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1. 发明申请

US20080082057A1 Method and apparatus for diagnosing meibomian gland dysfunction 审中-公开
标题翻译：用于诊断睑板腺功能障碍的方法和装置
公开(公告)号：US20080082057A1
公开(公告)日：2008-04-03
申请号：US11541240
申请日：2006-09-29
申请人： Donald R. Korb , Benjamin T. Gravely , John M. Jans , Keith H. Gausmann
发明人： Donald R. Korb , Benjamin T. Gravely , John M. Jans , Keith H. Gausmann
IPC分类号： A61M35/00
CPC分类号： A61B3/101
摘要： An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland disease is provided. The apparatus comprises a handle, and a probe tip mounted for movement relative to said handle such that when the probe tip is placed against the eyelid and compressive force is applied, movement of the handle a preselected distance replicates the force required for natural expression of secretion from the meibomian gland. Movement of the handle relative to the probe tip the preselected distance exerts a force of between about 5 grams per 30 mm2 and 40 grams per 30 mm2 and preferably a force of approximately 15 grams per 30 mm2. An indicator means selected from the group consisting of auditory, visual and tactile signals is provided and when activated alerts the clinician that the required force has been reached.According to the method of the present invention a probe tip is located in contacting relation with the eyelid, the probe tip being connected to a handle. When pressure is exerted on the eyelid by pressing it against the eyelid, a preselected pressure is exerted thereon. In another embodiment of the invention, a handle having a probe tip is located on the eyelid, the probe tip is mounted for movement relative to said handle such that when the probe tip is placed against the eyelid and compressive force is applied, movement of the handle a preselected distance replicates the force required for natural expression of secretion from the meibomian gland
摘要翻译：提供了一种用于测试睑板腺病的人类眼皮睑板腺的装置。该装置包括手柄和安装成相对于所述手柄运动的探针尖端，使得当探针针尖靠着眼睑放置并施加压缩力时，手柄的移动预选距离复制了自然表达分泌所需的力从睑板腺。手柄相对于探针尖端的移动，预选距离施加约30g / 30mm 2和40g / 30mm 2之间的力，最好是大约15克/ 30毫米2。提供从由听觉，视觉和触觉信号组成的组中选择的指示符，并且当被激活时警告临床医生已经达到所需的力。根据本发明的方法，探针尖端与眼睑呈接触关系，探针尖端连接到手柄。当通过将眼压压在眼睑上而对眼睑施加压力时，施加预选压力。在本发明的另一个实施例中，具有探针尖端的手柄位于眼睑上，探针尖端安装成相对于所述手柄移动，使得当探头尖靠着眼睑放置并施加压力时，处理预选距离可以复制睑板腺分泌物的自然表达所需的力量

2. 发明申请

US20080081999A1 Meibomian gland illuminating and imaging 有权
标题翻译：睑板腺照明和成像
公开(公告)号：US20080081999A1
公开(公告)日：2008-04-03
申请号：US11893669
申请日：2007-08-17
申请人： Benjamin T. Gravely , Stephen M. Grenon , Timothy R. Willis , John M. Jans , Donald R. Korb
发明人： Benjamin T. Gravely , Stephen M. Grenon , Timothy R. Willis , John M. Jans , Donald R. Korb
IPC分类号： A61B6/00
CPC分类号： A61B3/10 , A61B5/0073 , A61B5/411 , A61B5/415 , A61B5/4261 , A61F9/00718 , A61F9/00772 , A61F9/0079 , A61F2007/0004 , A61F2007/0088 , A61N5/0625
摘要： In an illustrative embodiment, an apparatus for imaging a portion of a mammalian eyelid has an eye contact lenspiece configured to direct the light through an eyelid from posterior to anterior surface to thereby trans-illuminate the eyelid, when the light source illuminates the contact lens. An imaging device receives an image of the eyelid as it is trans-illuminated. Other methods and apparatus are presented in various embodiments, hence this abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在说明性实施例中，用于对哺乳动物眼睑的一部分进行成像的装置具有眼睛接触透镜，其配置为当光源照射隐形眼镜时将光从后表面引导到前表面，从而反射照射眼睑。成像装置在反转照射时接收眼睑的图像。其他方法和装置在各种实施例中呈现，因此该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

