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1. 发明授权

US4919817A Blood cell washing systems and methods 失效
标题翻译：血细胞清洗系统及方法
公开(公告)号：US4919817A
公开(公告)日：1990-04-24
申请号：US159446
申请日：1988-02-18
申请人： Donald W. Schoendorfer , Lee H. Williamson
发明人： Donald W. Schoendorfer , Lee H. Williamson
IPC分类号： B01D61/14 , A61M1/02 , A61M1/26 , A61M1/34 , A61M1/36 , B01D63/16
CPC分类号： A61M1/34 , A61M1/265 , A61M1/3692
摘要： A system and method for cleaning contaminants from shed blood to enable reinfusion of a cell concentrate in the patient employs successive rotary membrane filtering stages in which Taylor vortices are generated. Shed blood led into the first rotary membrane stage is filtered to a hematocrit in the range of 50-60 with some of the waste matter being removed. The intermediate cell concentrate is passed to the second filter stage where further waste matter is initially extracted. At any intermediate region, however, a major amount of wash solution is fed into the concentrate and effectively mixed by the Taylor vortices. In the remaining length of the second filter stage waste matter is entrained in wash solution and both waste and wash solution are filtered out to provide a cell concentrate from which the great majority of contaminants have been removed.
摘要翻译：用于从流出的血液清洁污染物以使患者能够再次输注细胞浓缩物的系统和方法采用生成泰勒涡流的连续旋转膜过滤阶段。导入第一个旋转膜阶段的血液过滤到50-60范围内的血细胞比容，其中一些废物被去除。将中间细胞浓缩物送至第二过滤器阶段，其中最初提取进一步的废物。然而，在任何中间区域，将主要量的洗涤溶液进料到浓缩物中并由泰勒涡流有效地混合。在第二过滤段的剩余长度中，废物被夹带在洗涤溶液中，并且废物和洗涤溶液都被过滤出来以提供细胞浓缩物，其中大部分污染物已被除去。

2. 发明授权

US5053121A Blood cell washing systems and methods 失效
标题翻译：血细胞清洗系统及方法
公开(公告)号：US5053121A
公开(公告)日：1991-10-01
申请号：US443550
申请日：1989-11-29
申请人： Donald W. Schoendorfer , Lee H. Williamson
发明人： Donald W. Schoendorfer , Lee H. Williamson
IPC分类号： B01D61/14 , A61M1/02 , A61M1/26 , A61M1/34 , A61M1/36 , B01D63/16
CPC分类号： A61M1/34 , A61M1/265 , A61M1/3692
摘要： A system and method for cleaning contaminants from shed blood to enable reinfusion of a cell concentrate in the patient employs successive rotary membrane filtering stages in which Taylor vortices are generated. Shed blood led into the first rotary membrane stage is filtered to produce a hematocrit in the range of 50-60 with some of the waste matter being removed. The intermediate cell concentrate is passed to the second filter stage where further waste matter is initially extracted. At any intermediate region, however, a major amount of wash solution is fed into the concentrate and effectively mixed therein. In the remaining length of the second filter stage, waste matter is entrained in the wash solution and both waste and wash solution are filtered out to provide a cell concentrate from which the great majority of contaminants have been removed.
摘要翻译：用于从流出的血液清洁污染物以使患者能够再次输注细胞浓缩物的系统和方法采用生成泰勒涡流的连续旋转膜过滤阶段。导入第一旋转膜级的血液过滤，以产生50-60范围内的血细胞比容，其中一些废物被去除。将中间细胞浓缩物送至第二过滤器阶段，其中最初提取进一步的废物。然而，在任何中间区域，将主要量的洗涤溶液进料到浓缩物中并有效地混合在其中。在第二过滤阶段的剩余长度中，废物被夹带在洗涤溶液中，废物和洗涤溶液都被过滤掉，以提供细胞浓缩物，大部分污染物从该浓缩物中除去。

3. 发明授权

US5817011A Method and apparatus for determination of chemical species in perspiration 失效
公开(公告)号：US5817011A
公开(公告)日：1998-10-06
申请号：US794284
申请日：1997-02-03
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61B5/00 , A61B10/00 , A61F13/00 , A61F13/15 , B01L3/00 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/14521 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , A61B5/6833 , A61M35/006 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61B5/14532 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491
摘要： A dermal patch to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection.

