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1. 发明申请

US20110275117A1 PHOTOBIOREACTOR SYSTEM WITH HIGH SPECIFIC GROWTH RATE AND LOW DILUTION RATE 审中-公开
标题翻译：具有高特异性生长速率和低稀释率的光电离子体系统
公开(公告)号：US20110275117A1
公开(公告)日：2011-11-10
申请号：US13123057
申请日：2009-10-06
申请人： Bruce E. Rittman , Chao Zhou , Raveender Vannela , Mark Holl , Jeff Houkal , Rhett Martineau
发明人： Bruce E. Rittman , Chao Zhou , Raveender Vannela , Mark Holl , Jeff Houkal , Rhett Martineau
IPC分类号： C12P1/00 , C12M1/12 , C12M1/36 , C12N1/12
CPC分类号： C12N1/12 , C12M21/02 , C12M29/02 , C12M31/04 , C12M33/14 , C12M41/08
摘要： Systems and methods for growing photosynthetic cells that may be used to produce a biomass. The systems and methods recycle liquid and can produce a high cell concentration harvested biomass.
摘要翻译：用于生长可用于生产生物质的光合细胞的系统和方法。系统和方法回收液体，可以产生高细胞浓度的生物量。

2. 发明申请

US20120138469A1 MICROFLUIDIC DEVICES FOR TRANSVERSE ELECTROPHORESIS AND ISOELECTRIC FOCUSING 审中-公开
标题翻译：用于横向电泳和电致电聚焦的微流体装置
公开(公告)号：US20120138469A1
公开(公告)日：2012-06-07
申请号：US11939292
申请日：2007-11-13
申请人： Paul Yager , Mark Holl , Darrel J. Bell , James Brody , Catherine R. Cabrera , Andrew E. Kamholz , Katerina Macounova , Dong Qin
发明人： Paul Yager , Mark Holl , Darrel J. Bell , James Brody , Catherine R. Cabrera , Andrew E. Kamholz , Katerina Macounova , Dong Qin
IPC分类号： B01D57/02
CPC分类号： G01N27/44795 , G01N27/44769
摘要： Devices and methods are provided for separation of particles of a first selected electrophoretic mobility or isoelectric point from a fluid comprising particles of at least one other selected electrophoretic mobility or isoelectric point. The devices comprise a microchannel; electrodes to either side of the microchannel for applying a selected voltage to produce an electrical field across the microchannel orthogonal to the length of the microchannel; and outlets in said microchannel placed to receive outlet portions of the fluid containing enhanced concentrations of each type of particle. The devices may be used for particle detection, quantification, separation, mixing, dilution and concentration; to release, separate and detect interior particles of cells or organisms, and to separate particles such as proteins and microorganisms from biological fluids such as blood; or to separate and detect airborne contaminants such as bacterial warfare agents from air.
摘要翻译：提供了设备和方法，用于从包含至少一个其它选择的电泳迁移率或等电点的颗粒的流体分离第一选择的电泳迁移率或等电点的颗粒。所述装置包括微通道; 电极到微通道的任一侧，用于施加所选择的电压，以跨过与微通道长度正交的微通道产生电场; 并且所述微通道中的出口被设置成接收含有增强浓度的每种类型的颗粒的流体的出口部分。该装置可用于颗粒检测，定量，分离，混合，稀释和浓缩; 释放，分离和检测细胞或生物体的内部颗粒，并将诸如蛋白质和微生物的颗粒与生物液体如血液分离; 或从空气中分离和检测空气污染物，如细菌战剂。

