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1. 发明授权

US09072311B2 Absorption of fat-soluble nutrients 有权
标题翻译：吸收脂溶性营养素
公开(公告)号：US09072311B2
公开(公告)日：2015-07-07
申请号：US10530598
申请日：2004-06-21
申请人： Moti Harel , John Piechocki , David J. Kyle
发明人： Moti Harel , John Piechocki , David J. Kyle
IPC分类号： A23K1/18 , A23K1/16 , A23K1/00 , A23K1/175 , A61K31/065 , A61K31/66
CPC分类号： A61K31/685 , A23K20/158 , A23K20/174 , A23K20/179 , A23K20/22 , A23K20/26 , A23K40/30 , A23K50/75 , A23K50/80 , A61K31/065 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： Carotenoids are provided as dietary supplements to animal feed. These supplements improve the bioavailability of carotenoids by providing them in combination with phospholipids. The invention provides animal feeds for aquatic and terrestrial animals, and methods for making the feeds.
摘要翻译：提供类胡萝卜素作为动物饲料的膳食补充剂。这些补充剂通过将其与磷脂组合提供来提高类胡萝卜素的生物利用度。本发明提供了用于水生和陆生动物的动物饲料以及用于制备饲料的方法。

2. 发明申请

US20060258623A1 Absorption of fat-soluble nutrients 有权
公开(公告)号：US20060258623A1
公开(公告)日：2006-11-16
申请号：US10530598
申请日：2004-06-21
申请人： Moti Harel , John Piechocki , David Kyle
发明人： Moti Harel , John Piechocki , David Kyle
IPC分类号： A61K31/685 , A23K1/165 , A61K31/12 , A61K31/015
CPC分类号： A61K31/685 , A23K20/158 , A23K20/174 , A23K20/179 , A23K20/22 , A23K20/26 , A23K40/30 , A23K50/75 , A23K50/80 , A61K31/065 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： Carotenoids are provided as dietary supplements to animal feed. These supplements improve the bioavailability of carotenoids by providing them in combination with phospholipids. The invention provides animal feeds for aquatic and terrestrial animals, and methods for making the feeds.

3. 发明申请

US20060265766A1 Fish and the production thereof 审中-公开
标题翻译：鱼及其生产
公开(公告)号：US20060265766A1
公开(公告)日：2006-11-23
申请号：US10549730
申请日：2004-03-19
申请人： David Kyle , Moti Harel , John Piechocki
发明人： David Kyle , Moti Harel , John Piechocki
IPC分类号： A23L1/325 , A01K67/033 , A01K67/027
CPC分类号： A01K61/10 , A01K61/00 , A01K61/51 , A23K20/105 , A23K20/158 , A23K20/174 , A23K20/179 , A23K50/30 , A23K50/40 , A23K50/80 , A23L17/40 , A23L17/50 , A23L17/65 , A23L33/12 , A23V2002/00 , A23V2250/1868 , A23V2250/0644
摘要： This invention is directed to the composition, method of production, and use of improved edible fish, crustacean, or mollusk products enriched with one or more components that provide health benefits to humans or other animals consuming the product.
摘要翻译：本发明涉及富含一种或多种为消费产品的人或其他动物提供健康益处的成分的改良食用鱼，甲壳类或软体动物产品的组合物，生产方法和使用。

4. 发明申请

US20200154702A1 Stable Bioactive Substances and Methods of Making 审中-公开
公开(公告)号：US20200154702A1
公开(公告)日：2020-05-21
申请号：US16751708
申请日：2020-01-24
申请人： Moti Harel , Qiong Tang , Erin E. Dickey
发明人： Moti Harel , Qiong Tang , Erin E. Dickey
IPC分类号： A01N25/10 , A61K9/14 , A61K47/26 , A23L33/00 , A23L33/10 , A23K20/189 , A23K20/163 , A01N25/22 , A61K38/44 , A61K38/48 , A61K9/20 , A61K38/47 , C11D3/39 , C11D3/386 , C11D3/00 , A61K38/46 , C11D3/48 , C11D3/33 , C11D3/22 , A23K40/20 , A61K31/714
摘要： The present invention relates to stable bioactive substances and preparation thereof. A preparation method includes dissolving a bioactive material in a solution substantially free of solutes to make a bioactive solution, adsorbing the bioactive solution onto dry polysaccharide particles to make bioactive loaded polysaccharide particles, and drying the bioactive loaded polysaccharide particles.

