专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08722698B2 Berbamine derivatives 有权
标题翻译：伯胺衍生物
公开(公告)号：US08722698B2
公开(公告)日：2014-05-13
申请号：US12783535
申请日：2010-05-19
申请人： David Horne , Jun Xie , Angela L. Perkins Harki , Richard Jove , Sangkil Nam , Wendong Huang , Rongzhen Xu
发明人： David Horne , Jun Xie , Angela L. Perkins Harki , Richard Jove , Sangkil Nam , Wendong Huang , Rongzhen Xu
IPC分类号： C07D491/18 , A61K31/4745
CPC分类号： C07D491/147 , A61K31/4745
摘要： The invention provides novel berbamine derivatives, and compositions or pharmaceutical compositions thereof. These berbamine derivatives have shown higher potency in killing cancer/tumor cells comparing to berbamine, and can be used in cancer/tumor treatments.
摘要翻译：本发明提供新颖的柏柏胺衍生物及其组合物或药物组合物。与berbamine相比，这些berbamine衍生物在杀死癌症/肿瘤细胞方面表现出较高的效力，可用于癌症/肿瘤治疗。

2. 发明申请

US20080033004A1 SYNTHESIS OF GROSSULARINES-1 AND ANALOGS THEREOF AND METHOD OF USE 有权
标题翻译： GRASSULARINES-1及其类似物的合成及其使用方法
公开(公告)号：US20080033004A1
公开(公告)日：2008-02-07
申请号：US11742383
申请日：2007-04-30
申请人： David Horne , Richard Jove , Sangkil Nam , Kenichi Yakushijin
发明人： David Horne , Richard Jove , Sangkil Nam , Kenichi Yakushijin
IPC分类号： A61K31/437 , A61P35/00 , C07D471/14 , C07D471/22
CPC分类号： C07D471/14
摘要： In one embodiment of the present invention, a synthesis of grossularine-1 and N,N-didesmethylgrossularine-1 2 and analogs thereof based on a novel oxidative dimerization-electrocyclization sequence of 2-amino-4-(3-indolyl)imidazoles derived from oxotryptamine 3 is described.
摘要翻译：在本发明的一个实施方案中，基于由2-氨基-4-（3-吲哚基）咪唑衍生的新的氧化二聚化 - 电循环序列，合成粗略1和N，N-二甲基十八烷基-1,2及其类似物描述了氧杂色胺3。

3. 发明申请

US20120302815A1 MULTI-VALENT POLY-UBL CHAIN INHIBITORS AND METHODS OF USE 有权
标题翻译：多功能多环链抑制剂及其使用方法
公开(公告)号：US20120302815A1
公开(公告)日：2012-11-29
申请号：US13401642
申请日：2012-02-21
申请人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
发明人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
IPC分类号： C07F1/12 , A61L2/08 , A61M37/00 , C12N5/09
CPC分类号： A61K38/00 , A61K41/0038 , A61K47/6923 , B82Y5/00 , C07D233/64 , C07K5/06034 , C07K5/06043 , C07K5/06052
摘要： A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.
摘要翻译：提供了用于开发用于研究细胞功能和治疗癌症中的Ubl修饰的试剂的组合物。该组合物包含金纳米颗粒（AuNP） - 偶联物，其包含至少两个组分：金纳米颗粒（AuNP）和修饰的泛素或泛素样相互作用基序（UIM或ULIM）模拟物。在一个实施方案中，修饰的ULM模拟物是修饰的SUMO相互作用基序（SIM）模拟物。根据本文所述的实施方案，化合物抑制泛素或泛素样蛋白（Ubl）介导的蛋白质 - 蛋白质相互作用并使细胞对电离辐射敏感。修饰的UIM和ULIM模拟物可以与AuNP缀合，使得每个AuNP与多个修饰的UIM或ULIM模拟物缀合。修饰的ULIM模拟物可以通过硫醇基团与AuNP缀合。

