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1. 发明申请

US20080038839A1 Fluid Delivery System And Method 有权
标题翻译：流体输送系统和方法
公开(公告)号：US20080038839A1
公开(公告)日：2008-02-14
申请号：US10587156
申请日：2005-01-26
申请人： Vincent Linder , Samuel Sia , George Whitesides
发明人： Vincent Linder , Samuel Sia , George Whitesides
IPC分类号： G01N33/566 , B01J19/00 , B01L11/00 , B05D5/06 , G01N1/00 , G01N21/01 , G01N33/553
CPC分类号： B01L3/0293 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , G01N21/11 , G01N33/54366 , G01N33/54386 , G01N33/553 , G01N35/08 , G01N35/1002 , Y10T436/25
摘要： A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.
摘要翻译：一种用于递送一种或多种流体的方法和装置。流体可以从普通容器依次递送到化学，生物或生化过程。

2. 发明申请

US20060138083A1 Patterning and alteration of molecules 审中-公开
标题翻译：分子的形成和改变
公开(公告)号：US20060138083A1
公开(公告)日：2006-06-29
申请号：US11222500
申请日：2005-09-08
申请人： Declan Ryan , Babak Amirparviz , Vincent Linder , Vincent Semetey , Samuel Sia , Jing Su , Milan Mrksich , George Whitesides
发明人： Declan Ryan , Babak Amirparviz , Vincent Linder , Vincent Semetey , Samuel Sia , Jing Su , Milan Mrksich , George Whitesides
IPC分类号： C23F1/00 , B44C1/22 , C03C25/68 , G03F1/00
CPC分类号： G03F7/165 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B82Y5/00 , B82Y30/00 , C03C17/28 , C03C23/0005 , C03C2218/32 , C40B80/00 , G03F7/203
摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.
摘要翻译：本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

3. 发明申请

US20070298433A1 Assay Device and Method 有权
标题翻译：测定装置和方法
公开(公告)号：US20070298433A1
公开(公告)日：2007-12-27
申请号：US10584819
申请日：2004-12-29
申请人： Samuel Sia , Vincent Linder , Adam Siegel , George Whitesides , Babak Amir-Parviz
发明人： Samuel Sia , Vincent Linder , Adam Siegel , George Whitesides , Babak Amir-Parviz
IPC分类号： G01N33/566 , G01N33/20 , G01N33/53
CPC分类号： G01N33/56988 , B01L3/502707 , B01L2300/0822 , B01L2300/168 , G01N21/05 , G01N21/59 , G01N33/5302 , G01N33/543 , G01N33/585 , G01N2021/0346 , Y10T436/11 , Y10T436/117497 , Y10T436/118339
摘要： An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion (140) of a surface (130) of a microfluidic chamber (120,122,124); passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
摘要翻译：描述了测定方法，其包括以下步骤：将待检测分析物（例如，抗体或抗原）的结合配偶体（例如，抗原或抗体）固定在表面（130）的部分（140）上微流体室（120,122,124）; 将流体样品通过表面并允许分析物结合到结合配偶体; 允许金属胶体，例如金共轭抗体与结合的分析物缔合; 在表面上流动金属溶液，例如银溶液，以形成不透明的金属层; 并且例如通过目视检查或通过在将金属溶液流过表面之后测量金属溶液中的层的透光率，层的导电性或电阻或金属浓度来检测所述金属层的存在。

4. 发明申请

US20070000866A1 Patterning and alteration of molecules 有权
标题翻译：分子的形成和改变
公开(公告)号：US20070000866A1
公开(公告)日：2007-01-04
申请号：US11401485
申请日：2006-04-10
申请人： Declan Ryan , Babak Amir-Parviz , Vincent Linder , Vincent Semetey , Samuel Sia , George Whitesides
发明人： Declan Ryan , Babak Amir-Parviz , Vincent Linder , Vincent Semetey , Samuel Sia , George Whitesides
IPC分类号： C23F1/00 , H01L21/302 , B44C1/22
CPC分类号： G03F7/165 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B82Y5/00 , B82Y30/00 , C03C17/28 , C03C23/0005 , C03C2218/32 , C40B80/00 , G03F7/203
摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.
摘要翻译：本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

5. 发明申请

US20170091379A1 METHODS AND APPARATUSES FOR CONDUCTING ANALYSES 审中-公开
公开(公告)号：US20170091379A1
公开(公告)日：2017-03-30
申请号：US15197148
申请日：2016-06-29
申请人： Andrew J. Vickers , Peter T. Scardino , Hans Lilja , Vincent Linder , David Steinmiller
发明人： Andrew J. Vickers , Peter T. Scardino , Hans Lilja , Vincent Linder , David Steinmiller
IPC分类号： G06F19/18 , G06F19/24 , G01N33/543 , G06F19/00 , C12Q1/68
摘要： Methods and apparatuses for conducting analyses are provided.

