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1. 发明授权

US5607579A Apheresis apparatus for separating an intermediate density component from whole blood 失效
标题翻译：用于从全血中分离中密度成分的单采血液分离装置
公开(公告)号：US5607579A
公开(公告)日：1997-03-04
申请号：US536499
申请日：1995-09-28
申请人： Allen Latham, Jr. , Glen E. Jorgensen , Theodoor H. S. Sibinga , Joseph R. Plante , Tracey E. Knapp
发明人： Allen Latham, Jr. , Glen E. Jorgensen , Theodoor H. S. Sibinga , Joseph R. Plante , Tracey E. Knapp
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , A61M1/38 , B01D21/32 , B04B11/02
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B2005/0464 , B04B2005/0471
摘要： An apheresis apparatus for increasing the purity and yield of platelets separated from donated whole blood by centrifugation incorporates a centrifuge for separating whole blood into lower, intermediate, and higher density components. The centrifuge has inlet and outlet ports in selective fluid communication with a container for receiving lower density blood component from the outlet port. A pump is coupled to the container and the inlet port for recirculating lower density blood component from the first container through the inlet port into the centrifuge at a first, substantially constant, rate so as to widen the region of the centrifuge occupied by the intermediate density component without causing the intermediate density component to exit the centrifuge, and subsequently at a second rate, so as to displace intermediate density component from the centrifuge.
摘要翻译：用于通过离心提高与所捐献的全血分离的血小板的纯度和产量的分离装置包括用于将全血分离成较低，中等和较高密度组分的离心机。离心机具有与容器选择性流体连通的入口和出口端口，用于从出口端口接收较低密度的血液成分。泵联接到容器和入口端口，用于将第一容器的较低密度的血液成分从第一容器通过入口端口以第一，基本上恒定的速率再循环到离心机中，以便扩大离心机的由中间密度占据的区域组分，而不会使中间密度组分离开离心机，然后以第二速率离心，以便从离心机中取代中间密度组分。

2. 发明授权

US4059108A Process for pheresis procedure and disposable pheresis bowl therefor 失效
标题翻译：采集过程和一次性一次性过滤碗
公开(公告)号：US4059108A
公开(公告)日：1977-11-22
申请号：US596148
申请日：1975-07-15
申请人： Allen Latham, Jr.
发明人： Allen Latham, Jr.
IPC分类号： A61K35/14 , A61M1/02 , B04B5/04 , A61M5/00 , B04B11/00
CPC分类号： B04B5/0442
摘要： A pheresis process and apparatus for carrying it out. Blood from a donor is transferred to a pheresis bowl formed to have a red cell reservoir and a plasma reservoir in fluid communication through plasma ducts. The pheresis bowl is adapted for centrifuging to separate the red cells and plasma. This separation is accomplished simultaneously with the withdrawal of blood from the donor. At the end of the withdrawal the red cells are returned to the donor. The connection with the donor is thus continuously maintained during the entire procedure. The process is safe, fast and economical.
摘要翻译：用于进行除血的过程和装置。来自供体的血液被转移到形成为具有红细胞储存器和通过等离子体管道流体连通的等离子体储存器的血液分离器碗。将白血球用于离心分离红细胞和血浆。这种分离是与供体的血液抽出同时完成的。在撤回结束时，红细胞返回给供体。因此，与供体的连接在整个过程中持续保持。该过程安全，快速，经济。