4. 发明授权

US08163783B2 Ribonucleotide reductase inhibitors and methods of use 有权
标题翻译：核糖核苷酸还原酶抑制剂及其使用方法
公开(公告)号：US08163783B2
公开(公告)日：2012-04-24
申请号：US13093389
申请日：2011-04-25
申请人： Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
发明人： Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
IPC分类号： A61K31/426 , A61K31/4168
CPC分类号： C12N9/99 , C07D277/46 , C07D417/12
摘要： Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
摘要翻译：本文提供通过结合RRM2并干扰RRM1 / RRM2全酶的活性来抑制核糖核苷酸还原酶（RR）的新型化合物。这些抑制剂可用于抑制RR活性并治疗与RRM2表达相关的各种病症，例如某些癌症类型，线粒体疾病或退行性疾病。

5. 发明授权

US08796202B2 Multi-valent poly-Ubl chain inhibitors and methods of use 有权
标题翻译：多价多聚Ubl链抑制剂及其使用方法
公开(公告)号：US08796202B2
公开(公告)日：2014-08-05
申请号：US13401642
申请日：2012-02-21
申请人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
发明人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
IPC分类号： A61K38/00
CPC分类号： A61K38/00 , A61K41/0038 , A61K47/6923 , B82Y5/00 , C07D233/64 , C07K5/06034 , C07K5/06043 , C07K5/06052
摘要： A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.
摘要翻译：提供了用于开发用于研究细胞功能和治疗癌症中的Ubl修饰的试剂的组合物。该组合物包含金纳米颗粒（AuNP） - 偶联物，其包含至少两个组分：金纳米颗粒（AuNP）和修饰的泛素或泛素样相互作用基序（UIM或ULIM）模拟物。在一个实施方案中，修饰的ULM模拟物是修饰的SUMO相互作用基序（SIM）模拟物。根据本文所述的实施方案，化合物抑制泛素或泛素样蛋白（Ubl）介导的蛋白质 - 蛋白质相互作用并使细胞对电离辐射敏感。修饰的UIM和ULIM模拟物可以与AuNP缀合，使得每个AuNP与多个修饰的UIM或ULIM模拟物缀合。修饰的ULIM模拟物可以通过硫醇基团与AuNP缀合。

6. 发明申请

US20110245304A1 RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE 有权
标题翻译： RIBONUCLEOTIDE还原抑制剂及其使用方法
公开(公告)号：US20110245304A1
公开(公告)日：2011-10-06
申请号：US13093389
申请日：2011-04-25
申请人： Yun YEN , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L. Perkins Harki , Leila Su
发明人： Yun YEN , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L. Perkins Harki , Leila Su
IPC分类号： A61K31/426 , C12N9/99 , A61K31/4168 , A61P35/00
CPC分类号： C12N9/99 , C07D277/46 , C07D417/12
摘要： Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
摘要翻译：本文提供通过结合RRM2并干扰RRM1 / RRM2全酶的活性来抑制核糖核苷酸还原酶（RR）的新型化合物。这些抑制剂可用于抑制RR活性并治疗与RRM2表达相关的各种病症，例如某些癌症类型，线粒体疾病或退行性疾病。

7. 发明授权

US07956076B2 Ribonucleotide reductase inhibitors and methods of use 有权
标题翻译：核糖核苷酸还原酶抑制剂及其使用方法
公开(公告)号：US07956076B2
公开(公告)日：2011-06-07
申请号：US12420713
申请日：2009-04-08
申请人： Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
发明人： Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
IPC分类号： A61K31/426 , A61K31/4168 , C07D277/46 , C07D233/88
CPC分类号： C12N9/99 , C07D277/46 , C07D417/12
摘要： Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
摘要翻译：本文提供通过结合RRM2并干扰RRM1 / RRM2全酶的活性来抑制核糖核苷酸还原酶（RR）的新型化合物。这些抑制剂可用于抑制RR活性并治疗与RRM2表达相关的各种病症，例如某些癌症类型，线粒体疾病或退行性疾病。

