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1. 发明授权

US08070802B2 Mitral valve system 有权
标题翻译：二尖瓣系统
公开(公告)号：US08070802B2
公开(公告)日：2011-12-06
申请号：US12028572
申请日：2008-02-08
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman, III
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman, III
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如通过经导管技术。瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着血流方向。瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

2. 发明申请

US20080221672A1 Mitral Valve System 有权
标题翻译：二尖瓣系统
公开(公告)号：US20080221672A1
公开(公告)日：2008-09-11
申请号：US12028572
申请日：2008-02-08
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如通过反式导管技术。瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着血流方向。瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

3. 发明授权

US07753949B2 Valve prosthesis systems and methods 有权
标题翻译：阀门假体系统及方法
公开(公告)号：US07753949B2
公开(公告)日：2010-07-13
申请号：US11869972
申请日：2007-10-10
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和第二组织接合区域与第一组织接合区域间隔开。定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内，其中第一和第二组织接合区域中的每一个向外指向用于接合组织。瓣膜假体还可以包括相对于弹性环安装的阀裙。

4. 发明申请

US20080208332A1 Valve Prosthesis Systems and Methods 有权
标题翻译：瓣膜假体系统和方法
公开(公告)号：US20080208332A1
公开(公告)日：2008-08-28
申请号：US11869972
申请日：2007-10-10
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和第二组织接合区域与第一组织接合区域间隔开。定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内，其中第一和第二组织接合区域中的每一个向外指向用于接合组织。瓣膜假体还可以包括相对于弹性环安装的阀裙。

5. 发明申请

US20080208328A1 Systems and Methods For Placement of Valve Prosthesis System 审中-公开
标题翻译：瓣膜假体系统的放置系统与方法
公开(公告)号：US20080208328A1
公开(公告)日：2008-08-28
申请号：US11870001
申请日：2007-10-10
申请人： Joseph D. Antocci , David G. Lamphere , Salvatore Castro , Gregorio Ramon M. Abesames , Howard C. Herrmann
发明人： Joseph D. Antocci , David G. Lamphere , Salvatore Castro , Gregorio Ramon M. Abesames , Howard C. Herrmann
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided.
摘要翻译：提供了用于放置这种瓣膜假体的瓣膜假体系统和方法/系统，其有助于有效，可靠和微创的递送方式。放置系统和方法允许瓣膜假体的远程操作和定位，使得可以实现相对于解剖结构（例如心脏环）的期望的放置。瓣膜假体包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。递送系统包括终止于瓣膜假体处的第一细长元件，并且可由操作者操纵以相对于柔性环远程旋转定位元件。第二细长元件终止在瓣膜假体处，并且可由操作者操纵以将瓣膜假体向下远进地推进到解剖环形中。第二细长元件可以被操纵以将瓣膜假体远程地推进到解剖环空中，以呈现用于在原位支撑瓣膜假体的植入后功能的位置。可以进一步操作第一细长元件以相对于柔性环远程旋转定位元件，以使得定位元件接合与解剖学环带相关联的组织，并由此原位维持瓣膜假体的植入后位置。还提供了用于瓣膜假体部署的方法。

6. 发明授权

US5637575A Methods of inhibiting restenosis 失效
标题翻译：抑制再狭窄的方法
公开(公告)号：US5637575A
公开(公告)日：1997-06-10
申请号：US81493
申请日：1993-06-23
申请人： Howard C. Herrmann , Elliot Barnathan , Paul Weisz
发明人： Howard C. Herrmann , Elliot Barnathan , Paul Weisz
IPC分类号： A61K31/335 , A61K31/395 , A61K31/57 , A61K31/724 , A61K31/737 , A61K38/18 , A61K47/48 , A61L15/28 , A61L26/00 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/54 , A61L33/00 , C07K14/50 , C08B37/16 , A61K31/70 , C08B37/02
CPC分类号： B82Y5/00 , A61K31/335 , A61K31/395 , A61K31/57 , A61K31/724 , A61K31/737 , A61K47/48969 , A61L15/28 , A61L26/0023 , A61L27/20 , A61L27/34 , A61L27/54 , A61L33/0005 , C07K14/50 , C07K14/503 , C08B37/0012 , A61K38/00 , A61L2300/232 , A61L2300/416 , A61L2300/802
摘要： Disclosed are compositions and methods effective for inhibiting restenosis. In particular, the present invention provides compositions for inhibiting undesired smooth muscle cell growth or proliferation following angioplasty in mammals, said composition comprising active agents comprising a very water-soluble derivative of cyclodextrin. The invention also provides methods of inhibiting undesired smooth muscle cell growth or proliferation following angioplasty in mammals comprising orally administering to the mammal a growth-inhibiting amount of an active agent comprising a very water-soluble derivative of cyclodextrin.
摘要翻译：公开了有效抑制再狭窄的组合物和方法。特别地，本发明提供用于在哺乳动物血管成形术之后抑制不期望的平滑肌细胞生长或增殖的组合物，所述组合物包含包含非常水溶性的环糊精衍生物的活性剂。本发明还提供了抑制哺乳动物血管成形术后不期望的平滑肌细胞生长或增殖的方法，包括向哺乳动物施用生长抑制量的包含非常水溶性的环糊精衍生物的活性剂。

