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1. 发明申请

US20120016275A1 APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管性功能障碍的装置
公开(公告)号：US20120016275A1
公开(公告)日：2012-01-19
申请号：US13242068
申请日：2011-09-23
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61F9/00
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： An apparatus for treating meibomian gland dysfunction caused by meibomian gland obstruction in order to restore the natural flow of secretion from the meibomian gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由睑板腺阻塞引起的睑板腺功能障碍以恢复睑板腺分泌物的自然流动的装置包括施加能量，吸力，振动，热，吸入，化学药剂和药物剂的组合以松动和之后除去阻塞物质。

2. 发明申请

US20100259723A1 Ocular surface interferometry (OSI) methods for imaging and measuring ocular tear film layer thickness(es) 有权
标题翻译：用于成像和测量眼泪膜层厚度的眼表干涉测量（OSI）方法
公开(公告)号：US20100259723A1
公开(公告)日：2010-10-14
申请号：US12798326
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
IPC分类号： A61B3/14
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

3. 发明申请

US20100259721A1 Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness (ES) 有权
标题翻译：用于成像和测量眼泪膜层厚度（ES）的眼表干涉仪（OSI）装置和系统
公开(公告)号：US20100259721A1
公开(公告)日：2010-10-14
申请号：US12798324
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
IPC分类号： A61B3/14
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

4. 发明授权

US07758190B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US07758190B2
公开(公告)日：2010-07-20
申请号：US11820664
申请日：2007-06-20
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

5. 发明授权

US09060843B2 Method and apparatus for treating gland dysfunction employing heated medium 有权
标题翻译：使用加热培养基治疗腺体功能障碍的方法和装置
公开(公告)号：US09060843B2
公开(公告)日：2015-06-23
申请号：US11931398
申请日：2007-10-31
申请人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61B7/00 , A61F9/007 , A61H7/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H15/00 , A61N7/00
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以便恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动其后清除阻塞物。

6. 发明授权

US08600484B2 Meibomian gland imaging 有权
标题翻译：睑板腺成像
公开(公告)号：US08600484B2
公开(公告)日：2013-12-03
申请号：US13472654
申请日：2012-05-16
申请人： Stephen M. Grenon , Timothy R. Willis , Benjamin T. Gravely , Donald R. Korb
发明人： Stephen M. Grenon , Timothy R. Willis , Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B6/00
CPC分类号： A61B3/10 , A61B5/0066 , A61B5/0073 , A61B5/411 , A61B5/4261
摘要： A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：一种评估人眼干眼症的方法，其中由于眼睑中睑板腺的阻塞的存在而导致眼睛天然分泌物的流动减少或停止的方法包括对眼睑施加模拟在眨眼期间施加的压力的压力; 并同时对腺体进行成像，以诊断睑板腺的状况。该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

7. 发明申请

US20120226156A1 MEIBOMIAN GLAND IMAGING 有权
公开(公告)号：US20120226156A1
公开(公告)日：2012-09-06
申请号：US13472654
申请日：2012-05-16
申请人： Stephen M. Grenon , Timothy R. Willis , Benjamin T. Gravely , Donald R. Korb
发明人： Stephen M. Grenon , Timothy R. Willis , Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B6/00 , A61B8/00 , A61F9/007
CPC分类号： A61B3/10 , A61B5/0066 , A61B5/0073 , A61B5/411 , A61B5/4261
摘要： A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：一种评估人眼干眼症的方法，其中由于眼睑中睑板腺的阻塞的存在而导致眼睛天然分泌物的流动减少或停止的方法包括对眼睑施加模拟在眨眼期间施加的压力的压力; 并同时对腺体进行成像，以诊断睑板腺的状况。该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

8. 发明授权

US08187311B2 Method and apparatus for treating gland dysfunction 有权
公开(公告)号：US08187311B2
公开(公告)日：2012-05-29
申请号：US13025990
申请日：2011-02-11
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely , Stephen M. Grenon
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61F9/007
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.

9. 发明授权

US08025689B2 Method and apparatus for treating meibomian gland dysfunction 有权
公开(公告)号：US08025689B2
公开(公告)日：2011-09-27
申请号：US12821183
申请日：2010-06-23
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.

10. 发明申请

US20110137214A1 METHOD AND APPARATUS FOR TREATING GLAND DYSFUNCTION 有权
公开(公告)号：US20110137214A1
公开(公告)日：2011-06-09
申请号：US13025951
申请日：2011-02-11
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely , Stephen M. Grenon
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61F9/00 , A61N7/02
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.

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