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1. 发明授权

US5993441A Control of photorefractive keratectomy 失效
$Control of photorefractive keratectomy$
标题翻译：控制光折射角膜切除术
公开(公告)号：US5993441A
公开(公告)日：1999-11-30
申请号：US695673
申请日：1996-08-08
申请人： David F. Muller , Alex C. Sacharoff , Peter J. Klopotek
发明人： David F. Muller , Alex C. Sacharoff , Peter J. Klopotek
IPC分类号： A61B17/00 , A61B19/00 , A61F9/01 , A61N5/06
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00808 , A61B2017/00017 , A61B2017/00176 , A61B2017/00181 , A61B2017/00194 , A61B90/30 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/00895
摘要： A method and system are described for performing photorefractive keratectomy procedure employing pulses of photoablative radiation to selectively ablate corneal tissue of a patient's eye in an ablation zone on the anterior corneal surface to produce a desired refractive correction in the corneal tissue. The method and system employ control of the effect of ocular fluid at the corneal surface so as to reduce the disturbance of such fluid on the desired ablation process while maintaining hydration of the corneal tissue. Controlling the average repetition rate of the radiation pulses applied to the corneal surface so as to reduce intrapulse fluid accumulation at the corneal surface without dehydrating the corneal tissue, selecting an increased fluence level of the pulse applied to the corneal surface to reduce the effect of fluid accumulation at the corneal surface, and applying evaporative energy to the site of incidence of a pulse of an ablative beam prior to incidence of said pulse at said site are shown as ways to effect this control. Application of the new method and system to wide area ablation techniques and to scanning techniques are described Reduction of irregularities when ablating large areas, e.g., grater than 5.5 cm is made possible in either case.
摘要翻译：描述了一种用于进行光折射角膜切除术的方法和系统，其使用光消融辐射的脉冲来选择性地在前角膜表面上的消融区域中烧蚀患者眼睛的角膜组织，以在角膜组织中产生期望的屈光矫正。该方法和系统采用对角膜表面上的眼液的影响的控制，以便在保持角膜组织的水合作用的同时减少所需消融过程中的这种流体的干扰。控制施加到角膜表面的辐射脉冲的平均重复率，以减少角膜表面的脉冲内液体积聚，而不会使角膜组织脱水，选择施加到角膜表面的脉冲的增加的注量水平以减少流体的影响在所述位置处的所述脉冲入射之前，在角膜表面积聚并将蒸发能量施加到烧蚀光束的脉冲的入射部位被示出为实现该控制的方式。描述了将新方法和系统应用于广域消融技术和扫描技术的描述。在任何一种情况下，当切割大面积（例如，大于5.5cm）时，减少不规则性成为可能。

2. 发明授权

US5196006A Method and apparatus for excision endpoint control 失效
标题翻译：切除终点控制的方法和装置
公开(公告)号：US5196006A
公开(公告)日：1993-03-23
申请号：US773781
申请日：1991-10-10
申请人： Peter J. Klopotek , Alex C. Sacharoff , Richard G. Caro
发明人： Peter J. Klopotek , Alex C. Sacharoff , Richard G. Caro
IPC分类号： A61B17/00 , A61B19/00 , A61F9/008 , A61F9/01 , A61F9/013
CPC分类号： A61F9/013 , A61F9/00804 , A61B2017/00106 , A61B2090/062 , A61F2009/00844 , A61F2009/00872
摘要： Methods and apparatus for determining the depth of excision generated by a material removal process, for determining the thickness of unablated material below the excision or incision, and for providing endpoint control of a material removal process utilize acoustic transducers for measuring the time delay between a first acoustic pulse resulting from material removal and a second acoustic pulse reflected from a distal surface or boundary layer of the material. The time delay between the two pulses detected by the transducer provides a measure of excision depth and of the depth of material below the excision. Endpoint control is provided by terminating material removal when a selected excision depth is detected. The invention can be used, for example, as a real-time monitor of excision depth and residual lamella thickness under the excision during laser corneal surgery.
摘要翻译：用于确定通过材料去除过程产生的切除深度的方法和装置，用于确定在切除或切口下方的未消耗材料的厚度，以及用于提供材料去除过程的端点控制，利用声换能器来测量第一从材料去除产生的声脉冲和从材料的远端表面或边界层反射的第二声脉冲。由换能器检测到的两个脉冲之间的时间延迟提供切除深度和切除深度以下的材料的度量。当检测到所选择的切除深度时，通过终止材料去除来提供端点控制。本发明可用于例如激光角膜手术切除时的切除深度和残余薄片厚度的实时监测。

