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1. 发明授权

US08043839B2 Xylanases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：木聚糖酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：US08043839B2
公开(公告)日：2011-10-25
申请号：US12279326
申请日：2007-02-14
申请人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
发明人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
IPC分类号： C12N9/24 , C12N1/20 , C12N1/15 , C12N1/16 , C12N1/19 , C12N15/70 , C12P21/06 , C07H21/04 , A01H5/00
CPC分类号： C12N9/248 , A23K10/12 , A23K20/163 , A23L5/00 , A23L7/00 , A23L29/30 , A23L31/00 , A23L31/10 , A23L33/125 , A23V2002/00 , C12N9/2405 , C12N9/2437 , C12N9/2482 , C12N9/2488 , C12N9/2494 , C12P19/02 , C12P19/14 , C12Y302/01008 , D06L4/40 , D06L4/70 , D21C3/003 , D21C9/10 , D21H17/005 , Y02E50/16
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部-1,4-木糖苷键或内切-1,4-羟基化酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。此外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

2. 发明申请

US20090155238A1 XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译： XYLANASES，核酸编码它们及其制备和使用方法
公开(公告)号：US20090155238A1
公开(公告)日：2009-06-18
申请号：US12279326
申请日：2007-02-14
申请人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
发明人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
IPC分类号： A61K38/47 , C12N15/11 , C07H21/04 , C12N15/00 , C12N5/06 , C12N1/21 , C12N1/19 , C12P7/02 , A23K1/165 , D06L3/11 , C12P7/10 , D21C3/00 , C12N5/04 , A01K67/027 , A01H5/00 , C12N9/24 , C12P21/04
CPC分类号： C12N9/248 , A23K10/12 , A23K20/163 , A23L5/00 , A23L7/00 , A23L29/30 , A23L31/00 , A23L31/10 , A23L33/125 , A23V2002/00 , C12N9/2405 , C12N9/2437 , C12N9/2482 , C12N9/2488 , C12N9/2494 , C12P19/02 , C12P19/14 , C12Y302/01008 , D06L4/40 , D06L4/70 , D21C3/003 , D21C9/10 , D21H17/005 , Y02E50/16
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内-A-1,4-ghicanase键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。此外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

3. 发明申请

US20220343450A1 ARTIFICIAL INTELLIGENCE SYSTEM AND METHOD FOR PERFORMING SETTLEMENTS BASED ON ACTIVITY OF USERS 有权
公开(公告)号：US20220343450A1
公开(公告)日：2022-10-27
申请号：US17238236
申请日：2021-04-23
申请人： SRIKANT VEMPARALA , Thomas Todaro , Andrew Sack , Sriram Sunkari , Prabodh Reddy Kommidi , Mike Snow , Narendra Padala
发明人： SRIKANT VEMPARALA , Thomas Todaro , Andrew Sack , Sriram Sunkari , Prabodh Reddy Kommidi , Mike Snow , Narendra Padala
IPC分类号： G06Q50/34 , G06Q20/40 , G06Q20/38 , G06Q20/06 , G06N20/00
摘要： Exemplary embodiments of the present disclosure directed towards an artificial intelligence system and method for performing settlements based on activity, user groups, and set of virtual/physical entities. The artificial intelligence system comprises artificial intelligence settlement engine configured to enable users for activity and provide activity templates to the artificial intelligence settlement engine from the computing device by the users. Customize the activity templates fully/partially based on dynamic needs and then provide the customized activity templates to the artificial intelligence settlement engine. The artificial settlement engine configured to integrate settlement process steps and/or rules into the settlement process sequence on the artificial intelligence settlement engine and then map settlement process steps and/or rules with the activity templates by the artificial intelligence settlement engine. The artificial settlement engine configured to identify shortest paths on the computing device to settle amount between users by using dynamic parameters and/or settlement process steps and/or rules.

4. 发明申请

US20100136113A1 PHYTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译： PHYTASES，NUCLEIC ACID ENCODING THEM AND METHODS FOR MAKING AND USING THEM
公开(公告)号：US20100136113A1
公开(公告)日：2010-06-03
申请号：US12442207
申请日：2007-09-21
申请人： Brian Steer , Mark Dycaico , Katie A. Kline , Axel Trefzer , Thomas Todaro , Arne Solbak , Fatima El-Farrah , Alberto Alvarado , Gerhard Frey
发明人： Brian Steer , Mark Dycaico , Katie A. Kline , Axel Trefzer , Thomas Todaro , Arne Solbak , Fatima El-Farrah , Alberto Alvarado , Gerhard Frey
IPC分类号： A61K9/00 , C07H21/00 , C12N15/63 , C12N1/21 , C12N5/00 , C12N1/15 , C12N1/19 , C12N5/04 , A01K67/027 , A01H5/10 , A01H5/00 , C12N9/16 , A61K38/46 , C12N11/16 , C12N11/14 , C12N11/08 , C07K16/00 , A61P43/00 , C12P21/00 , C12P7/02 , C11C3/00 , C12N15/00 , C12N15/82 , C12N15/74 , C12S3/00 , A23K1/165 , A23K1/18 , A23J3/14 , A23L1/305
CPC分类号： C12N9/16 , A23K20/189 , A23L33/18 , A23V2002/00 , C12P7/10 , C12Y301/03008 , C12Y301/03026 , C12Y301/03072 , Y02E50/16 , Y02E50/17
摘要： This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and/or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.
摘要翻译：本发明涉及植酸酶，编码它们的多核苷酸，本发明的多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生和分离。特别地，本发明提供了在高温条件下具有植酸酶活性的多肽，以及暴露于高温后保留活性的植酸酶。除了较高的温度之外，本发明的植酸酶还可以在低温下耐热和/或耐热。本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。本发明的植酸酶可以配制成食物或饲料或补充剂，用于例如帮助消化植酸盐。本发明的食品或饲料可以是丸粒，液体，粉末等的形式。在一个方面，本发明的植酸酶在造粒期间对于热变性是稳定的; 并且这降低了植酸酶产品的成本，同时保持了体内功效并检测了饲料中的活性。

