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1. 发明授权

US06948881B1 Remediation injection vessel for marshes, tidal flats, and wetlands 失效
标题翻译：用于沼泽，潮汐和湿地的补救注射船
公开(公告)号：US06948881B1
公开(公告)日：2005-09-27
申请号：US10395037
申请日：2003-03-21
申请人： David Fredriksson , Thomas Ballestero , Stanley Boduch , Richard Clark , Nancy Kinner , Matthew Levander , Matthew Manning , Michael Mazzone , Glenn McGillicuddy , James Mulcahey , James Tyler
发明人： David Fredriksson , Thomas Ballestero , Stanley Boduch , Richard Clark , Nancy Kinner , Matthew Levander , Matthew Manning , Michael Mazzone , Glenn McGillicuddy , James Mulcahey , James Tyler
IPC分类号： B63B1/12 , B63B35/32 , B63B38/00 , B63H1/04 , B63H5/02 , E02D3/12
CPC分类号： B63B38/00 , B63B1/125 , B63B35/32 , B63H1/04 , B63H5/02
摘要： An injection vessel for injecting liquid amendment into contaminated subsurface sediment in ecologically sensitive areas such as shallow water salt marshes, tidal flats, or fresh water wetlands is disclosed. The injection vessel described herein includes a shallow-draft floating platform that has an injection system mounted thereon. The injection system includes an injection grid containing a plurality of injection syringes that receive liquid amendment from a metering pump. The injection grid is lowered such that the output of the injection syringes is within the contaminated sediment. The metering pump provides the liquid amendment to the injection syringes and a fluid path is established that injects the liquid amendment into the contaminated sediment. A propulsion system mounted on the floating platform provides for locomotive and maneuvering power. A control system allows the operation of the system either in a semi-autonomous mode in which an on-board controller is programmed to provide the command signals, or in a remote control mode with an operator providing real time command signals through either a wireless or wired controller. The control system provides propulsion commands to the propulsion system and injection commands to the injection system. The propulsion commands include both locomotive commands and maneuvering commands. The injection commands include the lowering and raising of the injection gird and the operation of the metering pump to dispense the predetermined amount of liquid amendment.
摘要翻译：公开了一种注入容器，用于将生物敏感地区如浅水盐沼，潮滩或淡水湿地中的污染地下沉积物注入液体。本文所述的注射容器包括具有安装在其上的注射系统的浅牵伸浮动平台。注射系统包括含有多个从计量泵接收液体修复的注射器的注射格栅。注射网格降低，使得注射器的输出在污染的沉积物内。计量泵提供对注射器的液体修正，并建立了将液体修补物注入污染沉积物的流体路径。安装在浮动平台上的推进系统提供机车和机动动力。控制系统允许系统的操作在半自主模式中，其中车载控制器被编程以提供命令信号，或者在远程控制模式中，操作者通过无线或无线电提供实时命令信号有线控制器。控制系统向推进系统提供推进命令，并向喷射系统提供喷射命令。推进指令包括机车指令和机动指令。注射指令包括降低和提高注射管和计量泵的操作以分配预定量的液体修正。

2. 发明授权

US08538868B2 Method and system for preparing a transfer document 有权
标题翻译：准备转让文件的方法和系统
公开(公告)号：US08538868B2
公开(公告)日：2013-09-17
申请号：US13295747
申请日：2011-11-14
申请人： Serge Rivest , Michael King , Richard Clark
发明人： Serge Rivest , Michael King , Richard Clark
IPC分类号： G06Q40/00
CPC分类号： G06Q40/06 , G06Q20/10 , G06Q20/102 , G06Q30/08 , G06Q40/00 , G06Q40/02 , G06Q40/025
摘要： A system and method of preparing a transfer document for a client to transfer services provided by counterparties that require recurring transactions using a first account to use a second account is provided. A cashflow analysis for the first account and a cashflow analysis for the second account are performed to determine for each counterparty and each service the desired date to effect the transfer to avoid undesirable cashflow spikes or interruptions in both accounts. A transfer document for transferring services requiring recurring transactions for each counterparty is electronically generated via at least one computer. Each transfer document identifies at least the service to be transferred, the client, the second account, the desired date for the transfer and proof of authorization from the client. A replica of an account document selected according to the service being transferred and the second account is included on the transfer document.
摘要翻译：提供了一种用于为客户端传送转让文件的系统和方法，用于传送由交易对手方提供的服务，该交易对手方需要使用第一个帐户使用第二个帐户的定期交易。执行第一个帐户的现金流量分析和第二个账户的现金流量分析，以确定每个交易对手和每个服务是实现转账的期望日期，以避免两个帐户中不必要的现金流尖峰或中断。通过至少一台计算机电子地生成用于转移需要每个交易对手的经常性交易的服务的转让文件。每个转让文件至少识别要传输的服务，客户端，第二个帐户，转移的期望日期和客户端的授权证明。根据正在转让的服务选择的帐户文件的副本和第二个帐户被包括在转让文件中。