3. 发明授权

US5437658A Method and system for laser thermokeratoplasty of the cornea 失效
标题翻译：角膜激光热机器人成形术的方法与系统
公开(公告)号：US5437658A
公开(公告)日：1995-08-01
申请号：US957702
申请日：1992-10-07
申请人： David F. Muller , Alex C. Sacharoff
发明人： David F. Muller , Alex C. Sacharoff
IPC分类号： A61F9/007 , A61F9/01 , A61N5/06
CPC分类号： A61F9/00821 , A61F2009/00844 , A61F2009/00853 , A61F2009/00872
摘要： The invention is a system and method for modifying the corneal curvature by irradiating the cornea to deliver thermal energy to the stroma. The system includes multiple irradiation ports for introducing electromagnetic radiation of a wavelength suitable for absorption in the stroma; positioning means, such as a hemi-spherical dome with several tracks for positioning the irradiation ports, respectively, at locations of a preselected geometric pattern relative to the pretreated cornea, the geometric pattern being selected to correspond to a desired modified shape of the cornea; transmission means adapted to deliver controlled amounts of the radiation from a radiation source to each of the irradiation ports; and the irradiation ports, positioned at the locations of the geometric pattern, constructed to introduce the radiation to treatment volumes of the stroma in a cooperative manner to induce desired shrinkage of the collagenous stromal tissue and cause change in the corneal curvature. Each treatment volume, formed by a radiation pattern emanating from one irradiation port or by intersection of radiation patterns emanating from multiple irradiation ports, is created in a controllable manner to have a desired volume and energy profile. The transmission means that includes fiber optic waveguides are connected to distribution means for dispensing controlled amounts of the radiation to each of the fiber optic waveguides. The system also includes inspection means for observing and evaluating the shrinkage of collagenous tissue.
摘要翻译：本发明是通过照射角膜以将热能传递给基质来改变角膜曲率的系统和方法。该系统包括用于引入适于吸收在基质中的波长的电磁辐射的多个辐射端口; 定位装置，例如具有多个轨道的半球形穹顶，分别用于将照射端口定位在相对于预处理的角膜的预选几何图案的位置处，几何图案被选择为对应于期望的角膜修改形状; 传输装置，适于将辐射源的辐射的受控量传送到每个照射端口; 并且位于几何图案位置处的照射端口被构造成以协作的方式将辐射引入基质的治疗体积，以引起胶原性基质组织的期望收缩并引起角膜曲率的变化。通过从一个照射端口发出的辐射图形或通过从多个照射端口发出的辐射图的相交形成的每个处理体积以可控的方式产生以具有期望的体积和能量分布。包括光纤波导的传输装置连接到分配装置，用于将受控量的辐射分配给每个光纤波导。该系统还包括用于观察和评估胶原组织收缩的检查装置。

4. 发明授权

US06805698B2 Microkeratome blade 有权
公开(公告)号：US06805698B2
公开(公告)日：2004-10-19
申请号：US10114808
申请日：2002-04-03
申请人： Jeffrey T. Shimmel , Alex C. Sacharoff , George A. Kocar , Peter Austin
发明人： Jeffrey T. Shimmel , Alex C. Sacharoff , George A. Kocar , Peter Austin
IPC分类号： A61F500
CPC分类号： A61F9/0133 , A61F9/013
摘要： A microkeratome blade for use for the removal of the epithelial layer and underlying Basement Membrane while leaving a smooth and undisturbed Bowman's Membrane in preparation for a laser refractive surgical procedure. The blade is capable of cutting through the epithelial layer and Basement Membrane, but not capable of cutting through Bowman's Membrane.

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