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1. 发明授权

US09763928B2 Multi-layer nicotine-containing pharmaceutical composition 有权
公开(公告)号：US09763928B2
公开(公告)日：2017-09-19
申请号：US13370505
申请日：2012-02-10
申请人： Donna Walker Duggins , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell
发明人： Donna Walker Duggins , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell
IPC分类号： A61K9/00 , A61K31/465 , A61K9/24 , A61K9/28
CPC分类号： A61K31/465 , A61K9/0056 , A61K9/209 , A61K9/2886
摘要： The invention provides a multi-layered pharmaceutical composition comprising two or more formulations with varying properties. In some embodiments, the pharmaceutical compositions provide combinations of different organoleptic properties within the same product. In certain embodiment, these combinations allow for a modified release profile of active ingredients as the user enjoys the pharmaceutical composition. The invention further provides methods for making and using the pharmaceutical composition.

2. 发明授权

US08991403B2 Thermal treatment process for tobacco materials 有权
标题翻译：烟草材料热处理工艺
公开(公告)号：US08991403B2
公开(公告)日：2015-03-31
申请号：US13228912
申请日：2011-09-09
申请人： Gong Chen , Anthony Richard Gerardi , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell , Frank Kelley St. Charles , Cheryl Cooper Scott
发明人： Gong Chen , Anthony Richard Gerardi , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell , Frank Kelley St. Charles , Cheryl Cooper Scott
IPC分类号： A24B1/02 , A24B15/30 , A24B15/20
CPC分类号： A24B15/302 , A24B15/20 , A24B15/306
摘要： A method of thermally processing a tobacco material is provided, the method including the steps of (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof, to form a moist tobacco mixture; (ii) heating the moist tobacco mixture at a temperature of at least about 60° C. to form a heat-treated tobacco mixture; and (iii) incorporating the heat-treated tobacco mixture into a tobacco product. Heat-treated tobacco composition prepared according to the method are also provided, such as heat-treated smokeless tobacco composition comprising a tobacco material, water, flavorant, binder, and filler, the heat-treated smokeless tobacco composition having an acrylamide content of less than about 2000 ppb.
摘要翻译：提供了一种热处理烟草材料的方法，所述方法包括以下步骤：（i）将烟草材料，水和选自赖氨酸，甘氨酸，组氨酸，丙氨酸，甲硫氨酸，谷氨酸，天冬氨酸的添加剂混合酸，脯氨酸，苯丙氨酸，缬氨酸，精氨酸，二价和三价阳离子，天冬酰胺酶，糖类，酚类化合物，还原剂，具有游离巯基的化合物，氧化剂，氧化催化剂，植物提取物及其组合，烟草混合物; （ii）在至少约60℃的温度下加热潮湿的烟草混合物以形成经热处理的烟草混合物; 和（iii）将经热处理的烟草混合物并入烟草制品中。还提供了根据该方法制备的热处理烟草组合物，例如包含烟草材料，水，香料，粘合剂和填料的热处理无烟烟草组合物，所述热处理的无烟烟草组合物的丙烯酰胺含量小于约2000 ppb

3. 发明授权

US08695609B2 Smokeless tobacco composition 有权
标题翻译：无烟烟草组成
公开(公告)号：US08695609B2
公开(公告)日：2014-04-15
申请号：US12878568
申请日：2010-09-09
申请人： Michael Francis Dube , Daniel Verdin Cantrell , John-Paul Mua , Darrell Eugene Holton, Jr. , Cynthia Stewart Stokes , James Neil Figlar
发明人： Michael Francis Dube , Daniel Verdin Cantrell , John-Paul Mua , Darrell Eugene Holton, Jr. , Cynthia Stewart Stokes , James Neil Figlar
IPC分类号： A24B3/14 , A24B15/12
CPC分类号： A24B13/00 , A24B15/283
摘要： A smokeless tobacco product configured for insertion into the mouth of a user of the product is provided, the tobacco product including a water-permeable pouch containing a tobacco formulation, the tobacco formulation including a tobacco material and a plurality of microcapsules dispersed within the tobacco material, the plurality of microcapsules including an outer shell encapsulating an internal payload. The internal payload may include an additive such as water, flavorants, binders, colorants, pH adjusters, buffering agents, fillers, disintegration aids, humectants, antioxidants, oral care ingredients, preservatives, additives derived from herbal or botanical sources, and mixtures thereof. Microencapsulated flavorants include tobacco-containing flavorants, such as tobacco extracts or a particulate tobacco material, sweeteners (e.g., sweeteners containing neotame), and vanillin (optionally in a complexed form).
摘要翻译：提供了构造成用于插入产品使用者的口中的无烟烟草产品，烟草制品包括含有烟草制剂的透水袋，烟草制剂包括烟草材料和分散在烟草材料内的多个微胶囊，所述多个微胶囊包括封装内部净荷的外壳。内部有效载荷可以包括添加剂，例如水，调味剂，粘合剂，着色剂，pH调节剂，缓冲剂，填充剂，崩解助剂，保湿剂，抗氧化剂，口腔护理成分，防腐剂，来自草药或植物来源的添加剂，及其混合物。微囊化香料包括含烟草的调味剂，例如烟草提取物或颗粒烟草材料，甜味剂（例如含有neotame的甜味剂）和香草醛（任选以络合形式）。