3. 发明授权

US08163769B2 Antibacterial compounds 有权
标题翻译：抗菌化合物
公开(公告)号：US08163769B2
公开(公告)日：2012-04-24
申请号：US10387318
申请日：2003-03-12
申请人： David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
发明人： David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D471/04
摘要： Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
摘要翻译：公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。

4. 发明授权

US07511475B2 Mobile member speed sensor 有权
标题翻译：移动成员速度传感器
公开(公告)号：US07511475B2
公开(公告)日：2009-03-31
申请号：US10537267
申请日：2003-12-01
申请人： Christophe Maerky , Geraint Jewell , Richard Clark , Paul Stewart
发明人： Christophe Maerky , Geraint Jewell , Richard Clark , Paul Stewart
IPC分类号： G01B7/14
CPC分类号： F16K31/0679 , F01L9/04 , F01L2009/0436 , F01L2009/0448 , F01L2009/0469 , F16K37/0033 , F16K37/0041 , G01P3/52 , H01F7/122 , H01F7/1615 , H01F21/06
摘要： A speed sensor for a moving member (8) comprises means (27; 34) for constituting a magnetic singularity on a portion of the moving member, and a sleeve slidably receiving said portion and including at least an annular coil (20, 21) and an annular permanent magnet (22, 23) disposed on a common axis between annular pole pieces (24, 25).
摘要翻译：用于移动构件（8）的速度传感器包括用于在移动构件的一部分上构成磁性奇点的装置（27; 34）和可滑动地容纳所述部分并且至少包括环形线圈（20,21）的套筒和设置在环形极片（24,25）之间的公共轴上的环形永磁体（22,23）。

5. 发明申请

US20090018331A1 CONDENSED IMIDAZOLE DERIVATIVES 失效
标题翻译：稠密咪唑衍生物
公开(公告)号：US20090018331A1
公开(公告)日：2009-01-15
申请号：US12199982
申请日：2008-08-28
申请人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
发明人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
IPC分类号： C07D498/14 , C07D473/04 , C07D487/04
CPC分类号： C07D473/30 , C07D471/04 , C07D473/04 , C07D473/06 , C07D473/18 , C07D473/36 , C07D473/40 , C07D487/04 , C07D491/14
摘要： The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.
摘要翻译：本发明涉及由下式表示的化合物或其盐或水合物，其中，T1表示在环中含有一个或两个氮原子的4至12元杂环基，其为单环或双环结构，其可以是具有一个或多个取代基; X表示可以具有一个或多个取代基的C 1-6烷基; Z 1和Z 2各自独立地表示氮原子或由式-CR 2表示的基团; R1和R2独立地表示氢原子，可以具有一个或多个取代基的C 1-6烷基或可以具有一个或多个取代基的C 1-6烷氧基等。这些是表现出优异的DPPIV抑制活性的新型化合物。

6. 发明申请

US20080132507A1 Hydrazide Derivatives 审中-公开
标题翻译：酰肼衍生物
公开(公告)号：US20080132507A1
公开(公告)日：2008-06-05
申请号：US11665385
申请日：2005-10-13
申请人： Richard Clark , Shinsuke Hirota , Hiroshi Azuma , Kazunobu Kira , Nobuhisa Watanabe , Tadashi Nagakura , Tatsuo Horizoe
发明人： Richard Clark , Shinsuke Hirota , Hiroshi Azuma , Kazunobu Kira , Nobuhisa Watanabe , Tadashi Nagakura , Tatsuo Horizoe
IPC分类号： A61K31/5375 , C07D213/02 , C07D239/24 , C07D333/02 , C07D307/02 , C07D215/00 , C07D295/00 , C07D249/04 , C07D241/10 , A61P9/10 , A61P11/00 , A61K31/4965 , A61K31/50 , A61K31/4192 , C07C63/00 , C07C57/00 , A61K31/19 , A61K31/44 , A61K31/505 , A61K31/381 , A61K31/47
CPC分类号： C07D209/48 , C07C257/18 , C07C311/49 , C07C317/14 , C07C317/44 , C07C337/06 , C07D209/08 , C07D213/30 , C07D213/54 , C07D213/71 , C07D213/77 , C07D213/80 , C07D213/82 , C07D213/86 , C07D213/87 , C07D213/89 , C07D215/38 , C07D233/90 , C07D237/20 , C07D239/28 , C07D239/42 , C07D249/18 , C07D257/04 , C07D295/32 , C07D307/68 , C07D333/24 , C07D471/04
摘要： A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.
摘要翻译：由下列通式（1）表示的化合物或其盐或其水合物是安全的，同时具有合适的物理化学稳定性，并且可用作与血栓形成相关的疾病的治疗或预防剂。其中R 1a，R 1b，R 1c和R 1d各自独立地表示氢等， O 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等，Z 1，Z 2， Z 3和Z 3各自独立地表示氢等，Z 4表示氢等，X表示单键或-CO-等。