3. 发明授权

US4417884A Centrifuge timer clamp 失效
标题翻译：离心机定时器夹
公开(公告)号：US4417884A
公开(公告)日：1983-11-29
申请号：US281650
申请日：1981-07-09
申请人： Donald W. Schoendorfer , Allen Latham, Jr.
发明人： Donald W. Schoendorfer , Allen Latham, Jr.
IPC分类号： B04B11/00 , B04B5/04 , B04B13/00
CPC分类号： B04B5/0442 , B04B13/00 , Y10T137/108 , Y10T137/1098
摘要： A timing and control mechanism for a centrifuge comprising a piston to which is attached a cam having cam surfaces which interact with flexible tubing to control the rate of flow through the tubing. The velocity of the piston in the centrifugal force field is determined by the resistance to flow of fluid which the piston displaces. The movement of the cam is therefore a measure of the speed and duration of the centrifugal force.
摘要翻译：一种用于离心机的定时和控制机构，包括活塞，附接有凸轮，所述凸轮具有凸轮表面，所述凸轮表面与柔性管相互作用以控制通过所述管的流速。活塞在离心力场中的速度由活塞位移的流体的阻力决定。因此，凸轮的运动是衡量离心力的速度和持续时间。

4. 发明授权

US4385630A Blood donation unit 失效
标题翻译：献血单位
公开(公告)号：US4385630A
公开(公告)日：1983-05-31
申请号：US182510
申请日：1980-08-29
申请人： Ronald O. Gilcher , Allen Latham, Jr. , Jonathan D. Schiff , Donald W. Schoendorfer
发明人： Ronald O. Gilcher , Allen Latham, Jr. , Jonathan D. Schiff , Donald W. Schoendorfer
IPC分类号： A61M1/02 , A61M5/00
CPC分类号： A61M1/02 , A61M2205/3344 , A61M2205/3351
摘要： A blood donation unit in which a reduced outside diameter phlebotomy needle is employed to minimize donor discomfort. The blood flow if, however, maintained at a flow level similar to that obtained with standard gauge phlebotomy needles by a roller pump which provides a predetermined pressure differential between the ends of the phlebotomy needle. The blood is mixed with a predetermined ratio of anticoagulant immediately after passing through the phlebotomy needle. The ratio of whole blood to anticoagulant is independent of the volume of whole blood collected.
摘要翻译：使用减少的外径静脉注射针的献血单元以使供体不适最小化。然而，如果血流维持在类似于用标准规格静脉注射针获得的流动水平，该流量水平由辊泵提供，其在静脉注射针的端部之间提供预定的压力差。在通过静脉注射针后立即将血液与预定比例的抗凝血剂混合。全血与抗凝剂的比例与全血采集量无关。

5. 发明授权

US4381776A Anticoagulant dispensing apparatus and method of use 失效
标题翻译：抗凝血剂分配装置及其使用方法
公开(公告)号：US4381776A
公开(公告)日：1983-05-03
申请号：US254078
申请日：1981-04-14
申请人： Allen Latham, Jr.
发明人： Allen Latham, Jr.
IPC分类号： A61J1/00 , A61J1/05 , A61M1/36 , A61M5/00
CPC分类号： A61J1/05 , A61M1/3672 , Y10S128/24
摘要： An aseptically pure dispensing anticoagulant device adapted to be connected to a blood collection set and which may be aseptically treated by ethylene oxide or other high diffusivity sterilant without deleterious effects upon the anticoagulant. Various embodiments are shown; in one, a collapsible pouch is provided which includes a barrier against diffusion of water vapor and ethylene oxide. In another embodiment, a rigid anticoagulant container is employed which necessitates a secondary volume of air in a surrounding pouch to provide air to displace liquid in the rigid container as it passes into the set.
摘要翻译：一种无菌纯分配抗凝剂装置，适于与血液收集装置连接，并可通过环氧乙烷或其他高扩散性消毒剂进行无菌处理，而对抗凝血剂无有害作用。示出了各种实施例; 在一个中，提供了可折叠的袋，其包括防止水蒸气和环氧乙烷扩散的阻挡层。在另一个实施方案中，使用刚性抗凝血剂容器，其需要在周围袋中的第二体积的空气以提供空气以便在刚性容器进入该组时置换刚性容器中的液体。