6. 发明授权

US08574924B2 Assay device and method 有权
标题翻译：测定装置和方法
公开(公告)号：US08574924B2
公开(公告)日：2013-11-05
申请号：US12769489
申请日：2010-04-28
申请人： Samuel K. Sia , Vincent Linder , Babak Amir-Parviz , Adam Siegel , George M. Whitesides
发明人： Samuel K. Sia , Vincent Linder , Babak Amir-Parviz , Adam Siegel , George M. Whitesides
IPC分类号： G01N33/553
CPC分类号： G01N33/56988 , B01L3/502707 , B01L2300/0822 , B01L2300/168 , G01N21/05 , G01N21/59 , G01N33/5302 , G01N33/543 , G01N33/585 , G01N2021/0346 , Y10T436/11 , Y10T436/117497 , Y10T436/118339
摘要： An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
摘要翻译：描述了一种测定方法，其包括将待检测分析物（例如抗体或抗原）的结合配偶体（例如，抗原或抗体）固定在微流体室表面的一部分上的步骤; 将流体样品通过表面并允许分析物结合到结合配偶体; 允许金属胶体，例如金共轭抗体与结合的分析物缔合; 在表面上流动金属溶液，例如银溶液，以形成不透明的金属层; 并且例如通过目视检查或通过在将金属溶液流过表面之后测量金属溶液中的层的透光率，层的导电性或电阻或金属浓度来检测所述金属层的存在。

7. 发明授权

US08475737B2 Fluidic connectors and microfluidic systems 有权
公开(公告)号：US08475737B2
公开(公告)日：2013-07-02
申请号：US13467627
申请日：2012-05-09
申请人： Vincent Linder , David Steinmiller , Samuel K. Sia
发明人： Vincent Linder , David Steinmiller , Samuel K. Sia
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/563 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/021 , B01L2300/041 , B01L2300/0627 , B01L2300/0672 , B01L2300/0838 , B01L2300/0861 , B01L2300/12 , B01L2400/049 , C12Q1/6834 , G01N21/6428 , G01N33/5302 , G01N33/5304 , G01N33/5306 , G01N33/545 , Y10T403/22 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.

8. 发明申请

US20120269701A1 FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS 有权
标题翻译：流体连接器和微流体系统
公开(公告)号：US20120269701A1
公开(公告)日：2012-10-25
申请号：US13467627
申请日：2012-05-09
申请人： Vincent Linder , David Steinmiller , Samuel K. Sia
发明人： Vincent Linder , David Steinmiller , Samuel K. Sia
IPC分类号： B01L3/00
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/563 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/021 , B01L2300/041 , B01L2300/0627 , B01L2300/0672 , B01L2300/0838 , B01L2300/0861 , B01L2300/12 , B01L2400/049 , C12Q1/6834 , G01N21/6428 , G01N33/5302 , G01N33/5304 , G01N33/5306 , G01N33/545 , Y10T403/22 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.
摘要翻译：提供了用于在微流体系统中进行分析（例如免疫测定）的流体连接器，方法和装置。在一些实施例中，具有流体路径的流体连接器用于连接形成在基板中的两个独立通道，以允许两个独立通道之间的流体连通。可以使用可用于进行分析的试剂（例如，抗体溶液，洗涤缓冲液和扩增试剂）预先填充一个或两个独立通道。这些试剂可以在使用前长时间（例如1年）存储在基质的通道中。

