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1. 发明授权

US08043839B2 Xylanases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：木聚糖酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：US08043839B2
公开(公告)日：2011-10-25
申请号：US12279326
申请日：2007-02-14
申请人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
发明人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
IPC分类号： C12N9/24 , C12N1/20 , C12N1/15 , C12N1/16 , C12N1/19 , C12N15/70 , C12P21/06 , C07H21/04 , A01H5/00
CPC分类号： C12N9/248 , A23K10/12 , A23K20/163 , A23L5/00 , A23L7/00 , A23L29/30 , A23L31/00 , A23L31/10 , A23L33/125 , A23V2002/00 , C12N9/2405 , C12N9/2437 , C12N9/2482 , C12N9/2488 , C12N9/2494 , C12P19/02 , C12P19/14 , C12Y302/01008 , D06L4/40 , D06L4/70 , D21C3/003 , D21C9/10 , D21H17/005 , Y02E50/16
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部-1,4-木糖苷键或内切-1,4-羟基化酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。此外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

2. 发明申请

US20090221051A1 XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译： XYLANASES，核酸编码它们及其制备和使用方法
公开(公告)号：US20090221051A1
公开(公告)日：2009-09-03
申请号：US12402421
申请日：2009-05-07
申请人： Brian STEER , Walter Callen , Shaun Healey , Geoff Hazlewood , Di Wu , David Blum , Alireza Esteghlalian
发明人： Brian STEER , Walter Callen , Shaun Healey , Geoff Hazlewood , Di Wu , David Blum , Alireza Esteghlalian
IPC分类号： C12P7/10 , C12N15/11 , C12N15/00 , C12N1/21 , D21C3/00
CPC分类号： C12N9/248 , A01K2217/05 , C07K2319/00 , C07K2319/02 , C12N9/2434 , C12N9/2482 , C12P19/14 , C12Y302/01008 , D21C5/005 , D21H17/005 , Y02E50/16 , Y02E50/17
摘要： The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及木聚糖酶和编码木聚糖酶的多核苷酸。此外，还提供了设计新的木聚糖酶的方法及其使用方法。木聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

3. 发明申请

US20090155238A1 XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译： XYLANASES，核酸编码它们及其制备和使用方法
公开(公告)号：US20090155238A1
公开(公告)日：2009-06-18
申请号：US12279326
申请日：2007-02-14
申请人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
发明人： David Weiner , David Blum , Alexander Varvak , Shaun Healey , Kristine Chang , Geoff Hazlewood , Thomas Todaro , Grace Desantis , Hwai Chang , Connie Jo Hansen , Scott W. Beaver , Thomas Woodward , Charles Hancock
IPC分类号： A61K38/47 , C12N15/11 , C07H21/04 , C12N15/00 , C12N5/06 , C12N1/21 , C12N1/19 , C12P7/02 , A23K1/165 , D06L3/11 , C12P7/10 , D21C3/00 , C12N5/04 , A01K67/027 , A01H5/00 , C12N9/24 , C12P21/04
CPC分类号： C12N9/248 , A23K10/12 , A23K20/163 , A23L5/00 , A23L7/00 , A23L29/30 , A23L31/00 , A23L31/10 , A23L33/125 , A23V2002/00 , C12N9/2405 , C12N9/2437 , C12N9/2482 , C12N9/2488 , C12N9/2494 , C12P19/02 , C12P19/14 , C12Y302/01008 , D06L4/40 , D06L4/70 , D21C3/003 , D21C9/10 , D21H17/005 , Y02E50/16
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内-A-1,4-ghicanase键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。此外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

4. 发明授权

US07547534B2 Methods for making a composition to treat a wood, a pulp or a paper 有权
标题翻译：制备组合物以处理木材，纸浆或纸的方法
公开(公告)号：US07547534B2
公开(公告)日：2009-06-16
申请号：US10517939
申请日：2003-06-16
申请人： Brian Steer , Walter Callen , Shaun Healey , Geoff Hazlewood , Di Wu , David Blum , Alireza Esteghlalian
发明人： Brian Steer , Walter Callen , Shaun Healey , Geoff Hazlewood , Di Wu , David Blum , Alireza Esteghlalian
IPC分类号： C12N9/24 , A23L1/105 , C12S3/04 , C12S3/08
CPC分类号： C12N9/248 , A01K2217/05 , C07K2319/00 , C07K2319/02 , C12N9/2434 , C12N9/2482 , C12P19/14 , C12Y302/01008 , D21C5/005 , D21H17/005 , Y02E50/16 , Y02E50/17
摘要： The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及木聚糖酶和编码木聚糖酶的多核苷酸。此外，还提供了设计新的木聚糖酶的方法及其使用方法。木聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