5. 发明授权

US09623094B2 Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish 有权
公开(公告)号：US09623094B2
公开(公告)日：2017-04-18
申请号：US13260661
申请日：2010-03-26
申请人： Moti Harel , Brian Carpenter
发明人： Moti Harel , Brian Carpenter
IPC分类号： A61K39/12 , A61K39/02 , A61P31/14 , A61K47/36 , A61K9/14 , A61P31/00 , A61K47/30 , A61K39/00 , A61K9/00 , A61K39/145
CPC分类号： A61K39/39 , A61K9/0043 , A61K9/006 , A61K9/5015 , A61K39/00 , A61K39/0208 , A61K39/0233 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/522 , A61K2039/5254 , A61K2039/5258 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55555 , A61K2039/55583 , C12N7/00 , C12N2720/10011 , C12N2720/10023 , C12N2720/10034 , C12N2740/10011 , C12N2740/10034 , C12N2760/10034 , C12N2760/16011 , C12N2760/16022 , C12N2760/16034
摘要： The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.

6. 发明授权

US09504275B2 Dry storage stabilizing composition for biological materials 有权
标题翻译：用于生物材料的干燥储存稳定组合物
公开(公告)号：US09504275B2
公开(公告)日：2016-11-29
申请号：US13208459
申请日：2011-08-12
申请人： Moti Harel , Qiong Tang
发明人： Moti Harel , Qiong Tang
IPC分类号： A61K47/42 , A23L1/30 , A01N1/02 , A23L1/00 , A23L3/44 , A23P1/04 , A61K39/12 , C12N1/04 , A61K39/00
CPC分类号： A23K20/10 , A01N1/0221 , A01N1/0284 , A01N1/0289 , A23K10/18 , A23K20/142 , A23K20/147 , A23K20/163 , A23K40/30 , A23L3/44 , A23L33/135 , A23P10/30 , A61K39/12 , A61K2039/5252 , A61K2039/542 , C12N1/04 , C12N2760/16011 , C12N2760/16034
摘要： The present invention includes compositions and drying methods for preserving sensitive bioactive materials, such as peptides, proteins, hormones, nucleic acids, antibodies, drugs vaccines, yeast, bacteria (probiotic or otherwise), viruses and/or cell suspensions, in storage. The compositions include a carbohydrates component and a glass enhancer component, wherein the carbohydrate component includes a mixture of di-, oligo- and polysaccharides and the glass enhancer includes ions of organic acid and protein hydrolysates. The composition is prepared by dispersing all the solid components in a solution and then snap-frozen to form small beads, strings or droplets. The preferred drying method of the frozen beads, strings or droplets is initiated by a short purging and structure stabilizing step of the frozen particles under a vacuum pressure of less than 2000 mTORR and at a desired temperature. During the secondary and final drying step of the material a full vacuum pressure and elevated temperature are applied, to achieve a final desirable water activity of the dry material.
摘要翻译：本发明包括用于保存灵敏生物活性物质（例如肽，蛋白质，激素，核酸，抗体，药物疫苗，酵母，细菌（益生菌或其他）），病毒和/或细胞悬液的组合物和干燥方法。组合物包括碳水化合物组分和玻璃增强剂组分，其中碳水化合物组分包括二糖，寡糖和多糖的混合物，玻璃增强剂包括有机酸和蛋白质水解产物的离子。通过将所有固体组分分散在溶液中制备组合物，然后快速冷冻以形成小的珠粒，细丝或液滴。冻结的珠粒，丝束或液滴的优选干燥方法是通过在小于2000mTORR的真空压力下的冷冻颗粒的短清洗和结构稳定步骤引发的，随后在大于> 2000的真空压力下进行初步干燥步骤 mTORR并在所需温度下进行。在材料的二次和最终干燥步骤期间，施加完全真空压力和升高的温度，以达到干燥材料的最终期望的水活度。

7. 发明授权

US08329209B2 Encapsulated vaccines for the oral vaccination and boostering of fish and other animals 有权
标题翻译：用于口服疫苗接种和加强鱼类和其他动物的封装疫苗
公开(公告)号：US08329209B2
公开(公告)日：2012-12-11
申请号：US13204745
申请日：2011-08-08
申请人： Moti Harel
发明人： Moti Harel
IPC分类号： A61K39/00 , A61K47/00 , A61K38/00 , A61K9/16 , A23K1/165
CPC分类号： A61K39/145 , A23K50/30 , A23K50/75 , A23K50/80 , A61K9/1652 , A61K39/0233 , A61K39/0275 , A61K39/12 , A61K39/39 , A61K2039/521 , A61K2039/542 , A61K2039/552 , A61K2039/55566 , A61K2039/55583 , C12N2760/16134 , Y02A50/482
摘要： The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic animals.
摘要翻译：本发明涉及一种组合物，其包含药物活性剂和生物粘附递送系统，其提供疫苗口服递送至动物，特别是水生动物。

