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1. 发明授权

US06430513B1 Monitoring constituents of an animal organ using statistical correlation 有权
标题翻译：使用统计学相关性监测动物器官的成分
公开(公告)号：US06430513B1
公开(公告)日：2002-08-06
申请号：US09479642
申请日：2000-01-07
申请人： Yongdong Wang , David H. Tracy , Paul G. Saviano , Alan M. Ganz , Koichi Nishikida , Gitesh Kumar
发明人： Yongdong Wang , David H. Tracy , Paul G. Saviano , Alan M. Ganz , Koichi Nishikida , Gitesh Kumar
IPC分类号： G01N3100
CPC分类号： A61B5/6814 , A61B5/14546 , A61B5/14553 , G01N21/49
摘要： Constituents such as oxy- and deoxy-hemoglobin are monitored non-invasively in an animal organ such as a brain with a spectrometric instrument by passing radiation through the organ. Concentrations are computed from the spectral intensities and from a statistical correlation model. To predetermine the correlation model, the procedures are effected for a plurality of organs of a same type with each organ having established concentrations of the selected constituents, and the correlation model is statistically determined from the concentrations and corresponding intensities. For more accuracy computations are normalized to path length which may be determined by utilizing several discrete wavelengths with RF modulations.
摘要翻译：通过使辐射通过器官，通过光谱仪器在诸如脑的动物器官中非侵入性地监测诸如氧和血红蛋白的成分。浓度从光谱强度和统计相关模型计算。为了预先确定相关模型，对于具有确定的所选组分浓度的每个器官，对于多个相同类型的器官进行该程序，并且根据浓度和相应的强度统计地确定相关模型。为了更准确的计算，归一化到可以通过利用具有RF调制的几个离散波长来确定的路径长度。

2. 发明申请

US20120259599A1 Correction of Chemical Image Collected Using ATR Through Germanium Hemisphere 有权
标题翻译：使用ATR通过锗半球收集的化学图像的校正
公开(公告)号：US20120259599A1
公开(公告)日：2012-10-11
申请号：US13084261
申请日：2011-04-11
申请人： Francis J. DECK , Federico IZZIA , Koichi Nishikida
发明人： Francis J. DECK , Federico IZZIA , Koichi Nishikida
IPC分类号： G06F7/60 , G06G7/48
CPC分类号： G06T5/006 , G06F17/5009 , G06T2207/10056 , G06T2207/30136
摘要： A method and corresponding apparatus provide correction of chemical images collected with a germanium hemisphere ATR microscope. A modeled is developed for rays passing through a simulated germanium (Ge) hemisphere attenuated total reflection (ATR) microscope. The model determines a data set for rays reaching the detector plane. Movement of the hemisphere is simulated along a first axis between each data set determination. A calculated background spectrum is produced by multiplying the percentage of rays by a background spectrum to produce a calculated background spectrum. A real Ge hemisphere ATR microscope having parameters that substantially match those of the simulated Ge hemisphere microscope is then used to collect a chemical image of a sample that is in contact with the Ge hemisphere. The collected image is then corrected to produce a corrected chemical image.
摘要翻译：一种方法和相应的装置提供用锗半球ATR显微镜收集的化学图像的校正。模拟的射线通过模拟锗（Ge）半球衰减全反射（ATR）显微镜。该模型确定到达检测器平面的光线的数据集。在每个数据集确定之间沿着第一轴模拟半球的运动。通过将光线的百分比乘以背景谱产生计算的背景谱产生计算的背景谱。然后使用具有与模拟的Ge半球显微镜基本匹配的参数的真实Ge半球ATR显微镜来收集与Ge半球接触的样品的化学图像。然后校正收集的图像以产生校正的化学图像。

3. 发明申请

US20050162657A1 Optical resonance analysis system 审中-公开
标题翻译：光学共振分析系统
公开(公告)号：US20050162657A1
公开(公告)日：2005-07-28
申请号：US11074604
申请日：2005-03-07
申请人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
IPC分类号： G01N21/27 , G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

