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1. 发明授权

US5468649A Process for labeling acridinium to microparticles and application in an instrument 失效
标题翻译：将吖啶标记为微粒并用于仪器中的方法
公开(公告)号：US5468649A
公开(公告)日：1995-11-21
申请号：US196536
申请日：1994-02-15
申请人： Dinesh O. Shah , Tarun Chandra , Kurt Klosterman
发明人： Dinesh O. Shah , Tarun Chandra , Kurt Klosterman
IPC分类号： G01N21/75 , G01N33/58 , G01N33/543 , G01N33/546
CPC分类号： G01N33/585
摘要： Embodiments of the invention provide methods of preparing an activated acridinium microparticle. Generally, the methods involve direct covalent coupling or an affinity format. The direct covalent coupling method involves coating a microparticle with a proteinaceous compound. Then, a 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate is coupled to the proteinaceous compound. In the affinity format, a microparticle is coated with a biotinylated proteinaceous compound. The microparticle is reacted with an anti-biotin labelled 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate. Methods are also provided for using such a microparticle. Those methods of use can estimate transfer efficiency, calibrate optics, and measure membrane pore size of a chemiluminescence based instrument. Test elements for analytical instruments are also provided.
摘要翻译：本发明的实施方案提供了制备活化的吖啶微粒的方法。通常，该方法涉及直接共价偶联或亲和格式。直接共价偶联法包括用蛋白质化合物包被微粒。然后，将10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸酯与蛋白质化合物偶联。在亲和性形式中，微粒被生物素化的蛋白质化合物包被。将微粒与抗生物素标记的10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸盐反应。还提供了使用这种微粒的方法。这些使用方法可以估计传递效率，校准光学和测量基于化学发光的仪器的膜孔径。还提供了分析仪器的测试元件。

2. 发明授权

US08283124B2 Compositions for detecting antibodies to Babesia microti and methods of uses thereof 有权
标题翻译：用于检测巴西微生物的抗体的组合物及其使用方法
公开(公告)号：US08283124B2
公开(公告)日：2012-10-09
申请号：US11924131
申请日：2007-10-25
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Dinesh O. Shah , Yu Cheng , George J. Dawson
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Dinesh O. Shah , Yu Cheng , George J. Dawson
IPC分类号： G01N33/53
CPC分类号： G01N33/56905 , C07K14/44 , C07K16/20 , C07K2319/00
摘要： The present invention relates to one or more peptides which may be used to test for the presence of antibodies to B. microti. These peptide are selected based on the strength and specificity of the human antibody response to B. microti. These peptides alone or in combination have a variety of uses, for example, as a component of a diagnostic assay or kit.
摘要翻译：本发明涉及一种或多种可用于测试对微生物的抗体的存在的肽。这些肽基于人抗体对微生物的反应的强度和特异性来选择。单独或组合的这些肽具有多种用途，例如作为诊断测定或试剂盒的组分。

3. 发明授权

US06203974B1 Chemiluminescent immunoassay for detection of antibodies to various viruses 有权
标题翻译：用于检测各种病毒抗体的化学发光免疫测定
公开(公告)号：US06203974B1
公开(公告)日：2001-03-20
申请号：US09146093
申请日：1998-09-03
申请人： Dinesh O. Shah , James P. Mackowiak , Natalie Dubovoy
发明人： Dinesh O. Shah , James P. Mackowiak , Natalie Dubovoy
IPC分类号： C12Q170
CPC分类号： G01N33/582 , G01N2333/15 , G01N2333/161 , G01N2333/162 , G01N2333/44 , Y10S435/968 , Y10S435/969 , Y10S435/971 , Y10S435/974 , Y10S435/975
摘要： The subject invention relates generally to immunoassays for detection of antibodies by use chemiluminescent compounds. More particularly, the subject invention relates to chemiluminescent immunoassays to detect antibodies wherein a precomplex mixture is created and a two-step assay is performed resulting in a greater signal.
摘要翻译：本发明一般涉及通过使用化学发光化合物检测抗体的免疫测定。更具体地，本发明涉及用于检测抗体的化学发光免疫测定，其中产生预复合物混合物并进行两步测定，导致更大的信号。

