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1. 发明授权

US4442033A Azo dyestuff for use as a chromogen in detecting leukocytes 失效
标题翻译：偶氮染料用作检测白细胞的色原体
公开(公告)号：US4442033A
公开(公告)日：1984-04-10
申请号：US271342
申请日：1981-06-08
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
IPC分类号： C09B43/20 , C09B43/18 , C09B43/28 , G01N33/50 , C09B29/036 , C09B29/042 , C09B29/15
CPC分类号： C09B43/18 , G01N33/5094
摘要： Azo dyestuff ester of the formulaA--N.dbd.N--B(OR).sub.nwhereinA is a five- or six-membered heterocyclic radical of up to 2 hetero ring atoms selected from nitrogen, sulfur and oxygen, and wherein the heterocyclic ring may be substituted with at least one member of the group selected from halogen, lower alkyl and lower alkoxy; orA is phenyl substituted by at least one member of the group selected from lower alkyl, lower alkoxy, nitro, sulphanato and acylamino;B is benzene, naphthalene or quinoline, optionally substituted with one or two radicals selected from sulphanato, lower alkoxy and lower alkoxypoly-alkyleneoxy;R is a carboxylic acid residue or an amino acid or peptide residue having a nitrogen protective group; andn is 1 or 2.This dyestuff is particularly useful as a chromogen in a diagnostic composition for detecting leukocytes in body fluids.
摘要翻译：式AN = NB（OR）n的偶氮染料酯，其中A是选自氮，硫和氧的至多2个杂环原子的5或6元杂环基，并且其中杂环可以被选自卤素，低级烷基和低级烷氧基的基团中的至少一个成员; 或A是被选自低级烷基，低级烷氧基，硝基，磺酰基和酰氨基中的至少一个基团取代的苯基; B是苯，萘或喹啉，任选被一个或两个选自磺酰基，低级烷氧基和低级烷氧基聚 - 亚烷氧基的基团取代; R是具有氮保护基团的羧酸残基或氨基酸或肽残基; 并且n为1或2.该染料特别可用作用于检测体液中白细胞的诊断组合物中的色原体。

2. 发明授权

US4296202A Diagnostic composition for the detection of leukocytes and chromogens useful therein 失效
标题翻译：用于检测其中有用的白细胞和色原体的诊断组合物
公开(公告)号：US4296202A
公开(公告)日：1981-10-20
申请号：US63211
申请日：1979-08-02
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
IPC分类号： C09B43/20 , C09B43/18 , C09B43/28 , G01N33/50
CPC分类号： C09B43/18 , G01N33/5094
摘要： Novel diagnostic composition for the detection of leukocytes in body fluids, comprising an absorbent carrier impregnated with a buffer substance and a chromgen, wherein the chromogen is an azo dyestuff ester of the formulaA--N.dbd.N--B(OR).sub.nwhereinA is a five- or six-membered heterocyclic radical of up to 2 hetero ring atoms selected from nitrogen, sulfur and oxygen, and wherein the heterocyclic ring may be substituted with at least one member of the group selected from halogen, lower alkyl and lower alkoxy; orA is phenyl substituted by at least one member of the group selected from lower alkyl, lower alkoxy, nitro, sulphanato and acylamino;B is benzene, naphthalene or quinolone, optionally substituted with one or two radicals selected from sulphanato, lower alkoxy and lower alkoxypoly-alkyleneoxy;R is a carboxylic acid residue or an amino acid or peptide residue having a nitrogen protective group; andn is 1 or 2.
摘要翻译：用于检测体液中白细胞的新型诊断组合物，其包含浸渍有缓冲物质和染色剂的吸收剂载体，其中所述色原是式AN = NB（OR）n的偶氮染料酯，其中A是五或多至2个选自氮，硫和氧的杂环原子的六元杂环基，其中杂环可以被选自卤素，低级烷基和低级烷氧基中的至少一个基团取代; 或A是被选自低级烷基，低级烷氧基，硝基，磺酰基和酰氨基中的至少一个基团取代的苯基; B是苯，萘或喹诺酮，任选地被一个或两个选自磺酰基，低级烷氧基和低级烷氧基聚 - 亚烷氧基的基团取代; R是具有氮保护基团的羧酸残基或氨基酸或肽残基; n为1或2。