4. 发明授权

US07810507B2 Smokeless tobacco composition 有权
标题翻译：无烟烟草组成
公开(公告)号：US07810507B2
公开(公告)日：2010-10-12
申请号：US11781604
申请日：2007-07-23
申请人： Michael Francis Dube , Daniel Verdin Cantrell , John-Paul Mua , Darrell Eugene Holton, Jr. , Cynthia Stewart Stokes , James Neil Figlar
发明人： Michael Francis Dube , Daniel Verdin Cantrell , John-Paul Mua , Darrell Eugene Holton, Jr. , Cynthia Stewart Stokes , James Neil Figlar
IPC分类号： A24B15/00
CPC分类号： A24B13/00 , A24B15/283
摘要： A smokeless tobacco product configured for insertion into the mouth of a user of the product is provided, the tobacco product including a water-permeable pouch containing a tobacco formulation, the tobacco formulation including a tobacco material and a plurality of microcapsules dispersed within the tobacco material, the plurality of microcapsules including an outer shell encapsulating an internal payload. The internal payload may include an additive such as water, flavorants, binders, colorants, pH adjusters, buffering agents, fillers, disintegration aids, humectants, antioxidants, oral care ingredients, preservatives, additives derived from herbal or botanical sources, and mixtures thereof. Microencapsulated flavorants include tobacco-containing flavorants, such as tobacco extracts or a particulate tobacco material, sweeteners (e.g., sweeteners containing neotame), and vanillin (optionally in a complexed form).
摘要翻译：提供了构造成用于插入产品使用者的口中的无烟烟草产品，烟草制品包括含有烟草制剂的透水袋，烟草制剂包括烟草材料和分散在烟草材料内的多个微胶囊，所述多个微胶囊包括封装内部净荷的外壳。内部有效载荷可以包括添加剂，例如水，调味剂，粘合剂，着色剂，pH调节剂，缓冲剂，填充剂，崩解助剂，保湿剂，抗氧化剂，口腔护理成分，防腐剂，来自草药或植物来源的添加剂，及其混合物。微囊化香料包括含烟草的调味剂，例如烟草提取物或颗粒烟草材料，甜味剂（例如含有neotame的甜味剂）和香草醛（任选以络合形式）。

5. 发明授权

US08434496B2 Thermal treatment process for tobacco materials 有权
公开(公告)号：US08434496B2
公开(公告)日：2013-05-07
申请号：US12476621
申请日：2009-06-02
申请人： Gong Chen , Anthony Richard Gerardi , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell , Frank Kelley St. Charles
发明人： Gong Chen , Anthony Richard Gerardi , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell , Frank Kelley St. Charles
IPC分类号： A24B15/00
CPC分类号： A24B15/00 , A24B15/302 , A24B15/306
摘要： A method of thermally processing a tobacco material is provided, the method including the steps of (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof, to form a moist tobacco mixture; (ii) heating the moist tobacco mixture at a temperature of at least about 60° C. to form a heat-treated tobacco mixture; and (iii) incorporating the heat-treated tobacco mixture into a tobacco product. Heat-treated tobacco composition prepared according to the method are also provided, such as heat-treated smokeless tobacco composition comprising a tobacco material, water, flavorant, binder, and filler, the heat-treated smokeless tobacco composition having an acrylamide content of less than about 2000 ppb.

