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1. 发明授权

US6153568A Compositions comprising polyquaterniums in combination with polymeric biguanides for disinfecting contact lenses 有权
标题翻译：包含聚季铵盐与聚合双胍的组合物用于消毒隐形眼镜
公开(公告)号：US6153568A
公开(公告)日：2000-11-28
申请号：US190509
申请日：1998-11-12
申请人： David J. McCanna , Stephen E. Maier , David J. Heiler , Susan P. Spooner , Erning Xia
发明人： David J. McCanna , Stephen E. Maier , David J. Heiler , Susan P. Spooner , Erning Xia
IPC分类号： G02C13/00 , A01N47/44 , A01N59/00 , A61L2/18 , A61L12/14 , C11D3/00 , C11D3/37 , C11D3/48 , F61K31/155 , C11D3/30
CPC分类号： C11D3/48 , A61L12/142 , C11D3/0078 , C11D3/3723
摘要： The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising the combination of a polymeric biguanide and a polyquaternium polymer of a substituted or unsubstituted vinylimidazole or its vinylimidazoliuum salt, which copolymer has a weight average molecular weight of 5,000 to 5,000,000. The invention is also directed to an improved method of disinfecting a contact lens.
摘要翻译：本发明涉及用于隐形眼镜的眼用安全消毒溶液，其包含聚合双胍和取代或未取代的乙烯基咪唑或其乙烯基咪唑真盐的聚季铵盐聚合物的组合，该共聚物的重均分子量为5,000至5,000,000。本发明还涉及一种消毒隐形眼镜的改进方法。

2. 发明授权

US06323165B1 Composition and method for inhibiting of protein on contact lens 有权
标题翻译：隐形眼镜抑制蛋白质的组合物和方法
公开(公告)号：US06323165B1
公开(公告)日：2001-11-27
申请号：US09558436
申请日：2000-04-25
申请人： David J. Heiler , Stephen E. Maier , Susan P. Spooner
发明人： David J. Heiler , Stephen E. Maier , Susan P. Spooner
IPC分类号： B08B308
CPC分类号： A61L12/145 , C11D3/0078 , C11D3/3723 , C11D3/3773 , Y10S134/901 , Y10S514/839 , Y10S514/84
摘要： The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.
摘要翻译：本发明涉及用作亲水性隐形眼镜上的蛋白质沉积物的眼内和/或眼外抑制剂的组合物和方法。本发明的组合物包含选择性结合亲水性隐形眼镜以阻断蛋白质材料的结合的中等带电聚季铵盐聚合物。本发明的组合物可以用于隐形眼镜的多用途清洁溶液中，并且可以消除用于去除蛋白质物质的特殊酶清洁剂等的需要。

3. 发明授权

US6096138A Method for inhibiting the deposition of protein on contact lens 失效
标题翻译：抑制蛋白质沉积在隐形眼镜上的方法
公开(公告)号：US6096138A
公开(公告)日：2000-08-01
申请号：US846403
申请日：1997-04-30
申请人： David J. Heiler , Stephen E. Maier , Susan P. Spooner
发明人： David J. Heiler , Stephen E. Maier , Susan P. Spooner
IPC分类号： A61L12/14 , C11D3/00 , C11D3/37 , B08B3/08
CPC分类号： A61L12/145 , C11D3/0078 , C11D3/3723 , C11D3/3773 , Y10S134/901 , Y10S514/839 , Y10S514/84
摘要： The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.
摘要翻译：本发明涉及用作亲水性隐形眼镜上的蛋白质沉积物的眼内和/或眼外抑制剂的组合物和方法。本发明的组合物包含选择性结合亲水性隐形眼镜以阻断蛋白质材料的结合的中等带电聚季铵盐聚合物。本发明的组合物可以用于隐形眼镜的多用途清洁溶液中，并且可以消除用于去除蛋白质物质的特殊酶清洁剂等的需要。

