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1. 发明申请

US20080038207A1 Method and device for decreasing contamination 有权
公开(公告)号：US20080038207A1
公开(公告)日：2008-02-14
申请号：US11827031
申请日：2007-07-10
申请人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
发明人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
IPC分类号： A61K31/70 , A01N37/18
CPC分类号： A61B5/097 , G01N33/497
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as “over producers”, “super-producers”, or “superspreaders”). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

2. 发明申请

US20050207983A1 Formulations decreasing particle exhalation 审中-公开
标题翻译：减少颗粒呼气的配方
公开(公告)号：US20050207983A1
公开(公告)日：2005-09-22
申请号：US10990996
申请日：2004-11-17
申请人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
发明人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K9/00 , A61K47/02 , A61L9/04 , A61K31/70 , A61K31/715 , A61K38/17 , A61K48/00
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

3. 发明申请

US20070270502A1 Formulations decreasing particle exhalation 有权
标题翻译：减少颗粒呼气的配方
公开(公告)号：US20070270502A1
公开(公告)日：2007-11-22
申请号：US11714999
申请日：2007-03-06
申请人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
发明人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K47/00
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

4. 外观设计

USD631538S1 Food inhaler 有权
标题翻译：食物吸入器
公开(公告)号：USD631538S1
公开(公告)日：2011-01-25
申请号：US29334903
申请日：2009-04-03
申请人： David A. Edwards , Jonathan Jacques Kamler , Jonathan Man , Jose Sanchez
设计人： David A. Edwards , Jonathan Jacques Kamler , Jonathan Man , Jose Sanchez

5. 发明授权

US09179691B2 Delivering aerosolizable food products 有权
标题翻译：提供可雾化的食品
公开(公告)号：US09179691B2
公开(公告)日：2015-11-10
申请号：US12747703
申请日：2008-10-08
申请人： David A. Edwards , Jonathan Man , Jonathan Jacques Kamler , José Sanchez
发明人： David A. Edwards , Jonathan Man , Jonathan Jacques Kamler , José Sanchez
IPC分类号： A61M11/00 , A24F7/00 , A23G1/50 , A23G1/30
CPC分类号： A23G1/505 , A23G1/305 , A23G1/50 , A24F7/00 , A61M11/001 , A61M11/005
摘要： Aerosolized food products can be of sufficient size to deposit in the mouth without easily entering into the respiratory tract and of small enough size so as to allow for suspension in air. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a matter suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel manner of delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles of sufficient size to deposit in the mouth without substantial exposure or entry into the respiratory tract and of small enough size so as to allow for suspension in air.
摘要翻译：气溶胶食品可以具有足够的尺寸以沉积在口中，而不会容易地进入呼吸道和足够小的尺寸，以便允许在空气中悬浮。包含烟雾发生装置和食品的装置可以允许食物的雾化和其在适于吸入或沉积和随后摄入的物质中的输送。食物输送装置代表向食物和动物口中传送食物的新颖方式。实际上，本发明的装置被设计成产生，运输和引导足够尺寸的雾化的食物颗粒，以便在口中沉积而不会大量暴露于或进入呼吸道并且具有足够小的尺寸以允许在空气中悬浮。

6. 外观设计

USD659819S1 Food inhaler 有权
标题翻译：食物吸入器
公开(公告)号：USD659819S1
公开(公告)日：2012-05-15
申请号：US29352274
申请日：2009-12-18
申请人： David A. Edwards , Jóse Sanchez , Jonathan Man , Jonathan Jacques Kamler
设计人： David A. Edwards , Jóse Sanchez , Jonathan Man , Jonathan Jacques Kamler

7. 发明申请

US20120114809A1 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可溶性食品
公开(公告)号：US20120114809A1
公开(公告)日：2012-05-10
申请号：US13132469
申请日：2009-12-03
申请人： David A. Edwards , Jonathan Man , Jonathan Jacques Kamler , Jose Sanchez , Marc Bretillot
发明人： David A. Edwards , Jonathan Man , Jonathan Jacques Kamler , Jose Sanchez , Marc Bretillot
IPC分类号： B65D83/14 , A23P1/16
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译：确定粒度范围的气溶胶食品悬浮在空气中并沉积在口中，而不会容易地进入呼吸道。包含烟雾发生装置和食品的装置可以允许以适合于吸入或沉积并随后摄取的方式使食品雾化和输送。食物输送装置代表将食物输送到人类和动物口腔的新颖手段。实际上，本发明的装置被设计成生产，运输和引导悬浮在空气中的确定尺寸范围的雾化食物颗粒，以便沉积在口中而不会大量暴露或进入呼吸道。

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