4. 发明授权

US5676144A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5676144A
公开(公告)日：1997-10-14
申请号：US483504
申请日：1995-06-07
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61B5/00 , A61B10/00 , A61F7/03 , A61F13/00 , A61F13/15 , B01L3/00 , G01N1/10 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491 , A61F7/032
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。补片可以包括用于筛选多个分析物的多个测试区。还公开了另外的正负控制区。补片可以包括检测篡改贴片以产生假阴性结果的特征，特别是当用于滥用药物的屏幕时。除了作为滥用药物屏幕有用之外，该补丁可用于诊断目的。

5. 发明授权

US4944883A Continuous centrifugation system and method for directly deriving intermediate density material from a suspension 失效
标题翻译：连续离心系统和从悬浮液中直接得到中密度材料的方法
公开(公告)号：US4944883A
公开(公告)日：1990-07-31
申请号：US256234
申请日：1988-10-11
申请人： Donald W. Schoendorfer , Claude E. Berthe
发明人： Donald W. Schoendorfer , Claude E. Berthe
IPC分类号： A61M1/26 , A61M1/30 , A61M1/36 , B04B5/04
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3696 , B04B5/0442 , B04B2005/0464
摘要： A system for continuously separating lighter and intermediate density matter, such as plasma rich in platelets from whole blood moves blood through a diverging centrifugation gap between inner and outer walls of a rotor rotating about a central axis within an outer housing. The centrifugation action creates layered flow along an intermediate section. However by crating trailing wakes in the gap between the rotor and housing, localized remixing patterns tending to move in the opposite direction are induced in the layered matter. Platelet rich plasm may then be extracted through adjacent platelet concentrate ports on the inner wall of the rotor. An interior passageway system passes the platelet rich plasma to a platelet concentrate reservoir. Recirculation of blood in the rotor-housing gap between the output and input, and pumping action provided by the diverging centrifugation gap, aid in enhancing throughput and concentration levels. Prior to the centrifugation gap an initial narrow gap section is employed to limit backward propagation of the induced circulatory patterns.
摘要翻译：用于连续分离较轻和中等密度物质的系统，例如来自全血的富含血小板的血浆，使血液通过在外壳内围绕中心轴旋转的转子的内壁和外壁之间的发散的离心间隙移动。离心作用沿着中间部分产生分层流。然而，通过在转子和壳体之间的间隙中装配尾部的擦拭物，在分层物质中引起倾向于在相反方向移动的局部再混合模式。然后可以通过转子内壁上的相邻血小板浓缩物端口提取富血小板血浆。内部通道系统将富含血小板的血浆传递到血小板浓缩物储存器。在输出和输入之间的转子 - 壳体间隙中的血液再循环以及由分散离心间隙提供的泵送作用有助于提高产量和浓度水平。在离心间隙之前，采用初始窄间隙部分来限制诱导循环图案的反向传播。

6. 发明授权

US4850998A Method for wetting a plasmapheresis filter with anticoagulant 失效
标题翻译：用抗凝剂润湿血浆置换过滤器的方法
公开(公告)号：US4850998A
公开(公告)日：1989-07-25
申请号：US106089
申请日：1987-10-07
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61M1/02 , A61M1/34 , A61M1/36
CPC分类号： A61M1/3672
摘要： A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle, a plasma separation device connected in series by a fluid conduit, including operating the system such that an initial limited volume charge of anticoagulant is introduced into the conduit (for wetting the filter of the separation device) in advance of whole blood flowing from the donor towards to the separation device (and pushing the anticoagulant charge ahead of the whole blood into the separation device).
摘要翻译：一种在具有静脉穿刺针的血浆置换术系统中润湿血浆置换过滤器的方法，等离子体分离系统是通过流体导管串联连接的等离子体分离装置，包括操作该系统，使得将抗凝血剂的初始有限体积的电荷引入导管（用于在从供体朝向分离装置的全血流动之前（并将全血中的抗凝血剂推入分离装置）之前，分离装置的过滤器润湿）。

7. 发明授权

US4713176A Plasmapheresis system and method 失效
标题翻译：血浆置换系统和方法
公开(公告)号：US4713176A
公开(公告)日：1987-12-15
申请号：US722800
申请日：1985-04-12
申请人： Donald W. Schoendorfer , Lee E. Hansen
发明人： Donald W. Schoendorfer , Lee E. Hansen
IPC分类号： A61M1/00 , A61M1/02 , A61M1/26 , A61M1/30 , A61M1/34 , A61M1/36 , B01D13/00 , B01D21/26
CPC分类号： A61M1/3672 , A61M1/265 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3693
摘要： A reliable flow rate plasmapheresis system includes a rotating enhanced vortex of membrane filter coupled to receive a flow of anticoagulated whole blood and separate concentrate and filtrate in response thereto. An anticoagulant pump is coupled to mix controlled amounts of anticoagulant with the input blood flow. Degradation of plasma flow rate during multiple extraction-reinfusion cycles is inhibited by selecting the starting anticoagulant pH value and controlling the anticoagulant flow rate relative to the whole blood to establish a final whole blood/plasma pH value in the range of 6.8 to 7.2, with an anticoagulant to blood ratio in the range of 1:6 to 1:25.
摘要翻译：可靠的流速血浆置换系统包括旋转的膜过滤器的涡旋，其耦合以接收抗凝血全血流，并响应于此分离浓缩物和滤液。联合抗凝血泵将受控量的抗凝血剂与输入的血流混合。通过选择起始抗凝剂pH值并控制相对于全血的抗凝血流速来抑制在多次提取 - 再灌注循环期间血浆流速的降低，以建立6.8至7.2的最终全血/血浆pH值，其中血液抗凝血比例在1:6至1:25的范围内。

