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1. 发明授权

US4331760A Diagnostic agent for the detection of leukocytes and chromogens useful therein 失效
标题翻译：用于检测其中有用的白细胞和色素的诊断剂
公开(公告)号：US4331760A
公开(公告)日：1982-05-25
申请号：US42393
申请日：1979-05-25
申请人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Gunter Frey , Werner Guthlein , Wolfgang Werner
IPC分类号： G01N33/49 , C07D327/04 , C09B11/00 , C09B11/06 , G01N33/50 , C12Q1/44 , G01N33/48
CPC分类号： G01N33/5094 , C07D327/04 , Y02P20/55
摘要： Diagnostic agent for the detection of leukocytes in body fluids, comprising an absorbent carrier which is impregnated with a chromogen and a buffer substance, wherein the chromogen is a sulfonphthalein ester of the formula ##STR1## wherein R.sub.1 is a carboxylic acid residue optionally substituted by halogen or lower alkoxy; or is an amino acid or peptide residue having a nitrogen protective group;R.sub.2 is a halogen atom or a lower alkyl radical; andR.sub.3 and R.sub.4 are individually selected from hydrogen and halogen.Certain of the chromogen are provided as novel compounds.
摘要翻译：用于检测体液中白细胞的诊断剂，其包含用色素沉积物和缓冲物质浸渍的吸收剂载体，其中所述色原是式IMAMA的磺酞类，其中R1是任选被卤素取代的羧酸残基或低级烷氧基; 或具有氮保护基的氨基酸或肽残基; R2是卤素原子或低级烷基; 并且R 3和R 4分别选自氢和卤素。某些色原提供为新化合物。

2. 发明授权

US4278763A Diagnostic agents for the detection of proteolytic enzymes 失效
标题翻译：用于检测蛋白水解酶的诊断剂
公开(公告)号：US4278763A
公开(公告)日：1981-07-14
申请号：US99180
申请日：1979-11-30
申请人： Dieter Berger , Franz Braun , Werner Guthlein , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Werner Guthlein , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07D209/36 , C07D209/12 , C07D333/64 , C07K1/113 , C07K5/04 , C07K7/06 , C12Q1/37 , G01N33/48 , G01N33/50 , C12Q1/38
CPC分类号： C12Q1/37 , C12Q2334/50
摘要： The present invention provides a diagnostic agent for the detection of proteolytic enzymes, comprising an absorbent carrier, a film layer, a powder mixture, a lyophilisate, a solution or a reagent tablet, containing at least one chromogen and an appropriate buffer substance, wherein the chromogen used is an indoxyl- and/or thioindoxyl-amino acid ester and/or peptide ester of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, lower alkoxy, aryl, aralkyl, aralkoxy, hydroxyl, carboxy, carboxy lower alkoxy, aralkoxycarbonyl, aralkyloxycarbonyl lower alkoxy, nitro or lower acylamino radicals, whereby two adjacent substituents can also represent an optionally halogenated fused benzene ring, X is a sulphur atom or an imino group optionally substituted by a lower alkyl, aryl, aralkyl or acyl radical, A is an amino acid or peptide residue and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom.The present invention also provides new compounds of the above-given general formula and processes for the preparation thereof.Furthermore, the present invention is concerned with the use of the compounds of the above-given general formula for the production of diagnostic agents for the detection of proteolytic enzymes.
摘要翻译：本发明提供了用于检测蛋白水解酶的诊断剂，其包含含有至少一种色原体和适当的缓冲物质的吸收剂载体，膜层，粉末混合物，冻干物，溶液或试剂片剂，其中使用的色原是通式为：其中R 1，R 2，R 3和R 4可以相同或不同，为氢或卤素原子的通式如下的吲哚氧基和/或硫代吲哚氧基 - 氨基酸酯和/或肽酯：低级烷基，低级烷氧基，芳基，芳烷基，芳烷氧基，羟基，羧基，羧基低级烷氧基，芳烷氧基羰基，芳烷氧基羰基低级烷氧基，硝基或低级酰基氨基，其中两个相邻的取代基也可以表示任选卤代的稠合苯环，X是硫原子或任选被低级烷基，芳基，芳烷基或酰基取代的亚氨基，A是氨基酸或肽残基，B是肽化学中常规的氮保护基或从其衍生。本发明还提供了上述给出的通式的新化合物及其制备方法。此外，本发明涉及上述给出的通式的化合物用于产生用于检测蛋白水解酶的诊断剂的用途。