5. 发明授权

US07416596B2 Use of a pigment composition comprising mixed crystals based on CI pigment yellow 74 有权
标题翻译：使用包含基于CI颜料黄74的混合晶体的颜料组合物
公开(公告)号：US07416596B2
公开(公告)日：2008-08-26
申请号：US10590828
申请日：2005-02-11
申请人： Karl-Heinz Schweikart , David Blum , Felix W. Grimm , Martin U. Schmidt , Josef Geisenberger
发明人： Karl-Heinz Schweikart , David Blum , Felix W. Grimm , Martin U. Schmidt , Josef Geisenberger
IPC分类号： C09D11/00 , C09D11/02 , C09B67/22 , G02B5/20
CPC分类号： C09D11/32 , C09D11/101 , C09D11/322 , C09D11/34
摘要： The invention relates to the use of a pigment composition containing between 86.0 and 99.9 total mol % of C.I. Pigment Yellow 74 molecules and between 14.0 and 0.1 total mol % of at least one monoazo pigment of the formula (1) wherein R1 represents Cl, OCH3, OH3 or NO2 as a coloring agent for pigmenting ink-jet inks and color filters.
摘要翻译：本发明涉及使用含有86.0-99.9％总摩尔％的C.I.的颜料组合物。颜料黄74分子和14.0至0.1总摩尔％的至少一种式（1）的单偶氮颜料，其中R 1表示Cl，OCH 3，OH， > 3或NO 2 2作为用于着色喷墨油墨和滤色器的着色剂。

6. 发明申请

US20070149499A1 Process for preparing beta-lactamase inhibitors 审中-公开
标题翻译：制备β-内酰胺酶抑制剂的方法
公开(公告)号：US20070149499A1
公开(公告)日：2007-06-28
申请号：US11508037
申请日：2006-08-22
申请人： Ronald Michalak , Rocco Galante , David Blum , Julianne Blum , Lisa Routel , Haris Durutlic , Charles Guinosso , John Considine , Kenneth Kremer
发明人： Ronald Michalak , Rocco Galante , David Blum , Julianne Blum , Lisa Routel , Haris Durutlic , Charles Guinosso , John Considine , Kenneth Kremer
IPC分类号： A61K31/43 , C07D499/46
CPC分类号： C07D513/04 , C07D277/60
摘要： The present invention relates to processes for preparing β-alkylidene penem derivatives that can be important as broad spectrum β-lactamase inhibitors and anti-bacterial agents.
摘要翻译： β-亚烷基半乳聚糖衍生物的制备方法本发明涉及作为广谱β-内酰胺酶抑制剂和抗菌剂可能是重要的β-亚烷基半乳聚糖衍生物的方法。

7. 发明申请

US20070058716A1 Bit-rate reduction for multimedia data streams 失效
标题翻译：多媒体数据流的比特率降低
公开(公告)号：US20070058716A1
公开(公告)日：2007-03-15
申请号：US11518298
申请日：2006-09-08
申请人： David Blum
发明人： David Blum
IPC分类号： H04N11/04 , H04B1/66
CPC分类号： H04N19/583 , H04N19/115 , H04N19/124 , H04N19/146 , H04N19/15 , H04N19/154 , H04N19/194 , H04N19/523 , H04N19/533 , H04N19/61 , H04N19/63 , H04N19/80 , H04N19/85
摘要： Systems and methods for reducing a bit-rate in a multimedia data stream while maintaining high image quality. Two consecutive frames of the multimedia data stream are spatially filtered, temporally filtered, and combined into a pre-processed frame. In one embodiment, the two consecutive frames are consecutive fields of an interlaced data stream that are deinterlaced by the spatial and temporal filtering process. The pre-processed frame is encoded multiple times using different quantization values to produce a plurality of encoded frames. One of the encoded frames is selected based on its image quality and/or size for inclusion in an encoded data stream. In one embodiment, the pre-processed frame undergoes a motion estimation method that performs an integer level search of overlapping locations around a co-located macroblock in a reference frame followed by a sub-pixel level diamond pattern search.
摘要翻译：用于降低多媒体数据流中的比特率同时保持高图像质量的系统和方法。多媒体数据流的两个连续帧被空间滤波，时间滤波，并组合成预处理帧。在一个实施例中，两个连续帧是通过空间和时间滤波处理去隔行扫描的隔行数据流的连续字段。使用不同的量化值对预处理的帧进行多次编码以产生多个编码帧。基于其图像质量和/或尺寸来选择编码帧之一以包含在编码数据流中。在一个实施例中，预处理帧经历运动估计方法，该方法对参考帧中的位于相邻位置的宏块周围的重叠位置执行整数级搜索，之后是子像素级菱形图案搜索。