8. 发明申请

US20120040010A1 MICROPARTICULATED VACCINES FOR THE ORAL OR NASAL VACCINATION AND BOOSTERING OF ANIMALS INCLUDING FISH 有权
标题翻译：用于口服或鼻内接种疫苗的微生物疫苗和包括鱼类在内的动物饲养
公开(公告)号：US20120040010A1
公开(公告)日：2012-02-16
申请号：US13260661
申请日：2010-03-26
申请人： Moti Harel , Brian Carpenter
发明人： Moti Harel , Brian Carpenter
IPC分类号： A61K39/12 , A61K39/02 , A61P31/14 , A61K47/36 , A61K9/14 , A61P31/00 , A61K47/30 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0043 , A61K9/006 , A61K9/5015 , A61K39/00 , A61K39/0208 , A61K39/0233 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/522 , A61K2039/5254 , A61K2039/5258 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55555 , A61K2039/55583 , C12N7/00 , C12N2720/10011 , C12N2720/10023 , C12N2720/10034 , C12N2740/10011 , C12N2740/10034 , C12N2760/10034 , C12N2760/16011 , C12N2760/16022 , C12N2760/16034
摘要： The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.
摘要翻译：本发明涉及一种用于制造半干或干燥颗粒的组合物和方法，其包含粘膜粘附聚合物和生物活性剂，例如但不限于免疫原性物质（例如疫苗），其允许口服或鼻内施用并且生物活性剂的输送基本上不变化到动物的粘膜表面，包括水生动物。

9. 发明申请

US20070082008A1 Feed formulation for terrestrial and aquatic animals 审中-公开
标题翻译：陆地和水生动物的饲料配方
公开(公告)号：US20070082008A1
公开(公告)日：2007-04-12
申请号：US10548363
申请日：2004-03-05
申请人： Moti Harel , Diane Clayton , Robert Bullis
发明人： Moti Harel , Diane Clayton , Robert Bullis
IPC分类号： A61K36/06 , A61K36/02 , A23K1/165
CPC分类号： A61K36/02 , A23K10/12 , A23K10/16 , A23K10/30 , A23K20/142 , A23K20/158 , A23K20/174 , A23K50/30 , A23K50/75 , A23K50/80 , A61K36/06 , A61K2300/00
摘要： The use of macroalgal, microalgal, and fungally-derived materials provide, in combination with higher-plant derived materials, complete feeds for animal husbandry. The products and methods of the invention provide nutritional feed formulations, that reduce or eliminate the need for animal-derived materials. The feeds are useful for terrestrial or aquatic animals, and comprise docosahexaenoic acid and eicosapentaenoic acid.
摘要翻译：使用大型藻类，微藻类和真菌来源的材料与高等植物来源的材料结合提供完整的畜牧饲料。本发明的产品和方法提供营养饲料制剂，其减少或消除对动物来源的材料的需要。饲料对陆生或水生动物有用，并且包含二十二碳六烯酸和二十碳五烯酸。

10. 发明授权

US09445613B2 Microencapsulation of bioactive substances and methods of making the same 有权
标题翻译：生物活性物质的微胶囊化及其制备方法
公开(公告)号：US09445613B2
公开(公告)日：2016-09-20
申请号：US13260388
申请日：2010-03-24
申请人： Moti Harel
发明人： Moti Harel
IPC分类号： A61K9/16 , A23L1/00 , A21D2/14 , A23L1/03 , A23L1/275 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305
CPC分类号： A23L33/16 , A21D2/14 , A23L5/44 , A23L29/06 , A23L33/12 , A23L33/15 , A23L33/175 , A23P10/35 , A23V2002/00 , A23V2200/224 , A23V2250/702 , A23V2250/7106 , A23V2250/7142
摘要： The present invention relates to microparticles and methods of making such microparticles that protect a bioactive substance from heat, humidity and oxidation. A microparticle comprising a bioactive substance, an agglomerating agent, an emulsifier and solid fats is disclosed. A method to produce a microparticle comprising an agglomerated bioactive substance enrobed in a double layer of solid fats and emulsifier is also disclosed.
摘要翻译：本发明涉及微粒以及保护生物活性物质免受热，湿度和氧化的微粒的制造方法。公开了包含生物活性物质，附聚剂，乳化剂和固体脂肪的微粒。还公开了一种生产包含在双层固体脂肪和乳化剂中包埋的附聚生物活性物质的微粒的方法。

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