014-09-09
申请号：US12266980
申请日：2008-11-07
申请人： James W. Yockman , Jonathan Brumbach , Lane V. Christensen , Sung Wan Kim
发明人： James W. Yockman , Jonathan Brumbach , Lane V. Christensen , Sung Wan Kim
IPC分类号： A61K47/48 , C08G63/48 , C08G63/91 , C08L89/00 , C12N15/00 , C08G65/334 , C08G73/02 , C08G65/333 , C08G65/332
CPC分类号： C08G65/3322 , C08G65/33306 , C08G65/33324 , C08G65/3342 , C08G65/3346 , C08G65/3348 , C08G73/0253 , C08G73/028 , C08L2205/05
摘要： Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
摘要翻译：公开了用于基因递送的改进的聚（酰胺乙烯亚胺）共聚物。一个说明性实施方案包括共价键合到支链聚（三亚乙基四胺/胱胺胺双丙烯酰胺）共聚物（聚（TETA / CBA））的聚乙二醇（PEG）。聚乙二醇可以是直链或支链的。另一个说明性实施方案包括与聚（TETA / CBA）-PEG缀合物共价结合的RGD肽。另一个说明性实施方案包括使用这些组合物用核酸转染细胞的方法。

4. 发明申请

US20140039152A1 POLY(ETHYLENEOXIDE) FUNCTIONALIZATION THROUGH ALKYLATION 有权
标题翻译：通过烷基化的聚（乙烯氧化物）官能化
公开(公告)号：US20140039152A1
公开(公告)日：2014-02-06
申请号：US13946924
申请日：2013-07-19
申请人： Seeo, Inc
发明人： Kulandaivelu Sivanandan , Hany Basam Eitouni , Yan Li , Russell Clayton Pratt
IPC分类号： C08G65/337
CPC分类号： C08G65/337 , C08G65/33324 , C08G65/336
摘要： A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers.
摘要翻译：描述了通过使用金属酰胺碱通过烷基化官能化高分子量聚合物的新的和有效的方法。该新方法也可用于合成在链端含有自由基引发基团的基于聚合物的大分子引发剂，用于合成嵌段共聚物。

5. 发明申请

US20110065808A1 CARBONYL COMPOUND REMOVER 审中-公开
标题翻译：碳化合物去除
公开(公告)号：US20110065808A1
公开(公告)日：2011-03-17
申请号：US12880434
申请日：2010-09-13
申请人： Takashi Yamamoto , Ryusuke Hirama , Toshihiro Hatanaka
发明人： Takashi Yamamoto , Ryusuke Hirama , Toshihiro Hatanaka
IPC分类号： C08G65/00 , A61K47/34
CPC分类号： B01J20/26 , B01J20/262 , B01J20/267 , C08G65/3322 , C08G65/33306 , C08G65/33324 , C08G65/33396 , C08G65/337 , C08G2650/50 , C08L71/02
摘要： A carbonyl compound remover comprising at least one polyether resin that includes a unit shown by any of the formulas (I) to (IV) as an active ingredient, a method of preventing coloration of an infusion comprising causing the carbonyl compound remover to come in contact with an infusion that may produce and accumulate a carbonyl compound during heat sterilization or storage, or an infusion that contains a carbonyl compound, and a novel crosslinked polyether resin are disclosed. The carbonyl compound remover that may suppress a Maillard reaction in a mixture of an amino acid infusion and a sugar infusion or the like to effectively prevent coloration due to a Maillard reaction, the method of preventing coloration of an infusion by using the remover, and the novel crosslinked polyether resin are offered in the present invention. In the formulas, n1 and n2 represent integers from 1 to 100, A represents a unit (A1) or (A2), or a combination of the (A1) and (A2), R represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and Q represents a group shown by CH2ONH2.
摘要翻译：一种羰基化合物去除剂，其包含至少一种包含式（I）至（IV）中任一项所示的单元作为活性成分的聚醚树脂，防止输注着色的方法，包括使羰基化合物去除剂接触在加热灭菌或储存期间产生并积累羰基化合物的输液，或含有羰基化合物的输注物和新型交联聚醚树脂。可以抑制氨基酸输注和糖输液等的混合物中的美拉德反应以有效防止美拉德反应引起的着色的羰基化合物去除剂，通过使用去除剂防止输注着色的方法，以及本发明提供了新型交联聚醚树脂。在式中，n1和n2表示1〜100的整数，A表示单元（A1）或（A2），或（A1）和（A2）的组合，R表示氢原子或1 至6个碳原子，Q表示由CH 2 ONH 2表示的基团。

