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1. 发明授权

US5579951A Apparatus for orienting and loading solid compact medicaments 失效
标题翻译：用于定向和装载固体紧凑型药物的装置
公开(公告)号：US5579951A
公开(公告)日：1996-12-03
申请号：US264391
申请日：1994-06-23
申请人： David J. Revelle , Peter A. Pastecki , Thomas C. Reiter
发明人： David J. Revelle , Peter A. Pastecki , Thomas C. Reiter
IPC分类号： A61J3/00 , A61J3/06 , B65B5/10 , B65B35/56 , B65G47/14 , B65G47/24 , G01N35/04 , B65G59/00
CPC分类号： A61J3/005 , B65G47/1492 , B65G2201/027
摘要： An apparatus (10) for orienting and loading solid compact medicaments, such as solid compact medicaments (A), into a carrier device (C) comprises a feeder (12) having a plurality of elongated first channels (20) through which the solid compact medicaments travel with an acute angle relative to a predetermined orientation of the carrier device (C). An orienting member (32) cooperating with the feeder (12) reorients the solid compact medicaments to the predetermined orientation as they exit the feeder (12). In an alternative embodiment, a pitch changing means (42) in fluid communications with the orienting means (32) provides for final orientation of the solid compact medicaments prior to loading in the carrier device (C).
摘要翻译：用于将固体致密药物（例如固体致密药物（A））定向和装载到载体装置（C）中的装置（10）包括具有多个细长的第一通道（20）的进料器（12），固体致密体药物相对于载体装置（C）的预定方向以锐角行进。与进料器（12）配合的取向件（32）在出口给料器（12）时将固体紧凑型药物重新定向至预定取向。在替代实施例中，与定向装置（32）流体连通的间距改变装置（42）在装载到载体装置（C）之前提供固体紧凑型药物的最终取向。

2. 发明授权

US5387287A Apparatus for holding solid compact medicaments during processing 失效
标题翻译：用于在加工过程中保持固体紧凑型药物的装置
公开(公告)号：US5387287A
公开(公告)日：1995-02-07
申请号：US88501
申请日：1993-07-07
申请人： Thomas C. Reiter , Peter A. Pastecki , Charles W. Pierson
发明人： Thomas C. Reiter , Peter A. Pastecki , Charles W. Pierson
IPC分类号： A23G3/24 , A61J3/00 , B05C3/09 , B05C13/00 , A61K9/00 , B23Q3/00 , B25B1/20
CPC分类号： A61J3/005 , A23G3/24 , B05C13/00 , B05C3/09
摘要： An apparatus for holding a solid compact medicament has relatively displaceable, substantially planar first and second members having opposed edge portions. Each edge portion has at least one notch having an interior wall. Housing is provided for holding members in a substantially co-planar relationship. When members are displaced, preferably along a fixed axis, to a first position, the interior walls of the opposed, aligned notches define an open gripping jaw for receiving and subsequently releasing the caplet. Further, when members are displaced to a second position, the open gripping jaw then partially closes, thereby capturing the caplet securely within the notches in the gripping jaw for processing.
摘要翻译：用于保持固体紧凑型药物的装置具有相对位移的基本上平面的具有相对边缘部分的第一和第二构件。每个边缘部分具有至少一个具有内壁的凹口。为保持构件提供基本上共平面关系的壳体。当构件优选地沿着固定的轴线移动到第一位置时，相对的对齐的凹口的内壁限定用于接收和随后释放盖子的敞开的夹持爪。此外，当构件被移动到第二位置时，打开的夹爪然后部分地关闭，从而将封盖片牢固地捕获在夹爪中的凹口内用于处理。