8. 发明授权

US4421503A Fluid processing centrifuge and apparatus thereof 失效
标题翻译：流体处理离心机及其设备
公开(公告)号：US4421503A
公开(公告)日：1983-12-20
申请号：US281655
申请日：1981-07-09
申请人： Allen Latham, Jr. , Donald W. Schoendorfer
发明人： Allen Latham, Jr. , Donald W. Schoendorfer
IPC分类号： B04B5/04 , B04B13/00 , B04B5/00
CPC分类号： B04B13/00 , B04B5/0428
摘要： A pressure plate blood processing centrifuge apparatus is described. A plate is disposed adjacent a flexible bag in which blood is being processed. Under the influence of centrifugal force the plate, which is disposed inwardly nearer the center of rotation than the bag, expels a separated blood component from the bag into a receiver container. The container may be located (1) radially inward or (2) radially outward from the bag or (3) adjacent and equidistant from the center of rotation.In the embodiment in which the container is located radially outward from the bag, a valve is provided which is responsive to the specific density of separated components to stop the flow. In other embodiments, the mass of the plate is selected so as to expel only the desired component. A plurality of alternate embodiments are described which make the apparatus useful for a variety of apparatus, such as plasma pheresis, platelet pheresis and cell-washing.
摘要翻译：描述了压板血液处理离心机装置。邻近一个正在处理血液的柔性袋布置板。在离心力的作用下，位于靠近旋转中心的板比该袋更靠内侧的板将分离的血液成分从袋中排出到接收容器中。容器可以从袋子径向向内或（2）径向向外定位（1），或者（3）从旋转中心相邻和等距离地定位。在其中容器从袋子径向向外定位的实施例中，提供了一种阀，其响应于分离的部件的特定密度来停止流动。在其他实施例中，选择板的质量以便仅排出所需的组分。描述了多个替代实施例，其使得该装置可用于各种装置，例如血浆置换，血小板置换和细胞洗涤。

9. 发明授权

US4412831A Two plane self-balancing centrifuge 失效
标题翻译：双平面自平衡离心机
公开(公告)号：US4412831A
公开(公告)日：1983-11-01
申请号：US281648
申请日：1981-07-09
申请人： Hollon B. Avery , Donald W. Schoendorfer
发明人： Hollon B. Avery , Donald W. Schoendorfer
IPC分类号： B04B9/12 , B04B9/14 , B04B9/00
CPC分类号： B04B9/14 , B04B9/12
摘要： A two plane self-balancing centrifuge is disclosed herein in which the centrifuge rotor is driven by a shaft attached to bearings. The bearings are supported by upper and lower flexible bearing mounts. This results in two horizontally flexible bearing mounting planes to provide a greater degree of freedom for the axis of rotation of the rotor to move into a coincident relationship with the angular momentum vector of the rotor as it changes with dynamic imbalance thereby to compensate for any imbalance which may occur in the centrifuge rotor during processing. The centrifuge particularly suited for use in processing blood.
摘要翻译：本文公开了一种双平面自平衡离心机，其中离心机转子由附接到轴承的轴驱动。轴承由上下柔性轴承座支撑。这导致两个水平柔性的轴承安装平面，以便为转子的旋转轴线提供更大的自由度，以随着其随动态不平衡而变化而与转子的角动量向量移动成一致的关系，从而补偿任何不平衡这可能在处理过程中在离心机转子中发生。离心机特别适用于加工血液。

10. 发明授权

US5817012A Method of determining an analyte 失效
标题翻译：测定分析物的方法
公开(公告)号：US5817012A
公开(公告)日：1998-10-06
申请号：US909538
申请日：1997-08-12
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61B10/00 , B01L3/00 , A61B5/00
CPC分类号： B01L3/505 , A61B10/0035 , A61B10/0045 , A61B10/0051 , A61B10/0064 , A61B2010/0009
摘要： A membrane (250) comprising an adhesive is secured to the skin (12) of a subject. The membrane (250) retains concentrated analyte in or on the membrane (250) itself, in the adhesive, and in the desquamated keratinized stratum corneum cells of the skin (12).
摘要翻译：包含粘合剂的膜（250）固定到受试者的皮肤（12）上。膜（250）将浓缩的分析物保留在膜（250）中或膜上（250）本身，粘合剂中以及皮肤脱皮角化角质层细胞（12）中。

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