5. 发明申请

US20070022841A1 Direct casting utilizing stack filtration 审中-公开
标题翻译：直接铸造利用堆叠过滤
公开(公告)号：US20070022841A1
公开(公告)日：2007-02-01
申请号：US11359032
申请日：2006-02-21
申请人： Thomas Todaro , David Warren , David Lazor , Karl Schwenk , Michael Kohler
发明人： Thomas Todaro , David Warren , David Lazor , Karl Schwenk , Michael Kohler
IPC分类号： C22B9/02
CPC分类号： C22B9/023 , B22D43/004 , Y02P10/234
摘要： A casting system includes a filtration assembly including a filter vessel housing spaced filters pre-heated to a temperature approximating a pouring temperature of molten material to be filtered to prevent breakage of the filter due to thermal shock from contact with the molten material. Preferably, an induction coil is used to inductively heat a susceptor adjacent the filter vessel or inductively heat filters which themselves serve as susceptors. Typically, the filter vessel is disposed below a pouring vessel and above a mold, pour cup and any sprue system used and is heated independently from the same. The filters are heated during pouring to facilitate flow of the molten material therethrough whereby very fine filters may be used. Spacing of the filters enhances flow control and allows a head of molten material to form whereby dross floats to the top of the head to prevent its entry into the mold.
摘要翻译：浇铸系统包括过滤组件，该过滤组件包括过滤器容器，该过滤器容纳间隔开的过滤器，该过滤器预热到接近要过滤的熔融材料的浇注温度的温度，以防止由于热冲击而与熔融材料接触而使过滤器破裂。优选地，感应线圈用于感应加热邻近过滤容器的感受器或感应加热本身用作基座的过滤器。通常，过滤容器设置在浇注容器的下方和模具上方，倒杯和任何使用的浇道系统并且独立于其加热。在浇注过程中加热过滤器以促进熔融材料流过其中，从而可以使用非常精细的过滤器。过滤器的间距增强了流量控制，并允许形成熔融材料的头部，从而浮渣浮于头部顶部以防止其进入模具。

6. 发明申请

US20060263358A1 Method for reducing sepsis or cardiogenic shock associated with myocardial injury 审中-公开
标题翻译：减少与心肌损伤相关的败血症或心源性休克的方法
公开(公告)号：US20060263358A1
公开(公告)日：2006-11-23
申请号：US11436440
申请日：2006-05-18
申请人： Thomas Todaro , Kevin Malloy
发明人： Thomas Todaro , Kevin Malloy
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/70
摘要： Methods of reducing sepsis or cardiogenic shock in patients experiencing myocardial injury are described. More specifically, this disclosure relates to the administration of a C5-C9 terminal complement inhibitor to patients who have had coronary artery bypass grafting or an acute myocardial infarction thereby reducing the incidence of sepsis.
摘要翻译：描述了在经历心肌损伤的患者中减少败血症或心源性休克的方法。更具体地，本公开涉及对具有冠状动脉旁路移植或急性心肌梗死的患者施用C5-C9末端补体抑制剂，从而降低败血症的发生率。

7. 发明申请

US20060050763A1 Induction furnace for melting semi-conductor materials 有权
公开(公告)号：US20060050763A1
公开(公告)日：2006-03-09
申请号：US11193790
申请日：2005-07-29
申请人： David Lazor , Daniel Pupillo , Jeffrey Deeter , Thomas Todaro , Anthony Tenzek
发明人： David Lazor , Daniel Pupillo , Jeffrey Deeter , Thomas Todaro , Anthony Tenzek
IPC分类号： H05B6/22
CPC分类号： F27B14/14 , F27B14/10 , H05B6/24
摘要： An induction furnace includes an induction coil, an electrically non-conductive crucible having an inner diameter disposed within the induction coil, and an electrically conductive member disposed below the crucible and having an outer diameter which is further from the induction coil than is the inner diameter of the crucible. Due to the non-conductive nature of material disposed within the crucible at lower temperatures, the induction coil initially inductively heats the conductive member, which transfers heat to the material to melt a portion of the material. Once the material is susceptible to inductive heating (usually upon melting) the susceptible material is inductively heated by the induction coil. During the process, inductive heating of the material greatly increases as inductive heating of the conductive member greatly decreases due to low resistivity of the molten material and due to the molten material being closer to the coil than is the conductive member.

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