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1. 发明授权

US09694081B2 Protease triggered release of molecules from hydrogels 有权
公开(公告)号：US09694081B2
公开(公告)日：2017-07-04
申请号：US13805501
申请日：2011-06-17
申请人： Jason Alan Burdick , Robert C. Gorman , Joseph H. Gorman, III , Brendan Patrick Purcell
发明人： Jason Alan Burdick , Robert C. Gorman , Joseph H. Gorman, III , Brendan Patrick Purcell
IPC分类号： A61K38/00 , C07K7/00 , A61K47/42 , A61K9/06 , A61K38/10 , A61K38/18 , A61K38/57 , A61K47/24
CPC分类号： A61K47/42 , A61K9/06 , A61K38/10 , A61K38/1866 , A61K38/57 , A61K47/24
摘要： The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.

2. 发明授权

US09289291B2 Valve prosthesis 有权
标题翻译：瓣膜假体
公开(公告)号：US09289291B2
公开(公告)日：2016-03-22
申请号：US13505885
申请日：2010-11-05
申请人： Joseph H. Gorman, III , Robert C. Gorman , Matthew J. Gillespie
发明人： Joseph H. Gorman, III , Robert C. Gorman , Matthew J. Gillespie
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0076 , A61F2220/0008 , A61F2230/0054 , A61F2230/0058 , A61F2230/0078 , A61F2250/003 , A61F2250/0039 , A61F2250/0069
摘要： The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.
摘要翻译：本公开涉及可替换为用于基于导管的部署到植入部位的瓣膜置换装置，以及用于递送瓣膜假体的系统，包括具有所公开的瓣膜置换装置的特殊特征的假体。这些装置包括用于安全和持久精密植入的高效粘附机构。附着机构可以采用独特的密封机构，其包括缓慢扩张的袖带，由此装置未固定就位直到完成植入程序。植入的装置，可选地与袖带一起防止了周围的泄漏并且并入适当的小叶系统以便在原位可靠地起作用。

3. 发明申请

US20110288418A1 IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION 有权
标题翻译：人体功能测量
公开(公告)号：US20110288418A1
公开(公告)日：2011-11-24
申请号：US12935755
申请日：2009-04-01
申请人： Joseph H. Gorman, III , Robert C. Gorman , Mahsa Ranji
发明人： Joseph H. Gorman, III , Robert C. Gorman , Mahsa Ranji
IPC分类号： A61B6/00
CPC分类号： A61B5/413 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.
摘要翻译：本文公开了用于评估活体受试者的线粒体功能的装置，其包括导管，其包括限定内腔，远端和近端的护套，所述护套包括用于将光照射到受试者内的靶上的光导，并用于接收来自目标; 光源，其中所述导管适于将光从所述光源传输到所述光导; 以及用于从光导接收荧光信号并将荧光信号与靶的线粒体功能相关联的检测器。还公开了评估活体受试者线粒体功能的方法，包括将导管放置在受试者内的感兴趣位点附近; 使用导管从感兴趣的位点的细胞获得荧光信号; 并将荧光信号与细胞的线粒体功能相关联。

4. 发明申请

US20120148630A1 PREVENTION OF INFARCT EXPANSION 有权
标题翻译：预防输血扩张
公开(公告)号：US20120148630A1
公开(公告)日：2012-06-14
申请号：US12679147
申请日：2008-09-19
申请人： Robert C. Gorman , Joseph H. Gorman , Liam P. Ryan
发明人： Robert C. Gorman , Joseph H. Gorman , Liam P. Ryan
IPC分类号： A61K33/42 , A61P9/10 , A61K33/00 , A61M25/00 , A61K9/14
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/14 , A61L27/10 , A61L27/12 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/20
摘要： Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.
摘要翻译：提供了用于安全和有效治疗的方法和试剂盒，其可以在心脏病发作后早期施用，以防止进行性心脏扩张并导致功能丧失。该疗法包括将颗粒组合物施用于包括梗塞或其部分的区域。

5. 发明申请

US20120303116A1 VALVE PROSTHESIS 有权
标题翻译：阀门优先
公开(公告)号：US20120303116A1
公开(公告)日：2012-11-29
申请号：US13505885
申请日：2010-11-05
申请人： Joseph H. Gorman, III , Robert C. Gorman , Matthew J. Gillespie
发明人： Joseph H. Gorman, III , Robert C. Gorman , Matthew J. Gillespie
IPC分类号： A61F2/24 , A61F2/84
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0076 , A61F2220/0008 , A61F2230/0054 , A61F2230/0058 , A61F2230/0078 , A61F2250/003 , A61F2250/0039 , A61F2250/0069
摘要： The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.
摘要翻译：本公开涉及可替换为用于基于导管的部署到植入部位的瓣膜置换装置，以及用于递送瓣膜假体的系统，包括具有所公开的瓣膜置换装置的特殊特征的假体。这些装置包括用于安全和持久精密植入的高效粘附机构。附着机构可以采用独特的密封机构，其包括缓慢扩张的袖带，由此装置未固定就位直到完成植入程序。植入的装置，可选地与袖带一起防止了周围的泄漏并且并入适当的小叶系统以便在原位可靠地起作用。