3. 发明授权

US6126987A Process for the gelatin coating of medicaments 有权
标题翻译：药物明胶包衣的方法
公开(公告)号：US6126987A
公开(公告)日：2000-10-03
申请号：US274761
申请日：1999-03-23
申请人： Jeffrey D. Brehaut , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
发明人： Jeffrey D. Brehaut , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
IPC分类号： A61J3/06 , A23G3/24 , A23G7/00 , A61J3/00 , B05B15/12 , B05C3/10 , B65D1/36 , A61J3/07 , B05C3/09
CPC分类号： A23G7/0025 , A23G3/24 , A61J3/005 , B65D1/36 , B05B15/1207 , B05C3/10 , Y10S53/90
摘要： A process and apparatus for the gelatin coating of medicaments which includes a continuous conveyer system to advance a plurality of pallets through a loading station, at least one dipping station, at least one dryer station, a reorientation station and an unloading station. Medicaments to be coated are loaded into pallets at the loading station and advanced to the first dipping station where a vacuum is applied to secure the medicament to the pallet. The pallet is inverted and a first portion of each of the medicaments is dipped into a coating mixture. The pallet is then returned to its upright position, the vacuum is removed and the coating is dried. The medicaments are then transferred from the first pallet to a second pallet by a reorientation mechanism. The second pallet is then advanced to a second dipping station which operates in the same manner as the first dipping station. The second pallet is advanced through the dryer station and the fully coated medicaments are ejected from the pallet into a container. The pallets used to hold the medicaments include a plate-like support member, on which rests a flexible mat having a rectangular array of receptacles including compliant diaphragm portions such that when a vacuum is applied to the pallet, the medicaments are secured thereto. The drying means includes air directing plates having sinusoidal rows of air directing apertures under which the medicaments to be dried are passed.
摘要翻译：用于药物明胶涂层的方法和装置，其包括连续输送系统，以通过装载站，至少一个浸渍站，至少一个干燥站，重新定向站和卸载站推进多个托盘。待涂覆的药物装载在装载站的托盘中并且前进到第一浸渍站，在那里施加真空以将药剂固定到托盘上。托盘倒置，每个药物的第一部分浸入涂料混合物中。然后将托盘返回到其直立位置，除去真空并将涂层干燥。然后通过重新定向机构将药物从第一托盘转移到第二托盘。然后将第二托盘推进到以与第一浸渍站相同的方式操作的第二浸渍站。第二个托盘通过干燥站前进，完全涂覆的药物从托盘中排出到容器中。用于保持药物的托盘包括板状支撑构件，其上放置有具有矩形阵列的容器的柔性垫，其包括顺应性膜部分，使得当将真空施加到托盘时，药物被固定到其上。干燥装置包括具有正弦排的空气引导孔的空气引导板，待干燥的药物在该空气引导孔下通过。

4. 发明授权

US5942034A Apparatus for the gelatin coating of medicaments 失效
标题翻译：用于药物明胶涂层的装置
公开(公告)号：US5942034A
公开(公告)日：1999-08-24
申请号：US900225
申请日：1997-07-24
申请人： Jeffrey D. Brehant , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
发明人： Jeffrey D. Brehant , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
IPC分类号： A61J3/06 , A23G3/24 , A23G7/00 , A61J3/00 , B05B15/12 , B05C3/10 , B65D1/36 , A23G3/00
CPC分类号： A23G7/0025 , A23G3/24 , A61J3/005 , B65D1/36 , B05B15/1207 , B05C3/10 , Y10S53/90
摘要： A process and apparatus for the gelatin coating of medicaments which includes a continuous conveyer system to advance a plurality of pallets through a loading station, at least one dipping station, at least one dryer station, a reorientation station and an unloading station. Medicaments to be coated are loaded into pallets at the loading station and advanced to the first dipping station where a vacuum is applied to secure the medicament to the pallet. The pallet is inverted and a first portion of each of the medicaments is dipped into a coating mixture. The pallet is then returned to its upright position, the vacuum is removed and the coating is dried. The medicaments are then transferred from the first pallet to a second pallet by a reorientation mechanism. The second pallet is then advanced to a second dipping station which operates in the same manner as the first dipping station. The second pallet is advanced through the dryer station and the fully coated medicaments are ejected from the pallet into a container. The pallets used to hold the medicaments include a plate-like support member, on which rests a flexible mat having a rectangular array of receptacles including compliant diaphragm portions such that when a vacuum is applied to the pallet, the medicaments are secured thereto. The drying means includes air directing plates having sinusoidal rows of air directing apertures under which the medicaments to be dried are passed.
摘要翻译：用于药物明胶涂层的方法和装置，其包括连续输送系统，以通过装载站，至少一个浸渍站，至少一个干燥站，重新定向站和卸载站推进多个托盘。待涂覆的药物装载在装载站的托盘中并且前进到第一浸渍站，在那里施加真空以将药剂固定到托盘上。托盘倒置，每个药物的第一部分浸入涂料混合物中。然后将托盘返回到其直立位置，除去真空并将涂层干燥。然后通过重新定向机构将药物从第一托盘转移到第二托盘。然后将第二托盘推进到以与第一浸渍站相同的方式操作的第二浸渍站。第二个托盘通过干燥站前进，完全涂覆的药物从托盘中排出到容器中。用于保持药物的托盘包括板状支撑构件，其上放置有具有矩形阵列的容器的柔性垫，其包括顺应性膜部分，使得当将真空施加到托盘时，药物被固定到其上。干燥装置包括具有正弦排的空气引导孔的空气引导板，待干燥的药物在该空气引导孔下通过。