3. 发明授权

US4469789A Amino acid and peptide esters of leuko-indoaniline compounds and compositions for the detection of proteolytic enzymes 失效
标题翻译：白 - 吲哚苯胺化合物的氨基酸和肽酯以及用于检测蛋白水解酶的组合物
公开(公告)号：US4469789A
公开(公告)日：1984-09-04
申请号：US229205
申请日：1981-01-28
申请人： Dieter Berger , Franz Braun , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07C301/00 , C07C67/00 , C07C227/18 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/54 , C07C269/06 , C07C271/22 , C07C303/40 , C07C311/00 , C07C311/33 , C07C313/00 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/48 , C07C323/40 , C07C323/62 , C07C323/63 , C07C323/65 , C07D215/38 , C07D295/135 , C07K1/00 , C07K5/04 , C07K5/06 , C07K5/083 , C07K7/06 , C09B53/00 , C12Q1/34 , C12Q1/37 , C12Q1/38 , C12Q1/36
CPC分类号： C07D295/135 , C07D215/38 , C07K5/06026 , C07K5/0806 , C12Q1/34 , C12Q1/37 , C12Q2334/00
摘要： This invention relates to new amino acid and peptide esters of leuko-indoaniline compounds and to a process for their preparation. In additional aspect, the invention relates to compositions containing such compounds for the detection of proteolytic enzymes and to methods for detecting such enzymes.
摘要翻译：本发明涉及白 - 印度苯胺化合物的新氨基酸和肽酯及其制备方法。另外方面，本发明涉及包含用于检测蛋白水解酶的这种化合物的组合物和用于检测这些酶的方法。

4. 发明授权

US4331760A Diagnostic agent for the detection of leukocytes and chromogens useful therein 失效
标题翻译：用于检测其中有用的白细胞和色素的诊断剂
公开(公告)号：US4331760A
公开(公告)日：1982-05-25
申请号：US42393
申请日：1979-05-25
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Wolfgang Werner
IPC分类号： G01N33/49 , C07D327/04 , C09B11/00 , C09B11/06 , G01N33/50 , C12Q1/44 , G01N33/48
CPC分类号： G01N33/5094 , C07D327/04 , Y02P20/55
摘要： Diagnostic agent for the detection of leukocytes in body fluids, comprising an absorbent carrier which is impregnated with a chromogen and a buffer substance, wherein the chromogen is a sulfonphthalein ester of the formula ##STR1## wherein R.sub.1 is a carboxylic acid residue optionally substituted by halogen or lower alkoxy; or is an amino acid or peptide residue having a nitrogen protective group;R.sub.2 is a halogen atom or a lower alkyl radical; andR.sub.3 and R.sub.4 are individually selected from hydrogen and halogen.Certain of the chromogen are provided as novel compounds.
摘要翻译：用于检测体液中白细胞的诊断剂，其包含用色素沉积物和缓冲物质浸渍的吸收剂载体，其中所述色原是式IMAMA的磺酞类，其中R1是任选被卤素取代的羧酸残基或低级烷氧基; 或具有氮保护基的氨基酸或肽残基; R2是卤素原子或低级烷基; 并且R 3和R 4分别选自氢和卤素。某些色原提供为新化合物。

5. 发明授权

US4551428A Agent for the determination of esterolytic and/or proteolytic enzymes 失效
标题翻译：用于测定酯水解和/或蛋白水解酶的试剂
公开(公告)号：US4551428A
公开(公告)日：1985-11-05
申请号：US260616
申请日：1981-05-05
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom; and the method of preparation and use.
摘要翻译：酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基并且B是肽化学中常规的或由其衍生的氮保护基; 以及制备和使用的方法。

6. 发明授权

US4749648A Agent for the determination of esterolytic and/or proteolytic enzymes 失效
标题翻译：用于测定酯水解和/或蛋白水解酶的试剂
公开(公告)号：US4749648A
公开(公告)日：1988-06-07
申请号：US606984
申请日：1984-05-04
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom and the method of preparation and use.
摘要翻译：酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基并且B是肽化学中常规的或由其衍生的氮保护基及其制备和使用方法。

7. 发明授权

US4299917A Diagnostic agents for the detection of leukocytes in body fluids 失效
标题翻译：用于检测体液中白细胞的诊断剂
公开(公告)号：US4299917A
公开(公告)日：1981-11-10
申请号：US114143
申请日：1980-01-21
申请人： Dieter Berger , Gunter Frey , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07D327/04 , C09B11/08 , C09B43/20 , C12Q1/04 , C12Q1/37 , C12Q1/44 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/16 , G01N31/14
CPC分类号： C12Q1/37 , C09B11/08 , C09B43/20 , C12Q1/04 , C12Q1/44 , C12Q2334/40 , C12Q2334/50
摘要： This invention relates to diagnositc agents and methods for the detection of leukocytes in body fluids. In additional aspect, the invention provides a process for the production of such diagnostic agents.
摘要翻译：本发明涉及用于检测体液中白细胞的诊断剂和方法。另外方面，本发明提供了生产这种诊断剂的方法。

