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1. 发明授权

US5603897A Method for indicating neutralization of contact lens disinfecting solutions 失效
标题翻译：表示隐形眼镜消毒溶液中和的方法
公开(公告)号：US5603897A
公开(公告)日：1997-02-18
申请号：US268473
申请日：1994-06-30
申请人： David J. Heiler , Matthew S. Jonasse , David A. Marsh , Jill S. Rogalskyj
发明人： David J. Heiler , Matthew S. Jonasse , David A. Marsh , Jill S. Rogalskyj
IPC分类号： G02C13/00 , A61L2/18 , A61L2/26 , A61L12/08 , G01N31/22 , A61L2/16
CPC分类号： G01N31/22 , A61L12/08 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555
摘要： A method of treating contact lenses comprising the use of an iodine-chromophore to indicate neutralization of oxidative disinfectants.
摘要翻译：一种治疗隐形眼镜的方法，包括使用碘发色团来表示氧化消毒剂的中和。

2. 发明授权

US5451303A Cleaning hydrophilic contact lenses by electrochemical means 失效
标题翻译：用电化学方法清洁亲水性隐形眼镜
公开(公告)号：US5451303A
公开(公告)日：1995-09-19
申请号：US175883
申请日：1993-12-30
申请人： David J. Heiler , David A. Marsh , Matthew S. Jonasse , Rick Panicucci
发明人： David J. Heiler , David A. Marsh , Matthew S. Jonasse , Rick Panicucci
IPC分类号： G02C13/00 , B08B3/08 , C11D3/00 , C11D3/39 , C11D7/18 , C11D7/38 , G02C7/04 , C25B7/00
CPC分类号： C11D3/3942 , C11D3/0042 , C11D3/0078 , C11D3/39
摘要： A composition and method for cleaning and disinfecting of contact lenses that employ an electrical field applied to a lens that causes contaminating deposits to migrate therefrom is described. The composition of the invention includes a pair of component materials having different electrochemical potentials wherein the materials are substantially contained in a form wherein each material remains sufficiently physically separated when in contact with opposite sides of the lens such that the difference in electrochemical potential between the two materials is sufficient to cause charged contaminating deposits to migrate from the lens. The method of the invention requires placing a contaminated lens between a pair of component materials having different electrochemical potentials wherein physical separation is maintained, preferably, by including one of the components in a gel while the other component is in solution or another gel. Preferably, one component of the pair of materials is an oxidizing agent while the second component is a reducing agent. An example of a suitable pair is hydrogen peroxide suspended in a carbopol gel and a solution of sodium thiosulfate, as the reducing agent. A lens is coated with the oxidant gel, placed in the reductant solution and held at room temperature for 2-4 hours, wherein the electrochemical field established between the pair achieves about a 29% protein removal.
摘要翻译：描述了一种用于清洁和消毒隐形眼镜的组合物和方法，所述隐形眼镜采用施加到使得污染沉积物迁移的透镜的电场。本发明的组合物包括具有不同电化学电位的一对组分材料，其中材料基本上包含在其中每个材料在与透镜的相对侧接触时保持足够物理分离的形式，使得两者之间的电化学电位差材料足以引起带电的污染沉积物从透镜迁移。本发明的方法需要将污染的透镜放置在具有不同电化学电位的一对组分材料之间，其中保持物理分离，优选通过将一种组分包含在凝胶中而另一种组分在溶液或另一种凝胶中。优选地，一对材料中的一种组分是氧化剂，而第二组分是还原剂。合适的一个例子是悬浮在卡波胶中的过氧化氢和硫代硫酸钠的溶液作为还原剂。将透镜涂覆有氧化剂凝胶，置于还原剂溶液中并在室温下保持2-4小时，其中建立在该对之间的电化学场达到约29％的蛋白质去除。

3. 发明授权

US5925317A Dual neutralization system for iodine treatment of contact lenses 失效
标题翻译：双重中和系统用于治疗隐形眼镜
公开(公告)号：US5925317A
公开(公告)日：1999-07-20
申请号：US760915
申请日：1996-12-06
申请人： Jill S. Rogalskyj , David J. Heiler , Alyce K. Dobie
发明人： Jill S. Rogalskyj , David J. Heiler , Alyce K. Dobie
IPC分类号： G02C13/00 , A01N59/12 , A61L2/18 , A61L12/10
CPC分类号： A61L12/105 , Y10S514/84
摘要： A method and system for disinfecting contact lenses with iodine using a neutralizing solution having a first, rapid neutralizing component which completes its reaction with available iodine in less than five seconds and a second, slower neutralizing component which completes its reaction with available iodine in about 3 to 30 minutes.
摘要翻译：一种使用中和溶液消毒隐形眼镜的方法和系统，该中和溶液具有第一快速中和组分，其在少于5秒内完成其与可用碘的反应，第二，较慢的中和组分完成其与约3的可用碘的反应至30分钟。