4. 发明授权

US5283079A Process to make magnetically responsive fluorescent polymer particles 失效
标题翻译：制备磁响应荧光聚合物颗粒的方法
公开(公告)号：US5283079A
公开(公告)日：1994-02-01
申请号：US452099
申请日：1989-12-14
申请人： Chao-Huei J. Wang , Dinesh O. Shah
发明人： Chao-Huei J. Wang , Dinesh O. Shah
IPC分类号： A61M1/36 , B01J8/00 , B01J20/28 , B03C1/01 , C08F257/02 , C08F285/00 , C12Q1/68 , G01N33/543 , G01N33/58 , H01F1/11 , A01N1/02
CPC分类号： B01J20/28004 , A61M1/3618 , B01J20/28009 , B01J20/28016 , B01J8/008 , B03C1/01 , C08F257/02 , C08F285/00 , C12Q1/6816 , C12Q1/6834 , G01N33/54326 , G01N33/5434 , G01N33/582 , G01N33/585 , H01F1/111 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86
摘要： This invention provides a novel process of producing magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.
摘要翻译：本发明提供了一种制备磁响应荧光聚合物颗粒的新方法，其包括均匀地涂覆有含有磁响应金属氧化物的聚合物层的聚合物芯颗粒。尺寸范围为1至100微米的多种聚合物颗粒可用于核心颗粒并转化为磁响应聚合物颗粒。这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。这些磁响应荧光聚合物颗粒可用于生物材料如抗原，抗体，酶或DNA / RNA杂交的被动或共价偶联，并用作各种类型的免疫测定的固相，DNA / RNA杂交探针测定，亲和纯化，细胞分离等医疗，诊断和工业应用。

5. 发明授权

US4469486A Stable blend of coal and diesel oil 失效
标题翻译：稳定的煤和柴油混合
公开(公告)号：US4469486A
公开(公告)日：1984-09-04
申请号：US359277
申请日：1982-03-18
申请人： Dinesh O. Shah , K. C. Adiga , A. N. SunderRam
发明人： Dinesh O. Shah , K. C. Adiga , A. N. SunderRam
IPC分类号： C10L1/32 , F02B3/06
CPC分类号： C10L1/322 , F02B3/06
摘要： A stable dispersion of powdered coal in petroleum oil comprising:5-50% by weight of pulverized coal;45-90% by weight of diesel oil or Fuel Oil No. 2; and5-20% by weight of ethanol.This dispersion is particularly useful as a liquid fuel.
摘要翻译：粉煤在石油中的稳定分散体，其中包括：5-50％重量的粉煤; 45-90重量％柴油或燃油2号; 和5-20重量％的乙醇。该分散体作为液体燃料是特别有用的。

6. 发明申请

US20080311207A1 Micelles and Nanoemulsions for Preventive and Reactive Treatment of Atherosclerosis 审中-公开
标题翻译：胶束和纳米乳剂用于动脉粥样硬化的预防和反应性治疗
公开(公告)号：US20080311207A1
公开(公告)日：2008-12-18
申请号：US11662157
申请日：2005-09-08
申请人： Manoj Varshney , Dinesh O. Shah
发明人： Manoj Varshney , Dinesh O. Shah
IPC分类号： A61K9/14
CPC分类号： A61K9/1075
摘要： The subject invention is directed to microemulsion-based (ME) nanoparticles and methods of using same. The ME nanoparticles of the subject invention encompass self-assemblies of oil in water emulsions in the presence of at least two emulsifiers. One of the emulsifiers is a salt of a fatty acid, and the combined concentration of the at least two emulsifiers is sufficiently large to produce micelles, wherein the oil droplets are the hydrophobic core of the micelles. The subject invention also contemplates methods of modifying lipids, high density lipoprotein (HDL), and low density lipoprotein (LDL) in blood by contacting the blood with the ME nanoparticles of the subject invention. Another aspect concerns methods for treating atherosclerosis by administering the ME nanoparticles of the subject invention to a patient in need thereof.
摘要翻译：本发明涉及基于微乳液的（ME）纳米颗粒及其使用方法。本发明的ME纳米颗粒包括在至少两种乳化剂存在下的水包油乳液的自组装。乳化剂之一是脂肪酸的盐，并且至少两种乳化剂的组合浓度足够大以产生胶束，其中油滴是胶束的疏水核心。本发明还考虑通过使血液与本发明的ME纳米颗粒接触来改变血液中脂质，高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的方法。另一方面涉及通过将本发明的ME纳米颗粒给予有需要的患者来治疗动脉粥样硬化的方法。

