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1. 发明授权

US4780280A Test carrier 失效
标题翻译：测试载体
公开(公告)号：US4780280A
公开(公告)日：1988-10-25
申请号：US879378
申请日：1986-06-27
申请人： Dieter Berger , Elke Biegel , Gunter Frey , Hans-Rudiger Murawski
发明人： Dieter Berger , Elke Biegel , Gunter Frey , Hans-Rudiger Murawski
IPC分类号： C12Q1/00 , G01N31/22 , G01N33/52
CPC分类号： G01N33/525
摘要： A test support for support-bound tests for the determination of components of fluids, especially of human and animal body fluids. The test support is composed of a plurality of layers, and the joining of the layers is accomplished at least partially by sewing.
摘要翻译：用于确定流体，特别是人体和动物体液的组分的支持结合测试的测试支持。测试支架由多个层组成，并且层的连接至少部分地通过缝合来完成。

2. 发明授权

US4749648A Agent for the determination of esterolytic and/or proteolytic enzymes 失效
标题翻译：用于测定酯水解和/或蛋白水解酶的试剂
公开(公告)号：US4749648A
公开(公告)日：1988-06-07
申请号：US606984
申请日：1984-05-04
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom and the method of preparation and use.
摘要翻译：酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基并且B是肽化学中常规的或由其衍生的氮保护基及其制备和使用方法。

3. 发明授权

US4299917A Diagnostic agents for the detection of leukocytes in body fluids 失效
标题翻译：用于检测体液中白细胞的诊断剂
公开(公告)号：US4299917A
公开(公告)日：1981-11-10
申请号：US114143
申请日：1980-01-21
申请人： Dieter Berger , Gunter Frey , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07D327/04 , C09B11/08 , C09B43/20 , C12Q1/04 , C12Q1/37 , C12Q1/44 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/16 , G01N31/14
CPC分类号： C12Q1/37 , C09B11/08 , C09B43/20 , C12Q1/04 , C12Q1/44 , C12Q2334/40 , C12Q2334/50
摘要： This invention relates to diagnositc agents and methods for the detection of leukocytes in body fluids. In additional aspect, the invention provides a process for the production of such diagnostic agents.
摘要翻译：本发明涉及用于检测体液中白细胞的诊断剂和方法。另外方面，本发明提供了生产这种诊断剂的方法。

4. 发明授权

US4442033A Azo dyestuff for use as a chromogen in detecting leukocytes 失效
标题翻译：偶氮染料用作检测白细胞的色原体
公开(公告)号：US4442033A
公开(公告)日：1984-04-10
申请号：US271342
申请日：1981-06-08
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
IPC分类号： C09B43/20 , C09B43/18 , C09B43/28 , G01N33/50 , C09B29/036 , C09B29/042 , C09B29/15
CPC分类号： C09B43/18 , G01N33/5094
摘要： Azo dyestuff ester of the formulaA--N.dbd.N--B(OR).sub.nwhereinA is a five- or six-membered heterocyclic radical of up to 2 hetero ring atoms selected from nitrogen, sulfur and oxygen, and wherein the heterocyclic ring may be substituted with at least one member of the group selected from halogen, lower alkyl and lower alkoxy; orA is phenyl substituted by at least one member of the group selected from lower alkyl, lower alkoxy, nitro, sulphanato and acylamino;B is benzene, naphthalene or quinoline, optionally substituted with one or two radicals selected from sulphanato, lower alkoxy and lower alkoxypoly-alkyleneoxy;R is a carboxylic acid residue or an amino acid or peptide residue having a nitrogen protective group; andn is 1 or 2.This dyestuff is particularly useful as a chromogen in a diagnostic composition for detecting leukocytes in body fluids.
摘要翻译：式AN = NB（OR）n的偶氮染料酯，其中A是选自氮，硫和氧的至多2个杂环原子的5或6元杂环基，并且其中杂环可以被选自卤素，低级烷基和低级烷氧基的基团中的至少一个成员; 或A是被选自低级烷基，低级烷氧基，硝基，磺酰基和酰氨基中的至少一个基团取代的苯基; B是苯，萘或喹啉，任选被一个或两个选自磺酰基，低级烷氧基和低级烷氧基聚 - 亚烷氧基的基团取代; R是具有氮保护基团的羧酸残基或氨基酸或肽残基; 并且n为1或2.该染料特别可用作用于检测体液中白细胞的诊断组合物中的色原体。