5. 发明授权

US5514216A Apparatus for holding solid compact medicaments during coating processing 失效
标题翻译：用于在涂覆处理期间保持固体紧凑型药物的装置
公开(公告)号：US5514216A
公开(公告)日：1996-05-07
申请号：US88500
申请日：1993-07-07
申请人： Peter A. Pastecki , Thomas C. Reiter , Charles W. Pierson
发明人： Peter A. Pastecki , Thomas C. Reiter , Charles W. Pierson
IPC分类号： A23G3/24 , A61J3/00 , B05C3/09 , B05C13/00 , B05C13/02
CPC分类号： A23G3/24 , A61J3/005 , B05C13/00 , B05C3/09
摘要： An apparatus for holding and subsequently releasing a solid compact medicament, such as a caplet. The apparatus has a first and a second member each having an upper and a lower surface. The first and second members each have at least one notch opposed to each other and correspondingly aligned and extending beyond the respective upper and lower surfaces of each member. The first and second members have chambers adjacent to each of the notches, and each of the notches is moveable in the respective chamber of the opposing member so that the opposing notches form a gripping jaw that can move between a first and a second position. When the gripping jaw is in an open first position, it can receive a solid compact medicament, and in a closed second position, the gripping jaw can grip the medicament.
摘要翻译：一种用于保持和随后释放固体致密药物的装置，例如囊片。该装置具有分别具有上表面和下表面的第一和第二构件。第一和第二构件各自具有彼此相对的至少一个切口，并且相应地对准并延伸超过每个构件的相应的上表面和下表面。第一和第二构件具有与每个凹口相邻的腔室，并且每个凹口可在相对构件的相应室中移动，使得相对的凹口形成可在第一和第二位置之间移动的夹爪。当夹爪处于打开的第一位置时，其可以容纳固体紧凑的药物，并且在闭合的第二位置中，夹爪可夹持药物。

6. 发明授权

US5391230A Apparatus for holding solid compact medicaments during processing 失效
标题翻译：用于在加工过程中保持固体紧凑型药物的装置
公开(公告)号：US5391230A
公开(公告)日：1995-02-21
申请号：US88467
申请日：1993-07-07
申请人： Peter A. Pastecki , Thomas C. Reiter , Charles W. Pierson
发明人： Peter A. Pastecki , Thomas C. Reiter , Charles W. Pierson
IPC分类号： A23G3/24 , A61J3/00 , B05C3/09 , B05C13/00 , A61K9/00 , B23Q3/00 , B25B1/20
CPC分类号： B05C3/09 , A23G3/24 , A61J3/005 , B05C13/00
摘要： An apparatus for capturing and holding a solid compact medicament, such as a caplet, has first, second and third members each having a surface having at least one throughole therein. Througholes have a diameter somewhat greater than the thickness of the solid compact medicament and the interior wall of the througholes 1as an axial length smaller than the length of the solid compact medicament. First and third members are fixed relative to one another. Second member is displaceable between first and third members between a first position wherein the througholes in members are aligned thereby defining an open gripping jaw for receiving and subsequently releasing the solid compact medicament, to a second position wherein the second member firmly engages a circumferential portion of solid compact medicament thereby engagingly capturing solid compact medicament in partially closed gripping jaw for processing.
摘要翻译：用于捕获和保持固体紧凑药物（例如囊片）的装置具有第一，第二和第三构件，每个构件具有在其中具有至少一个通孔的表面。排水孔的直径略大于固体紧凑型药物的厚度，并且导流孔1的内壁的轴向长度小于固体压实药物的长度。第一和第三个成员是相对于彼此固定的。第二构件可在第一位置和第三构件之间移动，第一位置和第二位置之间，其中，构件中的通孔对齐，从而限定用于接收和随后将固体致密药物释放的打开的夹爪，到第二位置，其中第二构件牢固地接合固体压实药物，从而在部分闭合的夹爪中接合捕获固体致密药物用于加工。