3. 发明授权

US4469789A Amino acid and peptide esters of leuko-indoaniline compounds and compositions for the detection of proteolytic enzymes 失效
标题翻译：白 - 吲哚苯胺化合物的氨基酸和肽酯以及用于检测蛋白水解酶的组合物
公开(公告)号：US4469789A
公开(公告)日：1984-09-04
申请号：US229205
申请日：1981-01-28
申请人： Dieter Berger , Franz Braun , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Franz Braun , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07C301/00 , C07C67/00 , C07C227/18 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/54 , C07C269/06 , C07C271/22 , C07C303/40 , C07C311/00 , C07C311/33 , C07C313/00 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/48 , C07C323/40 , C07C323/62 , C07C323/63 , C07C323/65 , C07D215/38 , C07D295/135 , C07K1/00 , C07K5/04 , C07K5/06 , C07K5/083 , C07K7/06 , C09B53/00 , C12Q1/34 , C12Q1/37 , C12Q1/38 , C12Q1/36
CPC分类号： C07D295/135 , C07D215/38 , C07K5/06026 , C07K5/0806 , C12Q1/34 , C12Q1/37 , C12Q2334/00
摘要： This invention relates to new amino acid and peptide esters of leuko-indoaniline compounds and to a process for their preparation. In additional aspect, the invention relates to compositions containing such compounds for the detection of proteolytic enzymes and to methods for detecting such enzymes.
摘要翻译：本发明涉及白 - 印度苯胺化合物的新氨基酸和肽酯及其制备方法。另外方面，本发明涉及包含用于检测蛋白水解酶的这种化合物的组合物和用于检测这些酶的方法。

4. 发明授权

US4070495A Microscope slide 失效
标题翻译：显微镜幻灯片
公开(公告)号：US4070495A
公开(公告)日：1978-01-24
申请号：US672572
申请日：1976-03-31
申请人： Dieter Berger , Werner Guthlein , Wolfgang Werner , Peter Rieckmann
发明人： Dieter Berger , Werner Guthlein , Wolfgang Werner , Peter Rieckmann
IPC分类号： G01N33/48 , G01N1/30 , G01N33/16 , G01N21/60 , G01N31/22
CPC分类号： G01N1/30
摘要： Microscope slide for blood investigation having a coating of highly purified methylene blue N and highly purified cresyl violet acetate in a weight ratio of from 1:1.5 to 1:5.
摘要翻译：用于血液研究的显微镜载玻片，其重量比为1:1.5至1:5，具有高度纯化的亚甲基蓝N和高度纯化的甲酚紫乙酸酯的涂层。

5. 发明授权

US4749648A Agent for the determination of esterolytic and/or proteolytic enzymes 失效
标题翻译：用于测定酯水解和/或蛋白水解酶的试剂
公开(公告)号：US4749648A
公开(公告)日：1988-06-07
申请号：US606984
申请日：1984-05-04
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom and the method of preparation and use.
摘要翻译：酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基并且B是肽化学中常规的或由其衍生的氮保护基及其制备和使用方法。

6. 发明授权

US4299917A Diagnostic agents for the detection of leukocytes in body fluids 失效
标题翻译：用于检测体液中白细胞的诊断剂
公开(公告)号：US4299917A
公开(公告)日：1981-11-10
申请号：US114143
申请日：1980-01-21
申请人： Dieter Berger , Gunter Frey , Manfred Kuhr , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Manfred Kuhr , Wolfgang Werner
IPC分类号： C07D327/04 , C09B11/08 , C09B43/20 , C12Q1/04 , C12Q1/37 , C12Q1/44 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/16 , G01N31/14
CPC分类号： C12Q1/37 , C09B11/08 , C09B43/20 , C12Q1/04 , C12Q1/44 , C12Q2334/40 , C12Q2334/50
摘要： This invention relates to diagnositc agents and methods for the detection of leukocytes in body fluids. In additional aspect, the invention provides a process for the production of such diagnostic agents.
摘要翻译：本发明涉及用于检测体液中白细胞的诊断剂和方法。另外方面，本发明提供了生产这种诊断剂的方法。

7. 发明授权

US4551428A Agent for the determination of esterolytic and/or proteolytic enzymes 失效
标题翻译：用于测定酯水解和/或蛋白水解酶的试剂
公开(公告)号：US4551428A
公开(公告)日：1985-11-05
申请号：US260616
申请日：1981-05-05
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom; and the method of preparation and use.
摘要翻译：酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基并且B是肽化学中常规的或由其衍生的氮保护基; 以及制备和使用的方法。

8. 发明授权

US3988208A 9-Substituted 3-aminocarbazole compounds and test strip indicator compositions 失效
标题翻译： 9-取代的3-氨基咔唑化合物和测试条指示剂组合物
公开(公告)号：US3988208A
公开(公告)日：1976-10-26
申请号：US559273
申请日：1975-03-17
申请人： Wolfgang Werner , Peter Vogel , Hugo Tiedemann , Werner Guthlein
发明人： Wolfgang Werner , Peter Vogel , Hugo Tiedemann , Werner Guthlein
IPC分类号： C07D209/88 , C12Q1/28 , C12Q1/54 , C12K1/04
CPC分类号： C12Q1/54 , C07D209/88 , C12Q1/28 , C12Q2326/00 , C12Q2326/14
摘要： Novel 3-aminocarbazole compounds of the formula: ##SPC1##WhereinX is hydrogen or halogen,Y is oxygen or represents two hydrogen atoms; andR.sub.1 and R.sub.2, which can be the same or different, are hydrogen, lower alkyl or hydroxyalkyl or amino; andN is 1 or 2, with the proviso that when n is2, X, Y, R.sub.1 and R.sub.2 cannot all be hydrogen atoms, as well as the salts thereof with inorganic and organic acids; are outstandingly effective indicators for the determination of glucose and provide stable compositions for such glucose determination.
摘要翻译：新型3-氨基咔唑化合物，具有下式：

