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1. 发明申请

US20140296128A1 MATERIALS AND METHODS FOR TREATMENT OF CANCER AND IDENTIFICATION OF ANTI-CANCER COMPOUNDS 审中-公开
标题翻译：治疗癌症和抗癌化合物鉴定的材料与方法
公开(公告)号：US20140296128A1
公开(公告)日：2014-10-02
申请号：US14246798
申请日：2014-04-07
申请人： SAID M. SEBTI , RICHARD JOVE
发明人： SAID M. SEBTI , RICHARD JOVE
IPC分类号： A61K31/575 , G01N33/574 , A61K45/06
CPC分类号： A61K31/575 , A61K31/56 , A61K31/58 , A61K45/06 , G01N33/5011 , G01N33/574 , G01N33/6872 , G01N2333/4706 , G01N2500/00
摘要： The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK and/or STAT3 inhibition and anti-tumor activity.
摘要翻译：本发明涉及肿瘤和癌组织的治疗以及通过调节JAK / STAT3细胞内信号传导来预防肿瘤发生和恶性转化。本发明涉及含有葫芦素I或其药学上可接受的盐或类似物的药物组合物。本发明的另一方面涉及通过向患者施用葫芦素I或其药学上可接受的盐或类似物来抑制肿瘤生长的方法，其中所述肿瘤的特征在于JAK / STAT3细胞内信号传导途径的组成型激活。本发明还涉及使用葫芦素I或其药学上可接受的盐或类似物在体外或体内缓和JAK和/或STAT3信号传导途径的方法。本发明的另一方面涉及用于筛选候选化合物用于JAK和/或STAT3抑制和抗肿瘤活性的方法。

2. 发明申请

US20090227489A1 STAT3 Agonists and Antagonists and Therapeutic Uses Thereof 审中-公开
标题翻译： STAT3激动剂及其拮抗剂及其治疗用途
公开(公告)号：US20090227489A1
公开(公告)日：2009-09-10
申请号：US12420704
申请日：2009-04-08
申请人： Hua Yu , Drew Pardoll , Richard Jove , William Dalton
发明人： Hua Yu , Drew Pardoll , Richard Jove , William Dalton
IPC分类号： A61K38/02 , A61K31/7105 , A61K31/711
CPC分类号： C12N5/0693 , A61K38/1709 , A61K38/204 , A61K48/005 , C12N2501/60 , C12N2510/00
摘要： The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.
摘要翻译：本发明涉及调节，即激动或拮抗Stat3（Transcription3的信号转导和激活因子）用于基因治疗的信号传导活性的方法。 Stat3信号传导的抑制和/或激活是调节血管生成和用于治疗和/或预防炎症，感染，炎症，免疫疾病和缺血的免疫应答的有效方法。

3. 发明授权

US07998947B2 Materials and methods for treatment of cancer and identification of anti-cancer compounds 有权
标题翻译：用于治疗癌症的材料和方法以及抗癌化合物的鉴定
公开(公告)号：US07998947B2
公开(公告)日：2011-08-16
申请号：US10472056
申请日：2002-03-28
申请人： Said M. Sebti , Richard Jove
发明人： Said M. Sebti , Richard Jove
IPC分类号： A61K31/56
CPC分类号： A61K31/575 , A61K31/56 , A61K31/58 , A61K45/06 , G01N33/5011 , G01N33/574 , G01N33/6872 , G01N2333/4706 , G01N2500/00
摘要： The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog therof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK AND/or STAT3 inhibition and anti-tumor activity.
摘要翻译：本发明涉及肿瘤和癌组织的治疗以及通过调节JAK / STAT3细胞内信号传导来预防肿瘤发生和恶性转化。本发明涉及含有葫芦素I或其药学上可接受的盐或类似物的药物组合物。本发明的另一方面涉及通过向患者施用葫芦素I或其药学上可接受的盐或类似物来抑制肿瘤生长的方法，其中所述肿瘤的特征在于JAK / STAT3细胞内信号传导途径的组成型激活。本发明还涉及使用葫芦素I或其药学上可接受的盐或类似物来体外或体内缓和JAK和/或STAT3信号通路的方法。本发明的另一方面涉及用于筛选候选化合物用于JAK和/或STAT3抑制和抗肿瘤活性的方法。