8. 发明申请

US20100298369A1 BERBAMINE DERIVATIVES 有权
标题翻译： BERBAMINE衍生物
公开(公告)号：US20100298369A1
公开(公告)日：2010-11-25
申请号：US12783535
申请日：2010-05-19
申请人： David Horne , Wendong Huang
发明人： David Horne , Wendong Huang
IPC分类号： A61K31/4745 , C07D491/18 , A61P35/00 , A61P35/02
CPC分类号： C07D491/147 , A61K31/4745
摘要： The invention provides novel berbamine derivatives, and compositions or pharmaceutical compositions thereof. These berbamine derivatives have shown higher potency in killing cancer/tumor cells comparing to berbamine, and can be used in cancer/tumor treatments.
摘要翻译：本发明提供新颖的柏柏胺衍生物及其组合物或药物组合物。与berbamine相比，这些berbamine衍生物在杀死癌症/肿瘤细胞方面表现出较高的效力，可用于癌症/肿瘤治疗。

9. 发明授权

US09648589B2 Multiple radio devices for implementing dynamic band access background 有权
公开(公告)号：US09648589B2
公开(公告)日：2017-05-09
申请号：US13996682
申请日：2012-06-06
申请人： Geoff Weaver , Carlos Cordeiro , Srikathyayani Srikanteswara , Bahareh Sadeghi , Reza Arefi , David Horne , Takashi Shono
发明人： Geoff Weaver , Carlos Cordeiro , Srikathyayani Srikanteswara , Bahareh Sadeghi , Reza Arefi , David Horne , Takashi Shono
IPC分类号： H04W72/00 , H04L29/06 , H04W4/00 , H04W72/04 , H04W16/14 , H04W4/24 , H04W24/08 , H04W28/16 , H04L12/24 , H04W16/10 , H04W72/12 , H04W76/02 , H04W74/00 , H04W88/06
CPC分类号： H04W72/04 , H04L41/0896 , H04W4/24 , H04W16/10 , H04W16/14 , H04W24/08 , H04W28/16 , H04W72/0486 , H04W72/0493 , H04W72/1257 , H04W74/002 , H04W76/10 , H04W88/06
摘要： A system and method are provided to implement dynamic spectrum access with individual multi-mode devices that incorporate multiple radios in a single device. A multi-mode device is configured to make use of the incremental spectrum by maintaining a data communication link via a base station that is operated by a primary operator to support communications in the primary operator's exclusively-licensed spectrum. This data communication link is maintained by a first radio, the data communication link being used to support a first level of data communication as well as to signal an availability of additional spectrum to the multi-mode device. The multi-mode device may request access to additional spectrum. A second radio may facilitate access to received additional spectrum with the multi-radio multi-mode device.

10. 发明申请

US20050051646A1 Plastic recycling system and process 审中-公开
标题翻译：塑料回收系统和工艺
公开(公告)号：US20050051646A1
公开(公告)日：2005-03-10
申请号：US10769439
申请日：2004-01-30
申请人： David Horne
发明人： David Horne
IPC分类号： B02C18/14 , B29B17/00 , B29B17/04 , B29C47/00 , B29C47/38 , B29C47/52 , B02C19/12
CPC分类号： B29B17/0412 , B02C18/144 , B02C18/148 , B29B17/0036 , B29B2017/0021 , B29B2017/046 , B29B2017/048 , B29C48/00 , B29C48/0022 , B29C48/03 , B29C48/04 , B29C48/395 , B29C48/46 , B29C48/53 , B29C2793/009 , Y02W30/62 , Y02W30/625
摘要： The present invention provides a plastic recycling system, including a first granulator for reducing plastic waste to a first particle size. The system also includes a second granulator for reducing plastic waste to a second particle size. A frictional melting stricture is provided which melts the first particles and the second particles via use of a rotating plate.
摘要翻译：本发明提供一种塑料回收系统，其包括用于将塑料废物减少至第一粒度的第一造粒机。该系统还包括用于将塑料废物减少至第二颗粒尺寸的第二造粒机。提供摩擦熔融的狭缝，其通过使用旋转板熔化第一颗粒和第二颗粒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式