3. 发明授权

US08255039B2 Meibomian gland illuminating and imaging 有权
标题翻译：睑板腺照明和成像
公开(公告)号：US08255039B2
公开(公告)日：2012-08-28
申请号：US11893669
申请日：2007-08-17
申请人： Benjamin T. Gravely , Stephen M. Grenon , Timothy R. Willis , John M. Jans , Donald R. Korb
发明人： Benjamin T. Gravely , Stephen M. Grenon , Timothy R. Willis , John M. Jans , Donald R. Korb
IPC分类号： A61B6/00
CPC分类号： A61B3/10 , A61B5/0073 , A61B5/411 , A61B5/415 , A61B5/4261 , A61F9/00718 , A61F9/00772 , A61F9/0079 , A61F2007/0004 , A61F2007/0088 , A61N5/0625
摘要： In an illustrative embodiment, an apparatus for imaging a portion of a mammalian eyelid has an eye contact lenspiece configured to direct the light through an eyelid from posterior to anterior surface to thereby trans-illuminate the eyelid, when the light source illuminates the contact lens. An imaging device receives an image of the eyelid as it is trans-illuminated. Other methods and apparatus are presented in various embodiments, hence this abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在说明性实施例中，用于对哺乳动物眼睑的一部分进行成像的装置具有眼睛接触透镜，其配置为当光源照射隐形眼镜时将光从后表面引导到前表面，从而反射照射眼睑。成像装置在反转照射时接收眼睑的图像。其他方法和装置在各种实施例中呈现，因此该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

4. 发明申请

US20120088980A1 MEIBOMIAN GLAND ILLUMINATING AND IMAGING 审中-公开
标题翻译： MEIBOMIAN GLAND照明和成像
公开(公告)号：US20120088980A1
公开(公告)日：2012-04-12
申请号：US13325586
申请日：2011-12-14
申请人： Benjamin T. Gravely , Stephen M. Grenon , Timothy R. Willis , John M. Jans , Donald R. Korb
发明人： Benjamin T. Gravely , Stephen M. Grenon , Timothy R. Willis , John M. Jans , Donald R. Korb
IPC分类号： A61B1/06
CPC分类号： A61B3/10 , A61B5/0066 , A61B5/0073 , A61B5/411 , A61B5/4261
摘要： In an illustrative embodiment, an apparatus for imaging a portion of a mammalian eyelid has an eye contact lenspiece configured to direct the light through an eyelid from posterior to anterior surface to thereby trans-illuminate the eyelid, when the light source illuminates the contact lens. An imaging device receives an image of the eyelid as it is trans-illuminated. Other methods and apparatus are presented in various embodiments, hence this abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在说明性实施例中，用于对哺乳动物眼睑的一部分进行成像的装置具有眼睛接触透镜，其配置为当光源照射隐形眼镜时将光从后表面引导到前表面，从而反射照射眼睑。成像装置在反转照射时接收眼睑的图像。其他方法和装置在各种实施例中呈现，因此该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

5. 发明申请

US20120016275A1 APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管性功能障碍的装置
公开(公告)号：US20120016275A1
公开(公告)日：2012-01-19
申请号：US13242068
申请日：2011-09-23
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61F9/00
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： An apparatus for treating meibomian gland dysfunction caused by meibomian gland obstruction in order to restore the natural flow of secretion from the meibomian gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由睑板腺阻塞引起的睑板腺功能障碍以恢复睑板腺分泌物的自然流动的装置包括施加能量，吸力，振动，热，吸入，化学药剂和药物剂的组合以松动和之后除去阻塞物质。

6. 发明申请

US20100259723A1 Ocular surface interferometry (OSI) methods for imaging and measuring ocular tear film layer thickness(es) 有权
标题翻译：用于成像和测量眼泪膜层厚度的眼表干涉测量（OSI）方法
公开(公告)号：US20100259723A1
公开(公告)日：2010-10-14
申请号：US12798326
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
IPC分类号： A61B3/14
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

7. 发明申请

US20100259721A1 Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness (ES) 有权
标题翻译：用于成像和测量眼泪膜层厚度（ES）的眼表干涉仪（OSI）装置和系统
公开(公告)号：US20100259721A1
公开(公告)日：2010-10-14
申请号：US12798324
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
IPC分类号： A61B3/14
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

8. 发明授权

US07758190B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US07758190B2
公开(公告)日：2010-07-20
申请号：US11820664
申请日：2007-06-20
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

9. 发明授权

US08746883B2 Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权
标题翻译：用于成像，加工和/或显示眼泪膜的眼表干涉仪（OSI）装置和系统
公开(公告)号：US08746883B2
公开(公告)日：2014-06-10
申请号：US12798275
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

10. 发明授权

US08585204B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08585204B2
公开(公告)日：2013-11-19
申请号：US13455628
申请日：2012-04-25
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： A61B3/101
摘要： A method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye. Light is directed to the lipid layer of a patient's eye with an illuminator that is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis.
摘要翻译：用于测量眼表面上的角膜前泪膜的脂质层成分的相对厚度的方法。光被引导到患者眼睛的脂质层，其中照射器是覆盖可见区域的宽光谱光源，并且是透明光发射器，使得光源被镜面反射从脂质层并经历建构性和相消干涉脂质层。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。集电极还产生代表镜面反射光的输出信号，适用于进一步的分析。

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