8. 发明申请

US20060003433A1 Xylanases, nucleic acids encoding them and methods for making and using them 有权
公开(公告)号：US20060003433A1
公开(公告)日：2006-01-05
申请号：US10517939
申请日：2003-06-16
申请人： Brian Steer , Walter Callen , Shaun Healey , Geoff Hazlewood , Di Wu , David Blum , Alireza Esteghlalian
发明人： Brian Steer , Walter Callen , Shaun Healey , Geoff Hazlewood , Di Wu , David Blum , Alireza Esteghlalian
IPC分类号： C12N9/42 , C07H21/04 , C12P21/06
CPC分类号： C12N9/248 , A01K2217/05 , C07K2319/00 , C07K2319/02 , C12N9/2434 , C12N9/2482 , C12P19/14 , C12Y302/01008 , D21C5/005 , D21H17/005 , Y02E50/16 , Y02E50/17
摘要： The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.

9. 发明授权

US4958020A Process for producing .beta.-lactamase inhibitor 失效
标题翻译：生产β-内酰胺酶抑制剂的方法
公开(公告)号：US4958020A
公开(公告)日：1990-09-18
申请号：US350966
申请日：1989-05-12
申请人： Raghavan Krishnan , Jesse Gamble , David Blum , William V. Curran , Ving J. Lee , Ransom B. Conrow
发明人： Raghavan Krishnan , Jesse Gamble , David Blum , William V. Curran , Ving J. Lee , Ransom B. Conrow
IPC分类号： C07D499/87 , A61K31/43 , A61P31/04 , C07D499/00 , C07D499/86 , C07D499/897
CPC分类号： C07D499/00
摘要： A process for producing the compound [2S-(2.alpha.,3.beta.,5.alpha.)]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-methyl)-4-thia-1-azabicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol is toluene at 80.degree.-100.degree. C. for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0.degree.-10.degree. C.

10. 发明申请

US20130245754A1 ADAPTIVE INTRAOCULAR LENS 审中-公开
标题翻译：自适应眼科镜片
公开(公告)号：US20130245754A1
公开(公告)日：2013-09-19
申请号：US13885366
申请日：2011-11-14
申请人： Ronald David Blum , Rudy Mazzocchi
发明人： Ronald David Blum , Rudy Mazzocchi
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61F2/1613 , A61F2/1627 , A61F2/1635 , A61F2/1648 , A61F2210/008 , A61F2210/009
摘要： An implantable ophthalmic device with flexible, fluid-filled membranes provide dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia without moving parts or reducing the amount of transmitted light. Actuating the device causes the fluid-filled membrane to change curvature, which produces a corresponding change in optical power. For instance, squeezing the edge of the membrane causes the center of the membrane to bulge by an amount proportional to the squeezing force. Alternatively, heating or applying a voltage to the membrane may cause the liquid in the membrane to undergo a phase transition accompanied by a corresponding change in volume that causes the membrane to inflate so as to change the optical power of the device.
摘要翻译：具有柔性流体填充膜的可植入眼科装置提供动态可变的光学功率，以恢复患有老花眼或无晶状体的个体的失去的适应性，而无需移动部件或减少透射光量。驱动该装置导致流体填充的膜改变曲率，这产生相应的光功率变化。例如，挤压膜的边缘导致膜的中心膨胀与挤压力成比例的量。或者，加热或向膜施加电压可能导致膜中的液体经历伴随相应的体积变化的相变，导致膜膨胀以改变装置的光功率。

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