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1. 发明授权

US07244730B2 2-iminopyrrolidine derivatives 有权
标题翻译： 2-亚氨基吡咯烷衍生物
公开(公告)号：US07244730B2
公开(公告)日：2007-07-17
申请号：US10475188
申请日：2002-04-19
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musya , Motoji Kogushi , Tsutomu Kawada , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musya , Motoji Kogushi , Tsutomu Kawada , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K31/535 , A61K31/40 , C07D265/30 , C07D241/04 , C07D209/44
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译：由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

2. 发明授权

US5438045A 1,4-diazepine derivative and its pharmaceutical use 失效
标题翻译： 1,4-二氮杂衍生物及其药物用途
公开(公告)号：US5438045A
公开(公告)日：1995-08-01
申请号：US52721
申请日：1993-04-27
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , A61K31/55
CPC分类号： C07D495/14
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OOO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译：公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，尤其适用于过敏性疾病。其中R 1和R 2是氢或烷基，R 3是氢或卤素，R 4是氢或烷基，X是-O-，-NHCO-，-CO-或其它，Y是环烷基，环烷基烷基，炔基等。

3. 发明授权

US5262565A Naphthalene derivatives 失效
标题翻译：萘衍生物
公开(公告)号：US5262565A
公开(公告)日：1993-11-16
申请号：US790541
申请日：1991-11-12
申请人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Takashi Inoue , Hiroshi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada
发明人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Takashi Inoue , Hiroshi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada
IPC分类号： A61K31/165 , A61K31/19 , A61K31/192 , A61K31/197 , A61K31/215 , A61K31/22 , A61K31/222 , A61K31/275 , A61P19/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07C39/40 , C07C43/20 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/84 , C07C59/90 , C07C69/157 , C07C69/734 , C07C69/738 , C07C235/34 , C07C251/48 , C07C255/41 , C07C62/06 , C07C69/76
CPC分类号： C07C255/41 , C07C251/48 , C07C39/40 , C07C43/202 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/738 , C07C2101/08
摘要： Compounds of the formula: ##STR1## where R.sup.1 is a hydrogen atom or a lower alkyl group;R.sub.2 is a lower alkoxy group;R.sub.3 is a hydroxyl or lower alkoxy group;Z is represented by the formula: ##STR2## where R.sub.2 and R.sub.3 may be the same or different from each other and each stands for a hydrogen atom or a lower alkyl;Y is represented by the formula: --(CH.sub.2).sub.n -- where n is 0 or an integer of 1 to 2 or a group represented by the formula: ##STR3## where R.sup.2 and R.sup.3 may be the same or different from each other and each stands for a lower alkyl group; andR.sup.4 represents a group of the formula: ##STR4## where p is 0 or an integer of 1 to 3 and R.sup.12 is hydrogen, a halogen atom, a lower alkyl or a lower alkoxy group a hydrogen atom, R.sup.2 is a methoxy group, R.sup.3 is a hydroxy group and R.sup.4 is a benzyl group having anti-inflammatory activity.

4. 发明申请

US20070229087A1 Ion Balance Sensor 审中-公开
标题翻译：离子平衡传感器
公开(公告)号：US20070229087A1
公开(公告)日：2007-10-04
申请号：US11596890
申请日：2005-06-01
申请人： Kazuo Okano
发明人： Kazuo Okano
IPC分类号： G01N27/62
CPC分类号： G01R29/24 , G01N27/4148 , G01R29/12
摘要： To enable accurate detection of ion balance with a simple configuration, thereby enabling small size and reduction of a manufacturing cost, and detection of the ion balance near the surface of an object to be discharged. An ion balance sensor includes an antenna 20 charged with positive ions or negative ions, and a normally-on type MOSFET 11 in which a gate electrode G is connected to the antenna 20, an ion balance-detecting resistance R is connected between a grounded source electrode S and the gate electrode G, and a DC power source VDS and a load resistance RL are serially connected between the source electrode S and a drain electrode D. A voltage of the gate electrode G is changed due to a voltage drop by a current flowing between the charged antenna 20 and an earth via the ion balance-detecting resistance R, and a change of drain current due to the voltage of the gate electrode G is detected, thereby detecting positive and negative balance of ions used for charging the antenna 20.
摘要翻译：为了能够以简单的结构精确地检测离子平衡，从而能够实现小尺寸并降低制造成本，并且检测待排出物体表面附近的离子平衡。离子平衡传感器包括充有正离子或负离子的天线20以及其中栅电极G连接到天线20的常导型MOSFET 11，离子平衡检测电阻R连接在接地源电极S和栅极电极G以及直流电源V DS DS和负载电阻R L L串联连接在源电极S和漏电极D之间。栅电极G的电压由于通过经过离子平衡检测电阻R而在充电天线20与地之间流动的电流的电压下降而变化，并且由于栅电极G的电压引起的漏极电流的变化是从而检测用于对天线20充电的离子的正和负平衡。