7. 发明申请

US20070225332A1 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 失效
标题翻译：新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用
公开(公告)号：US20070225332A1
公开(公告)日：2007-09-27
申请号：US11675410
申请日：2007-02-15
申请人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
发明人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/42 , C07D417/14 , C07D413/02
CPC分类号： C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译：本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。

8. 发明申请

US20070100177A1 Fuel compositions 有权
标题翻译：燃料组成
公开(公告)号：US20070100177A1
公开(公告)日：2007-05-03
申请号：US11506273
申请日：2006-08-11
申请人： Richard Clark , John Davenport , Jurgen Louis
发明人： Richard Clark , John Davenport , Jurgen Louis
IPC分类号： C10L1/08
CPC分类号： C10L10/02 , C10L10/12 , Y10S208/95
摘要： Fuel composition containing a blend of a non-Fischer-Tropsch derived, preferably petroleum derived, diesel base fuel and a Fischer-Tropsch derived kerosene fuel product, optionally together with a Fischer-Tropsch derived gas oil is provided. The Fischer Tropsch derived kerosene fuel product may be included for the purpose of improving the performance of a combustion engine or vehicle which is running or is intended to be run on the fuel composition. It may also be used to reduce vehicle emissions and/or improve the cold flow performance of the composition and/or increase the cetane number of the composition.
摘要翻译：提供了包含非费 - 托衍生，优选石油衍生的柴油基础燃料和费 - 托衍生的煤油燃料产物的混合物的燃料组合物，任选地与费 - 托衍生的瓦斯油一起。可以包括费托衍生的煤油燃料产品，目的是改善运行或预期在燃料组合物上运行的内燃机或车辆的性能。它还可用于减少车辆排放和/或改善组合物的冷流性能和/或增加组合物的十六烷值。

9. 发明申请

US20050245592A1 2-Iminopyrrolidine derivatives 审中-公开
标题翻译： 2-亚氨基吡咯烷衍生物
公开(公告)号：US20050245592A1
公开(公告)日：2005-11-03
申请号：US11158941
申请日：2005-06-22
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00 , C07D209/48 , C07D471/02
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译：由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

10. 发明申请

US20050014833A1 Cyclic compound and ppar agonist 失效
标题翻译：循环化合物和ppar激动剂
公开(公告)号：US20050014833A1
公开(公告)日：2005-01-20
申请号：US10486396
申请日：2002-08-16
申请人： Richard Clark , Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara
发明人： Richard Clark , Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara
IPC分类号： A61P1/00 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P19/10 , A61P29/00 , A61P35/00 , A61P37/02 , C07C233/87 , C07C251/60 , C07D213/53 , C07D263/32 , C07D277/56 , C07D307/24 , C07D307/30 , C07D317/32 , C07D339/08 , C07D405/06 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07C229/02 , A61K31/195
CPC分类号： C07D213/53 , C07C233/87 , C07C251/60 , C07C2601/02 , C07C2601/14 , C07D263/32 , C07D277/56 , C07D307/24 , C07D307/30 , C07D317/32 , C07D339/08 , C07D405/06 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R1 to R6 are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.; A1 and A2 are the same as or different from each other and each represents a single bond, an oxygen atom, etc.; L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.; W represents a carboxyl group; the partial structure represented by the formula: represents a single bond or a double bond; X represents a single bond, an oxygen atom, —NRX1CQ1O—, etc.; Y represents Y1—Y2— (wherein Y1 represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y2 represents a single bond or a 5 to 14-membered aromatic ring); and the ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.
摘要翻译：本发明提供具有优异的PPAR激动剂作用的新化合物。更具体地，它提供由下式表示的化合物，其盐，其酯或它们的水合物。其中a，b和c彼此相同或不同，各自表示0〜4; R 1〜R 6彼此相同或不同，表示氢原子，羟基，氰基，卤素原子等; A 1和A 2彼此相同或不同，各自表示单键，氧原子等; L，M和T各自表示单键，具有1〜6个碳原子的亚烷基等; W表示羧基; 由式表示的部分结构表示单键或双键; X表示单键，氧原子，-NR X 1 C 10 O等; Y表示Y 1 -Y 2 - （其中Y 1表示具有1〜4个取代基的5〜14元芳环等，Y 2表示单键或5〜14个芳环）; 并且环Z表示具有一至四个选自上述A组的取代基的5至14元芳环，可具有一个或多个杂原子并且可部分饱和。

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