4. 发明授权

US08521491B2 Correction of chemical image collected using ATR through germanium hemisphere 有权
标题翻译：使用ATR通过锗半球收集的化学图像的校正
公开(公告)号：US08521491B2
公开(公告)日：2013-08-27
申请号：US13084261
申请日：2011-04-11
申请人： Francis J. Deck , Koichi Nishikida , Federico Izzia
发明人： Francis J. Deck , Koichi Nishikida , Federico Izzia
IPC分类号： G06G7/48
CPC分类号： G06T5/006 , G06F17/5009 , G06T2207/10056 , G06T2207/30136
摘要： A method and corresponding apparatus provide correction of chemical images collected with a germanium hemisphere ATR microscope. A model is developed for rays passing through a simulated germanium (Ge) hemisphere attenuated total reflection (ATR) microscope. The model determines a data set for rays reaching the detector plane. Movement of the hemisphere is simulated along a first axis between each data set determination. A calculated background spectrum is produced by multiplying the percentage of rays by a background spectrum to produce a calculated background spectrum. A real Ge hemisphere ATR microscope having parameters that substantially match those of the simulated Ge hemisphere microscope is then used to collect a chemical image of a sample that is in contact with the Ge hemisphere. The collected image is then corrected to produce a corrected chemical image.
摘要翻译：一种方法和相应的装置提供用锗半球ATR显微镜收集的化学图像的校正。开发了通过模拟锗（Ge）半球衰减全反射（ATR）显微镜的射线的模型。该模型确定到达检测器平面的光线的数据集。在每个数据集确定之间沿着第一轴模拟半球的运动。通过将光线的百分比乘以背景谱产生计算的背景谱产生计算的背景谱。然后使用具有与模拟的Ge半球显微镜基本匹配的参数的真实Ge半球ATR显微镜来收集与Ge半球接触的样品的化学图像。然后校正收集的图像以产生校正的化学图像。

5. 发明授权

US07251085B2 Optical resonance analysis system 有权
标题翻译：光学共振分析系统
公开(公告)号：US07251085B2
公开(公告)日：2007-07-31
申请号：US11460932
申请日：2006-07-28
申请人： Dar Bahatt , Jerry E. Cahill , Koichi Nishikida , Enrico G. Picozza , Paul G. Saviano , David H. Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry E. Cahill , Koichi Nishikida , Enrico G. Picozza , Paul G. Saviano , David H. Tracy , Yongdong Wang
IPC分类号： G02B27/00 , G01N21/55 , C12M3/00
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

6. 发明申请

US20060262313A1 Optical Resonance Analysis System 有权
标题翻译：光学共振分析系统
公开(公告)号：US20060262313A1
公开(公告)日：2006-11-23
申请号：US11460932
申请日：2006-07-28
申请人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

7. 发明授权

US06873417B2 Optical resonance analysis system 有权
标题翻译：光学共振分析系统
公开(公告)号：US06873417B2
公开(公告)日：2005-03-29
申请号：US10425799
申请日：2003-04-28
申请人： Dar Bahatt , Jerry E. Cahill , Koichi Nishikida , Enrico G. Picozza , Paul G. Saviano , David H. Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry E. Cahill , Koichi Nishikida , Enrico G. Picozza , Paul G. Saviano , David H. Tracy , Yongdong Wang
IPC分类号： G01N21/27 , G01N21/55 , G01N21/47
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

8. 发明授权

US06600563B1 Optical resonance analysis system 有权
标题翻译：光学共振分析系统
公开(公告)号：US06600563B1
公开(公告)日：2003-07-29
申请号：US09486424
申请日：2000-07-17
申请人： Dar Bahatt , Jerry E. Cahill , Koichi Nishikida , Enrico G. Picozza , Paul G. Saviano , David H. Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry E. Cahill , Koichi Nishikida , Enrico G. Picozza , Paul G. Saviano , David H. Tracy , Yongdong Wang
IPC分类号： G01N2155
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

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