6. 发明授权

US5494592A Apheresis apparatus and method 失效
标题翻译：分离装置和方法
公开(公告)号：US5494592A
公开(公告)日：1996-02-27
申请号：US372890
申请日：1995-01-13
申请人： Allen Latham, Jr. , Glen E. Jorgensen , Theodoor H. S. Sibinga , Joseph R. Plante , Tracey E. Knapp
发明人： Allen Latham, Jr. , Glen E. Jorgensen , Theodoor H. S. Sibinga , Joseph R. Plante , Tracey E. Knapp
IPC分类号： A61M1/02 , A61M1/36 , A61M37/00 , B01D21/26
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B2005/0464 , B04B2005/0471
摘要： An apheresis apparatus and method is disclosed for increasing the purity and yield of platelets separated from donated whole blood in a centrifuge. The whole blood in the centrifuge is diluted by recirculating fluid, such as plasma or saline, at a first flow rate, to mix with further withdrawn whole blood prior to entering the centrifuge. As plasma is collected, it is recirculated through the centrifuge at a second flow rate to further improve the separation between the intermediate density components, i.e., platelets and white blood cells in the "buffy coat." The plasma is then recirculated through the centrifuge at a third flow rate and platelets are displaced out of the centrifuge while the plasma is recirculating through the centrifuge at the third flow rate.
摘要翻译：公开了用于提高在离心机中从捐献的全血分离的血小板的纯度和产量的单采血液成像装置和方法。离心机中的全血通过再循环流体例如血浆或盐水以第一流速稀释，以便在进入离心机之前与进一步取出的全血混合。当血浆被收集时，其以第二流速再循环通过离心机，以进一步改善中间密度组分即“血沉棕黄层”中的血小板和白细胞之间的分离。然后等离子体以第三流速再循环通过离心机，血小板以第三流速再循环通过离心机，血小板从离心机中移出。

7. 发明授权

US4421503A Fluid processing centrifuge and apparatus thereof 失效
标题翻译：流体处理离心机及其设备
公开(公告)号：US4421503A
公开(公告)日：1983-12-20
申请号：US281655
申请日：1981-07-09
申请人： Allen Latham, Jr. , Donald W. Schoendorfer
发明人： Allen Latham, Jr. , Donald W. Schoendorfer
IPC分类号： B04B5/04 , B04B13/00 , B04B5/00
CPC分类号： B04B13/00 , B04B5/0428
摘要： A pressure plate blood processing centrifuge apparatus is described. A plate is disposed adjacent a flexible bag in which blood is being processed. Under the influence of centrifugal force the plate, which is disposed inwardly nearer the center of rotation than the bag, expels a separated blood component from the bag into a receiver container. The container may be located (1) radially inward or (2) radially outward from the bag or (3) adjacent and equidistant from the center of rotation.In the embodiment in which the container is located radially outward from the bag, a valve is provided which is responsive to the specific density of separated components to stop the flow. In other embodiments, the mass of the plate is selected so as to expel only the desired component. A plurality of alternate embodiments are described which make the apparatus useful for a variety of apparatus, such as plasma pheresis, platelet pheresis and cell-washing.
摘要翻译：描述了压板血液处理离心机装置。邻近一个正在处理血液的柔性袋布置板。在离心力的作用下，位于靠近旋转中心的板比该袋更靠内侧的板将分离的血液成分从袋中排出到接收容器中。容器可以从袋子径向向内或（2）径向向外定位（1），或者（3）从旋转中心相邻和等距离地定位。在其中容器从袋子径向向外定位的实施例中，提供了一种阀，其响应于分离的部件的特定密度来停止流动。在其他实施例中，选择板的质量以便仅排出所需的组分。描述了多个替代实施例，其使得该装置可用于各种装置，例如血浆置换，血小板置换和细胞洗涤。

