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1. 发明申请

US20120135973A1 METHOD FOR TREATING CHRONIC PAIN 审中-公开
标题翻译：治疗慢性疼痛的方法
公开(公告)号：US20120135973A1
公开(公告)日：2012-05-31
申请号：US13227842
申请日：2011-09-08
申请人： Daniela Salvemini , William L. Neumann , Smita Rausaria
发明人： Daniela Salvemini , William L. Neumann , Smita Rausaria
IPC分类号： A61K31/555 , A61P25/00 , A61P25/04 , C07F13/00
CPC分类号： A61K9/0053 , A61K31/40 , A61K31/555 , A61K45/06 , C07D219/08 , C07D471/22 , C07D487/22 , C07D491/22 , C07D513/22 , C07D517/22
摘要： The present invention provides analgesic compounds comprising at least one modified metalloporphyrin compound. Also provided are methods of treating pain by orally administering an analgesic compounds comprising at least one modified metalloporphyrin compound.
摘要翻译：本发明提供包含至少一种改性金属卟啉化合物的止痛化合物。还提供了通过口服施用包含至少一种改性金属卟啉化合物的止痛化合物来治疗疼痛的方法。

2. 发明申请

US20080318917A1 POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS 有权
标题翻译：聚乙烯甘油超氧化物歧化酶
公开(公告)号：US20080318917A1
公开(公告)日：2008-12-25
申请号：US11766221
申请日：2007-06-21
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： A61K31/555 , A61P25/00 , A61P37/00 , C07D259/00
CPC分类号： A61K47/60
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide, dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了用于制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物反应，模拟物歧化酶，或者将超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

3. 发明授权

US06214817B1 Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity 有权
标题翻译：具有超氧化物歧化酶活性的取代的吡啶并五氮杂胞苷复合物
公开(公告)号：US06214817B1
公开(公告)日：2001-04-10
申请号：US09398120
申请日：1999-09-16
申请人： Dennis P. Riley , William L. Neumann , Susan L. Henke , Patrick Lennon , Karl W. Aston , Daniela Salvemini , James A. Sikorski , Yvette M. Fobian , Margaret Lanahan Grapperhaus , Carrie L. Kusturin
发明人： Dennis P. Riley , William L. Neumann , Susan L. Henke , Patrick Lennon , Karl W. Aston , Daniela Salvemini , James A. Sikorski , Yvette M. Fobian , Margaret Lanahan Grapperhaus , Carrie L. Kusturin
IPC分类号： C07D48722
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
摘要翻译：本发明涉及有效作为用于分解超氧化物的催化剂的化合物，更具体地说，涉及催化分解超氧化物的取代的，不饱和杂环五氮杂环十五烷配体的锰或铁络合物。

4. 发明申请

US20120301403A1 POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS 审中-公开
标题翻译：聚乙烯甘油超氧化物歧化酶
公开(公告)号：US20120301403A1
公开(公告)日：2012-11-29
申请号：US13526111
申请日：2012-06-18
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： A61K31/28 , A61P29/00 , A61P1/00 , A61P19/02 , A61P9/12 , A61P17/06 , A61P37/06 , A61P7/02 , A61P37/00 , A61P11/00 , A61P25/00 , A61P25/04 , A61P31/00 , A61K49/00 , C12Q1/18 , A61P9/10
CPC分类号： C12N9/0089 , A61K47/60 , C12Q1/26 , C12Q1/28 , G01N33/5014
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物歧化酶模拟物反应，或者使超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

5. 发明授权

US08217166B2 Polyethylene glycolated superoxide dismutase mimetics 有权
标题翻译：聚乙烯甘氨酸超氧化物歧化酶模拟物
公开(公告)号：US08217166B2
公开(公告)日：2012-07-10
申请号：US11766221
申请日：2007-06-21
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： A61K47/60
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物歧化酶模拟物反应，或者使超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

