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1. 发明申请

US20160215254A1 SYSTEM AND METHOD FOR LASER LYSIS 审中-公开
标题翻译：激光雷达系统和方法
公开(公告)号：US20160215254A1
公开(公告)日：2016-07-28
申请号：US14909195
申请日：2014-09-23
申请人： Deirdre MELDRUM , Shih-Hui (Joseph) CHAO , Thai TRAN , Laimonas BAUSKAS , Jeff HOUKAL , Andrew HATCH , Weimin GAO , David Wayne RICHARDSON
发明人： Deirdre Meldrum , Shih-Hui (Joseph) Chao , Thai Tran , Laimonas Kelbauskas , Jeff Houkal , Andrew Hatch , Weimin Gao , David Richardson
IPC分类号： C12M1/00 , G01N1/28 , C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/0293 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , C12M47/06 , C12Q1/6841 , C12Q1/6848 , C12Q1/686 , G01N1/286 , G01N2001/2886 , C12Q2547/101
摘要： The present invention provides a system and method for lysing individual cells in situ, including the steps of capturing a tissue sample comprising a cellular content, subjecting the tissue sample to a stream of continuous fluid flow, lysing a selected area of the tissue sample with a laser, thereby releasing at least a portion of the cellular content from the tissue sample, recovering at least one target molecule from the cellular content in the stream, and processing the at least one target molecule.
摘要翻译：本发明提供了一种用于原位裂解个体细胞的系统和方法，包括以下步骤：捕获包含细胞内容物的组织样品，使组织样品经受连续流体流动的流动，将组织样品的选定区域用激光，从而从组织样品中释放至少一部分细胞含量，从流中的细胞含量回收至少一种靶分子，以及处理该至少一种靶分子。

2. 发明申请

US20150133757A1 Endoscope for Analyte Consumption Rate Determination with Single Cell Resolution for In Vivo Applications 有权
标题翻译：用于体内应用的单细胞分辨率的分析物消耗率测定的内窥镜
公开(公告)号：US20150133757A1
公开(公告)日：2015-05-14
申请号：US14538557
申请日：2014-11-11
申请人： Deirdre Meldrum , Laimonas Kelbauskas , Jeff Houkal , Roger Johnson , Yanqing Tian , Cody Youngbull
发明人： Deirdre Meldrum , Laimonas Kelbauskas , Jeff Houkal , Roger Johnson , Yanqing Tian , Cody Youngbull
IPC分类号： A61B5/1459 , A61B1/07
CPC分类号： A61B5/1459 , A61B5/1455 , A61B5/6847
摘要： Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.
摘要翻译：包括使用光纤技术的改进的内窥镜和多个外在光学传感器的新型方法和装置，用于实现同时测定生物分析物在体内的单细胞分辨率的变化率。这些装置采用动态振荡致动来确定相对于电池的一个或多个方向的感兴趣的分析物的梯度。感兴趣的分析物的变化率或通量可以很容易地通过应用与流量和浓度梯度相关的第一个菲克定律来确定。器件的双重工作模式显着提高了测量灵敏度和精度。

3. 发明授权

US09597026B2 Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications 有权
公开(公告)号：US09597026B2
公开(公告)日：2017-03-21
申请号：US14538557
申请日：2014-11-11
申请人： Deirdre Meldrum , Laimonas Kelbauskas , Jeff Houkal , Roger Johnson , Yanqing Tian , Cody Youngbull
发明人： Deirdre Meldrum , Laimonas Kelbauskas , Jeff Houkal , Roger Johnson , Yanqing Tian , Cody Youngbull
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/1455 , A61B5/6847
摘要： Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.

4. 发明授权

US11045807B2 Integrated platform for characterization of single cells or small cell clusters 有权
公开(公告)号：US11045807B2
公开(公告)日：2021-06-29
申请号：US16479729
申请日：2018-02-26
申请人： Deirdre Meldrum , Laimonas Kelbauskas , Yanqing Tian , Honor Glenn , Clifford Anderson , Kristen Lee , Ganquan Song , Liqiang Zhang , Jeff Houkal , Fengyu Su , Benjamin Ueberroth , Jacob Messner , Hong Wang , Kimberly Bussey
发明人： Deirdre Meldrum , Laimonas Kelbauskas , Yanqing Tian , Honor Glenn , Clifford Anderson , Kristen Lee , Ganquan Song , Liqiang Zhang , Jeff Houkal , Fengyu Su , Benjamin Ueberroth , Jacob Messner , Hong Wang , Kimberly Bussey
IPC分类号： B01L3/00 , G01N15/14 , G02B21/34 , G01N15/10
摘要： An integrated technological platform enabling real-time quantitative multiparameter metabolic profiling, utilizing either or both of extra and intracellular optical sensors, individually or simultaneously. A scalable embedded micropocket array structure, generally fabricated on fused silica substrates, facilitates the integration of multiple, spatially separated extracellular sensors for multiparameter analysis in a container formed with the use of an activation mechanism forming part of a device configured to hold the container during the measurements. The creation of hermetically sealed microchambers is carried out with a pneumatically and/or mechanically and/or electromechanically driven device that is “floating” within the holding device and that is optionally equipped with a vacuum/suction mechanism to hold a component of the container at its surface.