5. 发明申请

US20070159762A1 Corona discharge ionizer 审中-公开
标题翻译：电晕放电电离器
公开(公告)号：US20070159762A1
公开(公告)日：2007-07-12
申请号：US10587594
申请日：2005-03-31
申请人： Kazuo Okano
发明人： Kazuo Okano
IPC分类号： H02H1/00
CPC分类号： H01T19/00
摘要： To provide a corona discharge ionizer that makes it possible to use a piezoelectric transformer by adding an effective ion balance function with a simple structure without applying particular changes to the structure, and that realizes noise reduction. In a corona discharge ionizer 10, a control electrode 6 is disposed in a cylindrical portion of an air supply pipe 2 which also functions as a shield body and at a location where ions are balanced. When a cylindrical inner diameter of the air supply pipe 2 is defined as Ds and an annular outer diameter of the control electrode 6 is defined as Dc, 2Dc
摘要翻译：提供一种电晕放电电离器，其可以通过以简单的结构添加有效的离子平衡功能而使用压电变压器，而不对结构进行特别的改变，并且实现降噪。在电晕放电电离器10中，控制电极6设置在空气供给管2的圆筒部，空气供给管2也用作屏蔽体，并且在离子平衡的位置。当供气管2的圆筒形内径被定义为Ds且控制电极6的环形外径被定义为Dc时，满足2Dc

6. 发明申请

US20050004197A1 2-iminoimidazole derivatives (2) 失效
标题翻译： 2-亚氨基咪唑衍生物（2）
公开(公告)号：US20050004197A1
公开(公告)日：2005-01-06
申请号：US10475118
申请日：2002-04-19
申请人： Shichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumuhiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukuda , Fumiyoshi Maatsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-Ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumuhiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukuda , Fumiyoshi Maatsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-Ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00 , A61K31/4172
CPC分类号： C07D209/44
摘要： A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.
摘要翻译：由下式表示的2-亚氨基咪唑衍生物：其中R 1，R 2和R 3表示氢，任选取代的C 1-6烷基等; R 6表示氢，C 1-6烷基，C 1-6烷氧羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 并且Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基，C 1-6烷氧基等，R 11和R 12 >或R 12和R 13可以键合在一起形成5-至8-元杂环等}或其盐。

7. 发明授权

US5064848A Benzophenone oxime ether compounds, pharmaceutical compositions and treatment methods 失效
标题翻译：苯并噻吩醚化合物，药物组合物和治疗方法
公开(公告)号：US5064848A
公开(公告)日：1991-11-12
申请号：US518816
申请日：1990-05-04
申请人： Youji Yamagishi , Kozo Akasaka , Takeshi Suzuki , Mitsuaki Miyamoto , Kouji Nakamoto , Kazuo Okano , Shinya Abe , Hironori Ikuta , Kenji Hayashi , Hiroyuki Yoshimura , Tohru Fujimori , Koukichi Harada , Isao Yamatsu
发明人： Youji Yamagishi , Kozo Akasaka , Takeshi Suzuki , Mitsuaki Miyamoto , Kouji Nakamoto , Kazuo Okano , Shinya Abe , Hironori Ikuta , Kenji Hayashi , Hiroyuki Yoshimura , Tohru Fujimori , Koukichi Harada , Isao Yamatsu
IPC分类号： C07C57/42 , A61K31/15 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/277 , A61K31/33 , A61P7/02 , A61P9/08 , A61P9/10 , C07C51/00 , C07C59/64 , C07C67/00 , C07C69/618 , C07C231/00 , C07C231/02 , C07C233/01 , C07C233/02 , C07C233/11 , C07C235/14 , C07C235/34 , C07C237/20 , C07C239/00 , C07C241/00 , C07C251/40 , C07C251/60 , C07C253/00 , C07C253/30 , C07C255/04 , C07C255/32 , C07C255/34 , C07C255/37 , C07C255/41 , C07C255/61 , C07C255/62 , C07C257/04 , C07C257/06 , C07C257/10 , C07C257/18 , C07C301/00 , C07C303/38 , C07C311/00 , C07C311/13 , C07C311/15 , C07C311/17 , C07C325/00 , C07C327/00 , C07C327/58 , C07D207/46 , C07D213/40 , C07D213/72 , C07D213/75 , C07D249/12 , C07D257/04 , C07D339/08 , C07D521/00
CPC分类号： C07D257/04 , C07C235/14 , C07C235/34 , C07C251/40 , C07C251/60 , C07C255/00 , C07C255/41 , C07C255/62 , C07C257/06 , C07C257/18 , C07C311/13 , C07C311/17 , C07C327/58 , C07C59/64 , C07D207/46 , C07D213/40 , C07D213/75 , C07D231/12 , C07D233/56 , C07D249/08 , C07D339/08
摘要： A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.
摘要翻译：二苯基甲烷衍生物。式（I）为新的（其中R 1和R 2各自为H，OH或低级烷氧基; U = -C XY或= NOW; X = H，CN或-COR 6; R 6 = OH或NH 2; Y = COOR 3，-CONR 4 R 5，-CH 2 NHSO 2 -C 6 H 5或-C（R 8）= NR 7; R 3 = H或低级烷氧基; R 10 =支链1-3C亚烷基; R 4和R 5各自为H，低级烷基或低级芳基烷基; 低级烷氧基或芳基; R8 = -VR9; V = O，S或N; R9 =烷基或芳基; W = -CH2-CO-CH2-COOR13，-CH2-C（= NOR14）-CH2-COOR15，-CH （CN） - （CH 2）q -COOR 16或 - （CH 2）pZ; R 13 = H或低级烷基; R 14 =低级烷基; R 15 = H或低级烷基; R 16 = H或低级烷基; q = = -SH，-SCN或衍生自5-或6-元环选择的单价gp，通过环中具有1个或更多个S的环; p = 1或2。

