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1. 发明申请

US20080194504A1 Rna-Mediated Interference to Control Disease in Terrestrial and Aquaculture Animals 审中-公开
标题翻译： Rna介导的对陆地和水产养殖动物控制疾病的干扰
公开(公告)号：US20080194504A1
公开(公告)日：2008-08-14
申请号：US10588414
申请日：2005-02-04
申请人： David J. Kyle , Arun K. Dhar
发明人： David J. Kyle , Arun K. Dhar
IPC分类号： A61K31/7105 , A61P31/04 , A61P31/10 , A61P31/12
CPC分类号： C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32
摘要： The invention is directed to compositions (e.g., feeds, feed supplements, and therapeutic products) and methods for inhibiting an animal pathogen using RNA-interference technology.
摘要翻译：本发明涉及使用RNA干扰技术抑制动物病原体的组合物（例如饲料，饲料添加剂和治疗产品）和方法。

2. 发明授权

US09072311B2 Absorption of fat-soluble nutrients 有权
标题翻译：吸收脂溶性营养素
公开(公告)号：US09072311B2
公开(公告)日：2015-07-07
申请号：US10530598
申请日：2004-06-21
申请人： Moti Harel , John Piechocki , David J. Kyle
发明人： Moti Harel , John Piechocki , David J. Kyle
IPC分类号： A23K1/18 , A23K1/16 , A23K1/00 , A23K1/175 , A61K31/065 , A61K31/66
CPC分类号： A61K31/685 , A23K20/158 , A23K20/174 , A23K20/179 , A23K20/22 , A23K20/26 , A23K40/30 , A23K50/75 , A23K50/80 , A61K31/065 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： Carotenoids are provided as dietary supplements to animal feed. These supplements improve the bioavailability of carotenoids by providing them in combination with phospholipids. The invention provides animal feeds for aquatic and terrestrial animals, and methods for making the feeds.
摘要翻译：提供类胡萝卜素作为动物饲料的膳食补充剂。这些补充剂通过将其与磷脂组合提供来提高类胡萝卜素的生物利用度。本发明提供了用于水生和陆生动物的动物饲料以及用于制备饲料的方法。

3. 发明授权

US6027900A Methods and tools for transformation of eukaryotic algae 有权
标题翻译：用于转化真核藻类的方法和工具
公开(公告)号：US6027900A
公开(公告)日：2000-02-22
申请号：US155972
申请日：1998-10-09
申请人： F. C. Thomas Allnutt , David J. Kyle , Arthur R. Grossman , Kirk R. Apt
发明人： F. C. Thomas Allnutt , David J. Kyle , Arthur R. Grossman , Kirk R. Apt
IPC分类号： C12N15/65 , C12N15/79 , C12Q1/68
CPC分类号： C12N15/79 , C12N15/65
摘要： Genetic fusions for use in genetic engineering of eukaryotic algae employ a promoter from a light harvesting protein fused to a protein of interest. The fusions can be introduced and selected using an antibiotic resistance determinant. One gene useful for such selection is the sh ble gene encoding a bleomycin binding protein.
摘要翻译： PCT No.PCT / US97 / 06021 Sec。 371日期：1998年10月9日 102（e）日期1998年10月9日PCT 1997年4月11日PCT PCT。 WO97 / 39106 PCT公开号日期1997年10月23日用于真核藻类遗传工程的遗传融合使用与感兴趣的蛋白质融合的光收获蛋白质的启动子。可以使用抗生素抗性决定簇引入和选择融合体。用于这种选择的一个基因是编码博来霉素结合蛋白的sh ble基因。

4. 发明授权

US5376540A Triglyceride oils labelled with .sup.13 C prepared by cultivation of microorganisms 失效
标题翻译：通过培养微生物制备的用13C标记的甘油三酯油
公开(公告)号：US5376540A
公开(公告)日：1994-12-27
申请号：US936248
申请日：1992-09-24
申请人： David J. Kyle
发明人： David J. Kyle
IPC分类号： A61K49/00 , A61K51/12 , C07C57/12 , C11B1/00 , C11B1/10 , C12N1/06 , C12P7/62 , C12P7/64 , C12R1/89 , G01N33/497 , G01N33/60
CPC分类号： A61K51/1206 , C11B1/00 , C12N1/06 , C12P7/6463 , C12P7/6472 , G01N33/497 , A61K2123/00 , Y10S435/946
摘要： Labelled triglyceride oils are produced for use in diagnostic breath tests. The process involves the cultivation of microorganisms capable of producing the oils in an appropriately controlled environment wherein the microorganisms are feed .sup.13 C or .sup.14 C labeled carbon substrates to induce the microorganisms to produce the labeled oils. The preferred labelled carbon substrate is a substrate containing .sup.13 C. The oil produced is preferrably enriched in oleic acid. The microorganisms can be induced to produce the oil by nitrogen depletion during cultivation.
摘要翻译：生产标记的甘油三酯油用于诊断性呼气试验。该方法包括培养能够在适当控制的环境中生产油的微生物，其中微生物进料13C或14C标记的碳底物以诱导微生物产生标记的油。优选的标记碳底物是含有13℃的底物。产生的油优选地富含油酸。在培养过程中，微生物可通过氮耗竭诱导产生油。