8. 发明授权

US4300717A Rotary centrifuge seal 失效
标题翻译：旋转离心机密封
公开(公告)号：US4300717A
公开(公告)日：1981-11-17
申请号：US201336
申请日：1980-10-27
申请人： Allen Latham, Jr.
发明人： Allen Latham, Jr.
IPC分类号： A61M1/36 , B04B5/04 , B04B9/12 , B04B15/00
CPC分类号： B04B5/0442 , A61M1/3693 , B04B9/12 , B04B2005/0464
摘要： An improved rotary centrifuge seal is disclosed of the type formed from a rotatable ring member (40) and a non-rotatable ring member (42) having a sealing face of each in contact to provide a dynamic seal between rotatable and stationary centrifuge elements. This improved seal is provided with means for entrapping solid particulate matter generated at areas of contact (44) and means for directing entrapped particles back to the area of contact where they are ingested. This prevents contamination of fluid being processed in the centrifuge with such solid particles, which is particularly important in blood-processing centrifuges.
摘要翻译：公开了一种改进的旋转离心机密封件，其由可旋转的环件（40）和不可旋转的环件（42）形成，其中每个接头的密封面具有可旋转和固定的离心机元件之间的动态密封。这种改进的密封件设置有夹带在接触区域（44）处产生的固体颗粒物质的装置和用于将捕获的颗粒引导回其被摄取的接触区域的装置。这样可以防止在离心机中用这种固体颗粒污染被处理的流体，这在血液处理离心机中尤为重要。

9. 发明授权

US4204537A Process for pheresis procedure and disposable plasma 失效
标题翻译：白血病手术和一次性血浆的方法
公开(公告)号：US4204537A
公开(公告)日：1980-05-27
申请号：US810213
申请日：1977-06-27
申请人： Allen Latham, Jr.
发明人： Allen Latham, Jr.
IPC分类号： B04B5/04 , A61M5/00 , A61J1/00
CPC分类号： B04B5/0442
摘要： A pheresis process and apparatus for carrying it out. Blood from a donor is transferred to a pheresis bowl formed to have a red cell reservoir and a plasma reservoir in fluid communication through plasma ducts. The pheresis bowl is adapted for centrifuging to separate the red cells and plasma. This separation is accomplished simultaneously with the withdrawal of blood from the donor. At the end of the withdrawal the red cells are returned to the donor. The connection with the donor is thus continuously maintained during the entire procedure. The process is safe, fast and economical.
摘要翻译：用于进行除血的过程和装置。来自供体的血液被转移到形成为具有红细胞储存器和通过等离子体管道流体连通的等离子体储存器的血液分离器碗。将白血球用于离心分离红细胞和血浆。这种分离是与供体的血液抽出同时完成的。在撤回结束时，红细胞返回给供体。因此，与供体的连接在整个过程中持续保持。该过程安全，快速，经济。

10. 发明授权

US4086924A Plasmapheresis apparatus 失效
标题翻译：血浆置换术
公开(公告)号：US4086924A
公开(公告)日：1978-05-02
申请号：US730106
申请日：1976-10-06
申请人： Allen Latham, Jr.
发明人： Allen Latham, Jr.
IPC分类号： A61M1/34 , A61M1/02 , A61M1/30 , A61M1/36 , B04B1/02 , B04B5/04 , A61M5/00 , A61M1/03
CPC分类号： B04B5/0442 , A61M1/304 , A61M1/3693 , A61M1/3696 , B04B2005/0464
摘要： Plasmapheresis apparatus is disclosed which comprises a unique combination of blood withdrawal, separation and return means, together with automatic cycle control means. This apparatus can withdraw whole blood from a donor, separate it into plasma and non-plasma components, and return the non-plasma component to the donor while the donor remains connected to the apparatus throughout the entire procedure. Standard quantities of separated plasma can be obtained in significantly reduced times, and the possibility of mistakenly returning wrong blood components to the donor is eliminated.
摘要翻译：公开了血浆置换装置，其包括抽血，分离和返回装置的独特组合，以及自动循环控制装置。该装置可以从供体抽出全血，将其分离成等离子体和非等离子体组分，并且在供体在整个过程中保持与装置连接时将非血浆组分返回给供体。可以以显着减少的时间获得标准量的分离血浆，并且消除错误地将错误的血液成分返回给供体的可能性。

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