5. 外观设计

USD732187S1 Aliquot tray 有权
标题翻译：等分盘
公开(公告)号：USD732187S1
公开(公告)日：2015-06-16
申请号：US29445084
申请日：2013-02-07
申请人： Jeff Houkal , Jordan Yaron
设计人： Jeff Houkal , Jordan Yaron

6. 发明申请

US20120231533A1 DEVICE AND METHOD FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
标题翻译：用于细胞和组织功能研究的装置和方法
公开(公告)号：US20120231533A1
公开(公告)日：2012-09-13
申请号：US13126700
申请日：2009-10-28
申请人： Mark R. Holl , Deirdre R. Meldrum , A. Cody Youngbull , Haixin Zhu , Jeff Houkal , Yanqing Tian , Shashanka Ashili , Laimonas Kelbauskas , Roger Johnson , Shih-hui Chao , Peter Wiktor , Alex Jen , Lloyd Burgess , Sarah McQuaid , Ai Brunner , Peter Kahn
发明人： Mark R. Holl , Deirdre R. Meldrum , A. Cody Youngbull , Haixin Zhu , Jeff Houkal , Yanqing Tian , Shashanka Ashili , Laimonas Kelbauskas , Roger Johnson , Shih-hui Chao , Peter Wiktor , Alex Jen , Lloyd Burgess , Sarah McQuaid , Ai Brunner , Peter Kahn
IPC分类号： C12M1/34
CPC分类号： C12M23/16 , C12M23/12 , C12M23/22 , C12M23/38 , C12M41/46
摘要： A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when closed and in use, the sensor remains spatially apart from the at least one cell.
摘要翻译：用于分析活细胞的室装置。腔室装置包括底座和盖子，当可逆地按压时，盖子产生一个腔室。基底配置有光学透明的孔以容纳至少一个细胞。盖子的宽度大于基座，并被配置成包含至少一个传感器。盖子进一步配置有唇部，当在盖子和基座之间被按压时，唇部产生不可渗透的密封。底座和盖被构造成使得当关闭并且在使用中时，传感器在空间上保持与至少一个单元隔开。

7. 发明申请

US20090140570A1 REMOVABLE WHEEL SYSTEM 审中-公开
标题翻译：可拆卸车轮系统
公开(公告)号：US20090140570A1
公开(公告)日：2009-06-04
申请号：US12363622
申请日：2009-01-30
申请人： Jeff Houkal
发明人： Jeff Houkal
IPC分类号： B60B37/00
CPC分类号： A63C17/01 , A63C17/0093 , A63C17/226
摘要： The present invention is directed to devices having wheels, and more specifically, a method and device for making the wheels readily detachable and interchangeable by users. The removable wheel system comprises a removable axle, a wheel, an optional shield, and a hangar to be assembled in connection with a skateboard. The present invention provides a wheel and hangar using a removable axle for a removable wheel system that is easily removable, replaceable, durable, and protectable against dust accumulation while providing the strength necessary to withstand the rigors and stresses imposed on the system during use.
摘要翻译：本发明涉及具有车轮的装置，更具体地说，涉及用于使车轮易于拆卸和使用者互换的方法和装置。可拆卸车轮系统包括可移动轴，车轮，可选的护罩和与滑板相连接组装的机库。本发明提供了一种车轮和机库，其使用可拆卸车轮系统的可拆卸车轮，其可以容易地移除，可替换，耐用和可防止灰尘积聚，同时提供在使用期间承受严格条件和施加在系统上的应力所必需的强度。

8. 发明申请

US20060131826A1 Removable wheel system 审中-公开
标题翻译：可拆卸轮系
公开(公告)号：US20060131826A1
公开(公告)日：2006-06-22
申请号：US11312798
申请日：2005-12-20
申请人： Von Schonblom , Jeff Houkal
发明人： Von Schonblom , Jeff Houkal
IPC分类号： B62M1/00
CPC分类号： A63C17/01 , A63C17/0093 , A63C17/226
摘要： The present invention is directed to devices having wheels, and specifically, a method and device for making the wheels easily detachable and interchangeable.
摘要翻译：本发明涉及具有车轮的装置，具体地说，涉及用于制造车轮容易拆卸和互换的方法和装置。

9. 外观设计

USD841832S1 Aliquot tray 有权
公开(公告)号：USD841832S1
公开(公告)日：2019-02-26
申请号：US29594415
申请日：2017-02-17
申请人： Jeff Houkal , Jordan Yaron
设计人： Jeff Houkal , Jordan Yaron

10. 发明申请

US20110275117A1 PHOTOBIOREACTOR SYSTEM WITH HIGH SPECIFIC GROWTH RATE AND LOW DILUTION RATE 审中-公开
标题翻译：具有高特异性生长速率和低稀释率的光电离子体系统
公开(公告)号：US20110275117A1
公开(公告)日：2011-11-10
申请号：US13123057
申请日：2009-10-06
申请人： Bruce E. Rittman , Chao Zhou , Raveender Vannela , Mark Holl , Jeff Houkal , Rhett Martineau
发明人： Bruce E. Rittman , Chao Zhou , Raveender Vannela , Mark Holl , Jeff Houkal , Rhett Martineau
IPC分类号： C12P1/00 , C12M1/12 , C12M1/36 , C12N1/12
CPC分类号： C12N1/12 , C12M21/02 , C12M29/02 , C12M31/04 , C12M33/14 , C12M41/08
摘要： Systems and methods for growing photosynthetic cells that may be used to produce a biomass. The systems and methods recycle liquid and can produce a high cell concentration harvested biomass.
摘要翻译：用于生长可用于生产生物质的光合细胞的系统和方法。系统和方法回收液体，可以产生高细胞浓度的生物量。

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