4. 发明授权

US06309596B1 Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by a poloxamine 有权
标题翻译：用包含由泊洛沙胺稳定的双胍消毒剂的水溶液处理隐形眼镜
公开(公告)号：US06309596B1
公开(公告)日：2001-10-30
申请号：US09211547
申请日：1998-12-15
申请人： Erning Xia , David J. Heiler
发明人： Erning Xia , David J. Heiler
IPC分类号： A01N208
CPC分类号： A61L12/141 , A61L12/142 , A61L12/145
摘要： The present invention is directed to a biguanide-containing disinfecting solution containing a particular type of poloxamine for stabilizing a polymeric biguanide. The poloxamine surfactant comprises at least about 90 weight percent of poly(oxyethylene) and poly(oxypropylene) segments, in one or more copolymer chains, wherein the weight average molecular weight of said surfactant is from about 10,000 to about 30,000 and wherein at least about 70 weight percent of said poly(oxyethylene) and poly(oxypropylene) segments are poly(oxyethylene) segments, and wherein the HLB value is at least 27. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution. Products according to the present invention provide enhanced cleaning while maintaining biocidal efficacy.
摘要翻译：本发明涉及含有特定类型的泊洛沙胺以稳定聚合双胍的含双胍类消毒溶液。泊洛沙胺表面活性剂在一个或多个共聚物链中包含至少约90重量％的聚（氧乙烯）和聚（氧化丙烯）链段，其中所述表面活性剂的重均分子量为约10,000至约30,000，并且其中至少约 70重量％的所述聚（氧乙烯）和聚（氧化丙烯）链段是聚（氧化乙烯）链段，其中HLB值至少为27.本发明的方法包括用上述方法清洁和消毒隐形眼镜解。根据本发明的产品提供增强的清洁，同时保持杀生物效力。

5. 发明申请

US20070148127A1 ANTIMICROBIAL OPHTHALMIC TREATMENT SYSTEM AND METHOD 审中-公开
标题翻译：抗微生物眼科治疗系统及方法
公开(公告)号：US20070148127A1
公开(公告)日：2007-06-28
申请号：US11611369
申请日：2006-12-15
申请人： David J. Heiler , Joseph C. Salamone , Richard V. Smerbeck , Matthew S. Jonasse
发明人： David J. Heiler , Joseph C. Salamone , Richard V. Smerbeck , Matthew S. Jonasse
IPC分类号： A61K31/785 , A61K31/155
CPC分类号： A61L12/142 , A01N47/44 , A01N25/08 , A01N25/34 , A01N2300/00
摘要： An ophthalmic treatment system comprises an ophthalmic treatment solution and a biguanide antimicrobial agent in solid form and in contact with said treatment solution such as to inhibit bacterial and/or fungal growth in said solution. The biguanide is partially or wholly terminated with an amine compound.
摘要翻译：眼科治疗系统包括固体形式的眼科治疗溶液和双胍抗微生物剂，并与所述治疗溶液接触，以抑制所述溶液中的细菌和/或真菌生长。双胍部分或全部用胺化合物封端。

6. 发明授权

US06348508B1 Method for treating dry eye 失效
标题翻译：干眼症治疗方法
公开(公告)号：US06348508B1
公开(公告)日：2002-02-19
申请号：US09542332
申请日：2000-04-04
申请人： John Denick, Jr. , David J. Heiler , Zhenze Hu , Joseph C. Salamone , Richard V. Smerbeck
发明人： John Denick, Jr. , David J. Heiler , Zhenze Hu , Joseph C. Salamone , Richard V. Smerbeck
IPC分类号： A61K4732
CPC分类号： A61K31/717 , A61K9/0048
摘要： The present invention is directed to a method of treating dry eye by instilling eyedrops of a composition containing a cationic cellulosic polymer. Such compositions have been found to alleviate the symptoms of dry eye without requiring the presence of anionic therapeutic agents. Low ionic strength solutions are particularly preferred.
摘要翻译：本发明涉及通过滴注含有阳离子纤维素聚合物的组合物的滴眼剂来治疗干眼症的方法。已经发现这样的组合物可以缓解干眼症状，而不需要存在阴离子治疗剂。低离子强度溶液是特别优选的。