7. 发明授权

US06258400B1 Process and apparatus for holding medicaments to be coated 有权
标题翻译：用于保持待涂药剂的方法和装置
公开(公告)号：US06258400B1
公开(公告)日：2001-07-10
申请号：US09274759
申请日：1999-03-23
申请人： Jeffrey D. Brehant , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
发明人： Jeffrey D. Brehant , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
IPC分类号： A61J103
CPC分类号： A23G7/0025 , A23G3/24 , A61J3/005 , B05B16/20 , B05C3/10 , B65D1/36 , Y10S53/90
摘要： A process and apparatus for holding a plurality of medicaments to be coated is disclosed. A support member is provided having a receiving surface with a plurality of channels to communicate a vacuum across the receiving surface and an aperture operable to couple the plurality of channels to a vacuum source. A flexible mat having a perimeter shaped to engage the support member in a sealed relation is provided on the support member. The flexible mat includes a plurality of medicament receptacles mounted to a first surface and adapted to receive the medicaments. The medicament receptacles initially are in a first position when no vacuum is applied. In the first position, the medicament receptacles are positioned to receive a medicament. When a vacuum is applied, the medicament receptacles change to a second position in which the medicament receptacles are positioned to hold the medicament and permit coating thereof.
摘要翻译：公开了一种用于保持待涂覆的多种药物的方法和装置。提供了一种支撑构件，其具有接收表面，该接收表面具有多个通道以在接收表面上传递真空，以及可操作以将多个通道耦合到真空源的孔。在支撑构件上设置有具有成形为以密封关系与支撑构件接合的周边的柔性垫。柔性垫包括安装到第一表面并适于接收药物的多个药物容器。当不施加真空时，药物容器最初处于第一位置。在第一位置，药物容器被定位成容纳药物。当施加真空时，药物容器改变到第二位置，在该第二位置，药物容器被定位成保持药物并允许其涂覆。