4. 发明授权

US07951374B2 Methods for inhibiting STAT3 signaling in immune cells 有权
标题翻译：抑制免疫细胞STAT3信号传导的方法
公开(公告)号：US07951374B2
公开(公告)日：2011-05-31
申请号：US11300619
申请日：2005-12-14
申请人： Hua E. Yu , Richard Jove , Marcin Kortylewski , Drew M. Pardoll
发明人： Hua E. Yu , Richard Jove , Marcin Kortylewski , Drew M. Pardoll
IPC分类号： A61K39/00
CPC分类号： A61K31/28 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Methods of enhancing antitumor activity of an immune cell comprising contacting the immune cell with a Stat3 inhibitor are described. Also described are methods of killing a tumor cell or inhibiting tumor growth in a subject comprising contacting an immune cell of the subject with a Stat3 inhibitor.
摘要翻译：描述了增强免疫细胞的抗肿瘤活性的方法，包括使免疫细胞与Stat3抑制剂接触。还描述了杀死肿瘤细胞或抑制受试者肿瘤生长的方法，包括使受试者的免疫细胞与Stat3抑制剂接触。

5. 发明授权

US07615638B2 Synthesis of grossularines-1 and analogs thereof and method of use 有权
标题翻译：粗略-1及其类似物的合成及其使用方法
公开(公告)号：US07615638B2
公开(公告)日：2009-11-10
申请号：US11742383
申请日：2007-04-30
申请人： David A. Horne , Richard Jove , Sangkil Nam , Kenichi Yakushijin , Fumiko Y. Yakushijin
发明人： David A. Horne , Richard Jove , Sangkil Nam , Kenichi Yakushijin , Fumiko Y. Yakushijin
IPC分类号： C07D471/22 , C07D487/22
CPC分类号： C07D471/14
摘要： In one embodiment of the present invention, a synthesis of grossularine-1 and N,N-didesmethylgrossularine-1 2 and analogs thereof based on a novel oxidative dimerization-electrocyclization sequence of 2-amino-4-(3-indolyl)imidazoles derived from oxotryptamine 3 is described.
摘要翻译：在本发明的一个实施方案中，基于由2-氨基-4-（3-吲哚基）咪唑衍生的新的氧化二聚化 - 电循环序列，合成粗略1和N，N-二甲基十八烷基-1,2及其类似物描述了氧杂色胺3。

6. 发明申请

US20080214436A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES 审中-公开
标题翻译：治疗癌症或其他疾病的方法和组成
公开(公告)号：US20080214436A1
公开(公告)日：2008-09-04
申请号：US11966423
申请日：2007-12-28
申请人： Hua YU , Marcin KORTYLEWSKI , Richard JOVE , Piotr Marek SWIDERSKI , John J. ROSSI
发明人： Hua YU , Marcin KORTYLEWSKI , Richard JOVE , Piotr Marek SWIDERSKI , John J. ROSSI
IPC分类号： A61K38/00 , C07H21/00 , C07K1/00 , A61P43/00 , A61K31/70
CPC分类号： C07H21/02 , A61K31/7105 , A61K31/713 , A61K47/549
摘要： The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.
摘要翻译：本发明涉及用于治疗疾病的方法和组合物，包括癌症，感染性疾病和自身免疫性疾病。本发明还涉及用于改善免疫功能的方法和组合物。更具体地，本发明涉及能够递送到感兴趣的细胞用于治疗疾病和改善免疫功能的多功能分子。

7. 发明授权

US07342095B2 Peptidomimetic inhibitors of STAT activity and uses thereof 有权
标题翻译： STAT活性的拟肽抑制剂及其用途
公开(公告)号：US07342095B2
公开(公告)日：2008-03-11
申请号：US10784309
申请日：2004-02-20
申请人： James Turkson , Richard Jove , Said M. Sebti , Andrew D. Hamilton
发明人： James Turkson , Richard Jove , Said M. Sebti , Andrew D. Hamilton
IPC分类号： A61K38/06 , A61K38/00 , A61K38/16
CPC分类号： C07K7/06 , A61K38/00 , C07K5/06191 , C07K5/0827
摘要： The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include compounds of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.
摘要翻译：本发明涉及用于阻断癌细胞生长或增殖和/或诱导癌细胞死亡的组合物和方法。本发明的组合物是抑制STAT功能的肽模拟物。本发明的肽模拟物包括式RY * L（其中Y *表示磷酸酪氨酸）的化合物，其中R基团在Y-1位。本发明的肽模拟物破坏Stat3的活化和功能。本发明的肽模拟物显着抑制肿瘤细胞生长并诱导肿瘤细胞死亡。

