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2. 发明授权

US5854234A Amidino dervatives useful as nitric oxide synthase inhibitors 失效
标题翻译：用作一氧化氮合酶抑制剂的脒基衍生物
公开(公告)号：US5854234A
公开(公告)日：1998-12-29
申请号：US448473
申请日：1995-06-06
申请人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng
发明人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng
IPC分类号： C07D207/32 , A61K31/12 , A61K31/15 , A61K31/16 , A61K31/215 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4458 , A61K31/4468 , A61K31/451 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , A61P3/08 , A61P9/00 , A61P9/08 , A61P9/10 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P43/00 , C07C251/44 , C07D207/22 , C07D207/263 , C07D207/273 , C07D207/28 , C07D209/44 , C07D209/46 , C07D211/72 , C07D211/74 , C07D211/76 , C07D213/16 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D223/16 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06 , C07D471/08 , C07D498/04 , C07D513/04 , C07D267/06 , C07D281/02
CPC分类号： C07D213/06 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D207/22 , C07D209/44 , C07D211/72 , C07D211/74 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06
摘要： The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： PCT No.PCT / US94 / 11832 Sec。 371日期：1998年6月6日 102（e）1998年6月6日PCT 1994年10月20日PCT PCT。出版物WO95 / 11231 日期1995年04月27日本发明公开了含有用作一氧化氮合酶抑制剂的吖庚因衍生物的有用的药物组合物。

3. 发明授权

US06448286B1 Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：可用作一氧化氮合酶抑制剂的亚氨基吡咯烷衍生物
公开(公告)号：US06448286B1
公开(公告)日：2002-09-10
申请号：US09123720
申请日：1998-07-28
申请人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng
发明人： Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng
IPC分类号： A61K3154
CPC分类号： C07D213/06 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D207/22 , C07D209/44 , C07D211/72 , C07D211/74 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06
摘要： The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
摘要翻译：本发明公开了含有用作一氧化氮合酶抑制剂的脒基衍生物的有用的药物组合物。

5. 发明授权

US06489323B1 Heterobicyclic and tricyclic nitric oxide synthase inhibitors 失效
标题翻译：异环和三环一氧化氮合酶抑制剂
公开(公告)号：US06489323B1
公开(公告)日：2002-12-03
申请号：US09329583
申请日：1999-06-10
申请人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
发明人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
IPC分类号： C07D49804
CPC分类号： C07D487/04 , C07D513/04 , C07D515/04 , C07F9/6561
摘要： The current invention relates to compounds of Formula I pharmaceutical compositions and methods of use as nitric oxide synthase inhibitors, wherein the substituents are defined in the application.
摘要翻译：本发明涉及式I药物组合物的化合物和用作一氧化氮合酶抑制剂的方法，其中取代基在本申请中定义。

6. 发明授权

US06552052B2 Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors 失效
标题翻译：吡咯并[2,1-c] [1,2,4]噻二唑和Pyrollo [2,1-c] [1,12,4]恶二唑可用作一氧化氮合酶抑制剂
公开(公告)号：US06552052B2
公开(公告)日：2003-04-22
申请号：US09818297
申请日：2001-03-26
申请人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
发明人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
IPC分类号： C07D27112
CPC分类号： C07D487/04 , C07D513/04 , C07D515/04 , C07F9/6561
摘要： Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.
摘要翻译：具有下式的吡咯并[2,1-c] [1,2,4]噻二唑或pyrollo [2,1-c] [1,2,4]恶二唑或其药学上可接受的盐，其可用作一氧化氮合酶抑制剂，其中每个取代基在本文中定义。

7. 发明授权

US5830917A L-N.sup.6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：可用作一氧化氮合酶抑制剂的L-N6-（1-亚氨基乙基）赖氨酸衍生物
公开(公告)号：US5830917A
公开(公告)日：1998-11-03
申请号：US526147
申请日：1995-09-11
申请人： William M. Moore , E. Ann Hallinan
发明人： William M. Moore , E. Ann Hallinan
IPC分类号： A61K31/00 , A61K31/155 , A61P43/00 , C07C257/14 , C07C279/12 , C07C311/05 , A61K31/18
CPC分类号： C07C311/05 , C07C257/14 , C07C279/12 , Y10S514/824 , Y10S514/866 , Y10S514/921 , Y10S514/929
摘要： There is disclosed a novel amino alcohol amine derivatives of L-N.sup.6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.
摘要翻译：公开了L-N6-（1-亚氨基乙基）赖氨酸的新型氨基醇胺衍生物，含有这些新化合物的药物组合物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。