8. 发明授权

US4954523A Benzophenone oxime ether compounds, pharmaceutical compositions and treatment methods 失效
标题翻译：二苯甲酮肟醚化合物，药物组合物和处理方法
公开(公告)号：US4954523A
公开(公告)日：1990-09-04
申请号：US364712
申请日：1989-06-09
申请人： Youji Yamagishi , Kozo Akasaka , Takeshi Suzuki , Mitsuaki Miyamoto , Kouji Nakamoto , Kazuo Okano , Shinya Abe , Hironori Ikuta , Kenji Hayashi , Hiroyuki Yoshimura , Tohru Fujimori , Koukichi Harada , Isao Yamatsu
发明人： Youji Yamagishi , Kozo Akasaka , Takeshi Suzuki , Mitsuaki Miyamoto , Kouji Nakamoto , Kazuo Okano , Shinya Abe , Hironori Ikuta , Kenji Hayashi , Hiroyuki Yoshimura , Tohru Fujimori , Koukichi Harada , Isao Yamatsu
IPC分类号： C07C57/42 , A61K31/15 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/277 , A61K31/33 , A61P7/02 , A61P9/08 , A61P9/10 , C07C51/00 , C07C59/64 , C07C67/00 , C07C69/618 , C07C231/00 , C07C231/02 , C07C233/01 , C07C233/02 , C07C233/11 , C07C235/14 , C07C235/34 , C07C237/20 , C07C239/00 , C07C241/00 , C07C251/40 , C07C251/60 , C07C253/00 , C07C253/30 , C07C255/04 , C07C255/32 , C07C255/34 , C07C255/37 , C07C255/41 , C07C255/61 , C07C255/62 , C07C257/04 , C07C257/06 , C07C257/10 , C07C257/18 , C07C301/00 , C07C303/38 , C07C311/00 , C07C311/13 , C07C311/15 , C07C311/17 , C07C325/00 , C07C327/00 , C07C327/58 , C07D207/46 , C07D213/40 , C07D213/72 , C07D213/75 , C07D249/12 , C07D257/04 , C07D339/08 , C07D521/00
CPC分类号： C07D257/04 , C07C235/14 , C07C235/34 , C07C251/40 , C07C251/60 , C07C255/00 , C07C255/41 , C07C255/62 , C07C257/06 , C07C257/18 , C07C311/13 , C07C311/17 , C07C327/58 , C07C59/64 , C07D207/46 , C07D213/40 , C07D213/75 , C07D231/12 , C07D233/56 , C07D249/08 , C07D339/08
摘要： A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower aralalkyl, --CH2--NHSO3--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.
摘要翻译：二苯基甲烷衍生物。式（I）为新的（其中R 1和R 2各自为H，OH或低级烷氧基; U = -C XY或= NOW; X = H，CN或-COR 6; R 6 = OH或NH 2; Y = COOR 3，-CONR 4 R 5，-CH 2 NHSO 2 -C 6 H 5或-C（R 8）= NR 7; R 3 = H或低级烷氧基; R 10 =支链1-3C亚烷基; R 4和R 5各自为H，低级烷基或低级芳基烷基; 低级烷氧基或芳基; R8 = -VR9; V = O，S或N; R9 =烷基或芳基; W = -CH2-CO-CH2-COOR13，-CH2-C（= NOR14）-CH2-COOR15，-CH （CN） - （CH 2）q -COOR 16或 - （CH 2）pZ; R 13 = H或低级烷基; R 14 =低级烷基; R 15 = H或低级烷基; R 16 = H或低级烷基; q = = -SH，-SCN或衍生自5-或6-元环选择的单价gp，通过环中具有1个或更多个S的环; p = 1或2。

9. 发明申请

US20050245592A1 2-Iminopyrrolidine derivatives 审中-公开
标题翻译： 2-亚氨基吡咯烷衍生物
公开(公告)号：US20050245592A1
公开(公告)日：2005-11-03
申请号：US11158941
申请日：2005-06-22
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00 , C07D209/48 , C07D471/02
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译：由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

10. 发明授权

US5382579A Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals 失效
标题翻译：三氮唑-1,4-二氮杂衍生物及其在药物中的应用
公开(公告)号：US5382579A
公开(公告)日：1995-01-17
申请号：US751632
申请日：1991-08-26
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译：公开了以下给定式的三唑并-1,1-吖庚因化合物及其药理学上可接受的盐，并且在制药领域尤其是过敏性疾病中有用。和其中R 1和R 2为氢或烷基，R 3为氢或卤素，R 4为氢或烷基，X为-OCO - ， - NHCO - ， - CO-或其它物质的

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