7. 发明授权

US5902799A Methods of modulating tissue growth and regeneration 失效
标题翻译：调节组织生长和再生的方法
公开(公告)号：US5902799A
公开(公告)日：1999-05-11
申请号：US906501
申请日：1997-08-05
申请人： Howard C. Herrmann , Elliot Barnathan , Paul B. Weisz
发明人： Howard C. Herrmann , Elliot Barnathan , Paul B. Weisz
IPC分类号： A61K31/724 , A61K31/737 , A61K38/18 , A61L15/28 , A61L26/00 , A61L27/20 , A61L27/34 , A61L27/54 , A61L33/00 , C07K14/50 , C08B37/16 , A61K31/715 , A61K31/735
CPC分类号： B82Y5/00 , A61K31/724 , A61K31/737 , A61L15/28 , A61L26/0023 , A61L27/20 , A61L27/34 , A61L27/54 , A61L33/0005 , C07K14/50 , C07K14/503 , C08B37/0012 , A61K38/00 , A61L2300/232 , A61L2300/414 , A61L2300/802 , Y10S530/81 , Y10S530/812 , Y10S530/813 , Y10S530/817
摘要： Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
摘要翻译：提供了环糊精的聚阴离子衍生物和制备这些衍生物的方法，其中环糊精的聚离子衍生物与生长因子，优选肝素结合生长因子组合。这些组合物具有低溶解度并且直接施加到伤口的位置。由于低溶解度，组合物在施用部位保持适当位置并缓慢释放生长因子。在替代实施方案中，环糊精衍生物在不存在生长因子的情况下给药，并且用于吸收存在于伤口位置的身体中的生长因子，以防止伤口反应的过度刺激。

8. 发明申请

US20100042208A1 Percutaneous Heart Valve 有权
标题翻译：经皮心脏瓣膜
公开(公告)号：US20100042208A1
公开(公告)日：2010-02-18
申请号：US12582986
申请日：2009-10-21
申请人： Howard C. Herrmann , Nilesh Mankame , Suresh G. K. Ananthasuresh
发明人： Howard C. Herrmann , Nilesh Mankame , Suresh G. K. Ananthasuresh
IPC分类号： A61F2/24 , A61M31/00
CPC分类号： A61F2/2412 , A61F2/243 , Y10S623/904
摘要： A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.
摘要翻译：经皮插入的双稳态心脏瓣膜假体折叠在导管内，用于经血管输送到患者的心脏用于植入。心脏瓣膜具有环形环，主体部件具有多个腿部，每个腿部在一端连接到环形环，通过施加外力从第一位置到第二位置可调节的爪，以允许进入周围的心脏组织进入第二位置的爪，以及连接到环形环，身体构件和/或腿的小叶膜，小叶膜具有用于阻止血液流过的第一位置和用于允许血液流动的第二位置通过。心脏瓣膜被设计成使得当去除外力时，爪弹性地回复到第一位置，以便夹紧位于爪内的心脏组织，从而将心脏瓣膜保持在适当位置。主体构件和爪可以集成成一体式设计。心脏瓣膜可用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于心脏的相应二尖瓣，主动脉，肺或三尖瓣开口。

9. 发明授权

US08118866B2 Method for heart valve implantation 有权
标题翻译：心脏瓣膜植入方法
公开(公告)号：US08118866B2
公开(公告)日：2012-02-21
申请号：US12582986
申请日：2009-10-21
申请人： Howard C. Herrmann , Nilesh Mankame , Suresh G. K. Ananthasuresh
发明人： Howard C. Herrmann , Nilesh Mankame , Suresh G. K. Ananthasuresh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , Y10S623/904
摘要： A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.
摘要翻译：经皮插入的双稳态心脏瓣膜假体折叠在导管内，用于经血管输送到患者的心脏用于植入。心脏瓣膜具有环形环，主体部件具有多个腿部，每个腿部在一端连接到环形环，通过施加外力从第一位置到第二位置可调节的爪，以允许进入周围的心脏组织进入第二位置的爪，以及连接到环形环，身体构件和/或腿的小叶膜，小叶膜具有用于阻止血液流过的第一位置和用于允许血液流动的第二位置通过。心脏瓣膜被设计成使得当去除外力时，爪弹性地回复到第一位置，以便夹紧位于爪内的心脏组织，从而将心脏瓣膜保持在适当位置。主体构件和爪可以集成成一体式设计。心脏瓣膜可用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于心脏的相应二尖瓣，主动脉，肺或三尖瓣开口。

10. 发明授权

US5874419A Compositions and methods for modulating growth of a tissue in a mammal 失效
公开(公告)号：US5874419A
公开(公告)日：1999-02-23
申请号：US905612
申请日：1997-08-04
申请人： Howard C. Herrmann , Elliot Barnathan , Paul B. Weisz
发明人： Howard C. Herrmann , Elliot Barnathan , Paul B. Weisz
IPC分类号： A61K31/724 , A61K31/737 , A61K38/18 , A61L15/28 , A61L26/00 , A61L27/20 , A61L27/34 , A61L27/54 , A61L33/00 , C07K14/50 , C08B37/16 , A61K31/735 , A61K47/02
CPC分类号： B82Y5/00 , A61K31/724 , A61K31/737 , A61L15/28 , A61L26/0023 , A61L27/20 , A61L27/34 , A61L27/54 , A61L33/0005 , C07K14/50 , C07K14/503 , C08B37/0012 , A61K38/00 , A61L2300/232 , A61L2300/414 , A61L2300/802 , Y10S530/81 , Y10S530/812 , Y10S530/813 , Y10S530/817
摘要： Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.

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