8. 发明授权

US06927037B2 Ion-exchange resin/enzyme activity assay 失效
标题翻译：离子交换树脂/酶活性测定
公开(公告)号：US06927037B2
公开(公告)日：2005-08-09
申请号：US09888008
申请日：2001-06-22
申请人： Thomas P. Kasten , Mark G. Currie , William M. Moore , Kay Broschat
发明人： Thomas P. Kasten , Mark G. Currie , William M. Moore , Kay Broschat
IPC分类号： C12Q1/00 , C12Q1/48 , C12Q1/15
CPC分类号： C12Q1/00 , C12Q1/485
摘要： The present invention relates to a rapid high-throughput ion-exchange resin assay for determining enzyme activity. This novel assay uses a radiometric technique which separates the radioactive substrate from the product (or the radioactive product from the substrate) by exploiting the differences in the net charges of the molecules using ion-exchange resin. This assay is useful, for example, for studies of enzyme kinetics, the identification of functional sites in the enzyme, and in the automated screening of compound libraries for pharmaceutical drug development.
摘要翻译：本发明涉及用于测定酶活性的快速高通量离子交换树脂测定法。这种新型测定法使用辐射技术，其通过使用离子交换树脂利用分子的净电荷差异将放射性底物与产物（或放射性产物与底物）分离。该测定法可用于例如酶动力学的研究，酶的功能位点的鉴定以及用于药物开发的化合物文库的自动筛选。

9. 发明授权

US4752578A Collagenase inducing factor 失效
标题翻译：胶原酶诱导因子
公开(公告)号：US4752578A
公开(公告)日：1988-06-21
申请号：US851039
申请日：1986-04-11
申请人： William M. Moore , Curtis A. Spilburg
发明人： William M. Moore , Curtis A. Spilburg
IPC分类号： C07K14/47 , C12P39/00 , C12P21/00 , C12N9/64 , C12P1/00
CPC分类号： C12P39/00 , C07K14/4705
摘要： A method for the production of collagenase inducing factor is disclosed which comprises growing the human liver adenocarcinoma cell line SK-HEP-1 in nutrient culture medium at 35.degree.-38.degree. C. and recovering the resulting collagenase inducing factor from the spent cells or conditioned medium.
摘要翻译：公开了一种生产胶原酶诱导因子的方法，其包括在营养培养基中在35℃-38℃培养人肝腺癌细胞系SK-HEP-1，并从废细胞中回收得到的胶原酶诱导因子或条件中。

10. 发明授权

US4031704A Thermal engine system 失效
标题翻译：热力发动机系统
公开(公告)号：US4031704A
公开(公告)日：1977-06-28
申请号：US714300
申请日：1976-08-16
申请人： Marvin L. Moore , William M. Moore
发明人： Marvin L. Moore , William M. Moore
IPC分类号： F03G7/06 , F04B17/00
CPC分类号： F03G7/06 , F04B17/00
摘要： A thermal engine system is characterized by a cylinder having a suitable working fluid disposed therein and having a piston reciprocally movable in first and second directions within the cylinder, the piston dividing the cylinder into first and second pressurization regions. In one embodiment, a thermally responsive, expansible member is operatively connected directly at one free terminus thereof to the piston. In an alternate embodiment, the free terminus of the thermally responsive, expansible member is indirectly attached to one or more double-acting piston-cylinders through lever connections. The thermally responsive, expansible member is connected at the second end thereof to suitable means for maintaining the second end of the expansible member in a substantially stationary position. The thermally responsive, expansible member responds to the temperature of driving fluids introduced thereto to alternately thermally expand and contract to thereby cause reciprocating motion of the piston within the cylinder. Reciprocation of the piston within the cylinder alternatively pressurizes working fluid disposed within the first and the second regions of the cylinder. The pressure energy transmitted to the working fluid in the first and second regions of the cylinder is stored within a suitable energy storing arrangement to be utilized in any desired manner.
摘要翻译：热力发动机系统的特征在于具有设置在其中的合适工作流体的气缸，具有在气缸内沿第一和第二方向往复运动的活塞，活塞将气缸分成第一和第二加压区域。在一个实施例中，热响应的可膨胀构件在其一个自由终端处直接可操作地连接到活塞。在替代实施例中，热响应的可膨胀构件的自由终端通过杠杆连接间接连接到一个或多个双作用活塞缸。热响应性可膨胀构件在其第二端处连接到用于将可膨胀构件的第二端保持在基本上静止位置的适当装置。热响应的可膨胀构件响应于引入其中的驱动流体的温度交替地热膨胀和收缩，从而引起活塞在气缸内的往复运动。气缸内的活塞的往复交替地加压设置在气缸的第一和第二区域内的工作流体。在气缸的第一和第二区域中传递到工作流体的压力能量被储存在合适的储能装置中以便以任何所需的方式使用。

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