8. 发明授权

US08133692B2 Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments 有权
标题翻译：预测化疗药物反应性和选择治疗方法
公开(公告)号：US08133692B2
公开(公告)日：2012-03-13
申请号：US11490316
申请日：2006-07-20
申请人： Richard Jove , Susan E. Minton , Carlos A. Muro-Cacho , Daniel Sullivan , Eric Bruce Haura , Gerold Bepler
发明人： Richard Jove , Susan E. Minton , Carlos A. Muro-Cacho , Daniel Sullivan , Eric Bruce Haura , Gerold Bepler
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574 , G01N33/48 , G01N21/00 , G01N21/75 , G01N33/566
CPC分类号： G01N33/6872 , C12Q1/6886 , C12Q2600/106 , G01N33/574 , G01N2800/52
摘要： Methods are provided for predicting responsiveness of cancer cells to chemotherapy by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Also provided are methods of selecting a chemotherapeutic treatment for a subject diagnosed with cancer by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Kits for performing the methods are also provided. Methods for modulating Survivin-dependent apoptosis in a cancer cell are also disclosed.
摘要翻译：提供了通过测量癌症中磷酸化Stat的水平或存活蛋白表达水平，并将癌细胞中的水平与对照中的各个水平进行比较来预测癌细胞对化疗的反应性的方法。还提供了通过测量癌症中磷酸化Stat的水平或Survivin的表达水平，并将癌细胞中的水平与对照中的各个水平进行比较来选择被诊断为癌症的受试者的化学治疗的方法。还提供了用于执行方法的工具包。还公开了调节癌细胞中存活蛋白依赖性细胞凋亡的方法。

9. 发明申请

US20100297061A1 STAT3 ANTAGONISTS AND THEIR USES AS VACCINES AGAINST CANCER 审中-公开
标题翻译： STAT3拮抗剂及其作为疫苗的疫苗使用
公开(公告)号：US20100297061A1
公开(公告)日：2010-11-25
申请号：US12611732
申请日：2009-11-03
申请人： Hua Yu , Drew Pardoll , Richard Jove
发明人： Hua Yu , Drew Pardoll , Richard Jove
IPC分类号： A61K38/19 , A61P35/00 , A61K39/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P33/10
CPC分类号： C07K16/18 , A61K39/0011 , A61K48/00 , A61K2039/5152 , A61K2039/5154 , A61K2039/55522 , C12N5/0693 , C12N2501/60
摘要： The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcirption3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activation T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.
摘要翻译：本发明涉及治疗和/或预防癌症的方法。特别地，本发明涉及离体免疫治疗方法。所述方法包括降低肿瘤细胞中Stat3（信号转导和转录激活因子3）的表达和/或功能，并将此类细胞施用于需要治疗和/或预防的受试者。本发明的其它方法包括通过与具有降低的Stat3表达或功能的肿瘤细胞共培养T细胞来活化T细胞。本发明还包括降低Stat3在抗原呈递细胞中的表达或功能的降低，并且向患者共同施用具有降低的Stat3功能的肿瘤细胞和抗原呈递细胞。本发明还涉及刺激树突状细胞分化的方法。

10. 发明申请

US20100247427A1 Methods of inhibiting cell growth and methods of enhancing radiation responses 审中-公开
标题翻译：抑制细胞生长的方法和增强辐射反应的方法
公开(公告)号：US20100247427A1
公开(公告)日：2010-09-30
申请号：US11581293
申请日：2006-10-16
申请人： Javier F. Torres-Roca , Douglas P. Calvin , Madhavi Sekharam , Hua E. Yu , Richard Jove
发明人： Javier F. Torres-Roca , Douglas P. Calvin , Madhavi Sekharam , Hua E. Yu , Richard Jove
IPC分类号： C12N13/00 , A61K31/282 , A61K51/00 , A61P35/04 , A61N5/00
CPC分类号： A61K41/0038 , A61K31/282 , A61K41/00 , A61K2300/00
摘要： Provided herein are methods of enhancing the radiation response of a cell expressing activated Stat1, Stat3, or Stat5. Methods for synergistically affecting a cell expressing activated Stat1, Stat3, or Stat5 are also described. The described methods may also be used to synergistically affect or enhance the radiation response of a cell in a subject.
摘要翻译：本文提供增强表达活化的Stat1，Stat3或Stat5的细胞的辐射响应的方法。还描述了协同影响表达活化的Stat1，Stat3或Stat5的细胞的方法。所描述的方法还可以用于协同地影响或增强受试者中细胞的辐射响应。

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