7. 发明授权

US07101683B2 Methods for the simultaneous detection of HCV antigens and HCV antibodies 有权
公开(公告)号：US07101683B2
公开(公告)日：2006-09-05
申请号：US09891983
申请日：2001-06-26
申请人： Dinesh O. Shah , George J. Dawson , Anthony Scott Muerhoff , Xingli Jiang , Robin A. Gutierrez , Thomas P. Leary , Suresh Desai , James L. Stewart
发明人： Dinesh O. Shah , George J. Dawson , Anthony Scott Muerhoff , Xingli Jiang , Robin A. Gutierrez , Thomas P. Leary , Suresh Desai , James L. Stewart
IPC分类号： C11Q1/00 , C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , C12N2770/24222 , G01N33/5767 , G01N2469/10 , G01N2469/20
摘要： The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.

8. 发明授权

US5635346A Assay for Non-A Non-B hepatitis 失效
标题翻译：非甲非乙型肝炎检测
公开(公告)号：US5635346A
公开(公告)日：1997-06-03
申请号：US372723
申请日：1995-01-17
申请人： David C. Leahy , John A. Todd , Michael E. Jolley , Dinesh O. Shah , Delia R. Bethell , Terukatsu Arima
发明人： David C. Leahy , John A. Todd , Michael E. Jolley , Dinesh O. Shah , Delia R. Bethell , Terukatsu Arima
IPC分类号： A61K39/00 , C07K14/005 , C07K14/18 , G01N33/53 , G01N33/543 , G01N33/551 , G01N33/553 , G01N33/576 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/5767 , C12N2770/24222
摘要： New assays for diagnosing NANBH utilizing novel peptide fragments derived from polypeptide antigens reactive to antibodies present in the sera of infected patients are disclosed. In producing these peptides, the portion of the polypeptide contributing to high backgrounds is deleted thereby resulting in assays with an exceptionally high signal to background ratio.
摘要翻译：公开了利用衍生自对感染患者血清中存在的抗体具有反应性的多肽抗原的新肽片段来诊断NANBH的新的测定法。在生产这些肽时，有助于高背景的多肽的部分被缺失，从而导致具有非常高的信号与背景比的测定。

9. 发明授权

US4453947A Low viscosity stable mixtures of coal and fuel oil containing alcohol 失效
标题翻译：低粘度稳定的煤和含有燃料油的混合物
公开(公告)号：US4453947A
公开(公告)日：1984-06-12
申请号：US359372
申请日：1982-03-18
申请人： Dinesh O. Shah , K. C. Adiga , A. N. SunderRam
发明人： Dinesh O. Shah , K. C. Adiga , A. N. SunderRam
IPC分类号： C10L1/02 , C10L1/32
CPC分类号： C10L1/322 , C10L1/02
摘要： A stable homogeneous liquid fuel composition comprising a petroleum residual oil having a viscosity at room temperature of 1-2.5 poises, an alcohol of 1-2 carbon atoms, and a hydrocarbon coupling agent. This composition has utility as a fuel per se and as a liquid carrier in which powdered coal can be dispered to produce another liquid fuel.
摘要翻译：一种稳定均匀的液体燃料组合物，其包含在室温下为1-2.5泊的粘度，1-2个碳原子的醇和烃偶合剂的石油残油。该组合物作为燃料本身具有效用，并且作为液体载体可以分散粉煤以产生另一液体燃料。

10. 发明授权

US09073984B2 Anti-T. cruzi antibodies and methods of use 有权
标题翻译：反T 克鲁兹抗体和使用方法
公开(公告)号：US09073984B2
公开(公告)日：2015-07-07
申请号：US13353678
申请日：2012-01-19
申请人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
发明人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
IPC分类号： G01N33/53 , C07K16/00 , C07K16/20 , G01N33/569
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
摘要翻译：本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。

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