3. 发明申请

US20050070944A1 Method and apparatus for isolating cell nuclei from biopsy obtained tissue 审中-公开
标题翻译：用于从活组织检查获得的组织中分离细胞核的方法和装置
公开(公告)号：US20050070944A1
公开(公告)日：2005-03-31
申请号：US10847950
申请日：2004-05-14
申请人： Mark Holl , Andrew Miller , Matthew Stanton , Carissa Sanchez , Thomas Paulson , Brian Reid , Deirdre Meldrum
发明人： Mark Holl , Andrew Miller , Matthew Stanton , Carissa Sanchez , Thomas Paulson , Brian Reid , Deirdre Meldrum
IPC分类号： A61B17/14 , C12M3/08
CPC分类号： C12M47/06
摘要： A rotor (14) is located within a rotor chamber (12) formed in a housing (24). A drive shaft (16) extends from a motor and couples to the drive shaft interconnect (46) at the center of the rotor (14). One side of the rotor (14) is provided with circumferentially spaced apart radial rows of mincing edges (20). These edges (20) are situated on concentric circles or on a spiral. They are elongated circumferentially and may be situated substantially on an arc and substantially on an arc or on a chord. During use, the rotor (14) is rotated after biopsy obtained tissue (10) has been placed in the rotor chamber (12) on the side of the rotor (14) that includes the mincing edges (20). A fluid is delivered into and out from the rotor chamber (12) as the rotor (14) is being rotated to mince the biopsy, lyse the cells, and release the cell nuclei from the obtained tissue. Cell nuclei are expelled from the chamber (12) and are moved through a filter (58). The cell nuclei are collected and then delivered to a flow cytometry apparatus to be analyzed.
摘要翻译：转子（14）位于形成在壳体（24）内的转子室（12）内。驱动轴（16）从马达延伸并在转子（14）的中心处联接到驱动轴互连（46）。转子（14）的一侧设置有周向间隔开的排列的切割边缘（20）。这些边缘（20）位于同心圆或螺旋上。它们沿周向延伸并且可以基本上位于弧形上并且基本上位于弧形或弦上。在使用过程中，在活组织检查后，转子（14）在组装（10）被放置在转子室（12）的转子（14）的包括切碎边缘（20）的侧面上后旋转。当转子（14）旋转时，将流体输送到转子室（12）中并使其流出，从而破坏活组织检查，裂解细胞，并从获得的组织释放细胞核。细胞核从腔室（12）排出并移动通过过滤器（58）。收集细胞核，然后送至流式细胞术仪器进行分析。

4. 发明申请

US20070031819A1 Microfluidic systems for biological and molecular analysis and methods thereof 审中-公开
标题翻译：用于生物和分子分析的微流体系统及其方法
公开(公告)号：US20070031819A1
公开(公告)日：2007-02-08
申请号：US11412819
申请日：2006-04-26
申请人： John Koschwanez , Mark Holl , Robert Carlson , Michael McMurray , Daniel Gottschling , Deirdre Meldrum
发明人： John Koschwanez , Mark Holl , Robert Carlson , Michael McMurray , Daniel Gottschling , Deirdre Meldrum
IPC分类号： C12Q1/00 , G06K9/00 , C12M1/34
CPC分类号： G06K9/00127 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487 , G01N33/54326 , G01N33/585
摘要： Disclosed herein are systems, components, devices and methods for automated yeast pedigree analysis. Systems, components, devices and methods for analyzing microorganisms, cells, particles and molecules are also disclosed.
摘要翻译：本文公开了用于自动化酵母谱系分析的系统，组件，装置和方法。还公开了用于分析微生物，细胞，颗粒和分子的系统，组件，装置和方法。

5. 发明申请

US20060127275A1 Liquid analysis cartridge 有权
标题翻译：液体分析盒
公开(公告)号：US20060127275A1
公开(公告)日：2006-06-15
申请号：US11195328
申请日：2005-08-02
申请人： Mark Holl , Floyd Edwards , Robert Morff , Gerald Klein
发明人： Mark Holl , Floyd Edwards , Robert Morff , Gerald Klein
IPC分类号： G01N33/00
CPC分类号： B01L3/502707 , B01F5/0646 , B01F5/0647 , B01F5/0648 , B01F13/0059 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502776 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0655 , G01N15/14 , Y10T156/1064 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management. The analysis cartridge can be a self-contained disposable cartridge having an integral waste storage container. This invention further provides a sheath flow assembly. The sheath flow assembly includes a sample channel and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly also includes upper and lower sheath fluid chambers positioned above and below and converging with the sample channel. The flow cartridges of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated. This invention further provides a method of fabricating a laminated microfluidic flow device. In the method, flow elements are formed in rigid sheets and abutting surfaces of the sheets are bonded together.
摘要翻译：本发明提供一种用于储存含颗粒的液体的装置和方法。存储装置包括具有多个颗粒捕获区域的微流体回旋流动通道。存储通道优选地是各向同性的空间周期性通道。沉淀的颗粒可以在储存后重新悬浮。本发明还提供一种其中具有回旋存储通道的微流体分析盒。样品分析可以使用光学，电气，压力敏感或流量敏感检测。多个分析通道可以包括在单个盒中。分析通道可以连接到用于稀释剂，指示剂或裂解剂的试剂入口。混合通道可以位于试剂入口和分析区域之间，以允许试剂混合和反应。墨盒可以包括用于流量管理的附加阀和泵。分析盒可以是具有一体式废物储存容器的独立的一次性盒。本发明还提供一种鞘流组件。护套流动组件包括样品通道和位于样品通道两侧并与样品通道收敛的第一和第二鞘液通道。组件还包括位于上方和下方的上部和下部鞘液室，并与样品通道会聚。本发明的流动筒可以通过模制，机加工或蚀刻来形成。在优选实施例中，它们被层压。本发明还提供一种制造层压微流体流动装置的方法。在该方法中，流动元件形成为刚性片，并且片材的邻接表面粘合在一起。

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