6. 发明授权

US08944072B2 Thermal treatment process for tobacco materials 有权
标题翻译：烟草材料热处理工艺
公开(公告)号：US08944072B2
公开(公告)日：2015-02-03
申请号：US12855343
申请日：2010-08-12
申请人： Gong Chen , Anthony Richard Gerardi , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell , Frank Kelley St. Charles , Serban C. Moldoveanu , Paul Andrew Brinkley
发明人： Gong Chen , Anthony Richard Gerardi , John-Paul Mua , Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell , Frank Kelley St. Charles , Serban C. Moldoveanu , Paul Andrew Brinkley
IPC分类号： A24B3/18 , A24C5/00 , A24D3/00 , A24B15/20 , A24B3/12 , A24B15/30
CPC分类号： A24B15/18 , A24B3/12 , A24B13/00 , A24B15/20 , A24B15/30 , A24B15/306 , A24B15/307 , A24C5/00 , A24D3/00
摘要： A method of preparing a tobacco material for use in a smoking article is provided, including (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof; (ii) heating the mixture; and (iii) incorporating the heat-treated mixture into a smoking article as a smokable material. A smoking article in the form of a cigarette is also provided that includes a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke. Upon smoking, the smoking article is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article.
摘要翻译：提供一种制备用于吸烟制品的烟草材料的方法，包括（i）将烟草材料，水和选自赖氨酸，甘氨酸，组氨酸，丙氨酸，甲硫氨酸，谷氨酸，天冬氨酸的添加剂混合酸，脯氨酸，苯丙氨酸，缬氨酸，精氨酸，二价和三价阳离子，天冬酰胺酶，糖类，酚类化合物，还原剂，具有游离巯基的化合物，氧化剂，氧化催化剂，植物提取物及其组合; （ii）加热混合物; 和（iii）将热处理的混合物并入作为吸烟材料的吸烟制品中。还提供了一种卷烟形式的吸烟制品，其包括预处理以抑制天冬酰胺在主流烟气中形成丙烯酰胺的反应的烟草材料。吸烟时，吸烟制品的特征在于主流烟雾的丙烯酰胺含量相对于未处理的对照吸烟制品而减少。

7. 发明授权

US07861728B2 Smokeless tobacco composition having an outer and inner pouch 有权
标题翻译：具有外袋和内袋的无烟烟草组合物
公开(公告)号：US07861728B2
公开(公告)日：2011-01-04
申请号：US11351919
申请日：2006-02-10
申请人： Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell
发明人： Darrell Eugene Holton, Jr. , Daniel Verdin Cantrell
IPC分类号： A24B15/00 , A24B3/14 , A24B15/12
CPC分类号： A24B13/00 , A24B15/283
摘要： A smokeless tobacco product includes a powdered or granular smokeless tobacco formulation that is contained within a moisture-permeable packet or pouch. The smokeless tobacco formulation may include finely ground particles of tobacco in powder-like form and other ingredients such as sweeteners, binders, colorants, pH adjusters, fillers, flavoring ingredients, disintegration aids, antioxidants and preservatives. The tobacco formulation may have a dry or moist form. The container has the form of a pouch or bag, such as is the type commonly used for the manufacture of snus products. The container preferably contains at least one capsule, such as a spherical breakable capsule. The container is intended to be placed in the mouth of the tobacco user, such that the tobacco formulation within the container may be enjoyed by the user. After the tobacco user is finished using the smokeless tobacco product, the container is removed from the user's mouth for disposal. Alternatively, the container is dissolvable or dispersible in the mouth of the user.
摘要翻译：无烟烟草制品包括粉末状或颗粒状无烟烟草制剂，其包含在透湿包装袋内。无烟烟草制剂可以包括粉末状形式的细磨的烟草颗粒和其它成分如甜味剂，粘合剂，着色剂，pH调节剂，填充剂，调味成分，崩解助剂，抗氧化剂和防腐剂。烟草制剂可以具有干燥或潮湿的形式。容器具有袋或袋的形式，例如通常用于制造鼻塞产品的类型。容器优选包含至少一个胶囊，例如球形可破坏胶囊。该容器旨在放置在烟草使用者的口中，使得容器内的烟草制剂可以由使用者享用。在烟草使用者完成使用无烟烟草制品之后，将容器从用户口中取出以便处理。或者，容器可溶解或分散在使用者的口中。