5. 发明授权

US4296202A Diagnostic composition for the detection of leukocytes and chromogens useful therein 失效
标题翻译：用于检测其中有用的白细胞和色原体的诊断组合物
公开(公告)号：US4296202A
公开(公告)日：1981-10-20
申请号：US63211
申请日：1979-08-02
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Manfred Kuhr
IPC分类号： C09B43/20 , C09B43/18 , C09B43/28 , G01N33/50
CPC分类号： C09B43/18 , G01N33/5094
摘要： Novel diagnostic composition for the detection of leukocytes in body fluids, comprising an absorbent carrier impregnated with a buffer substance and a chromgen, wherein the chromogen is an azo dyestuff ester of the formulaA--N.dbd.N--B(OR).sub.nwhereinA is a five- or six-membered heterocyclic radical of up to 2 hetero ring atoms selected from nitrogen, sulfur and oxygen, and wherein the heterocyclic ring may be substituted with at least one member of the group selected from halogen, lower alkyl and lower alkoxy; orA is phenyl substituted by at least one member of the group selected from lower alkyl, lower alkoxy, nitro, sulphanato and acylamino;B is benzene, naphthalene or quinolone, optionally substituted with one or two radicals selected from sulphanato, lower alkoxy and lower alkoxypoly-alkyleneoxy;R is a carboxylic acid residue or an amino acid or peptide residue having a nitrogen protective group; andn is 1 or 2.
摘要翻译：用于检测体液中白细胞的新型诊断组合物，其包含浸渍有缓冲物质和染色剂的吸收剂载体，其中所述色原是式AN = NB（OR）n的偶氮染料酯，其中A是五或多至2个选自氮，硫和氧的杂环原子的六元杂环基，其中杂环可以被选自卤素，低级烷基和低级烷氧基中的至少一个基团取代; 或A是被选自低级烷基，低级烷氧基，硝基，磺酰基和酰氨基中的至少一个基团取代的苯基; B是苯，萘或喹诺酮，任选地被一个或两个选自磺酰基，低级烷氧基和低级烷氧基聚 - 亚烷氧基的基团取代; R是具有氮保护基团的羧酸残基或氨基酸或肽残基; n为1或2。

6. 发明授权

US4551428A Agent for the determination of esterolytic and/or proteolytic enzymes 失效
标题翻译：用于测定酯水解和/或蛋白水解酶的试剂
公开(公告)号：US4551428A
公开(公告)日：1985-11-05
申请号：US260616
申请日：1981-05-05
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom; and the method of preparation and use.
摘要翻译：酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基并且B是肽化学中常规的或由其衍生的氮保护基; 以及制备和使用的方法。

7. 发明授权

US4331760A Diagnostic agent for the detection of leukocytes and chromogens useful therein 失效
标题翻译：用于检测其中有用的白细胞和色素的诊断剂
公开(公告)号：US4331760A
公开(公告)日：1982-05-25
申请号：US42393
申请日：1979-05-25
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Wolfgang Werner
IPC分类号： G01N33/49 , C07D327/04 , C09B11/00 , C09B11/06 , G01N33/50 , C12Q1/44 , G01N33/48
CPC分类号： G01N33/5094 , C07D327/04 , Y02P20/55
摘要： Diagnostic agent for the detection of leukocytes in body fluids, comprising an absorbent carrier which is impregnated with a chromogen and a buffer substance, wherein the chromogen is a sulfonphthalein ester of the formula ##STR1## wherein R.sub.1 is a carboxylic acid residue optionally substituted by halogen or lower alkoxy; or is an amino acid or peptide residue having a nitrogen protective group;R.sub.2 is a halogen atom or a lower alkyl radical; andR.sub.3 and R.sub.4 are individually selected from hydrogen and halogen.Certain of the chromogen are provided as novel compounds.
摘要翻译：用于检测体液中白细胞的诊断剂，其包含用色素沉积物和缓冲物质浸渍的吸收剂载体，其中所述色原是式IMAMA的磺酞类，其中R1是任选被卤素取代的羧酸残基或低级烷氧基; 或具有氮保护基的氨基酸或肽残基; R2是卤素原子或低级烷基; 并且R 3和R 4分别选自氢和卤素。某些色原提供为新化合物。

8. 发明授权

US4469789A Amino acid and peptide esters of leuko-indoaniline compounds and compositions for the detection of proteolytic enzymes 失效
标题翻译：白 - 吲哚苯胺化合物的氨基酸和肽酯以及用于检测蛋白水解酶的组合物
公开(公告)号：US4469789A
公开(公告)日：1984-09-04
申请号：US229205
申请日：1981-01-28
申请人： Dieter Berger , Franz Braun , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07C301/00 , C07C67/00 , C07C227/18 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/54 , C07C269/06 , C07C271/22 , C07C303/40 , C07C311/00 , C07C311/33 , C07C313/00 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/48 , C07C323/40 , C07C323/62 , C07C323/63 , C07C323/65 , C07D215/38 , C07D295/135 , C07K1/00 , C07K5/04 , C07K5/06 , C07K5/083 , C07K7/06 , C09B53/00 , C12Q1/34 , C12Q1/37 , C12Q1/38 , C12Q1/36
CPC分类号： C07D295/135 , C07D215/38 , C07K5/06026 , C07K5/0806 , C12Q1/34 , C12Q1/37 , C12Q2334/00
摘要： This invention relates to new amino acid and peptide esters of leuko-indoaniline compounds and to a process for their preparation. In additional aspect, the invention relates to compositions containing such compounds for the detection of proteolytic enzymes and to methods for detecting such enzymes.
摘要翻译：本发明涉及白 - 印度苯胺化合物的新氨基酸和肽酯及其制备方法。另外方面，本发明涉及包含用于检测蛋白水解酶的这种化合物的组合物和用于检测这些酶的方法。