5. 发明授权

US5244921A Eicosapentaenoic acids and methods for their production 失效
标题翻译：特殊生物酸及其生产方法
公开(公告)号：US5244921A
公开(公告)日：1993-09-14
申请号：US496572
申请日：1990-03-21
申请人： David J. Kyle , Raymond Gladue
发明人： David J. Kyle , Raymond Gladue
IPC分类号： A23D9/00 , A23K1/00 , A23K1/16 , A23K1/18 , A23L1/30 , A61K8/30 , A61K8/36 , A61K8/37 , A61K8/96 , A61K8/97 , A61K8/99 , A61K31/20 , A61K31/23 , A61K36/02 , A61P17/00 , C07C57/03 , C11B1/00 , C12N1/12 , C12P7/64 , C12R1/89
CPC分类号： C12P7/6472 , A23K20/158 , A23K50/80 , C07C57/03 , C12N1/12
摘要： This invention describes a process for producing single cell edible oils containing eicosapentaenoic acid (EPA) from heterotrophic diatoms. The diatoms are cultivated in a fermentor in a nutrient solution containing nitrogen and silicate. Withdrawal of the nitrogen followed by withdrawal of the silicate induces the diatoms to synthesize large quantities of edible oil containing EPA which subsequently is recovered. The edible oil, and uses for it, also form parts of this invention as do mutant diatoms capable of producing large quantities of EPA.
摘要翻译：本发明描述了从异养硅藻生产含有二十碳五烯酸（EPA）的单细胞食用油的方法。硅藻在含有氮和硅酸盐的营养液中的发酵罐中培养。退出氮气后，硅酸盐的抽出物会诱导硅藻合成大量含EPA的食用油，随后将其回收。食用油及其用途也与能够产生大量EPA的突变硅藻一样形成本发明的一部分。

6. 发明授权

US07939710B1 Trophic conversion of obligate phototrophic algae through metabolic engineering 失效
公开(公告)号：US07939710B1
公开(公告)日：2011-05-10
申请号：US09839536
申请日：2001-04-23
申请人： Kirk Emil Apt , F. C. Thomas Allnutt , David J. Kyle , James Casey Lippmeier
发明人： Kirk Emil Apt , F. C. Thomas Allnutt , David J. Kyle , James Casey Lippmeier
IPC分类号： C12N15/82
CPC分类号： C12N15/8209 , C12N1/12 , C12N15/65 , C12N15/79 , C12N15/8207 , Y10S435/946
摘要： Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization. Finally, this work also represents critical progress toward large-scale commercial exploitation of obligate phototrophic algae through the use of microbial fermentation technology, eliminating significant limitations resulting from light-dependent growth.

7. 发明申请

US20080138851A1 TROPHIC CONVERSION OF OBLIGATE PHOTOTROPHIC ALGAE THROUGH METABOLIC ENGINEERING 失效
标题翻译：通过代谢工程进行的白藜芦醇的热转化
公开(公告)号：US20080138851A1
公开(公告)日：2008-06-12
申请号：US11842898
申请日：2007-08-21
申请人： Kirk Emil Apt , F.C. Thomas Allnutt , David J. Kyle , James Casey Lippmeier
发明人： Kirk Emil Apt , F.C. Thomas Allnutt , David J. Kyle , James Casey Lippmeier
IPC分类号： C12Q1/02 , C12N1/12 , C12N15/74
CPC分类号： C12N15/8209 , C12N1/12 , C12N15/65 , C12N15/79 , C12N15/8207 , Y10S435/946
摘要： Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization. Finally, this work also represents critical progress toward large-scale commercial exploitation of obligate phototrophic algae through the use of microbial fermentation technology, eliminating significant limitations resulting from light-dependent growth.
摘要翻译：大多数微藻是专性光自养体，其生长严格依赖于光合作用衍生能量的产生。在这项研究中，显示微藻Phaeodaclylurn三角褐豆可以通过引入编码葡萄糖转运蛋白的基因进行工程化以导入葡萄糖并在黑暗中生长。人和小球藻凯斯勒葡萄糖转运蛋白都促进了三角褐指藻的葡萄糖摄取，使得细胞代谢外源有机碳，并且独立于光。这是通过代谢工程首次成功地营养专一性自养型营养转化，并且表明通过引入单一基因可以从根本上改变细胞营养的方法。由于用葡萄糖转运基因转化的菌株能够非光合作用生长，因此可以通过突变体的产生和表征来开发光合作用的分析。最后，这项工作也是通过使用微生物发酵技术大规模商业开发专用光营养藻类的重要进展，消除了光依赖性生长造成的重大限制。