6. 发明申请

US20180335385A1 Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH 审中-公开
公开(公告)号：US20180335385A1
公开(公告)日：2018-11-22
申请号：US15902759
申请日：2018-02-22
申请人： Karen L. Wooley , Richard B. Dorshow , John N. Freskos , William L. Neumann , Jeng J. Shieh , Nam S. Lee , Yun Lin , Guorong Sun
发明人： Karen L. Wooley , Richard B. Dorshow , John N. Freskos , William L. Neumann , Jeng J. Shieh , Nam S. Lee , Yun Lin , Guorong Sun
IPC分类号： G01N21/64 , G01N21/75 , G01N33/84 , C08F8/00 , A61B5/145 , G01N33/58 , A61K49/00 , A61B5/1455 , C08F293/00
CPC分类号： G01N21/6486 , A61B5/14539 , A61B5/1455 , A61K49/0021 , A61K49/0082 , A61K49/0093 , C08F8/00 , G01N21/75 , G01N33/582 , G01N33/84 , C08F293/005
摘要： Fluorescence methods and systems that use an optical agent for measuring the pH of a fluid. The optical agent is a photonic nanostructure having a supramolecular structure, such as a shell cross-linked micelle that incorporates at least one linking group that includes one or more photoactive moieties.

7. 发明申请

US20100233091A1 Pyrazine Derivatives with Extended Conjugation and Methods of Using the same in Optical Applications 有权
标题翻译：具有扩展共轭的吡嗪衍生物及其在光学应用中的使用方法
公开(公告)号：US20100233091A1
公开(公告)日：2010-09-16
申请号：US12305700
申请日：2007-06-20
申请人： William L. Neumann , Raghavan Rajagopalan , Richard B. Dorshow
发明人： William L. Neumann , Raghavan Rajagopalan , Richard B. Dorshow
IPC分类号： A61K49/00 , A61K31/497 , A61K31/5377 , A61K31/4965 , A61P13/12
CPC分类号： C07D405/04 , A61K49/0021 , C07D241/12 , C07D241/20 , C07D241/24 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/04 , C07D417/04 , C07D473/18 , C07D473/34
摘要： The present invention relates to pyrazine derivatives capable of absorbing and emanating spectral energy in the visible and/or near infrared spectrum. Pyrazine derivatives of the invention may be administered to a patient in the form of a pharmaceutically acceptable composition and utilized in medical (e.g., diagnostic imaging) procedures.
摘要翻译：本发明涉及能够吸收和发出可见光和/或近红外光谱中的光谱能量的吡嗪衍生物。本发明的吡嗪衍生物可以以药学上可接受的组合物的形式施用于患者，并用于医学（例如，诊断成像）程序中。

8. 发明申请

US20100021382A1 Pyrazine Derivatives and Uses Thereof 有权
标题翻译：吡嗪衍生物及其用途
公开(公告)号：US20100021382A1
公开(公告)日：2010-01-28
申请号：US12351891
申请日：2009-01-12
申请人： Richard B. Dorshow , John Freskos , William L. Neumann , Amruta Reddy Poreddy , Raghavan Rajagopalan
发明人： Richard B. Dorshow , John Freskos , William L. Neumann , Amruta Reddy Poreddy , Raghavan Rajagopalan
IPC分类号： A61K49/00 , C07D241/20 , A61P13/12
CPC分类号： C07D241/28
摘要： Disclosed herein are pyrazine derivatives and methods of using the same.
摘要翻译：本文公开的是吡嗪衍生物及其使用方法。

9. 发明授权

US07015223B1 Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade 失效
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基1,2,4-三嗪酮
公开(公告)号：US07015223B1
公开(公告)日：2006-03-21
申请号：US10275856
申请日：2000-11-20
申请人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
发明人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
IPC分类号： C07D253/07 , C07D413/02 , A61K31/53 , A61P7/02
CPC分类号： C07D401/04
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译：本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

10. 发明授权

US06969715B2 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade 失效
标题翻译：可用于选择性抑制凝血级联的6元杂环化合物
公开(公告)号：US06969715B2
公开(公告)日：2005-11-29
申请号：US10263637
申请日：2002-10-03
申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
IPC分类号： C07D249/12 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/513 , A61K31/53 , A61K31/535 , A61K45/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07C257/18 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

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