6. 发明申请

US20100233264A1 TEMPERATURE AND pH-SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT SAFTY IN VIVO AND HYDROGEL AND DRUG DELIVERY SYSTEM USING THEREOF 有权
标题翻译：温度和pH敏感性嵌段共聚物在血液和水凝胶和药物输送系统中具有优异的保湿性
公开(公告)号：US20100233264A1
公开(公告)日：2010-09-16
申请号：US12676828
申请日：2008-09-05
申请人： Doo Sung Lee , Minh Khanh Nguyen , Bong Sup Kim
发明人： Doo Sung Lee , Minh Khanh Nguyen , Bong Sup Kim
IPC分类号： A61K9/10 , A61K38/21 , A61K39/395 , A61K31/337 , A61K31/195 , A61K38/28 , A61K45/00 , A61K38/16 , A61P31/12 , A61P29/00 , A61P37/00 , A61P23/00 , A61P5/24 , A61P31/00 , A61K39/00 , A61K47/30 , C08F220/00
CPC分类号： C08G65/30 , A61K9/0024 , A61K47/34 , C08G65/3322 , C08G65/33317 , C08G65/33324 , C08L2203/02 , C08L2205/05
摘要： Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (β-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (β-amino ester)-based oligomer and then coupling them.
摘要翻译：本文公开了具有优异安全性的pH和温度敏感性嵌段共聚物及其制备方法以及使用该嵌段共聚物的水凝胶和药物载体。根据本发明，pH和温度敏感性嵌段共聚物包括：（a）聚乙二醇基化合物（A）的共聚获得的; 和（b）聚（（bgr。 - 氨基酯）的低聚物（B）或聚（酰氨基胺）的低聚物（C）或其混合物（D）的偶联。为了控制生物降解速率，将嵌段共聚物与基于聚（酰胺基胺）的低聚物混合，而不是基于聚（（ - （ - 氨基酯））的低聚物，然后偶联它们。

7. 发明授权

US10005723B2 Process to produce polycarbamate, polycarbamate produced thereby and a coating composition comprising the polycarbamate 有权
公开(公告)号：US10005723B2
公开(公告)日：2018-06-26
申请号：US14912157
申请日：2014-08-15
申请人： Dow Global Technologies LLC
发明人： Xinrui Yu , Yiyong He , John W. Hull, Jr. , Daryoosh Beigzadeh , Duane Romer , Thomas Clark , Peter Margl , Congcong Lu
IPC分类号： C07C271/00 , C07C269/00 , C08G65/333 , C08G71/04 , C07C271/10 , C09D7/12 , C09D175/04 , C09D7/63
CPC分类号： C07C269/00 , C07C271/10 , C08G65/33303 , C08G65/33324 , C08G71/04 , C09D7/63 , C09D175/04
摘要： A process to prepare polycarbamate comprising adding urea to a polyol in the presence of at least one catalyst selected from the group consisting of compounds having the following formula MmZn; wherein M is a trivalent metal, and Z is an anionic functionality or a functionality capable of forming a covalent bond with M and wherein n times a valence number of Z equals X and m times three equals Y wherein the absolute value of X equals the absolute value of Y is provided. Also provided are a polycarbamate produced according to the process and a coating composition comprising the polycarbamate.