4. 发明申请

US20070148127A1 ANTIMICROBIAL OPHTHALMIC TREATMENT SYSTEM AND METHOD 审中-公开
标题翻译：抗微生物眼科治疗系统及方法
公开(公告)号：US20070148127A1
公开(公告)日：2007-06-28
申请号：US11611369
申请日：2006-12-15
申请人： David J. Heiler , Joseph C. Salamone , Richard V. Smerbeck , Matthew S. Jonasse
发明人： David J. Heiler , Joseph C. Salamone , Richard V. Smerbeck , Matthew S. Jonasse
IPC分类号： A61K31/785 , A61K31/155
CPC分类号： A61L12/142 , A01N47/44 , A01N25/08 , A01N25/34 , A01N2300/00
摘要： An ophthalmic treatment system comprises an ophthalmic treatment solution and a biguanide antimicrobial agent in solid form and in contact with said treatment solution such as to inhibit bacterial and/or fungal growth in said solution. The biguanide is partially or wholly terminated with an amine compound.
摘要翻译：眼科治疗系统包括固体形式的眼科治疗溶液和双胍抗微生物剂，并与所述治疗溶液接触，以抑制所述溶液中的细菌和/或真菌生长。双胍部分或全部用胺化合物封端。

5. 发明授权

US5364637A Method and composition for cleaning contact lenses with cyclodextrins 失效
标题翻译：用环糊精清洁隐形眼镜的方法和组成
公开(公告)号：US5364637A
公开(公告)日：1994-11-15
申请号：US852427
申请日：1992-03-16
申请人： Nimai C. De , David J. Heiler , David A. Marsh , Suzanne F. Groemminger
发明人： Nimai C. De , David J. Heiler , David A. Marsh , Suzanne F. Groemminger
IPC分类号： A61L2/18 , A61L12/08 , C11D3/00 , C11D3/22 , G02C13/00 , A61K9/20 , A61K31/715
CPC分类号： A61L12/08 , C11D3/0078 , C11D3/222 , Y10S514/839 , Y10S514/84
摘要： Contact lenses are cleaned by contacting the lenses with a composition containing an effective amount of one or more cyclodextrins. The compositions can also be employed at elevated temperatures or may contain suitable antimicrobial agents in order to simultaneously clean and disinfect the lenses.
摘要翻译：通过使镜片与含有有效量的一种或多种环糊精的组合物接触来清洁隐形眼镜。组合物也可以在升高的温度下使用或者可以含有合适的抗微生物剂，以便同时对透镜进行清洁和消毒。

6. 发明授权

US06348508B1 Method for treating dry eye 失效
标题翻译：干眼症治疗方法
公开(公告)号：US06348508B1
公开(公告)日：2002-02-19
申请号：US09542332
申请日：2000-04-04
申请人： John Denick, Jr. , David J. Heiler , Zhenze Hu , Joseph C. Salamone , Richard V. Smerbeck
发明人： John Denick, Jr. , David J. Heiler , Zhenze Hu , Joseph C. Salamone , Richard V. Smerbeck
IPC分类号： A61K4732
CPC分类号： A61K31/717 , A61K9/0048
摘要： The present invention is directed to a method of treating dry eye by instilling eyedrops of a composition containing a cationic cellulosic polymer. Such compositions have been found to alleviate the symptoms of dry eye without requiring the presence of anionic therapeutic agents. Low ionic strength solutions are particularly preferred.
摘要翻译：本发明涉及通过滴注含有阳离子纤维素聚合物的组合物的滴眼剂来治疗干眼症的方法。已经发现这样的组合物可以缓解干眼症状，而不需要存在阴离子治疗剂。低离子强度溶液是特别优选的。