9. 发明授权

US4219336A Diagnostic agent and method for the detection of occult blood in feces 失效
标题翻译：用于检测粪便中隐匿性血液的诊断剂和方法
公开(公告)号：US4219336A
公开(公告)日：1980-08-26
申请号：US892359
申请日：1978-03-31
申请人： Werner Guthlein , Hans Wielinger , Walter Rittersdorf , Wolfgang Werner
发明人： Werner Guthlein , Hans Wielinger , Walter Rittersdorf , Wolfgang Werner
IPC分类号： G01N33/50 , A61K36/18 , C07G99/00 , C12Q1/28 , G01N33/72 , G01N33/16
CPC分类号： C12Q1/28 , G01N33/725 , C12Q2326/00 , Y10S436/904
摘要： A diagnostic agent for the detection of occult blood in feces comprising hydrogen peroxide and, as a chromogen, guaiaconic acid A, optionally with a stabilizer. The invention provides, as a novel substance, guaiaconic acid A having a specific extinction E.sub.1 cm.sup.1% at 600 nm of at least 200, determined by the reaction with peroxidase and hydrogen peroxide, having infra-red bands at1600 cm.sup.-1 (m);1505 cm.sup.-1 (v.s.);1260 cm.sup.-1 (s;b);1115 cm.sup.-1 (m);1025 cm.sup.-1 (m); and1200 cm.sup.-1 (s;b)and having an R.sub.F value of 0.45 (toluene/dioxan/glacial acetic acid; 90:25:10 v/v/v).
摘要翻译：用于检测粪便中的潜血的诊断剂，其包含过氧化氢和任选地与稳定剂作为色原，愈创木酸A。本发明提供作为新物质，通过与过氧化物酶和过氧化氢的反应确定在600nm处具有600nm以上的具有特定消光度E1cm1％的愈创木酸A至少为200，在1600cm -1处具有红外线

10. 发明授权

US4385114A Oxidation indicators comprising 3,3',5,5'-tetraalkylbenzidine compounds 失效
标题翻译：包含3,3'，5,5'-四烷基联苯胺化合物的氧化指示剂
公开(公告)号：US4385114A
公开(公告)日：1983-05-24
申请号：US236487
申请日：1981-02-23
申请人： Werner Guthlein , Walter Rittersdorf , Hugo Tiedemann , Peter Vogel , Wolfgang Werner
发明人： Werner Guthlein , Walter Rittersdorf , Hugo Tiedemann , Peter Vogel , Wolfgang Werner
IPC分类号： C07C211/50 , C07C67/00 , C07C209/00 , C07C209/54 , C12Q1/00 , C12Q1/26 , C12Q1/28 , G01N21/78 , G01N31/00 , G01N31/22 , G01N33/50 , C12Q1/60 , C12Q1/62
CPC分类号： C12Q1/26 , C12Q1/28 , G01N31/228 , C12Q2326/10 , C12Q2326/12 , Y10S435/805 , Y10S436/81 , Y10T436/144444 , Y10T436/206664
摘要： The detection and determination of (a) hydrogen peroxide or of a substance which reacts with the formation of hydrogen peroxide or (b) of peroxidase or a peroxidatively active substance, is carried out by contacting an unknown sample with a chromogen and, in case (a), with a peroxidatively active substance or in case (b) with hydrogen peroxide or a substance which reacts with the formation of hydrogen peroxide, and evaluating the coloration produced by the reaction, wherein, as the chromogen, there is used at least one 3,3',5,5'-tetraalkylbenzidine compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which can be the same or different, are straight-chained or branched alkyl radicals containing up to 6 and preferably up to 4 carbon atoms.
摘要翻译：（a）过氧化氢或与过氧化氢或过氧化物酶或过氧化物活性物质的（b）反应形成的物质的检测和测定是通过将未知样品与色原体接触进行的，如果（ a），具有过氧化活性物质或在（b）过氧化氢或与形成过氧化氢反应的物质的情况下，以及评价由反应产生的着色，其中作为色原，使用至少一种具有下式的3,3'，5,5'-四烷基联苯胺化合物：其中R 1，R 2，R 3和R 4可以相同或不同，是含有至多6个的直链或支链烷基，优选最多4个碳原子。

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