9. 发明授权

US5104811A Test carrier and method for the analytical determination of components of body fluids 失效
标题翻译：用于分析体内液体组分的测试载体和方法
公开(公告)号：US5104811A
公开(公告)日：1992-04-14
申请号：US134950
申请日：1987-12-18
申请人： Dieter Berger , Wolfgang-Reinhold Knappe , Robert Lorenz , Henry M. Grage, Jr. , Mark T. Skarstedt , Bernward Sojka , Manfred Bleisteiner
发明人： Dieter Berger , Wolfgang-Reinhold Knappe , Robert Lorenz , Henry M. Grage, Jr. , Mark T. Skarstedt , Bernward Sojka , Manfred Bleisteiner
IPC分类号： G01N31/22 , C12M1/34 , G01N21/77 , G01N33/49 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/525 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S436/81
摘要： On a carrier layer there are arranged several test layers which are at least partly in fluid contact with one another, enabling liquid exchange. On the carrier layer are arranged an application zone, a detection zone for the production of a detectable signal characteristic of the analytical determination, which contains at least one said test layer which is a reaction layer, and an absorption zone with a test layer which is an absorptive layer of an absorbent material, wherein the reaction layer and absorption zone are positioned next to each other. Between the application and the absorption zone is a capillary-active transport path on the carrier layer which connects the application zone and the absorption zone. The reaction layer is arranged parallel to the transport path between the application zone and the absorption zone in such a manner that it is in liquid contact with a liquid transported in the transport path. The absorption zone therefore absorbs excess liquid and permits dosing the reaction layer with a reproducible amount of sample.
摘要翻译：在载体层上布置有几个测试层，其至少部分地彼此流体接触，从而实现液体交换。在载体层上布置有应用区域，用于产生分析测定特征的可检测信号的检测区域，其包含至少一个作为反应层的测试层，以及具有测试层的吸收区，其为吸收材料的吸收层，其中反应层和吸收区彼此相邻放置。在应用和吸收区之间是在载体层上的连接施加区和吸收区的毛细管 - 主动传输路径。反应层以与输送路径中输送的液体液体接触的方式平行于施加区域和吸收区域之间的输送路径布置。因此，吸收区吸收多余的液体，并允许用可重复量的样品给反应层。

10. 发明授权

US4477575A Process and composition for separating plasma or serum from whole blood 失效
标题翻译：从全血中分离血浆或血清的方法和组成
公开(公告)号：US4477575A
公开(公告)日：1984-10-16
申请号：US289943
申请日：1981-08-04
申请人： Peter Vogel , Hans-Peter Braun , Dieter Berger , Wolfgang Werner
发明人： Peter Vogel , Hans-Peter Braun , Dieter Berger , Wolfgang Werner
IPC分类号： A61K35/14 , A61M1/00 , B01D39/20 , G01N33/48 , G01N33/49 , G01N33/52 , G01N1/18
CPC分类号： G01N33/491 , B01D39/2017 , G01N33/48 , G01N33/525 , Y10T436/25375
摘要： A composition and process for permitting the separation of plasma or serum from whole blood. The composition includes glass fibers having an average diameter of from 0.2.mu. to 5.mu. and a density of 0.1 g/cm.sup.2 to 0.5 g/cm.sup.2. The process includes the steps of slowly trickling whole blood onto one side of a layer composed of the composition of glass fibers, whereby plasma or serum separated from the blood becomes available at another side of the layer. The total volume of the plasma or serum separated from the blood is limited to at most 50% of the absorption volume of the glass fiber layer.
摘要翻译：允许血浆或血清从全血分离的组合物和方法。该组合物包含平均直径为0.2〜5μm，密度为0.1g / cm 2〜0.5g / cm 2的玻璃纤维。该方法包括以下步骤：将全血慢慢滴入由玻璃纤维组合物组成的层的一侧，从血液中分离的血浆或血清在层的另一侧可用。从血液分离的血浆或血清的总体积被限制在玻璃纤维层的吸收体积的至多50％。

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