8. 发明授权

US5466434A Method of diagnosing fatty acid metabolism or absorption disorders using labeled triglyceride oils produced by cultivation of microorganisms 失效
标题翻译：使用通过培养微生物产生的标记的甘油三酯油来诊断脂肪酸代谢或吸收障碍的方法
公开(公告)号：US5466434A
公开(公告)日：1995-11-14
申请号：US338755
申请日：1994-11-10
申请人： David J. Kyle
发明人： David J. Kyle
IPC分类号： A61K49/00 , A61K51/12 , C07C57/12 , C11B1/00 , C11B1/10 , C12N1/06 , C12P7/62 , C12P7/64 , C12R1/89 , G01N33/497 , G01N33/60 , C12Q1/64 , C12Q1/02
CPC分类号： A61K51/1206 , C11B1/00 , C12N1/06 , C12P7/6463 , C12P7/6472 , G01N33/497 , A61K2123/00 , Y10S435/946
摘要： Labelled triglyceride oils are produced for use in diagnostic breath test. The process involves the cultivation of microorganisms capable of producing the oils in an appropriately controlled environment wherein the microorganisms are fed .sup.13 C or .sup.14 C labeled carbon substrates to induce the microorganisms to produce the labeled oils. The preferred labelled carbon substrate is a substrate containing .sup.13 C. The oil produced is preferrably enriched in oleic acid. The microorganisms can be induced to produce the oil by nitrogen depletion during cultivation.
摘要翻译：生产标记的甘油三酯油用于诊断性呼气试验。该方法包括培养能够在适当控制的环境中生产油的微生物，其中微生物被供给13C或14C标记的碳底物以诱导微生物产生标记的油。优选的标记碳底物是含有13℃的底物。产生的油优选地富含油酸。在培养过程中，微生物可通过氮耗竭诱导产生油。

9. 发明申请

US20120034653A1 Trophic Conversion of Obligate Phototrophic Algae Through Metabolic Engineering 审中-公开
标题翻译：通过代谢工程营养转化特种光营养藻类
公开(公告)号：US20120034653A1
公开(公告)日：2012-02-09
申请号：US13188806
申请日：2011-07-22
申请人： Kirk Emil APT , F.C. Thomas Allnutt , David J. Kyle , James Casey Lippmeier
发明人： Kirk Emil APT , F.C. Thomas Allnutt , David J. Kyle , James Casey Lippmeier
IPC分类号： C12P21/00 , C12N15/79 , C12N1/13 , C07C29/74 , C11B1/10 , C07C35/21 , C07C7/00 , C07K14/405 , A23K1/00 , C07K1/14
CPC分类号： C12N15/8209 , C12N1/12 , C12N15/65 , C12N15/79 , C12N15/8207 , Y10S435/946
摘要： Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization. Finally, this work also represents critical progress toward large-scale commercial exploitation of obligate phototrophic algae through the use of microbial fermentation technology, eliminating significant limitations resulting from light-dependent growth.
摘要翻译：大多数微藻是专性光自养体，其生长严格依赖于光合作用衍生能量的产生。在这项研究中，显示微藻Phaeodaclylurn三角褐豆可以通过引入编码葡萄糖转运蛋白的基因进行工程化以导入葡萄糖并在黑暗中生长。人和小球藻凯斯勒葡萄糖转运蛋白都促进了三角褐指藻的葡萄糖摄取，使得细胞代谢外源有机碳，并且独立于光。这是通过代谢工程首次成功地营养专一性自养型营养转化，并且表明通过引入单一基因可以从根本上改变细胞营养的方法。由于用葡萄糖转运基因转化的菌株能够非光合作用生长，因此可以通过突变体的产生和表征来开发光合作用的分析。最后，这项工作也是通过使用微生物发酵技术大规模商业开发专用光营养藻类的重要进展，消除了光依赖性生长造成的重大限制。

10. 发明授权

US07932056B2 Crustaceans as production systems for therapeutic proteins 有权
标题翻译：甲壳动物作为治疗性蛋白质的生产系统
公开(公告)号：US07932056B2
公开(公告)日：2011-04-26
申请号：US12489905
申请日：2009-06-23
申请人： Ruth Barratt , F. C. Thomas Allnutt , Robert Bullis , David J. Kyle
发明人： Ruth Barratt , F. C. Thomas Allnutt , Robert Bullis , David J. Kyle
IPC分类号： C12P21/00 , C12N5/06 , C12N7/00
CPC分类号： C07K14/005 , A01K2227/70 , A01K2267/01 , A61K2039/5256 , C07K14/505 , C07K14/62 , C07K16/00 , C07K2317/10 , C12N7/00 , C12N9/16 , C12N15/86 , C12N2710/14043 , C12N2710/18043 , C12N2750/14043 , C12N2770/16022 , C12N2770/16034 , C12N2770/22043 , C12N2770/36143 , C12N2830/00 , C12N2830/75
摘要： A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.
摘要翻译：用表达外源蛋白质的病毒的重组感染性病毒感染甲壳类动物或轮虫。甲壳类或轮虫本身的基因组本身保持不变。甲壳动物，轮虫，昆虫或病毒启动子驱动插入重组病毒基因组中的基因的转录，并且病毒在甲壳类或轮状细胞细胞质中复制。受感染的甲壳动物或轮虫可以直接提供给人类或非人动物，或者在甲壳类动物或轮虫的生产和收获后，可提供纯化的重组蛋白或多肽。可以使用该生产系统快速且廉价地生产大量的生物药物。

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