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1. 发明申请

US20070000866A1 Patterning and alteration of molecules 有权
标题翻译：分子的形成和改变
公开(公告)号：US20070000866A1
公开(公告)日：2007-01-04
申请号：US11401485
申请日：2006-04-10
申请人： Declan Ryan , Babak Amir-Parviz , Vincent Linder , Vincent Semetey , Samuel Sia , George Whitesides
发明人： Declan Ryan , Babak Amir-Parviz , Vincent Linder , Vincent Semetey , Samuel Sia , George Whitesides
IPC分类号： C23F1/00 , H01L21/302 , B44C1/22
CPC分类号： G03F7/165 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B82Y5/00 , B82Y30/00 , C03C17/28 , C03C23/0005 , C03C2218/32 , C40B80/00 , G03F7/203
摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.
摘要翻译：本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

2. 发明申请

US20060138083A1 Patterning and alteration of molecules 审中-公开
标题翻译：分子的形成和改变
公开(公告)号：US20060138083A1
公开(公告)日：2006-06-29
申请号：US11222500
申请日：2005-09-08
申请人： Declan Ryan , Babak Amirparviz , Vincent Linder , Vincent Semetey , Samuel Sia , Jing Su , Milan Mrksich , George Whitesides
发明人： Declan Ryan , Babak Amirparviz , Vincent Linder , Vincent Semetey , Samuel Sia , Jing Su , Milan Mrksich , George Whitesides
IPC分类号： C23F1/00 , B44C1/22 , C03C25/68 , G03F1/00
CPC分类号： G03F7/165 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B82Y5/00 , B82Y30/00 , C03C17/28 , C03C23/0005 , C03C2218/32 , C40B80/00 , G03F7/203
摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.
摘要翻译：本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

3. 发明申请

US20070298433A1 Assay Device and Method 有权
标题翻译：测定装置和方法
公开(公告)号：US20070298433A1
公开(公告)日：2007-12-27
申请号：US10584819
申请日：2004-12-29
申请人： Samuel Sia , Vincent Linder , Adam Siegel , George Whitesides , Babak Amir-Parviz
发明人： Samuel Sia , Vincent Linder , Adam Siegel , George Whitesides , Babak Amir-Parviz
IPC分类号： G01N33/566 , G01N33/20 , G01N33/53
CPC分类号： G01N33/56988 , B01L3/502707 , B01L2300/0822 , B01L2300/168 , G01N21/05 , G01N21/59 , G01N33/5302 , G01N33/543 , G01N33/585 , G01N2021/0346 , Y10T436/11 , Y10T436/117497 , Y10T436/118339
摘要： An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion (140) of a surface (130) of a microfluidic chamber (120,122,124); passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
摘要翻译：描述了测定方法，其包括以下步骤：将待检测分析物（例如，抗体或抗原）的结合配偶体（例如，抗原或抗体）固定在表面（130）的部分（140）上微流体室（120,122,124）; 将流体样品通过表面并允许分析物结合到结合配偶体; 允许金属胶体，例如金共轭抗体与结合的分析物缔合; 在表面上流动金属溶液，例如银溶液，以形成不透明的金属层; 并且例如通过目视检查或通过在将金属溶液流过表面之后测量金属溶液中的层的透光率，层的导电性或电阻或金属浓度来检测所述金属层的存在。

4. 发明申请

US20080038839A1 Fluid Delivery System And Method 有权
标题翻译：流体输送系统和方法
公开(公告)号：US20080038839A1
公开(公告)日：2008-02-14
申请号：US10587156
申请日：2005-01-26
申请人： Vincent Linder , Samuel Sia , George Whitesides
发明人： Vincent Linder , Samuel Sia , George Whitesides
IPC分类号： G01N33/566 , B01J19/00 , B01L11/00 , B05D5/06 , G01N1/00 , G01N21/01 , G01N33/553
CPC分类号： B01L3/0293 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , G01N21/11 , G01N33/54366 , G01N33/54386 , G01N33/553 , G01N35/08 , G01N35/1002 , Y10T436/25
摘要： A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.
摘要翻译：一种用于递送一种或多种流体的方法和装置。流体可以从普通容器依次递送到化学，生物或生化过程。