9. 发明授权

US08222049B2 Flow control in microfluidic systems 有权
标题翻译：微流体系统中的流量控制
公开(公告)号：US08222049B2
公开(公告)日：2012-07-17
申请号：US12428372
申请日：2009-04-22
申请人： Vincent Linder , David Steinmiller
发明人： Vincent Linder , David Steinmiller
IPC分类号： G01N33/536
CPC分类号： B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2200/12 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , Y10T137/0318 , Y10T137/0324
摘要： Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system. One method includes flowing a plug of a low viscosity fluid and a plug of a high viscosity fluid in a channel including a flow constriction region and a non-constriction region. In one embodiment, the low viscosity fluid flows at a first flow rate in the channel and the flow rate is not substantially affected by the flow constriction region. When the high viscosity fluid flows from the non-constriction region to the flow constriction region, the flow rates of the fluids decrease substantially, since the flow rates, in some systems, are influenced by the highest viscosity fluid flowing in the smallest cross-sectional area of the system (e.g., the flow constriction region). This causes the fluids to flow at the same flow rate at which the high viscosity fluid flows in the flow constriction region. Accordingly, by designing microfluidic systems with flow constriction regions positioned at particular locations and by choosing appropriate viscosities of fluids, a fluid can be made to speed up or slow down at different locations within the system without the use of valves and/or without external control.
摘要翻译：提供了微流体系统和包括提供流体流动控制的方法。这样的系统和方法可以用于例如基于通道几何形状的影响和系统内的一种或多种流体的粘度来控制压力驱动流。一种方法包括将低粘度流体塞和高粘度流体的塞子流入包括流动收缩区域和非收缩区域的通道中。在一个实施例中，低粘度流体在通道中以第一流速流动，并且流速基本上不受流动收缩区域的影响。当高粘度流体从非收缩区域流动到流动收缩区域时，流体的流速基本上降低，因为在一些系统中的流速受到最小横截面中流动的最高粘度流体的影响系统的区域（例如，流动收缩区域）。这导致流体以高粘度流体在流动收缩区域中流动的相同流速流动。因此，通过设计具有定位在特定位置处的流动收缩区域并通过选择流体的适当粘度的微流体系统，可以使流体在不使用阀和/或不进行外部控制的情况下在系统内的不同位置加速或减慢。

10. 发明授权

US08221700B2 Structures for controlling light interaction with microfluidic devices 有权
标题翻译：用于控制与微流体装置的光相互作用的结构
公开(公告)号：US08221700B2
公开(公告)日：2012-07-17
申请号：US12698451
申请日：2010-02-02
申请人： David Steinmiller , Vincent Linder
发明人： David Steinmiller , Vincent Linder
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/502715 , B01L2200/12 , B01L2300/04 , B01L2300/0627 , B01L2300/0654 , B01L2300/0861 , B01L2300/12 , C12Y304/21077 , G01N21/0303 , G01N21/59 , G01N33/53 , G01N33/54366 , G01N33/54373 , G01N33/545 , G01N33/57488 , G01N2333/96455 , Y10T436/11
摘要： Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems. In some embodiments, the optical elements comprise triangular grooves formed on or in a surface of the device. The draft angle of the triangular grooves may be chosen such that incident light normal to the surface of the device is redirected at an angle dependent upon the indices of refraction of the external medium (e.g., air) and the device material. Advantageously, certain optical elements described herein may be fabricated along with the fluidic channels of the device in one step, thereby reducing the costs of fabrication. Furthermore, in some cases the optical elements do not require alignment with a detector and, therefore, facilitate assembly and/or use by an end user.
摘要翻译：描述了通过流体系统改善吸光度/透射测量的系统和方法。具体来说，在一组实施例中，在与一系列流体通道相对的透明流体装置的一侧上制造光学元件。光学元件可以引导通过设备的入射光，使得大多数光从设备的特定区域分散，例如流体通道之间的中间部分。通过减少入射到这些中间部分的光量，当使用某些光学检测系统时，可以减少检测信号中的噪声量。在一些实施例中，光学元件包括形成在设备的表面上或表面上的三角形凹槽。可以选择三角形凹槽的拔模角使得垂直于装置表面的入射光以取决于外部介质（例如空气）和装置材料的折射率的角度被重定向。有利地，本文所述的某些光学元件可以在一个步骤中与装置的流体通道一起制造，从而降低制造成本。此外，在一些情况下，光学元件不需要与检测器对准，因此便于最终用户的组装和/或使用。

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