6. 发明申请

US20120251483A1 Infarction Treatment Compositions and Methods 有权
标题翻译：梗死治疗组合和方法
公开(公告)号：US20120251483A1
公开(公告)日：2012-10-04
申请号：US13430872
申请日：2012-03-27
申请人： Jason A. Burdick , Robert C. Gorman , Joseph H. Gorman, III , Jamie L. Ifkovits
发明人： Jason A. Burdick , Robert C. Gorman , Joseph H. Gorman, III , Jamie L. Ifkovits
IPC分类号： A61K31/785 , A61K31/25 , A61K31/722 , A61K31/717 , A61P9/10 , A61K31/727 , A61K35/12 , A61K35/14 , A61K38/18 , A61K31/728 , A61K31/734
CPC分类号： A61K9/0024 , A61K31/25 , A61K31/717 , A61K31/722 , A61K31/727 , A61K31/728 , A61K31/734 , A61K31/785 , A61K38/00 , A61K45/06 , A61K47/32 , A61K2300/00
摘要： Provided are methods of treating cardiac infarction by using an injectable material to influence cardiac structure and remodeling after infarction. Also provided are kits that comprise an injectable material to influence cardiac structure.
摘要翻译：提供通过使用可注射材料来治疗心肌梗塞以影响心肌结构和梗死后重建的方法。还提供了包含影响心脏结构的可注射材料的试剂盒。

7. 发明申请

US20080221672A1 Mitral Valve System 有权
标题翻译：二尖瓣系统
公开(公告)号：US20080221672A1
公开(公告)日：2008-09-11
申请号：US12028572
申请日：2008-02-08
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如通过反式导管技术。瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着血流方向。瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

8. 发明授权

US09486404B2 Infarction treatment compositions and methods 有权
标题翻译：梗死治疗组合物和方法
公开(公告)号：US09486404B2
公开(公告)日：2016-11-08
申请号：US13430872
申请日：2012-03-27
申请人： Jason A. Burdick , Robert C. Gorman , Joseph H. Gorman, III , Jamie L. Ifkovits
发明人： Jason A. Burdick , Robert C. Gorman , Joseph H. Gorman, III , Jamie L. Ifkovits
IPC分类号： A61K31/785 , A61K31/728 , A61K31/25 , A61K31/722 , A61K31/717 , A61K31/734 , A61K31/727 , A61K35/12 , A61K35/14 , A61K38/18 , A61K9/10 , A61K9/00 , A61K45/06 , A61K47/32 , A61K38/00
CPC分类号： A61K9/0024 , A61K31/25 , A61K31/717 , A61K31/722 , A61K31/727 , A61K31/728 , A61K31/734 , A61K31/785 , A61K38/00 , A61K45/06 , A61K47/32 , A61K2300/00
摘要： Provided are methods of treating cardiac infarction by using an injectable material to influence cardiac structure and remodeling after infarction. Also provided are kits that comprise an injectable material to influence cardiac structure.
摘要翻译：提供通过使用可注射材料来治疗心肌梗塞以影响心肌结构和梗死后重建的方法。还提供了包含影响心脏结构的可注射材料的试剂盒。

9. 发明授权

US09238046B2 Prevention of infarct expansion 有权
标题翻译：预防梗死扩张
公开(公告)号：US09238046B2
公开(公告)日：2016-01-19
申请号：US12679147
申请日：2008-09-19
申请人： Robert C. Gorman , Joseph H. Gorman, III , Liam P. Ryan
发明人： Robert C. Gorman , Joseph H. Gorman, III , Liam P. Ryan
IPC分类号： A61K9/00 , A61K33/42 , A61L27/10 , A61L27/12 , A61L27/50
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/14 , A61L27/10 , A61L27/12 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/20
摘要： Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.
摘要翻译：提供了用于安全和有效治疗的方法和试剂盒，其可以在心脏病发作后早期施用，以防止进行性心脏扩张并导致功能丧失。该疗法包括将颗粒组合物施用于包括梗塞或其部分的区域。

10. 发明申请

US20130195335A1 AUTOMATIC QUANTIFICATION OF MITRAL VALVE DYNAMICS WITH REAL-TIME 3D ULTRASOUND 有权
标题翻译：用实时三维超声波自动定量麻醉动力学
公开(公告)号：US20130195335A1
公开(公告)日：2013-08-01
申请号：US13580833
申请日：2011-02-25
申请人： Robert C. Gorman , Alison Pouch , Joseph H. Gorman, III , Chandra Sehgal , Paul A. Yushkevich , Benjamin Jackson
发明人： Robert C. Gorman , Alison Pouch , Joseph H. Gorman, III , Chandra Sehgal , Paul A. Yushkevich , Benjamin Jackson
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/174 , G06T2207/10076 , G06T2207/20128 , G06T2207/30048
摘要： A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.
摘要翻译：定量分析二尖瓣的一系列rt-3DE图像，以便例如预测复发性缺血性二尖瓣反流程度（IMR）的程度，并综合评估整个二尖瓣的小叶束缚和“起搏”。根据该方法，首先，rt-3DE图像以对称不同形态记录，以获得关于二尖瓣随时间变化的信息。其次，在心脏周期的每个时间点，二尖瓣与水平集或其他已知的分割方法分段，最小的用户交互作用。第三，关于二尖瓣结构的信息被简化为3D中间模型，形状的紧凑表示。换句话说，二尖瓣的体积分割被冷凝成适合临床相关形态测定的形式。

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