5. 发明申请

US20100239833A9 Elastomeric mask and use in fabrication of devices 审中-公开
标题翻译：弹性面膜和用于制造器件
公开(公告)号：US20100239833A9
公开(公告)日：2010-09-23
申请号：US11890326
申请日：2007-08-06
申请人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
发明人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
IPC分类号： B32B27/32
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/3211 , H01L27/3244 , H01L27/3281 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后通过上掩模的重新定向以暴露不同的一组下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

6. 发明申请

US20080063851A1 Elastomeric mask and use in fabrication of devices 审中-公开
标题翻译：弹性面膜和用于制造器件
公开(公告)号：US20080063851A1
公开(公告)日：2008-03-13
申请号：US11890326
申请日：2007-08-06
申请人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
发明人： Rebecca Jackman , David Duffy , George Whitesides , Kathleen Vaeth , Klavs Jensen
IPC分类号： B32B27/32
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/3211 , H01L27/3244 , H01L27/3281 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后通过上掩模的重新定向以暴露不同的一组下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

7. 发明申请

US20060210595A1 Device containing cytophilic islands that adhere cells separated by cytophobic regions 失效
公开(公告)号：US20060210595A1
公开(公告)日：2006-09-21
申请号：US11331849
申请日：2006-01-13
申请人： Rahul Singhvi , Amit Kumar , George Whitesides , Donald Ingber , Gabriel Lopez , Daniel Wang , Gregory Stephanopoulos
发明人： Rahul Singhvi , Amit Kumar , George Whitesides , Donald Ingber , Gabriel Lopez , Daniel Wang , Gregory Stephanopoulos
IPC分类号： A61F2/06 , A61F13/00
CPC分类号： C12N1/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B81B2201/0214 , B81C1/00206 , B81C2201/034 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N5/067 , C12N2535/10 , C12Q1/02 , C40B60/14
摘要： The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).

8. 发明授权

US06228248B1 Biomimetic pathways for assembling inorganic thin films and oriented mesoscopic silicate patterns through guided growth 失效
公开(公告)号：US06228248B1
公开(公告)日：2001-05-08
申请号：US09291549
申请日：1999-04-14
申请人： Ilhan A. Aksay , Mathias Trau , Srinivas Manne , Itaru Honma , George Whitesides
发明人： Ilhan A. Aksay , Mathias Trau , Srinivas Manne , Itaru Honma , George Whitesides
IPC分类号： C25D100
CPC分类号： C01B33/12 , Y10T428/31598
摘要： A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern. The electric field is sufficient to cause electro-osmotic fluid motion and enhanced rates of fossilization by localized Joule heating.

9. 发明授权

US09682856B2 MEMS force sensors fabricated using paper substrates 有权
公开(公告)号：US09682856B2
公开(公告)日：2017-06-20
申请号：US13557861
申请日：2012-07-25
申请人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
发明人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
IPC分类号： G01P15/12 , B81B7/02 , G01P15/08 , G01P15/18 , G01L1/18 , B81C1/00 , G01G3/13
CPC分类号： B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
摘要： MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.

10. 发明申请

US20080116608A1 Molded waveguides 审中-公开
标题翻译：模制波导
公开(公告)号：US20080116608A1
公开(公告)日：2008-05-22
申请号：US12001564
申请日：2007-12-12
申请人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca Jackman , Xiao-Mei Zhao , Stephen Smith , Mara Prentiss , George Whitesides , Christian Marzolin
发明人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca Jackman , Xiao-Mei Zhao , Stephen Smith , Mara Prentiss , George Whitesides , Christian Marzolin
IPC分类号： B29C45/16
CPC分类号： B81C1/00206 , A61K47/6957 , B01J19/0046 , B01J2219/00382 , B01J2219/00416 , B01J2219/0043 , B01J2219/00466 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00713 , B29C31/04 , B29C33/42 , B29C37/0053 , B29C39/24 , B29C43/021 , B29C67/246 , B29D11/00346 , B29D11/00663 , B29K2105/0002 , B29L2011/0016 , B81B2201/0214 , B81C1/00031 , B81C99/0085 , B81C2201/034 , B82Y30/00 , C40B60/14 , G01N21/7703 , G01N2021/7776 , G02B6/138 , H05K3/0079 , H05K3/061
摘要： Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
摘要翻译：化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。衬底表面可以是平面的或非平面的。聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。可以制作波导阵列，组合化学或生化图谱等。可以通过将由相同的预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生波导和包层的折射率差异。干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。改变和折射率可以通过光化学，化学等方式产生。还公开了传感器，包括生化传感器。

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