7. 发明授权

US6153568A Compositions comprising polyquaterniums in combination with polymeric biguanides for disinfecting contact lenses 有权
标题翻译：包含聚季铵盐与聚合双胍的组合物用于消毒隐形眼镜
公开(公告)号：US6153568A
公开(公告)日：2000-11-28
申请号：US190509
申请日：1998-11-12
申请人： David J. McCanna , Stephen E. Maier , David J. Heiler , Susan P. Spooner , Erning Xia
发明人： David J. McCanna , Stephen E. Maier , David J. Heiler , Susan P. Spooner , Erning Xia
IPC分类号： G02C13/00 , A01N47/44 , A01N59/00 , A61L2/18 , A61L12/14 , C11D3/00 , C11D3/37 , C11D3/48 , F61K31/155 , C11D3/30
CPC分类号： C11D3/48 , A61L12/142 , C11D3/0078 , C11D3/3723
摘要： The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising the combination of a polymeric biguanide and a polyquaternium polymer of a substituted or unsubstituted vinylimidazole or its vinylimidazoliuum salt, which copolymer has a weight average molecular weight of 5,000 to 5,000,000. The invention is also directed to an improved method of disinfecting a contact lens.
摘要翻译：本发明涉及用于隐形眼镜的眼用安全消毒溶液，其包含聚合双胍和取代或未取代的乙烯基咪唑或其乙烯基咪唑真盐的聚季铵盐聚合物的组合，该共聚物的重均分子量为5,000至5,000,000。本发明还涉及一种消毒隐形眼镜的改进方法。

8. 发明申请

US20080261841A1 BIGUANIDE COMPOSITION WITH LOW TERMINAL AMINE 有权
标题翻译：具有低端氨基酸的双胍组合物
公开(公告)号：US20080261841A1
公开(公告)日：2008-10-23
申请号：US11865746
申请日：2007-10-02
申请人： David J. Heiler
发明人： David J. Heiler
IPC分类号： C11D3/37
CPC分类号： C08G73/00 , A01N47/44 , A61L12/142 , C08L79/00
摘要： A polymeric biguanide composition comprising less than 18 mol % of terminal amine groups as measured by 13C NMR. The polymeric biguanide composition also is characterized by a relative increase in the molar concentration of terminal guanidine groups or terminal cyanoguanidino groups. The invention is also directed to ophthalmic compositions comprising the polymeric biguanide compositions. The polymeric biguanide compositions can be used as an antimicrobial component in an ophthalmic lens care solution, or as a preservative to in a pharmaceutical composition or other health care product.
摘要翻译：包含通过13 C NMR测量的小于18mol％的末端胺基的聚合双胍组合物。聚合双胍组合物的特征还在于末端胍基或末端氰胍基的摩尔浓度相对增加。本发明还涉及包含聚合双胍组合物的眼用组合物。聚合双胍组合物可用作眼用晶状体护理溶液中的抗微生物组分，或用作药物组合物或其它保健产品中的防腐剂。

9. 发明授权

US06323165B1 Composition and method for inhibiting of protein on contact lens 有权
标题翻译：隐形眼镜抑制蛋白质的组合物和方法
公开(公告)号：US06323165B1
公开(公告)日：2001-11-27
申请号：US09558436
申请日：2000-04-25
申请人： David J. Heiler , Stephen E. Maier , Susan P. Spooner
发明人： David J. Heiler , Stephen E. Maier , Susan P. Spooner
IPC分类号： B08B308
CPC分类号： A61L12/145 , C11D3/0078 , C11D3/3723 , C11D3/3773 , Y10S134/901 , Y10S514/839 , Y10S514/84
摘要： The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.
摘要翻译：本发明涉及用作亲水性隐形眼镜上的蛋白质沉积物的眼内和/或眼外抑制剂的组合物和方法。本发明的组合物包含选择性结合亲水性隐形眼镜以阻断蛋白质材料的结合的中等带电聚季铵盐聚合物。本发明的组合物可以用于隐形眼镜的多用途清洁溶液中，并且可以消除用于去除蛋白质物质的特殊酶清洁剂等的需要。

10. 发明授权

US5019380A Novel antimicrobial compositions and process for preparing the same 失效
标题翻译：新型抗微生物组合物及其制备方法
公开(公告)号：US5019380A
公开(公告)日：1991-05-28
申请号：US515394
申请日：1990-04-27
申请人： David J. Heiler
发明人： David J. Heiler
IPC分类号： A61K31/755 , A01N59/00 , A61K31/79 , A61L2/16 , A61P31/04
CPC分类号： A01N59/00 , Y10S514/912 , Y10S514/914
摘要： Novel compositions of matter are provided herein which are the reaction product of polyvinylpyrrolidone and hypochlorites. These compositions are useful as antimicrobial agents.

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