8. 发明授权

US09522192B2 Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides 有权
标题翻译：棕榈酰乙醇酰胺和类似的酰基乙醇酰胺的聚乙二醇衍生物
公开(公告)号：US09522192B2
公开(公告)日：2016-12-20
申请号：US14103463
申请日：2013-12-11
申请人： EPITECH GROUP S.r.l.
发明人： Antonio Calignano , Giuseppe D'Agostino , Sonia Laneri , Rosaria Meli , Carmine Ostacolo , Roberto Russo , Antonia Sacchi , Diana Tronino , Francesco Della Valle , Maria Federica Della Valle , Gabriele Marcolongo
IPC分类号： A61K31/164 , C07C235/08 , A61K47/48 , C07C231/12 , C07C235/20 , C08G59/00
CPC分类号： A61K47/48215 , A61K31/164 , A61K47/60 , C07C231/12 , C07C235/20 , C08G65/332 , C08G65/33324 , C08L2203/02
摘要： The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.
摘要翻译：一系列聚乙二醇共轭物（酯和碳酸酯）的一系列PEA及其类似的酰基乙醇酰胺的合成具有较高的水溶性和良好的亲水/亲油平衡，导致（i）改善组织（特别是皮肤和粘膜）中的积累，（ii ）延长释放，和（iii）增加的生物利用度。组织中特别是皮肤和粘膜中PEA和类似的乙酰乙酰胺水平的改善及其延长的释放是由于相关缀合物的生物利用度得到改善。共轭物能够延长PEA和类似的乙酰乙酰胺发挥其药理作用的时间框架。

9. 发明授权

US09468688B2 Boron cluster-modified PEG lipid derivative, and molecular assembly using same 有权
标题翻译：硼簇改性PEG脂质衍生物，以及使用其的分子组装
公开(公告)号：US09468688B2
公开(公告)日：2016-10-18
申请号：US14423049
申请日：2013-08-22
申请人： UNIVERSITY OF TSUKUBA
发明人： Akira Matsumura , Kei Nakai , Makoto Shirakawa
IPC分类号： A61K47/48 , A61K33/22 , A61K31/69 , C07F9/572 , C07F9/10 , C08G65/328 , A61K9/127 , A61K41/00
CPC分类号： A61K47/48215 , A61K9/1271 , A61K31/69 , A61K33/22 , A61K41/0095 , A61K47/544 , A61K47/554 , A61K47/6911 , C07F9/106 , C07F9/572 , C08G65/3322 , C08G65/33324 , C08G65/3353 , C08G65/337
摘要： The present invention provides a novel boron carrier compound that can be used for boron neutron capture therapy for cancer, and that can realize improvement in the efficiency of a Drug Delivery System (DDS) and an increase in the boron concentration in a tumor. The present invention provides a boron cluster-modified PEG lipid derivative represented by Formula (I): wherein, m and n are each independently an integer of 1-4, q is an integer of 1-280, and R1 and R2 are each independently a hydrocarbon group with a carbon number of 8-22, and a molecular assembly containing the same.

10. 发明授权

US09434825B2 Nucleophilic high molecular weight polymer functionalization through alkylation 有权
标题翻译：亲核高分子量聚合物通过烷基化官能化
公开(公告)号：US09434825B2
公开(公告)日：2016-09-06
申请号：US14672163
申请日：2015-03-28
申请人： Seeo, Inc
发明人： Kulandaivelu Sivanandan , Hany Basam Eitouni , Russell Clayton Pratt , Jonathan C. Pistorino
IPC分类号： C08G65/337 , C08G65/336 , C08J3/21 , C08G65/333
CPC分类号： C08J3/212 , C08G65/3322 , C08G65/33324 , C08G65/336 , C08J2363/00
摘要： A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal hetero alkylbase is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers.
摘要翻译：描述了通过使用金属杂烷基的烷基化官能化高分子量聚合物的新的和有效的方法。该新方法也可用于合成在链端含有自由基引发基团的基于聚合物的大分子引发剂，用于合成嵌段共聚物。

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