8. 发明授权

US4780280A Test carrier 失效
标题翻译：测试载体
公开(公告)号：US4780280A
公开(公告)日：1988-10-25
申请号：US879378
申请日：1986-06-27
申请人： Dieter Berger , Elke Biegel , Gunter Frey , Hans-Rudiger Murawski
发明人： Dieter Berger , Elke Biegel , Gunter Frey , Hans-Rudiger Murawski
IPC分类号： C12Q1/00 , G01N31/22 , G01N33/52
CPC分类号： G01N33/525
摘要： A test support for support-bound tests for the determination of components of fluids, especially of human and animal body fluids. The test support is composed of a plurality of layers, and the joining of the layers is accomplished at least partially by sewing.
摘要翻译：用于确定流体，特别是人体和动物体液的组分的支持结合测试的测试支持。测试支架由多个层组成，并且层的连接至少部分地通过缝合来完成。

9. 发明授权

US5457200A 3-aminopyrazolo heterocyclic derivatives, and use for colorimetric determinations 失效
标题翻译： 3-氨基吡唑并杂环衍生物，用于比色测定
公开(公告)号：US5457200A
公开(公告)日：1995-10-10
申请号：US67229
申请日：1993-05-25
申请人： Gerd Zimmermann , Joachim Siedel , Gunter Frey
发明人： Gerd Zimmermann , Joachim Siedel , Gunter Frey
IPC分类号： C07D471/04 , C07D487/04 , C07D513/04 , C09B57/00 , C12Q1/28 , C12Q1/54 , G01N21/77 , G01N31/00 , G01N31/22 , G01N33/50 , C07D487/00 , C07D231/00 , C07D249/08 , C07D473/00
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04 , C12Q1/28 , C12Q2326/00 , Y10S436/815 , Y10S436/904
摘要： The present invention is concerned with the use of certain 3-aminopyrazolo-heterocyclic compounds for the colorimetric determination of hydrogen peroxide, hydrogen peroxide-forming systems, peroxidase, peroxidate-active substances and electron-rich aromatic compounds. The present invention is also concerned with corresponding processes of determination and with agents appropriate therefor. Furthermore, the present invention is concerned with new 3-aminopyrazolo-heterocyclic compounds.
摘要翻译：本发明涉及某些3-氨基吡唑并杂环化合物用于比色测定过氧化氢，过氧化氢形成体系，过氧化物酶，过氧化物活性物质和富电子芳族化合物的用途。本发明还涉及相应的测定方法和与其合适的试剂。此外，本发明涉及新的3-氨基吡唑并 - 杂环化合物。

10. 发明授权

US4287917A Diaphragm device for damping vibrations in flowing liquids 失效
标题翻译：用于阻止流动液体振动的隔膜装置
公开(公告)号：US4287917A
公开(公告)日：1981-09-08
申请号：US92327
申请日：1979-11-08
申请人： Gunter Frey
发明人： Gunter Frey
IPC分类号： B01D27/08 , B01D35/02 , F02M37/22 , F16L55/05 , F16L55/04
CPC分类号： F02M37/22 , B01D27/08 , B01D35/02 , F16L55/05 , F02M2037/226 , Y10T137/7893
摘要： For the damping of high-frequency vibrations in liquids under high pressure in conduit systems there serves a diaphragm (2) loaded by a spring (3) and surrounded on all sides by the liquid of the conduit system. When the liquid is stationary the diaphragm (2) acts as barrier in a free flow cross-section of the conduit system. When the liquid is flowing the diaphragm (2) is situated in the state of suspense in which it is held by the energy of flow of the liquid against the counteracting force of the spring (3) loading the diaphragm (2). The diaphragm (2) is set in a housing (1) installed in the conduit system in such a way that the liquid on the upstream side of the diaphragm (2) flows through an annular space (6) radially around the diaphragm (2). The diaphragm (2) is especially suitable for installation in the housing (9) of a liquid filter.
摘要翻译：为了在管道系统中阻尼高压液体中的高频振动，可以通过弹簧（3）装载隔膜（2），并通过导管系统的液体将其全部包围。当液体静止时，隔膜（2）在导管系统的自由流动截面中作为阻挡层。当液体流动时，隔膜（2）处于悬浮状态，由液体的流动能量抵抗装载隔膜（2）的弹簧（3）的反作用力而被保持。隔膜（2）设置在安装在管道系统中的壳体（1）中，使得膜片（2）上游侧的液体流过环绕隔膜（2）的环形空间（6）。隔膜（2）特别适用于安装在液体过滤器的壳体（9）中。

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