8. 发明授权

US09237769B2 Smokeless tobacco composition 有权
标题翻译：无烟烟草组成
公开(公告)号：US09237769B2
公开(公告)日：2016-01-19
申请号：US13224986
申请日：2011-09-02
申请人： John-Paul Mua , Luis Rosete Monsalud, Jr. , Darrell Eugene Holton, Jr. , James Neil Figlar
发明人： John-Paul Mua , Luis Rosete Monsalud, Jr. , Darrell Eugene Holton, Jr. , James Neil Figlar
IPC分类号： A24B1/02 , A24B3/02 , A24B9/00 , A24B15/00 , A24B15/18 , A24B15/12 , A24B15/28 , A24B15/42
CPC分类号： A24B13/00 , A24B3/12 , A24B15/12 , A24B15/18 , A24B15/183 , A24B15/186 , A24B15/28 , A24B15/283 , A24B15/42 , A24F23/02 , B65B63/08
摘要： The invention provides a process for preparing a tobacco composition suitable for use as a smokeless tobacco composition, the process including: providing a slurry comprising water and a tobacco material, the slurry comprising at least about 75% by weight water, based on the total weight of the slurry; heating the slurry to a temperature of at least about 60° C. for a time sufficient to pasteurize the tobacco material; adding an amount of a base to the slurry sufficient to raise the pH of the slurry to at least about 8.5, thereby forming a pH-adjusted slurry; and continuing to heat the pH-adjusted slurry to a temperature of at least about 60° C. for a time sufficient for the pH of the slurry to drop at least about 0.5 pH unit following the adding step.
摘要翻译：本发明提供了一种制备适合用作无烟烟草组合物的烟草组合物的方法，该方法包括：提供包含水和烟草材料的浆料，所述浆料包含至少约75重量％的水，基于总重量的浆料; 将浆料加热到至少约60℃的温度足以巴戟草材料的时间; 向浆料中加入一定量的碱以使浆料的pH升至至少约8.5，由此形成pH调节浆料; 并继续将pH调节的浆料加热到至少约60℃的温度足以使浆料的pH在加入步骤后降至至少约0.5pH单位的时间。

9. 发明授权

US08061362B2 Smokeless tobacco composition 有权
标题翻译：无烟烟草组成
公开(公告)号：US08061362B2
公开(公告)日：2011-11-22
申请号：US11781666
申请日：2007-07-23
申请人： John-Paul Mua , Luis Rosete Monsalud, Jr. , Darrell Eugene Holton, Jr. , James Neil Figlar
发明人： John-Paul Mua , Luis Rosete Monsalud, Jr. , Darrell Eugene Holton, Jr. , James Neil Figlar
IPC分类号： A24B1/02 , A24B3/00 , A24B9/00 , A24B15/00
CPC分类号： A24B13/00 , A24B3/12 , A24B15/12 , A24B15/18 , A24B15/183 , A24B15/186 , A24B15/28 , A24B15/283 , A24B15/42 , A24F23/02 , B65B63/08
摘要： The invention provides a process for preparing a tobacco composition suitable for use as a smokeless tobacco composition, the process including: providing a slurry comprising water and a tobacco material, the slurry comprising at least about 75% by weight water, based on the total weight of the slurry; heating the slurry to a temperature of at least about 60° C. for a time sufficient to pasteurize the tobacco material; adding an amount of a base to the slurry sufficient to raise the pH of the slurry to at least about 8.5, thereby forming a pH-adjusted slurry; and continuing to heat the pH-adjusted slurry to a temperature of at least about 60° C. for a time sufficient for the pH of the slurry to drop at least about 0.5 pH unit following the adding step.
摘要翻译：本发明提供了一种制备适合用作无烟烟草组合物的烟草组合物的方法，该方法包括：提供包含水和烟草材料的浆料，所述浆料包含至少约75重量％的水，基于总重量的浆料; 将浆料加热到至少约60℃的温度足以巴戟草材料的时间; 向浆料中加入一定量的碱以使浆料的pH升至至少约8.5，由此形成pH调节浆料; 并继续将pH调节的浆料加热到至少约60℃的温度足以使浆料的pH在加入步骤后降至至少约0.5pH单位的时间。

10. 发明授权

US09675102B2 Smokeless tobacco product comprising effervescent composition 有权
公开(公告)号：US09675102B2
公开(公告)日：2017-06-13
申请号：US12876785
申请日：2010-09-07
申请人： Eric Taylor Hunt , Darrell Eugene Holton, Jr. , Frank Kelley St. Charles
发明人： Eric Taylor Hunt , Darrell Eugene Holton, Jr. , Frank Kelley St. Charles
IPC分类号： A24B15/00 , A24B15/28 , A24B13/00 , A24B15/42
CPC分类号： A24B15/281 , A24B13/00 , A24B15/186 , A24B15/42
摘要： The invention provides an smokeless tobacco composition adapted for oral use, the composition including a tobacco material and an effervescent material. The effervescent material includes an acid component and a base component, wherein the acid component includes a triprotic acid such as citric acid and at least one additional acid. The invention also provides a method for making a smokeless tobacco composition that involves first forming a granulation mixture, granulating the granulation mixture, and then blending the resulting granules with further blending components. Thereafter, the material can be formed into a predetermined shape, such as by compression or extrusion. The acid component of the effervescent material is divided into two portions, the first portion added to the granulation mixture and the remaining portion added during the blending step.

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