8. 发明授权

US06195911B1 Process and apparatus for drying a plurality of dip-coated medicaments 有权
标题翻译：用于干燥多种浸涂药物的方法和设备
公开(公告)号：US06195911B1
公开(公告)日：2001-03-06
申请号：US09274760
申请日：1999-03-23
申请人： Jeffrey D. Brehant , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
发明人： Jeffrey D. Brehant , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
IPC分类号： F26B300
CPC分类号： A23G7/0025 , A23G3/24 , A61J3/005 , B05B16/20 , B05C3/10 , B65D1/36 , Y10S53/90
摘要： A process and apparatus for the gelatin coating of medicaments which includes a continuous conveyer system to advance a plurality of pallets through a loading station, at least one dipping station, at least one dryer station, a reorientation station and an unloading station. Medicaments to be coated are loaded into pallets at the loading station and advanced to the first dipping station where a vacuum is applied to secure the medicament to the pallet. The pallet is inverted and a first portion of each of the medicaments is dipped into a coating mixture. The pallet is then returned to its upright position, the vacuum is removed and the coating is dried. The medicaments are then transferred from the first pallet to a second pallet by a reorientation mechanism. The second pallet is then advanced to a second dipping station which operates in the same manner as the first dipping station. The second pallet is advanced through the dryer station and the fully coated medicaments are ejected from the pallet into a container. The pallets used to hold the medicaments include a plate-like support member, on which rests a flexible mat having a rectangular array of receptacles including compliant diaphragm portions such that when a vacuum is applied to the pallet, the medicaments are secured thereto. The drying means includes air directing plates having sinusoidal rows of air directing apertures under which the medicaments to be dried are passed.
摘要翻译：用于药物明胶涂层的方法和装置，其包括连续输送系统，以通过装载站，至少一个浸渍站，至少一个干燥站，重新定向站和卸载站推进多个托盘。待涂覆的药物装载在装载站的托盘中并且前进到第一浸渍站，在那里施加真空以将药剂固定到托盘上。托盘倒置，每个药物的第一部分浸入涂料混合物中。然后将托盘返回到其直立位置，除去真空并将涂层干燥。然后通过重新定向机构将药物从第一托盘转移到第二托盘。然后将第二托盘推进到以与第一浸渍站相同的方式操作的第二浸渍站。第二个托盘通过干燥站前进，完全涂覆的药物从托盘中排出到容器中。用于保持药物的托盘包括板状支撑构件，其上放置有具有矩形阵列的容器的柔性垫，其包括顺应性膜部分，使得当将真空施加到托盘时，药物被固定到其上。干燥装置包括具有正弦排的空气引导孔的空气引导板，待干燥的药物在该空气引导孔下通过。

9. 发明授权

US6132159A Process and apparatus for reorienting medicaments to be coated 有权
标题翻译：用于重新取向待涂药剂的方法和装置
公开(公告)号：US6132159A
公开(公告)日：2000-10-17
申请号：US275052
申请日：1999-03-23
申请人： Jeffrey D. Brehaut , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
发明人： Jeffrey D. Brehaut , Linn C. Hoover , Thomas Kucharski , Thomas C. Reiter , David J. Revelle , Daniel A. Slater , Luis R. Torres , Patrick Vo
IPC分类号： A61J3/06 , A23G3/24 , A23G7/00 , A61J3/00 , B05B15/12 , B05C3/10 , B65D1/36 , B65G65/23
CPC分类号： A23G7/0025 , A23G3/24 , A61J3/005 , B65D1/36 , B05B15/1207 , B05C3/10 , Y10S53/90
摘要： Medicaments on a first pallet are transferred onto a second pallet, thereby reorienting the medicaments. The first pallet is received on a first lift plate and the second pallet is received on a second lift plate in vertical opposition to the first lift plate. A lift mechanism urges the first and second lift plates towards one another and the first and second lift plates are inverted so that the medicaments are transferred from said first pallet to said second pallet.
摘要翻译：将第一托盘上的药物转移到第二托盘上，由此重新定向药物。第一托盘被接收在第一提升板上，并且第二托盘被接收在垂直于第一提升板的第二提升板上。提升机构将第一和第二提升板朝向彼此推动，并且第一和第二提升板被倒置，使得药物从所述第一托盘传送到所述第二托盘。

10. 发明授权

US5756418A Binder for thermal transfer donor element 失效
标题翻译：用于热传递供体元件的粘合剂
公开(公告)号：US5756418A
公开(公告)日：1998-05-26
申请号：US757556
申请日：1996-11-27
申请人： William H. Simpson , Hoa A. Tang , Thomas C. Reiter
发明人： William H. Simpson , Hoa A. Tang , Thomas C. Reiter
IPC分类号： B41M5/385 , B41M5/035 , B41M5/30 , B41M5/39 , B41M5/395 , B41M5/38
CPC分类号： B41M5/395 , Y10S428/913 , Y10S428/914 , Y10T428/31855
摘要： This invention relates to a thermal transfer donor element comprising a support having thereon a dye layer comprising a dye dispersed in a polymeric binder, the dye layer being capable of being thermally transferred to a receiver element, wherein the polymeric binder is a phenoxy resin.
摘要翻译：本发明涉及一种热转移供体元件，其包括其上具有染料层的载体，所述染料层包含分散在聚合物粘合剂中的染料，所述染料层能够热转移到接受元件，其中所述聚合物粘合剂是苯氧树脂。！

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