7. 发明申请

US20080261841A1 BIGUANIDE COMPOSITION WITH LOW TERMINAL AMINE 有权
标题翻译：具有低端氨基酸的双胍组合物
公开(公告)号：US20080261841A1
公开(公告)日：2008-10-23
申请号：US11865746
申请日：2007-10-02
申请人： David J. Heiler
发明人： David J. Heiler
IPC分类号： C11D3/37
CPC分类号： C08G73/00 , A01N47/44 , A61L12/142 , C08L79/00
摘要： A polymeric biguanide composition comprising less than 18 mol % of terminal amine groups as measured by 13C NMR. The polymeric biguanide composition also is characterized by a relative increase in the molar concentration of terminal guanidine groups or terminal cyanoguanidino groups. The invention is also directed to ophthalmic compositions comprising the polymeric biguanide compositions. The polymeric biguanide compositions can be used as an antimicrobial component in an ophthalmic lens care solution, or as a preservative to in a pharmaceutical composition or other health care product.
摘要翻译：包含通过13 C NMR测量的小于18mol％的末端胺基的聚合双胍组合物。聚合双胍组合物的特征还在于末端胍基或末端氰胍基的摩尔浓度相对增加。本发明还涉及包含聚合双胍组合物的眼用组合物。聚合双胍组合物可用作眼用晶状体护理溶液中的抗微生物组分，或用作药物组合物或其它保健产品中的防腐剂。

8. 发明授权

US5603897A Method for indicating neutralization of contact lens disinfecting solutions 失效
标题翻译：表示隐形眼镜消毒溶液中和的方法
公开(公告)号：US5603897A
公开(公告)日：1997-02-18
申请号：US268473
申请日：1994-06-30
申请人： David J. Heiler , Matthew S. Jonasse , David A. Marsh , Jill S. Rogalskyj
发明人： David J. Heiler , Matthew S. Jonasse , David A. Marsh , Jill S. Rogalskyj
IPC分类号： G02C13/00 , A61L2/18 , A61L2/26 , A61L12/08 , G01N31/22 , A61L2/16
CPC分类号： G01N31/22 , A61L12/08 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555
摘要： A method of treating contact lenses comprising the use of an iodine-chromophore to indicate neutralization of oxidative disinfectants.
摘要翻译：一种治疗隐形眼镜的方法，包括使用碘发色团来表示氧化消毒剂的中和。

9. 发明授权

US5019380A Novel antimicrobial compositions and process for preparing the same 失效
标题翻译：新型抗微生物组合物及其制备方法
公开(公告)号：US5019380A
公开(公告)日：1991-05-28
申请号：US515394
申请日：1990-04-27
申请人： David J. Heiler
发明人： David J. Heiler
IPC分类号： A61K31/755 , A01N59/00 , A61K31/79 , A61L2/16 , A61P31/04
CPC分类号： A01N59/00 , Y10S514/912 , Y10S514/914
摘要： Novel compositions of matter are provided herein which are the reaction product of polyvinylpyrrolidone and hypochlorites. These compositions are useful as antimicrobial agents.

10. 发明授权

US08530641B2 Sterile hyaluronic acid solutions 有权
标题翻译：无菌透明质酸溶液
公开(公告)号：US08530641B2
公开(公告)日：2013-09-10
申请号：US13564161
申请日：2012-08-01
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
IPC分类号： A61K31/728 , C08B37/00 , C08B37/08
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译：含有重量平均分子量为0.6MDa至3.6Mda的0.04％至0.8％重量的透明质酸和一种或多种选自硼酸，硼酸钠和磷酸二氢钠的缓冲成分的灭菌水溶液。水溶液的离子强度相当于氯化钠的水溶液浓度为4〜18重量％，pH为6.4〜7.2。该溶液也通过平均孔径为0.25μm或更小的过滤介质过滤以提供无菌的高盐透明质酸溶液。

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